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Cited by 22Pregnancy and preeclampsia studiesCardiovascular Issues in PregnancyMaternal and fetal healthcare

Is stillbirth associated with long-term atherosclerotic morbidity?

Pariente, Gali, Shoham-Vardi, Ilana, Kessous, Roy, Sergienko, Ruslan, Sheiner, Eyal·2014·American Journal of Obstetrics and Gynecology
DOI 10.1016/j.ajog.2014.07.032
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Abstract

Objective The purpose of this study was to investigate whether women who experienced at least 1 stillbirth are at increased risk for subsequent maternal long-term atherosclerotic morbidity.Study design We conducted a population-based study that compared the incidence of long-term atherosclerotic morbidity in a cohort of women with and without previous stillbirth. Deliveries occurred during a 25-year period. Patients with known cardiovascular or renal disease before the index pregnancy were excluded from the study. Kaplan-Meier survival curves were used to estimate the cumulative incidence of cardiovascular- and renal-related hospitalizations. Cox proportional hazards models were used to estimate the adjusted hazards ratio for cardiovascular- and renal-related hospitalizations.Results Of 99,280 deliveries that met the inclusion criteria, 1879 deliveries (1.9%) occurred in patients who had had at least 1 stillbirth. After stillbirth, patients had a significantly higher cumulative incidence of cardiovascular and renal morbidity (Kaplan-Meier survival curve). During the follow-up period, patients with at least 1 stillbirth had higher rates of total cardiovascular and renal hospitalizations and had higher rates of simple and complex cardiovascular events. A significant stepwise increase was found between the number of stillbirths and future risk for cardiovascular morbidity. In a Cox proportional hazards model that was adjusted for confounders, previous stillbirth was associated independently with atherosclerotic morbidity.Conclusion Stillbirth is an independent risk factor for long-term maternal atherosclerotic morbidity. The risk is higher for patients with recurrent episodes of stillbirth.

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  • Prior studies reporting an increased risk of ischemic heart disease, stroke, and hypertension following preeclamptic pregnancy had between a 10- to 15-year follow-up period for most outcomes.

    “Finally, the follow-up for most of the studies may have been too short to find a meaningful difference in CVD outcomes among young women; as an example, prior studies reporting an increased risk of ischemic heart disease, stroke, and hypertension following preeclamptic pregnancy had between a 10-to 15-year follow-up period for most outcomes (6).”

    From Cardiovascular Risk Following Fertility Therapy (2017) · cites this paper as [6]

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Authors
Pariente, G., Shoham-Vardi, I., Kessous, R., Sergienko, R., & Sheiner, E.
Affiliations
Ben-Gurion University of the Negev (IL)
Corresponding author
Pariente, Gali
ORCID
Venue
American Journal of Obstetrics and Gynecology
Publisher
Elsevier BV
Published
2014-10
Volume
211
Issue
4
Pages
416.e1-416.e12
ISSN
0002-9378 (ISSN-L)
DOI
10.1016/j.ajog.2014.07.032
OpenAlex
W2057546279
Cited by
22
References
31
Citations by year
2026: 1 · 2025: 1 · 2024: 2 · 2022: 2 · 2021: 1 · 2020: 2 · 2019: 2 · 2018: 2 · 2017: 3 · 2016: 4 · 2015: 2
FWCI
3.19
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • American Journal of Obstetrics and Gynecology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Issues in Pregnancy
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Maternal and fetal healthcare
Keywords
stillbirth, cardiovascular hospitalization, long-term maternal health, cardiovascular risk factors, pregnancy outcomes
MeSH terms
Adult, Female, Follow-Up Studies, Humans, Pregnancy, Recurrence, Retrospective Studies, Risk Factors, Incidence, Proportional Hazards Models, Case-Control Studies, Atherosclerosis, Stillbirth, Kaplan-Meier Estimate

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