The DOI matches its Crossref record; 157 of the 157 references it cites were found in a registry or an index.
MicroRNAs in placental health and disease
Open accessAbstract
MicroRNAs (miRNAs) constitute a large family of small noncoding RNAs that are encoded by the genomes of most organisms. They regulate gene expression through posttranscriptional mechanisms to attenuate protein output in various genetic networks. The discovery of miRNAs has transformed our understanding of gene regulation and sparked intense efforts intended to harness their potential as diagnostic markers and therapeutic tools. Over the last decade, a flurry of studies has shed light on placental miRNAs but has also raised many questions regarding the scope of their biologic action. Moreover, the recognition that miRNAs of placental origin are released continually in the maternal circulation throughout pregnancy suggested that circulating miRNAs might serve as biomarkers for placental function during pregnancy. Although this generated much enthusiasm, recently recognized challenges have delayed the application of miRNA-based biomarkers and therapeutics in clinical practice. In this review, we summarize key findings in the field and discuss current knowledge related to miRNAs in the context of placental biology.
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“The human placenta expresses a wide variety of non-coding RNAs (398), but few data are available regarding their responsiveness to hypoxia.”
From Placental Origins of Chronic Disease (2016) · cites this paper as [398]
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Cites
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Cited by
Sorted by citations
Placental Origins of Chronic Disease
Burton, G. J., Fowden, A. L., & Thornburg, K. L. (2016) · Physiological Reviews · doi:10.1152/physrev.00029.2015 · Cited by 717
Update of syncytiotrophoblast derived extracellular vesicles in normal pregnancy and preeclampsia
Tannetta, D., Masliukaitė, I., Vatish, M., Redman, C. W. G., & Sargent, I. L. (2016) · Journal of Reproductive Immunology · doi:10.1016/j.jri.2016.08.008 · Cited by 212
“008 lipids and miRNAs (recently reviewed by (Tannetta and Sargent, 2013; Tannetta et al., 2014; Mouillet et al., 2015), whilst in PE both qualitative and quantitative differences in shed STBEV have been found, such as changes in the size of EV released and the molecular”
BackgroundInfluentialLapehn, S., & Paquette, A. G. (2022) · Current Environmental Health Reports · doi:10.1007/s40572-022-00354-8 · Cited by 166
“Identification of placenta-specific microRNAs secreted into the maternal blood from exosomes is an area of growing interest as a noninvasive biomarker for pregnancy health [17].”
BackgroundMicroRNAs: crucial regulators of placental development
Hayder, H., O’Brien, J. A., Nadeem, U., & Peng, C. (2018) · Reproduction · doi:10.1530/rep-17-0603 · Cited by 160
Yang, L., Semmes, E. C., Ovies, C., Megli, C., Permar, S. R., Gilner, J. B., & Coyne, C. B. (2022) · eLife · doi:10.7554/elife.79794 · Cited by 132
“To further confirm that TOs and DOs recapitulated their tissues of origin, we profiled the expression of three members of the chromosome 19 microRNA family (C19MC), which are specifically expressed in the human placenta (Mouillet et al., 2015).”
BackgroundSelf-citation
Metadata
- Authors
- Mouillet, J.-F., Ouyang, Y., Coyne, C. B., & Sadovsky, Y.
- Affiliations
- University of Pittsburgh (US)
- Corresponding author
- Sadovsky, Yoel
- Venue
- American Journal of Obstetrics and Gynecology
- Publisher
- Elsevier BV
- Published
- 2015-10
- Volume
- 213
- Issue
- 4
- Pages
- S163-S172
- ISSN
- 0002-9378 (ISSN-L)
- PMC
- PMC4592520
- OpenAlex
- W2128949071
- Cited by
- 195
- References
- 157
- Citations by year
- 2026: 8 · 2025: 9 · 2024: 13 · 2023: 20 · 2022: 25 · 2021: 25 · 2020: 23 · 2019: 18 · 2018: 19 · 2017: 19 · 2016: 15
- FWCI
- 2.61
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- American Journal of Obstetrics and Gynecology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Pennsylvania Department of Health
- National Institutes of Health (0863906)
- National Institute of Allergy and Infectious Diseases (R01AI081759)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (R21HD071707, R01HD065893, R01HD075665)
- Topics
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
- Keywords
- microRNA, placenta, placental function, placental disease, circulating microRNAs, pregnancy, biomarkers, post-transcriptional regulation, non-coding RNA, miRNA-based therapy
- MeSH terms
- Extracellular Space, Female, Humans, Placenta Diseases, Pregnancy, Biomarkers, MicroRNAs
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