The DOI matches its Crossref record; 106 of the 106 references it cites were found in a registry or an index.
Cesarean section and development of the immune system in the offspring
Abstract
This review examines the relation between the mode of delivery and development of the immune system in the offspring. Recent epidemiological studies provide evidence that elective cesarean section (CS) is associated with aberrant short-term immune responses in the newborn infant, and a greater risk of developing immune diseases such as asthma, allergies, type 1 diabetes, and celiac disease. However, it is still unknown whether CS causes a long-term effect on the immune system of the offspring that contributes to compromised immune health. With the dramatic increase in the rate of CS today, a greater emphasis should be placed on the discussion among both professionals and childbearing women on potential consequences of CS on the health of the offspring.
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“established links between cesarean birth and adverse child health outcomes, including asthma, type I diabetes, allergies9–11 and obesity12”
From The relation between cesarean birth and child cognitive development (2017) · cites this paper as [10]
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Cites
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The composition of the gut microbiota throughout life, with an emphasis on early life
Rodríguez, J. M., Murphy, K., Stanton, C., Ross, R. P., Kober, O. I., Juge, N., Avershina, E., Rudi, K., Narbad, A., Jenmalm, M. C., et al. (2015) · Microbial Ecology in Health and Disease · doi:10.3402/mehd.v26.26050 · Cited by 1,414
“a risk factor for allergy development (124, 127), was asso-”
BackgroundPsychobiotics: A novel class of psychotropic
Dinan, T. G., Stanton, C., & Cryan, J. F. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.05.001 · Cited by 1,287
Minireview: Gut microbiota: The neglected endocrine organ
Clarke, G., Stilling, R. M., Kennedy, P. J., Stanton, C., Cryan, J. F., & Dinan, T. G. (2014) · Molecular Endocrinology · doi:10.1210/me.2014-1108 · Cited by 1,192
“Whether or not cesarean section delivery affects the subsequent endocrine capacity of the gut microbiota is uncertain but likely, and higher rates of diabetes in such children have been established (26).”
BackgroundCesarean Section and Chronic Immune Disorders
Sevelsted, A., Stokholm, J., Bønnelykke, K., & Bisgaard, H. (2015) · PEDIATRICS · doi:10.1542/peds.2014-0596 · Cited by 482
The microbiome: stress, health and disease
Moloney, R. D., Desbonnet, L., Clarke, G., Dinan, T. G., & Cryan, J. F. (2014) · Mammalian Genome · doi:10.1007/s00335-013-9488-5 · Cited by 430
“…of microbiota composition, infants delivered by Caesareansection are more likely to suffer from allergies, asthma and diabetes later in life (Cho and Norman 2013; Relman 2012; Romero and Korzeniewski 2013), highlighting that the early life environment is fundamental in the development of a…”
Background
Metadata
- Authors
- Cho, C. E., & Norman, M.
- Affiliations
- University of Toronto (CA)
- Karolinska Institutet (SE)
- Corresponding author
- Cho, Clara E.
- Venue
- American Journal of Obstetrics and Gynecology
- Publisher
- Elsevier BV
- Published
- 2013-04
- Volume
- 208
- Issue
- 4
- Pages
- 249-254
- ISSN
- 0002-9378 (ISSN-L)
- OpenAlex
- W2069680673
- Cited by
- 301
- References
- 105
- Citations by year
- 2026: 9 · 2025: 12 · 2024: 17 · 2023: 11 · 2022: 15 · 2021: 26 · 2020: 28 · 2019: 28 · 2018: 40 · 2017: 27 · 2016: 26 · 2015: 29 · 2014: 21 · 2013: 10
- FWCI
- 3.23
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- American Journal of Obstetrics and Gynecology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Obstetrics and Gynecology › Maternal and Perinatal Health Interventions
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Keywords
- cesarean section, mode of delivery, immune system development, asthma, allergy, type 1 diabetes, celiac disease, immune disorders, offspring health
- MeSH terms
- Adult, Animals, Cesarean Section, Child, Child, Preschool, Female, Humans, Immune System, Immune System Diseases, Infant, Infant, Newborn, Pregnancy, Risk Factors, Rats
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