CRH as a Predictor of Preterm Birth in Minority Women
Open accessAbstract
Objective: To determine the predictive capability of corticotropin-releasing hormone (CRH) as a biomarker of preterm birth (PTB) in minority women. Study Design: Venous blood samples were obtained at 22–24 weeks’ gestation in a prospective, descriptive study of 707 minority women experiencing low-risk pregnancies. CRH was analyzed using a radioimmunoassay and methanol extraction protocol. Result: CRH predicted PTB in both African American and Hispanic women. The odds ratio was 1.8 times greater for having a PTB if the CRH level was >24 pg/ml. The median CRH for African American women having a PTB was 46.6 pg/ml and for Hispanic women was 35.03 pg/ml. Using a receiver–operating characteristic curve, the threshold for CRH among the African American women was 30.6 pg/ml and among the Hispanic women was 27.4 pg/ml. Conclusion: CRH may be an important biomarker for predicting PTB in minority women, especially when combined with other predictors.
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Increases of CRH early in pregnancy have predicted the onset of preterm labor.
“Increases of CRH early in pregnancy have predicted the onset of preterm labor in ours and other’s results [20–25].”
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- Authors
- Ruiz, R. J., Gennaro, S., O’Connor, C., Dwivedi, A., Gibeau, A., Keshinover, T., & Welsh, T.
- Affiliations
- Texas A&M Health Science Center (US)
- Boston College (US)
- Jacobi Medical Center (US)
- Columbia University Irving Medical Center (US)
- Lincoln Medical Center (US)
- Corresponding author
- Ruiz, R. Jeanne
- Venue
- Biological Research For Nursing
- Publisher
- SAGE Publications
- Published
- 2015-10-27
- Volume
- 18
- Issue
- 3
- Pages
- 316-321
- ISSN
- 1099-8004 (ISSN-L)
- 1552-4175
- PMC
- PMC5384468
- OpenAlex
- W1887190699
- Cited by
- 33
- References
- 28
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 2 · 2023: 4 · 2022: 4 · 2021: 6 · 2020: 5 · 2019: 3 · 2018: 1 · 2017: 2
- FWCI
- 0.78
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Biological Research For Nursing (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Nursing Research (R01NR010552, R01NR007891)
- Topics
- Health Sciences › Medicine › Epidemiology › Preterm Birth and Chorioamnionitis
- Health Sciences › Medicine › Obstetrics and Gynecology › Maternal and Perinatal Health Interventions
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Infant Development and Preterm Care
- Keywords
- corticotropin-releasing factor, preterm birth, biomarkers, minority women, African American women, Hispanic women, low-risk pregnancy, preterm birth prediction, early pregnancy
- MeSH terms
- Adult, Corticotropin-Releasing Hormone, Female, Gestational Age, Humans, Infant, Newborn, Minority Groups, Pregnancy, Pregnancy Trimester, Third, Prospective Studies, Fetal Development, Premature Birth
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