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Cited by 21Pregnancy and preeclampsia studiesGlobal Maternal and Child HealthMaternal and Neonatal Healthcare

Incidence and risk factors of fetal death in Norway: a case-control study

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HELGADOTTIR, LINDA BJÖRK, SKJELDESTAD, FINN EGIL, JACOBSEN, ANNE FLEM, SANDSET, PER MORTEN, JACOBSEN, EVA‐MARIE·2011·Acta Obstetricia Et Gynecologica Scandinavica
DOI 10.1111/j.1600-0412.2011.01079.x
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Abstract

OBJECTIVE: To estimate incidence and risk factors for intrauterine fetal death (IUFD) in a Norwegian study-population applying two different control groups. DESIGN: Case-control study. SETTING: Two university hospitals in Oslo, Norway, January 1990 through December 2003. SAMPLE: The cases: 377 women with IUFD. CONTROLS: 1) all women delivering at the study-hospitals in the period (facility-based), and 2) 1 215 women with live births at one study-hospital in the period (selected). METHODS: Information from cases and selected controls was collected from medical records. Data on facility-based controls were provided by the Medical Birth Registry of Norway. Data were analyzed using chi-squared test and logistic regression. MAIN OUTCOME MEASURES: Incidence of IUFD and adjusted odds ratios of risk factors. RESULTS: The incidence was 4.1/1 000 deliveries. Small-for-gestational age (SGA) and placental abruption were the strongest risk factors for IUFD. Hypertensive disorders were of low risk if not associated with SGA. Low to moderate risk factors were pre-pregnancy diabetes mellitus, thyroid disease, placenta previa, gestational diabetes, smoking and twin pregnancy. Advanced maternal age was significant when compared with facility-based controls. Risk estimates pointed in the same direction independent of control-group. Hypertension appeared overestimated when using facility-based controls, whereas advanced age was underestimated in the analysis among selected controls. CONCLUSION: SGA has a strong association with IUFD, and the risk of hypertensive disorders is mediated through SGA. The other risk factors, except placental abruption, are of low prevalence and of limited importance in the prevention of a relatively low incidence, although dramatic, event like IUFD.

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  1. Gonen R, Lavi N, Attias D, Schliamser L, Borochowitz Z, Toubi E, Ohel G. Absence of association of inherited thrombophilia with unexplained third-trimester intrauterine fetal death. Am J Obstet Gynecol 2005; 192: 742-6.
  2. Rey E, Kahn SR, David M, Shrier I. Thrombophilic disorders and fetal loss: a meta-analysis. Lancet 2003; 361: 901-8.
  3. Robertson L, Wu O, Langhorne P, Twaddle S, Clark P, Lowe GD, Walker ID, Greaves M, Brenkel I, Regan L, Greer IA. Thrombophilia in pregnancy: a systematic review. Br J Haematol 2006; 132: 171-96.
  4. Bocciolone L, Meroni P, Parazzini F, Tincani A, Radici E, Tarantini M, Rossi E, Bianchi C, Mezzanotte C, D'Angelo A. Antiphospholipid antibodies and risk of intrauterine late fetal death. Acta Obstet Gynecol Scand 1994; 73: 389-92.
  5. Gris JC, Quere I, Monpeyroux F, Mercier E, Ripart-Neveu S, Tailland ML, Hoffet M, Berlan J, Daures JP, Mares P. Case-control study of the frequency of thrombophilic disorders in couples with late foetal loss and no thrombotic antecedent--the Nimes Obstetricians and Haematologists Study 5 (NOHA5). Thromb Haemost 1999; 81: 891-9.
  6. Woods R. Long-term trends in fetal mortality: implications for developing countries. Bull World Health Organ 2008; 86: 460-6.
  7. Martin JA, Hoyert DL. The national fetal death file. Semin Perinatol 2002; 26: 3-11.
  8. Gissler M, Mohangoo AD, Blondel B, Chalmers J, Macfarlane A, Gaizauskiene A, Gatt M, Lack N, Sakkeus L, Zeitlin J, Euro-Peristat Group. Perinatal health monitoring in Europe: results from the EURO- PERISTAT project. Informatics for health & social care 2010; 35: 64-79.
  9. McClure EM, Wright LL, Goldenberg RL, Goudar SS, Parida SN, Jehan I, Tshefu A, Chomba E, Althabe F, Garces A, Harris H, Derman RJ, Panigrahi P, Engmann C, Buekens P, Hambidge M, Carlo WA, NICHD FIRST BREATH Study Group. The global network: a prospective study of stillbirths in developing countries. Am J Obstet Gynecol 2007; 197: 247.e1-5.
  10. Froen JF, Gordijn SJ, Abdel-Aleem H, Bergsjo P, Betran A, Duke CW, Fauveau V, Flenady V, Hinderaker SG, Hofmeyr GJ, Jokhio AH, Lawn J, Lumbiganon P, Merialdi M, Pattinson R, Shankar A. Making stillbirths count, making numbers talk -issues in data collection for stillbirths. BMC Pregnancy Childbirth 2009; 9: 58.
  11. Lawn JE, Blencowe H, Pattinson R, Cousens S, Kumar R, Ibiebele I, Gardosi J, Day LT, Stanton C, Lancet's Stillbirths Series steering committee. Stillbirths: Where? When? Why? How to make the data count? Lancet 2011; 377: 1448-63.
  12. Froen JF, Cacciatore J, McClure EM, Kuti O, Jokhio AH, Islam M, Shiffman J, Lancet's Stillbirths Series steering committee. Stillbirths: why they matter. Lancet 2011; 377: 1353-66.
  13. Cousens S, Blencowe H, Stanton C, Chou D, Ahmed S, Steinhardt L, Creanga AA, Tuncalp O, Balsara ZP, Gupta S, Say L, Lawn JE. National, regional, and worldwide estimates of stillbirth rates in 2009 with trends since 1995: a systematic analysis. Lancet 2011; 377: 1319-30.
  14. Ananth CV, Liu S, Joseph KS, Kramer MS, Fetal and Infant Health Study Group of the Canadian Perinatal Surveillance System. A comparison of foetal and infant mortality in the United States and Canada. Int J Epidemiol 2009; 38: 480-9.
  15. Smith GC. Predicting antepartum stillbirth. Curr Opin Obstet Gynecol 2006; 18: 625-30.
  16. McClure EM, Nalubamba-Phiri M, Goldenberg RL. Stillbirth in developing countries. Int J Gynaecol Obstet 2006; 94: 82-90.
  17. Flenady V, Middleton P, Smith GC, Duke W, Erwich JJ, Khong TY, Neilson J, Ezzati M, Koopmans L, Ellwood D, Fretts R, Froen JF, Lancet's Stillbirths Series steering committee. Stillbirths: the way forward in high-income countries. Lancet 2011; 377: 1703-17.
  18. Fellman J, Eriksson AW. Stillbirth rates in singletons, twins and triplets in Sweden, 1869 to 2001. Twin Research & Human Genetics: the Official Journal of the International Society for Twin Studies 2006; 9: 260-5.
  19. Luo ZC, Wilkins R, Kramer MS, Fetal and Infant Health Study Group of the Canadian Perinatal Surveillance System. Effect of neighbourhood income and maternal education on birth outcomes: a population-based study. CMAJ 2006; 174: 1415-20.
  20. Parsons L, Duley L, Alberman E. Socio-economic and ethnic factors in stillbirth and neonatal mortality in the NE Thames Regional Health Authority (NETRHA) 1983. Br J Obstet Gynaecol 1990; 97: 237-44.
  21. Di Mario S, Say L, Lincetto O. Risk factors for stillbirth in developing countries: a systematic review of the literature. Sex Transm Dis 2007; 34 (7 Suppl): S11-21.
  22. Lawn J, Shibuya K, Stein C. No cry at birth: global estimates of intrapartum stillbirths and intrapartum- related neonatal deaths. Bull World Health Organ 2005; 83: 409-17.
  23. Fauveau V. New indicator of quality of emergency obstetric and newborn care. Lancet 2007; 370: 1310.
  24. Flenady V, Koopmans L, Middleton P, Froen JF, Smith GC, Gibbons K, Coory M, Gordon A, Ellwood D, McIntyre HD, Fretts R, Ezzati M. Major risk factors for stillbirth in high-income countries: a systematic review and meta-analysis. Lancet 2011; 377: 1331-40.
  25. Kalter H. Five-decade international trends in the relation of perinatal mortality and congenital malformations: stillbirth and neonatal death compared. Int J Epidemiol 1991; 20: 173-9.
  26. Smith GC, Fretts RC. Stillbirth. Lancet 2007; 370: 1715-25.
  27. Wapner RJ, Lewis D. Genetics and metabolic causes of stillbirth. Semin Perinatol 2002; 26: 70-4.
  28. Gibbs RS. The origins of stillbirth: infectious diseases. Semin Perinatol 2002; 26: 75-8.
  29. Goldenberg RL, Thompson C. The infectious origins of stillbirth. Am J Obstet Gynecol 2003; 189: 861- 73.
  30. Goldenberg RL, McClure EM, Saleem S, Reddy UM. Infection-related stillbirths. Lancet 2010; 375: 1482- 90.
  31. Collins JH. Umbilical cord accidents: human studies. Semin Perinatol 2002; 26: 79-82.
  32. Ananth CV, Berkowitz GS, Savitz DA, Lapinski RH. Placental abruption and adverse perinatal outcomes. JAMA 1999; 282: 1646-51.
  33. Owen J, Stedman CM, Tucker TL. Comparison of predelivery versus postdelivery Kleihauer-Betke stains in cases of fetal death. Am J Obstet Gynecol 1989; 161: 663-6.
  34. Flenady V, Froen JF, Pinar H, Torabi R, Saastad E, Guyon G, Russell L, Charles A, Harrison C, Chauke L, Pattinson R, Koshy R, Bahrin S, Gardener G, Day K, Petersson K, Gordon A, Gilshenan K. An evaluation of classification systems for stillbirth. BMC Pregnancy Childbirth 2009; 9: 24. CESDI -Confidental enquiry into Stillbirths and Deaths in infancy. 8th Annual Report. London, England: Maternal and Child Health Research Consortium, 2001.
  35. Korteweg FJ, Gordijn SJ, Timmer A, Holm JP, Ravise JM, Erwich JJ. A placental cause of intra-uterine fetal death depends on the perinatal mortality classification system used. Placenta 2008; 29: 71-80.
  36. Fretts RC, Usher RH. Causes of fetal death in women of advanced maternal age. Obstet Gynecol 1997; 89: 40-5.
  37. Huang DY, Usher RH, Kramer MS, Yang H, Morin L, Fretts RC. Determinants of unexplained antepartum fetal deaths. Obstet Gynecol 2000; 95: 215-21.
  38. Alessandri LM, Stanley FJ, Newnham J, Walters BN. The epidemiological characteristics of unexplained antepartum stillbirths. Early Hum Dev 1992; 30: 147-61.
  39. Cnattingius S, Haglund B, Kramer MS. Differences in late fetal death rates in association with determinants of small for gestational age fetuses: population based cohort study. BMJ 1998; 316: 1483-7.
  40. Wigglesworth JS. Monitoring perinatal mortality. A pathophysiological approach. Lancet 1980; 2: 684-6.
  41. Froen JF, Pinar H, Flenady V, Bahrin S, Charles A, Chauke L, Day K, Duke CW, Facchinetti F, Fretts RC, Gardener G, Gilshenan K, Gordijn SJ, Gordon A, Guyon G, Harrison C, Koshy R, Pattinson RC, Petersson K, Russell L, Saastad E, Smith GC, Torabi R. Causes of death and associated conditions (Codac): a utilitarian approach to the classification of perinatal deaths. BMC Pregnancy Childbirth 2009; 9: 22.
  42. Korteweg FJ, Gordijn SJ, Timmer A, Erwich JJ, Bergman KA, Bouman K, Ravise JM, Heringa MP, Holm JP. The Tulip classification of perinatal mortality: introduction and multidisciplinary inter-rater agreement. BJOG 2006; 113: 393-401.
  43. Cole SK, Hey EN, Thomson AM. Classifying perinatal death: an obstetric approach. Br J Obstet Gynaecol 1986; 93: 1204-12.
  44. Baird D, Walker J, Thomson AM. The causes and prevention of stillbirths and first week deaths. III. A classification of deaths by clinical cause; the effect of age, parity and length of gestation on death rates by cause. J Obstet Gynaecol Br Emp 1954; 61: 433-48.
  45. Whitfield CR, Smith NC, Cockburn F, Gibson AA. Perinatally related wastage--a proposed classification of primary obstetric factors. Br J Obstet Gynaecol 1986; 93: 694-703.
  46. Chan A, King JF, Flenady V, Haslam RH, Tudehope DI. Classification of perinatal deaths: development of the Australian and New Zealand classifications. J Paediatr Child Health 2004; 40: 340-7.
  47. Bound JP, Butler NR, Spector WG. Classification and causes of perinatal mortality. II. Br Med J 1956; 2: 1260-5.
  48. Hey EN, Lloyd DJ, Wigglesworth JS. Classifying perinatal death: fetal and neonatal factors. Br J Obstet Gynaecol 1986; 93: 1213-23.
  49. de Galan-Roosen AE, Kuijpers JC, van der Straaten PJ, Merkus JM. Evaluation of 239 cases of perinatal death using a fundamental classification system. Eur J Obst Gynecol Reprod Biol 2002; 103: 37-42.
  50. Winbo IG, Serenius FH, Dahlquist GG, Kallen BA. A computer-based method for cause of death classification in stillbirths and neonatal deaths. Int J Epidemiol 1997; 26: 1298-306.
  51. Winbo IG, Serenius FH, Dahlquist GG, Kallen BA. NICE, a new cause of death classification for stillbirths and neonatal deaths. Neonatal and Intrauterine Death Classification according to Etiology. Int J Epidemiol 1998; 27: 499-504.
  52. Horn LC, Langner A, Stiehl P, Wittekind C, Faber R. Identification of the causes of intrauterine death during 310 consecutive autopsies. Eur J Obst Gynecol Reprod Biol 2004; 113: 134-8.
  53. Fretts RC, Elkin EB, Myers ER, Heffner LJ. Should older women have antepartum testing to prevent unexplained stillbirth? Obstet Gynecol 2004; 104: 56-64.
  54. Cnattingius S, Forman MR, Berendes HW, Isotalo L. Delayed childbearing and risk of adverse perinatal outcome. A population-based study. JAMA 1992; 268: 886-90.
  55. Olausson PO, Cnattingius S, Haglund B. Teenage pregnancies and risk of late fetal death and infant mortality. Br J Obstet Gynaecol 1999; 106: 116-21.
  56. Little RE, Weinberg CR. Risk factors for antepartum and intrapartum stillbirth. Am J Epidemiol 1993; 137: 1177-89.
  57. Cnattingius S, Bergstrom R, Lipworth L, Kramer MS. Prepregnancy weight and the risk of adverse pregnancy outcomes. N Engl J Med 1998; 338: 147-52.
  58. Sebire NJ, Jolly M, Harris JP, Wadsworth J, Joffe M, Beard RW, Regan L, Robinson S. Maternal obesity and pregnancy outcome: a study of 287,213 pregnancies in London. Int J Obes 2001; 25: 1175-82.
  59. Flegal KM, Carroll MD, Ogden CL, Johnson CL. Prevalence and trends in obesity among US adults, 1999-2000. JAMA 2002; 288: 1723-7.
  60. Stone JL, Lockwood CJ, Berkowitz GS, Alvarez M, Lapinski R, Berkowitz RL. Risk factors for severe preeclampsia. Obstet Gynecol 1994; 83: 357-61.
  61. Ramsay JE, Ferrell WR, Crawford L, Wallace AM, Greer IA, Sattar N. Maternal obesity is associated with dysregulation of metabolic, vascular, and inflammatory pathways. J Clin Endocrinol Metab 2002; 87: 4231-7.
  62. Retnakaran R, Hanley AJ, Raif N, Connelly PW, Sermer M, Zinman B. C-reactive protein and gestational diabetes: the central role of maternal obesity. J Clin Endocrinol Metab 2003; 88: 3507-12.
  63. Nohr EA, Bech BH, Davies MJ, Frydenberg M, Henriksen TB, Olsen J. Prepregnancy obesity and fetal death: a study within the Danish National Birth Cohort. Obstet Gynecol 2005; 106: 250-9.
  64. Sharma PP, Salihu HM, Oyelese Y, Ananth CV ,Kirby RS. Is race a determinant of stillbirth recurrence? Obstet Gynecol 2006; 107: 391-7.
  65. Stephansson O, Dickman PW, Johansson AL, Cnattingius S. The influence of socioeconomic status on stillbirth risk in Sweden. Int J Epidemiol 2001; 30: 1296-301.
  66. Jorgensen T, Mortensen LH, Andersen AM. Social inequality in fetal and perinatal mortality in the Nordic countries. Scand J Publ Health 2008; 36: 635-49.
  67. Vintzileos AM, Ananth CV, Smulian JC, Scorza WE, Knuppel RA. Prenatal care and black-white fetal death disparity in the United States: heterogeneity by high-risk conditions. Obstet Gynecol 2002; 99: 483-9.
  68. Healy AJ, Malone FD, Sullivan LM, Porter TF, Luthy DA, Comstock CH, Saade G, Berkowitz R, Klugman S, Dugoff L, Craigo SD, Timor-Tritsch I, Carr SR, Wolfe HM, Bianchi DW, D'Alton ME, FASTER Trial Research Consortium. Early access to prenatal care: implications for racial disparity in perinatal mortality. Obstet Gynecol 2006; 107: 625-31.
  69. Herschel M, Hsieh HL, Mittendorf R, Khoshnood B, Covert RF, Lee KS. Fetal death in a population of black women. Am J Prev Med 1995; 11: 185-9. 100
  70. Raleigh VS, Botting B, Balarajan R. Perinatal and postneonatal mortality in England and Wales among immigrants from the Indian subcontinent. Indian J Pediatr 1990; 57: 551-62. 101
  71. Saastad E, Vangen S, Froen JF. Suboptimal care in stillbirths -a retrospective audit study. Acta Obstet Gynecol Scand 2007; 86: 444-50. 102
  72. Ravelli AC, Tromp M, Eskes M, Droog JC, van der Post JA, Jager KJ, Mol BW, Reitsma JB. Ethnic differences in stillbirth and early neonatal mortality in The Netherlands. J Epidemiol Community Health 2011; 65: 696-701. 103
  73. Kleinman JC, Pierre MB, Jr., Madans JH, Land GH, Schramm WF. The effects of maternal smoking on fetal and infant mortality. Am J Epidemiol 1988; 127: 274-82. 104
  74. Naeye RL. Maternal age, obstetric complications, and the outcome of pregnancy. Obstet Gynecol 1983; 61: 210-6. 105
  75. Kramer MS, Usher RH, Pollack R, Boyd M, Usher S. Etiologic determinants of abruptio placentae. Obstet Gynecol 1997; 89: 221-6. 106
  76. Meyer MB, Tonascia JA. Maternal smoking, pregnancy complications, and perinatal mortality. Am J Obstet Gynecol 1977; 128: 494-502. 107
  77. Gupta PC, Subramoney S. Smokeless tobacco use and risk of stillbirth: a cohort study in Mumbai, India. Epidemiology 2006; 17: 47-51. 108
  78. Mishra V, Retherford RD, Smith KR. Cooking smoke and tobacco smoke as risk factors for stillbirth. Int J Environ Health Res 2005; 15: 397-410.
  79. Ahlsten G, Ewald U, Tuvemo T. Maternal smoking reduces prostacyclin formation in human umbilical arteries. A study on strictly selected pregnancies. Acta Obstet Gynecol Scand 1986; 65: 645-9.
  80. Longo LD. Carbon monoxide: effects on oxygenation of the fetus in utero. Science 1976; 194: 523-5.
  81. Morrow RJ, Ritchie JW, Bull SB. Maternal cigarette smoking: the effects on umbilical and uterine blood flow velocity. Am J Obstet Gynecol 1988; 159: 1069-71.
  82. Aliyu MH, Wilson RE, Zoorob R, Chakrabarty S, Alio AP, Kirby RS, Salihu HM. Alcohol consumption during pregnancy and the risk of early stillbirth among singletons. Alcohol 2008; 42: 369-74.
  83. Lutiger B, Graham K, Einarson TR, Koren G. Relationship between gestational cocaine use and pregnancy outcome: a meta-analysis. Teratology 1991; 44: 405-14.
  84. Hilder L, Costeloe K, Thilaganathan B. Prolonged pregnancy: evaluating gestation-specific risks of fetal and infant mortality. Br J Obstet Gynaecol 1998; 105: 169-73.
  85. West CR, Adi Y, Pharoah PO. Fetal and infant death in mono-and dizygotic twins in England and Wales 1982-91. Arch Dis Child Fetal Neonatal Ed 1999; 80: F217-F220.
  86. Gardner MO, Goldenberg RL, Cliver SP, Tucker JM, Nelson KG, Copper RL. The origin and outcome of preterm twin pregnancies. Obstet Gynecol 1995; 85: 553-7.
  87. Salihu HM, Aliyu MH, Rouse DJ, Kirby RS, Alexander GR. Potentially preventable excess mortality among higher-order multiples. Obstet Gynecol 2003; 102: 679-84.
  88. Ventura SJ, Martin JA, Curtin SC, Mathews TJ, Park MM. Births: final data for 1998. Natl Vital Stat Rep 2000; 48: 1-100.
  89. Lyall F. The human placental bed revisited. Placenta 2002; 23: 555-62.
  90. Smith GC. First trimester origins of fetal growth impairment. Semin Perinatol 2004; 28: 41-50.
  91. Smith GC, Crossley JA, Aitken DA, Pell JP, Cameron AD, Connor JM, Dobbie R. First-trimester placentation and the risk of antepartum stillbirth. JAMA 2004; 292: 2249-54.
  92. Lees C, Parra M, Missfelder-Lobos H, Morgans A, Fletcher O, Nicolaides KH. Individualized risk assessment for adverse pregnancy outcome by uterine artery Doppler at 23 weeks. Obstet Gynecol 2001; 98: 369-73.
  93. McDonald SD, Vermeulen MJ, Ray JG. Risk of fetal death associated with maternal drug dependence and placental abruption: a population-based study. JOGC 2007; 29: 556-9.
  94. Salihu HM, Bekan B, Aliyu MH, Rouse DJ, Kirby RS, Alexander GR. Perinatal mortality associated with abruptio placenta in singletons and multiples. Am J Obstet Gynecol 2005; 193: 198-203.
  95. Oyelese Y, Ananth CV. Placental abruption. Obstet Gynecol 2006; 108: 1005-16.
  96. Resnik R. Intrauterine growth restriction. Obstet Gynecol 2002; 99: 490-6.
  97. Clausson B, Gardosi J, Francis A, Cnattingius S. Perinatal outcome in SGA births defined by customised versus population-based birthweight standards. BJOG 2001; 108: 830-4. 129
  98. Surkan PJ, Stephansson O, Dickman PW, Cnattingius S. Previous preterm and small-for-gestational-age births and the subsequent risk of stillbirth. N Engl J Med 2004; 350: 777-85. 131
  99. Sibai B, Dekker G, Kupferminc M. Pre-eclampsia. Lancet 2005; 365: 785-99. 132
  100. Warland J, McCutcheon H, Baghurst P. Maternal blood pressure in pregnancy and stillbirth: a case-control study of third-trimester stillbirth. Am J Perinatol 2008; 25: 311-7. 133
  101. Smulian JC, Ananth CV, Vintzileos AM, Scorza WE, Knuppel RA. Fetal deaths in the United States. Influence of high-risk conditions and implications for management. Obstet Gynecol 2002; 100: 1183-9. 135
  102. McGovern PG, Llorens AJ, Skurnick JH, Weiss G, Goldsmith LT. Increased risk of preterm birth in singleton pregnancies resulting from in vitro fertilization-embryo transfer or gamete intrafallopian transfer: a meta-analysis. Fertil Steril 2004; 82: 1514-20. 136
  103. Olivennes F, Rufat P, Andre B, Pourade A, Quiros MC, Frydman R. The increased risk of complication observed in singleton pregnancies resulting from in-vitro fertilization (IVF) does not seem to be related to the IVF method itself. Hum Reprod 1993; 8: 1297-300. 137
  104. Reddy UM. Prediction and prevention of recurrent stillbirth. Obstet Gynecol 2007; 110: 1151-64. 138
  105. Cnattingius S, Berendes HW, Forman MR. Do delayed childbearers face increased risks of adverse pregnancy outcomes after the first birth? Obstet Gynecol 1993; 81: 512-6. 139
  106. Samueloff A, Xenakis EM, Berkus MD, Huff RW, Langer O. Recurrent stillbirth. Significance and characteristics. J Reprod Med 1993; 38: 883-6. 140
  107. Heinonen S, Kirkinen P. Pregnancy outcome after previous stillbirth resulting from causes other than maternal conditions and fetal abnormalities. Birth 2000; 27: 33-7. 141
  108. Robson S, Chan A, Keane RJ, Luke CG. Subsequent birth outcomes after an unexplained stillbirth: preliminary population-based retrospective cohort study. Aust N Z J Obstet Gynaecol 2001; 41: 29-35. 142
  109. Goldenberg RL, Mayberry SK, Copper RL, DuBard MB, Hauth JC. Pregnancy outcome following a second-trimester loss. Obstet Gynecol 1993; 81: 444-6. 143
  110. Smith GC, Pell JP, Dobbie R. Caesarean section and risk of unexplained stillbirth in subsequent pregnancy. Lancet 2003; 362: 1779-84. 144
  111. Smith GC, Shah I, White IR, Pell JP, Dobbie R. Previous preeclampsia, preterm delivery, and delivery of a small for gestational age infant and the risk of unexplained stillbirth in the second pregnancy: a retrospective cohort study, Scotland, 1992-2001. Am J Epidemiol 2007; 165: 194-202. 145
  112. Bahtiyar MO, Julien S, Robinson JN, Lumey L, Zybert P, Copel JA, Lockwood CJ, Norwitz ER. Prior cesarean delivery is not associated with an increased risk of stillbirth in a subsequent pregnancy: analysis of U.S. perinatal mortality data, 1995-1997. Am J Obstet Gynecol 2006; 195: 1373-8. 146 Silver RM. Fetal death. Obstet Gynecol 2007; 109: 153-67. 147 American College of Obstetricians and Gynecologists. Diabetes in pregnancy. Technical Bulletin, Number 200. Washington DC, USA: ACOG, 1994. 148
  113. Murphy JF, O'Riordan J, Newcombe RG, Coles EC, Pearson JF. Relation of haemoglobin levels in first and second trimesters to outcome of pregnancy. Lancet 1986; 1: 992-5. 150
  114. Froen JF, Moyland RA, Saugstad OD, Stray-Pedersen B. Maternal health in sudden intrauterine unexplained death: do urinary tract infections protect the fetus? Obstet Gynecol 2002; 100: 909-15. 151
  115. Stephansson O, Dickman PW, Johansson A, Cnattingius S. Maternal hemoglobin concentration during pregnancy and risk of stillbirth. JAMA 2000; 284: 2611-7. 152
  116. Wells PS, Ginsberg JS, Anderson DR, Kearon C, Gent M, Turpie AG, Bormanis J, Weitz J, Chamberlain M, Bowie D, Barnes D, Hirsh J. Use of a clinical model for safe management of patients with suspected pulmonary embolism. Ann Intern Med 1998; 129: 997-1005. 153
  117. Perrier A, Desmarais S, Miron MJ, de Moerloose P, Lepage R, Slosman D, Didier D, Unger PF, Patenaude JV, Bounameaux H. Non-invasive diagnosis of venous thromboembolism in outpatients. Lancet 1999; 353: 190-5. 154 Vine AK. Recent advances in haemostasis and thrombosis. Retina 2009; 29: 1-7. 155
  118. Crawley JT, Lane DA. The haemostatic role of tissue factor pathway inhibitor. Arterioscler Thromb Vasc Biol 2008; 28: 233-42. 157
  119. Kujovich JL. Thrombophilia and pregnancy complications. Am J Obstet Gynecol 2004; 191: 412-24. 158
  120. Thorelli E, Kaufman RJ, Dahlback B. Cleavage of factor V at Arg 506 by activated protein C and the expression of anticoagulant activity of factor V. Blood 1999; 93: 2552-8. 159
  121. Zoller B, Garcia de FP, Dahlback B. A common 4G allele in the promoter of the plasminogen activator inhibitor-1 (PAI-1) gene as a risk factor for pulmonary embolism and arterial thrombosis in hereditary protein S deficiency. Thromb Haemost 1998; 79: 802-7. 160
  122. Rees DC, Cox M, Clegg JB. World distribution of factor V Leiden. Lancet 1995; 346: 1133-4. 161
  123. Ridker PM, Miletich JP, Hennekens CH, Buring JE. Ethnic distribution of factor V Leiden in 4047 men and women. Implications for venous thromboembolism screening. JAMA 1997; 277: 1305-7. 162
  124. Berge E, Haug KB, Sandset EC, Haugbro KK, Turkovic M, Sandset PM. The factor V Leiden, prothrombin gene 20210GA, methylenetetrahydrofolate reductase 677CT and platelet glycoprotein IIIa 1565TC mutations in patients with acute ischemic stroke and atrial fibrillation. Stroke 2007; 38: 1069-71. 163
  125. Jacobsen AF, Dahm A, Bergrem A, Jacobsen EM,S andset PM. Risk of venous thrombosis in pregnancy among carriers of the factor V Leiden and the prothrombin gene G20210A polymorphisms. J Thromb Haemost 2010; 8: 2443-9. 164
  126. Rosendaal FR, Koster T, Vandenbroucke JP, Reitsma PH. High risk of thrombosis in patients homozygous for factor V Leiden (activated protein C resistance). Blood 1995; 85: 1504-8. 165
  127. Poort SR, Rosendaal FR, Reitsma PH, Bertina RM. A common genetic variation in the 3'-untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increase in venous thrombosis. Blood 1996; 88: 3698-703. 166
  128. Souto JC, Coll I, Llobet D, del RE, Oliver A, Mateo J, Borrell M, Fontcuberta J. The prothrombin 20210A allele is the most prevalent genetic risk factor for venous thromboembolism in the Spanish population. Thromb Haemost 1998; 80: 366-9. 167
  129. Girling J, de Swiet M. Inherited thrombophilia and pregnancy. Curr Opin Obstet Gynecol 1998; 10: 135- 44. 168
  130. Rao AK, Sheth S, Kaplan R. Inherited hypercoagulable states. Vasc Med 1997; 2: 313-20. 169
  131. Dahlback B. Advances in understanding pathogenic mechanisms of thrombophilic disorders. Blood 2008; 112: 19-27. 170
  132. Wells PS, Blajchman MA, Henderson P, Wells MJ, Demers C, Bourque R, McAvoy A. Prevalence of antithrombin deficiency in healthy blood donors: a cross-sectional study. Am J Hematol 1994; 45: 321-4. 171
  133. Tait RC, Walker ID, Perry DJ, Islam SI, Daly ME, McCall F, Conkie JA, Carrell RW. Prevalence of antithrombin deficiency in the healthy population. Br J Haematol 1994; 87: 106-12. 172
  134. Cerneca F, Ricci G, Simeone R, Malisano M, Alberico S, Guaschino S. Coagulation and fibrinolysis changes in normal pregnancy. Increased levels of procoagulants and reduced levels of inhibitors during pregnancy induce a hypercoagulable state, combined with a reactive fibrinolysis. Eur J Obst Gynecol Reprod Biol 1997; 73: 31-6. 173
  135. Lockwood CJ. Heritable coagulopathies in pregnancy. Obstet Gynecol Surv 1999; 54: 754-65. 174
  136. Tait RC, Walker ID, Reitsma PH, Islam SI, McCall F, Poort SR, Conkie JA, Bertina RM. Prevalence of protein C deficiency in the healthy population. Thromb Haemost 1995; 73: 87-93. 175
  137. Faught W, Garner P, Jones G, Ivey B. Changes in protein C and protein S levels in normal pregnancy. Am J Obstet Gynecol 1995; 172: 147-50. 176
  138. Lane DA, Mannucci PM, Bauer KA, Bertina RM, Bochkov NP, Boulyjenkov V, Chandy M, Dahlback B, Ginter EK, Miletich JP, Rosendaal FR, Seligsohn U. Inherited thrombophilia: Part 1. Thromb Haemost 1996; 76: 651-62. 177
  139. Dykes AC, Walker ID, McMahon AD, Islam SI, Tait RC. A study of Protein S antigen levels in 3788 healthy volunteers: influence of age, sex and hormone use, and estimate for prevalence of deficiency state. Br J Haematol 2001; 113: 636-41. 178
  140. Malm J, Laurell M, Dahlback B. Changes in the plasma levels of vitamin K-dependent proteins C and S and of C4b-binding protein during pregnancy and oral contraception. Br J Haematol 1988; 68: 437-43. 179
  141. Comp PC, Thurnau GR, Welsh J, Esmon CT. Functional and immunologic protein S levels are decreased during pregnancy. Blood 1986; 68: 881-5. 180
  142. Boerger LM, Morris PC, Thurnau GR, Esmon CT, Comp PC. Oral contraceptives and gender affect protein S status. Blood 1987; 69: 692-4. 181
  143. Henkens CM, Bom VJ, Van der Schaaf W, Pelsma PM, Sibinga CT, de Kam PJ, van der Meer J. Plasma levels of protein S, protein C, and factor X: effects of sex, hormonal state and age. Thromb Haemost 1995; 74: 1271-5. 182
  144. Mulder R, Ten Kate MK, Kluin-Nelemans HC, Mulder AB. Low cut-off values increase diagnostic performance of protein S assays. Thromb Haemost 2010; 104: 618-25. 183
  145. Greaves M. Acquired thrombophilia. Vasc Med 2004; 9: 215-8. 184
  146. Miyakis S, Lockshin MD, Atsumi T, Branch DW, Brey RL, Cervera R, Derksen RH, DE Groot PG, Koike T, Meroni PL, Reber G, Shoenfeld Y, Tincani A, Vlachoyiannopoulos PG, Krilis SA. International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS). J Thromb Haemost 2006; 4: 295-306. 185
  147. Petri M. Epidemiology of the antiphospholipid antibody syndrome. J Autoimmun 2000; 15: 145-51. 186
  148. Salafia CM, Minior VK, Pezzullo JC, Popek EJ, Rosenkrantz TS, Vintzileos AM. Intrauterine growth restriction in infants of less than thirty-two weeks' gestation: associated placental pathologic features. Am J Obstet Gynecol 1995; 173: 1049-57. 187 Greer IA. Thrombosis in pregnancy: maternal and fetal issues. Lancet 1999; 353: 1258-65. 188
  149. Clark P, Brennand J, Conkie JA, McCall F, Greer IA, Walker ID. Activated protein C sensitivity, protein C, protein S and coagulation in normal pregnancy. Thromb Haemost 1998; 79: 1166-70. 189
  150. Arias F, Romero R, Joist H, Kraus FT. Thrombophilia: a mechanism of disease in women with adverse pregnancy outcome and thrombotic lesions in the placenta. J Matern Fetal Med 1998; 7: 277-86. 190
  151. Mousa HA, Alfirevic1 Z. Do placental lesions reflect thrombophilia state in women with adverse pregnancy outcome? Hum Reprod 2000; 15: 1830-3. 191
  152. Rand JH, Wu XX, Guller S, Scher J, Andree HA, Lockwood CJ. Antiphospholipid immunoglobulin G antibodies reduce annexin-V levels on syncytiotrophoblast apical membranes and in culture media of placental villi. Am J Obstet Gynecol 1997; 177: 918-23. 192
  153. Regan L, Rai R. Thrombophilia and pregnancy loss. J Reprod Immunol 2002; 55: 163-80. 193
  154. Kupferminc MJ, Eldor A, Steinman N, Many A, Bar-Am A, Jaffa A, Fait G, Lessing JB. Increased frequency of genetic thrombophilia in women with complications of pregnancy. N Engl J Med 1999; 340: 9-13. 194
  155. Dizon-Townson D, Miller C, Sibai B, Spong CY, Thom E, Wendel G, Jr., Wenstrom K, Samuels P, Cotroneo MA, Moawad A, Sorokin Y, Meis P, Miodovnik M, O'Sullivan MJ, Conway D, Wapner RJ, Gabbe SG, National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network. The relationship of the factor V Leiden mutation and pregnancy outcomes for mother and fetus. Obstet Gynecol 2005; 106: 517-24. 195
  156. Bates SM, Greer IA, Pabinger I, Sofaer S, Hirsh J, American College of Chest Physicians. Venous thromboembolism, thrombophilia, antithrombotic therapy, and pregnancy: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition). Chest 2008; 133(6 Suppl): 844S- 86S. 196
  157. Rodger MA, Paidas M, Claire M, Middeldorp S, Kahn S, Martinelli I, Hague W, Rosene M, Greer I. Inherited thrombophilia and pregnancy complications revisited. Obstet Gynecol 2008; 112: 320-4. 198
  158. Rai R, Regan L, Hadley E, Dave M, Cohen H. Second-trimester pregnancy loss is associated with activated C resistance. Br J Haematol 1996; 92: 489-90. 199
  159. Sood R, Zogg M, Westrick RJ, Guo YH, Kerschen EJ, Girardi G, Salmon JE, Coughlin SR, Weiler H. Fetal gene defects precipitate platelet-mediated pregnancy failure in factor V Leiden mothers. J Exp Med 2007; 204: 1049-56. 200
  160. Isermann B, Sood R, Pawlinski R, Zogg M, Kalloway S, Degen JL, Mackman N, Weiler H. The thrombomodulin-protein C system is essential for the maintenance of pregnancy. Nat Med 2003; 9: 331-7. 201
  161. Martinelli I, Taioli E, Cetin I, Marinoni A, Gerosa S, Villa MV, Bozzo M, Mannucci PM. Mutations in coagulation factors in women with unexplained late fetal loss. N Engl J Med 2000; 343: 1015-8. 202
  162. Many A, Elad R, Yaron Y, Eldor A, Lessing JB, Kupferminc MJ. Third-trimester unexplained intrauterine fetal death is associated with inherited thrombophilia. Obstet Gynecol 2002; 99: 684-7. 203
  163. Barbour LA, ACOG Committee on Practice Bulletins. ACOG practice bulletin. Thrombembolism in pregnancy. Int J Gynaecol Obstet 2001; 75: 203-12. 204
  164. Meinardi JR, Middeldorp S, de Kam PJ, Koopman MM, van Pampus EC, Hamulyak K, Prins MH, Buller HR, van der Meer J. Increased risk for fetal loss in carriers of the factor V Leiden mutation. Ann Intern Med 1999; 130: 736-9. 205
  165. Bare SN, Poka R, Balogh I, Ajzner E. Factor V Leiden as a risk factor for miscarriage and reduced fertility. Aust N Z J Obstet Gynaecol 2000; 40: 186-90. 206
  166. Agorastos T, Karavida A, Lambropoulos A, Constantinidis T, Tzitzimikas S, Chrisafi S, Saravelos H, Vavilis D, Kotsis A, Bontis J. Factor V Leiden and prothrombin G20210A mutations in pregnancies with adverse outcome. J Matern-Fetal Neo M 2002; 12: 267-73. 207
  167. Volzke H, Grimm R, Robinson DM, Robinson C, Kohlmann T, Schuster G, Alte D, Herrmann FH, John U. Factor V Leiden and the risk of stillbirth in a German population. Thromb Haemost 2003; 90: 429-33. 208
  168. Clark P, Walker ID, Govan L, Wu O, Greer IA. The GOAL study: a prospective examination of the impact of factor V Leiden and ABO(H) blood groups on haemorrhagic and thrombotic pregnancy outcomes. Br J Haematol 2008; 140: 236-40. 209
  169. Kupferminc MJ, Peri H, Zwang E, Yaron Y, Wolman I, Eldor A. High prevalence of the prothrombin gene mutation in women with intrauterine growth retardation, abruptio placentae and second trimester loss. Acta Obstet Gynecol Scand 2000; 79: 963-7. 210
  170. Alonso A, Soto I, Urgelles MF, Corte JR, Rodriguez MJ, Pinto CR. Acquired and inherited thrombophilia in women with unexplained fetal losses. Am J Obstet Gynecol 2002; 187: 1337-42. 211
  171. Preston FE, Rosendaal FR, Walker ID, Briet E, Berntorp E, Conard J, Fontcuberta J, Makris M, Mariani G, Noteboom W, Pabinger I, Legnani C, Scharrer I, Schulman S, van der Meer FJ. Increased fetal loss in women with heritable thrombophilia. Lancet 1996; 348: 913-6. 212
  172. Oshiro BT, Silver RM, Scott JR, Yu H, Branch DW. Antiphospholipid antibodies and fetal death. Obstet Gynecol 1996; 87: 489-93. 213
  173. Lynch A, Marlar R, Murphy J, Davila G, Santos M, Rutledge J, Emlen W. Antiphospholipid antibodies in predicting adverse pregnancy outcome. A prospective study. Ann Intern Med 1994; 120: 470-5. 214
  174. Laurell AB, Nillson IM. Hypergammaglobulinemia, circulating anticoagulant, and biologic false positive Wassermann reaction; a study in two cases. J Lab Clin Med 1957; 49: 694-707. 215
  175. Lockshin MD, Druzin ML, Goei S, Qamar T, Magid MS, Jovanovic L, Ferenc M. Antibody to cardiolipin as a predictor of fetal distress or death in pregnant patients with systemic lupus erythematosus. N Engl J Med 1985; 313: 152-6. 216
  176. Triplett DA. Antiphospholipid antibodies and recurrent pregnancy loss. Am J Reprod Immunol 1989; 20: 52-67. 217
  177. Triplett DA, Brandt JT, Musgrave KA, Orr CA. The relationship between lupus anticoagulants and antibodies to phospholipid. JAMA 1988; 259: 550-4. 218
  178. Katano K, Aoki A, Sasa H, Ogasawara M, Matsuura E, Yagami Y. beta 2-Glycoprotein I-dependent anticardiolipin antibodies as a predictor of adverse pregnancy outcomes in healthy pregnant women. Hum Reprod 1996; 11: 509-12. 219
  179. Pattison NS, Chamley LW, McKay EJ, Liggins GC, Butler WS. Antiphospholipid antibodies in pregnancy: prevalence and clinical associations. Br J Obstet Gynaecol 1993; 100: 909-13. 220
  180. De Carolis S, Caruso A, Ferrazzani S, Carducci B, De SL, Mancuso S. Poor pregnancy outcome and anticardiolipin antibodies. Fet Diagn Ther 1994; 9: 296-9. 221
  181. Yasuda M, Takakuwa K, Tokunaga A, Tanaka K. Prospective studies of the association between anticardiolipin antibody and outcome of pregnancy. Obstet Gynecol 1995; 86: 555-9. 222
  182. Alfirevic Z, Mousa HA, Martlew V, Briscoe L, Perez-Casal M, Toh CH. Postnatal screening for thrombophilia in women with severe pregnancy complications. Obstet Gynecol 2001; 97: 753-9. 223
  183. Infante-Rivard C, David M, Gauthier R, Rivard GE. Lupus anticoagulants, anticardiolipin antibodies, and fetal loss. A case-control study. N Engl J Med 1991; 325: 1063-6. 224
  184. Kady SM, Gardosi J. Perinatal mortality and fetal growth restriction. Best Practice and Research in Clinical Obstetrics and Gynaecology 2004; 18: 397-410. 225
  185. Malcus P. Antenatal fetal surveillance. Curr Opin Obstet Gynecol 2004; 16: 123-8. 226
  186. Imdad A, Yakoob MY, Siddiqui S, Bhutta ZA. Screening and triage of intrauterine growth restriction (IUGR) in general population and high risk pregnancies: a systematic review with a focus on reduction of IUGR related stillbirths. BMC Public Health 2011; 11 Suppl 3: S1. 227
  187. Froen JF, Heazell AE, Tveit JV, Saastad E, Fretts RC, Flenady V. Fetal movement assessment. Semin Perinatol 2008; 32: 243-6. 228
  188. Moore TR, Piacquadio K. A prospective evaluation of fetal movement screening to reduce the incidence of antepartum fetal death. Am J Obstet Gynecol 1989; 160: 1075-80. 229
  189. Grant A, Elbourne D, Valentin L, Alexander S. Routine formal fetal movement counting and risk of antepartum late death in normally formed singletons. Lancet 1989; 2: 345-9. 230
  190. Neldam S. Fetal movements as an indicator of fetal well-being. Dan Med Bull 1983; 30: 274-8. 231
  191. Froen JF. A kick from within--fetal movement counting and the cancelled progress in antenatal care. J Perinat Med 2004; 32: 13-24. 232
  192. Rai R, Cohen H, Dave M, Regan L. Randomised controlled trial of aspirin and aspirin plus heparin in pregnant women with recurrent miscarriage associated with phospholipid antibodies (or antiphospholipid antibodies). BMJ 1997; 314: 253-7. 233
  193. Brenner B, Bar J, Ellis M, Yarom I, Yohai D, Samueloff A, Live-Enox I. Effects of enoxaparin on late pregnancy complications and neonatal outcome in women with recurrent pregnancy loss and thrombophilia: results from the Live-Enox study. Fertil Steril 2005; 84: 770-3. 234
  194. Greer IA, Nelson-Piercy C. Low-molecular-weight heparins for thromboprophylaxis and treatment of venous thromboembolism in pregnancy: a systematic review of safety and efficacy. Blood 2005; 106: 401- 7. 235
  195. Jacobsen AF, Skjeldestad FE, Sandset PM. Incidence and risk patterns of venous thromboembolism in pregnancy and puerperium--a register-based case-control study. Am J Obstet Gynecol 2008; 198: 233.e1- e7. 237
  196. Bergrem A, Jacobsen EM, Skjeldestad FE, Jacobsen AF, Skogstad M, Sandset PM. The association of antiphospholipid antibodies with pregnancy-related first time venous thrombosis -a population-based case- control study. Thromb Res 2010; 125: e222-7. 238
  197. Bergrem A, Dahm AE, Jacobsen AF, Mowinckel MC, Sandvik L, Sandset PM. Resistance to activated protein C is a risk factor for pregnancy-related venous thrombosis in the absence of the F5 rs6025 (factor V Leiden) polymorphism. Br J Haematol 2011; 154: 241-7. 239
  198. Schjetlein R, Sletnes KE, Wisloff F. A quantitative, semi-automated and computer-assisted test for lupus anticoagulant. Thromb Res 1993; 69: 239-50. 240
  199. Jacobsen EM, Barna-Cler L, Taylor JM, Triplett DA, Wisloff F. The Lupus Ratio test--an interlaboratory study on the detection of Lupus anticoagulants by an APTT-based, integrated, and semi-quantitative test. Fifth International Survey of Lupus Anticoagulants--ISLA 5. Thromb Haemost 2000; 83: 704-8. 241
  200. Gharavi AE, Harris EN, Asherson RA, Hughes GR. Anticardiolipin antibodies: isotype distribution and phospholipid specificity. Ann Rheum Dis 1987; 46: 1-6. 242

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Authors
HELGADOTTIR, L. B., SKJELDESTAD, F. E., JACOBSEN, A. F., SANDSET, P. M., & JACOBSEN, E.
Affiliations
  • UiT The Arctic University of Norway (NO)
  • Oslo University Hospital (NO)
  • University of Oslo (NO)
ORCID
Venue
Acta Obstetricia Et Gynecologica Scandinavica
Publisher
Wiley
Published
2011-03-04
Volume
90
Issue
4
Pages
390-397
ISSN
  • 0001-6349 (ISSN-L)
  • 1600-0412
DOI
10.1111/j.1600-0412.2011.01079.x
OpenAlex
W2138546398
Cited by
21
References
32
Citations by year
2026: 1 · 2025: 1 · 2023: 1 · 2022: 2 · 2021: 1 · 2017: 2 · 2015: 1 · 2014: 3 · 2013: 3 · 2012: 4
FWCI
4.94
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Acta Obstetricia Et Gynecologica Scandinavica (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Global Maternal and Child Health
  • Health Sciences › Health Professions › General Health Professions › Maternal and Neonatal Healthcare
Keywords
intrauterine fetal death, stillbirth, incidence, risk factors, small for gestational age, placental abruption, hypertensive disorders of pregnancy, thyroid dysfunction, placenta previa, gestational diabetes mellitus, smoking, twin pregnancy, advanced maternal age, control group selection, Medical Birth Registry of Norway
MeSH terms
Adolescent, Adult, Female, Fetal Death, Humans, Norway, Pregnancy, Retrospective Studies, Risk Factors, Incidence, Logistic Models, Case-Control Studies, Young Adult

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