Pregnancy outcome in Turner syndrome: a French multi-center study after the 2009 guidelines
Abstract
Objective This study aimed to assess the application of the French guidelines for pregnancies in Turner syndrome (TS) and their impact on perinatal prognosis.Study design We performed a French multi-center retrospective study (14 centers), including TS pregnant patients (spontaneously or by Assisted Reproductive Technology (ART)) between January 2006 and July 2017. Only clinical pregnancies were analyzed. The adjustment of medical follow-up modalities to French guidelines was evaluated for all pregnancies after 2009. Pregnancies from oocyte donation (OD) after 2009 were compared to those of a cohort of TS pregnancies obtained by OD before 2009, which were reported by the French Study Group for Oocyte Donation.Results One hundred seventy pregnancies in 103 patients were included: 35 spontaneous, 5 by means of intra-conjugal ART, and 130 with OD. No serious maternal complications were observed. We reported two stillbirths and one intra uterine fetal death. The French guidelines were partially respected. The preconceptional assessment was carried out in 74% of cases. Cardiology follow-up during pregnancy was performed in accordance with guidelines in 74% of patients. Postpartum cardiac ultrasonography was performed in 45% of pregnancies but only in 11% within 8 days post-partum. When compared to the 2009 historical cohort, the rates of high blood pressure (19% vs. 38%; p < 0.005) pre-eclampsia (8% vs. 21%; p < 0.005) and prematurity <35 weeks (15% vs 38%; p < 0.0001) were lower.Conclusions The implementation of guidelines has allowed the standardization of TS pregnancy care and improved perinatal indicators for both mothers and children. However, an effort must be done, in a postpartum survey.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Initial estimates of maternal deaths due to aortic dissections during pregnancy were much higher than in more recent studies, probably because pre-pregnancy cardiac evaluations were performed less frequently in older cohorts.
“Initial estimates of maternal deaths due to aortic dissections during pregnancy were much higher than in more recent studies, probably because pre-pregnancy cardiac evaluations were performed less frequently in older cohorts.510-513”
From Clinical practice guidelines for the care of girls and women with Turner syndrome. (2024) · cites this paper as [513]
Cites
Nielsen, J., & Wohlert, M. (1991) · Human Genetics · doi:10.1007/bf01213097 · Cited by 1,193 · see citing works
Gravholt, C. H., Andersen, N. H., Conway, G. S., Dekkers, O. M., Geffner, M. E., Klein, K. O., Lin, A. E., Mauras, N., Quigley, C. A., Rubin, K., et al. (2017) · European Journal of Endocrinology · doi:10.1530/eje-17-0430 · Cited by 1,101 · see citing works
Care of girls and women with Turner syndrome: a guideline of the Turner syndrome study group
Bondy, C. A. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-1374 · Cited by 1,005 · see citing works
Prevalence, incidence, diagnostic delay, and mortality in Turner syndrome
Stochholm, K., Juul, S., Juel, K., Naeraa, R. W., & Højbjerg Gravholt, C. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-0558 · Cited by 652 · see citing works
Lutjen, P., Trounson, A. O., LEETON, J. F., Findlay, J. K., Wood, C. E., & Renou, P. M. (1984) · Nature · doi:10.1038/307174a0 · Cited by 639 · see citing works
Rosenfeld, R. G. (1990) · Cited by 505 · see citing works
Blondel, B., Coulm, B., Bonnet, C., et al. (2017) · Journal of Gynecology Obstetrics and Human Reproduction · doi:10.1016/j.jogoh.2017.09.002 · Cited by 390 · see citing works
Spontaneous Pubertal Development in Turner's Syndrome
Pasquino, A. M., Passeri, F., Pucarelli, I., Segni, M., & Municchi, G. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.6.3970 · Cited by 385 · see citing works
Aortic Dilatation and Dissection in Turner Syndrome
Matura, L. A., Ho, V. B., Rosing, D. R., & Bondy, C. A. (2007) · Circulation · doi:10.1161/circulationaha.106.685487 · Cited by 364 · see citing works
Cardiovascular Malformations and Complications in Turner Syndrome
Sybert, V. P. (1998) · PEDIATRICS · doi:10.1542/peds.101.1.e11 · Cited by 326 · see citing works
Spontaneous fertility and pregnancy outcomes amongst 480 women with Turner syndrome
Bernard, V., Donadille, B., Zenaty, D., Courtillot, C., Salenave, S., Brac de la Perrière, A., Albarel, F., Fèvre, A., Kerlan, V., Brue, T., et al. (2016) · Human Reproduction · doi:10.1093/humrep/dew012 · Cited by 266 · see citing works
Congenital heart disease in patients with Turner’s syndrome
Mazzanti, L., & CACCIARI, E. (1998) · The Journal of Pediatrics · doi:10.1016/s0022-3476(98)70119-2 · Cited by 261 · see citing works
Prevalence of cardiovascular malformations and association with karyotypes in Turner's syndrome
Gotzsche, C. O., Krag-Olsen, B., Nielsen, J., Sorensen, K. E., & Kristensen, B. O. (1994) · Archives of Disease in Childhood · doi:10.1136/adc.71.5.433 · Cited by 260 · see citing works
Approach to the Patient with Turner Syndrome
Davenport, M. L. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-0926 · Cited by 252 · see citing works
Lippe, B. M. (1991) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/s0889-8529(18)30284-6 · Cited by 252 · see citing works
Pregnancies in women with Turner's syndrome
Hovatta, O. (1999) · Annals of Medicine · doi:10.3109/07853899908998785 · Cited by 251 · see citing works
Further Delineation of Aortic Dilation, Dissection, and Rupture in Patients With Turner Syndrome
Lin, A. E., Lippe, B. M., & Rosenfeld, R. G. (1998) · PEDIATRICS · doi:10.1542/peds.102.1.e12 · Cited by 231 · see citing works
Pregnancy in patients with Turner's syndrome: six new cases and review of literature
Tarani, L., Lampariello, S., Raguso, G., Colloridi, F., Pucarelli, I., Pasquino, A. M., & Bruni, L. A. (1998) · Gynecological Endocrinology · doi:10.3109/09513599809024955 · Cited by 228 · see citing works
Karnis, M. F., Zimon, A. E., Lalwani, S. I., Timmreck, L. S., Klipstein, S., & Reindollar, R. H. (2003) · Fertility and Sterility · doi:10.1016/s0015-0282(03)00974-9 · Cited by 206 · see citing works
Fertility and pregnancy outcome in Danish women with Turner syndrome
Birkebaek, N., Crüger, D., Hansen, J., Nielsen, J., & Bruun‐Petersen, G. (2002) · Clinical Genetics · doi:10.1034/j.1399-0004.2002.610107.x · Cited by 204 · see citing works
Follicles Are Found in the Ovaries of Adolescent Girls with Turner's Syndrome
Hreinsson, J. G., Otala, M., Fridström, M., Borgström, B., Rasmussen, C., Lundqvist, M., Tuuri, T., Simberg, N. H., Mikkola, M., Dunkel, L., et al. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.87.8.8753 · Cited by 192 · see citing works
Pregnancy rate and outcome in Swedish women with Turner syndrome
Bryman, I., Sylvén, L., Berntorp, K., Innala, E., Bergström, I., Hanson, C., Oxholm, M., & Landin-Wilhelmsen, K. (2011) · Fertility and Sterility · doi:10.1016/j.fertnstert.2010.12.039 · Cited by 190 · see citing works
Masoudian, P., Nasr, A., de Nanassy, J., Fung-Kee-Fung, K., Bainbridge, S. A., & El Demellawy, D. (2016) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2015.11.020 · Cited by 157 · see citing works
Turner's syndrome and fertility: current status and possible putative prospects
Abir, R. (2001) · Human Reproduction Update · doi:10.1093/humupd/7.6.603 · Cited by 154 · see citing works
Hadnott, T. N., Gould, H. N., Gharib, A. M., & Bondy, C. A. (2011) · Fertility and Sterility · doi:10.1016/j.fertnstert.2011.03.085 · Cited by 153 · see citing works
Chevalier, N., Letur, H., Lelannou, D., Ohl, J., Cornet, D., Chalas-Boissonnas, C., Frydman, R., Catteau-Jonard, S., Greck-Chassain, T., Papaxanthos-Roche, A., et al. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-0925 · Cited by 142 · see citing works
Cabanes, L., Chalas, C., Christin‐Maître, S., Donadille, B., Felten, M. L., Gaxotte, V., Jondeau, G., Lansac, E., Lansac, J., Letur, H., et al. (2010) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2010.05.019 · Cited by 126 · see citing works
Self-citationFertility preservation in Turner syndrome
Grynberg, M., Bidet, M., Bénard, J., Poulain, M., Sonigo, C., Cédrin‐Durnerin, I., & Polak, M. (2015) · Fertility and Sterility · doi:10.1016/j.fertnstert.2015.11.042 · Cited by 124 · see citing works
Hagman, A., Loft, A., Wennerholm, U.-B., Pinborg, A., Bergh, C., Aittomaki, K., Nygren, K.-G., Bente Romundstad, L., Hazekamp, J., & Soderstrom-Anttila, V. (2013) · Human Reproduction · doi:10.1093/humrep/det082 · Cited by 118 · see citing works
Bodri, D., Vernaeve, V., Figueras, F., Vidal, R., Guillén, J. J., & Coll, O. (2005) · Human Reproduction · doi:10.1093/humrep/dei396 · Cited by 114 · see citing works
Maternal and fetal outcomes in oocyte donation pregnancies
Savasi, V. M., Mandia, L., Laoreti, A., & Cetin, I. (2016) · Human Reproduction Update · doi:10.1093/humupd/dmw012 · Cited by 99 · see citing works
Yaron, Y., Ochshorn, Y., Amit, A., Yovel, I., Kogosowski, A., & Lessing, J. B. (1996) · Fertility and Sterility · doi:10.1016/s0015-0282(16)58350-2 · Cited by 88 · see citing works
Mathematic modeling of fetal growth: development of individual growth curve standards.
Rl, D., Rossavik, I. K., Harrist, R. B., & Fp, H. (1986) · PubMed · Cited by 82 · see citing works
Genetic Analysis of Mosaicism in 53 Women with Turner Syndrome
Hanson, L. Å., Bryman, I., Barrenäs, M., Janson, P.-O., Wahlström, J., Albertsson-Wikland, K. G., & Hanson, C. (2004) · Hereditas · doi:10.1111/j.1601-5223.2001.00153.x · Cited by 76 · see citing works
O'Donnell, R. L., Warner, P., Lee, R. J., Walker, J., Bath, L., Kelnar, C. J. H., Wallace, W. H., & Critchley, H. (2012) · Human Reproduction · doi:10.1093/humrep/des004 · Cited by 68 · see citing works
Conservation of fertility and oocyte genetics in a young woman with mosaic Turner syndrome
Balen, A., Harris, S., Chambers, E., & Picton, H. (2010) · BJOG: An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.2009.02423.x · Cited by 68 · see citing works
Pregnancy outcome after oocyte donation in patients with Turner's syndrome and partial X monosomy
Mercadal, B. A., Imbert, R., Demeestere, I., Englert, Y., & Delbaere, A. (2011) · Human Reproduction · doi:10.1093/humrep/der166 · Cited by 60 · see citing works
Reproductive performance in women with sex chromosome mosaicism.
Dn, S., Hara, S., Hw, F., et al. (1980) · PubMed · Cited by 40 · see citing works
Fertility and Pregnancy in Turner Syndrome
Bouet, P., Godbout, A., Hachem, H. E., Lefebvre, M., Bérubé, L., Dionne, M.-D., Kamga-Ngandé, C., & Lapensée, L. (2016) · Journal of Obstetrics and Gynaecology Canada · doi:10.1016/j.jogc.2016.02.007 · Cited by 33 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Clinical practice guidelines for the care of girls and women with Turner syndrome.
Gravholt, C. H., Andersen, N. H., Christin-Maitre, S., Davis, S. M., Duijnhouwer, A., Gawlik, A., Maciel-Guerra, A. T., Gutmark-Little, I., Fleischer, K., Hong, D., et al. (2024) · European Journal of Endocrinology · doi:10.1093/ejendo/lvae050 · Cited by 224 · see citing works
Lin, A. E., Prakash, S. K., Andersen, N. H., Viuff, M. H., Levitsky, L. L., Rivera‐Davila, M., Crenshaw, M. L., Hansen, L., Colvin, M. K., Hayes, F. J., et al. (2019) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.61310 · Cited by 50 · see citing works
Cardiovascular outcomes of pregnancy in Turner syndrome
Grewal, J., Valente, A. M., Egbe, A. C., Wu, F. M., Krieger, E. V., Sybert, V. P., van Hagen, I. M., Beauchesne, L. M., Rodriguez, F. H., Broberg, C. S., et al. (2021) · Heart · doi:10.1136/heartjnl-2020-316719 · Cited by 38 · see citing works
Hynes, J. S., Kuller, J. A., Goldstein, S. A., Ward, C. C., & Muasher, S. J. (2020) · Obstetrical & Gynecological Survey · doi:10.1097/ogx.0000000000000833 · Cited by 18 · see citing works
Więcek, M., Gawlik, J., Nowak, Z., & Gawlik, A. (2022) · Endocrine Connections · doi:10.1530/ec-22-0344 · Cited by 11 · see citing works
Dowlut-McElroy, T., & Shankar, R. K. (2022) · Journal of Pediatric and Adolescent Gynecology · doi:10.1016/j.jpag.2022.02.002 · Cited by 11 · see citing works
- Authors
- Cadoret, F., Parinaud, J., Bettiol, C., Pienkowski, C., Letur, H., Ohl, J., Sentilhes, L., Papaxanthos, A., Winer, N., Mathieu d’Argent, E., Catteau-Jonard, S., Chauleur, C., Biquard, F., Hieronimus, S., Pimentel, C., Le Lous, M., Fontaine, N., Chevreau, J., & Parant, O.
- Affiliations
- Centre Hospitalier Universitaire de Toulouse (FR)
- Université Toulouse III - Paul Sabatier (FR)
- Institute Mutualiste Montsouris (FR)
- Hôpitaux Universitaires de Strasbourg (FR)
- Centre Hospitalier Universitaire de Nantes (FR)
- Hôpital Jeanne de Flandre (FR)
- Centre Hospitalier Universitaire d'Angers (FR)
- Centre Hospitalier Universitaire de La Réunion (RE)
- Centre Hospitalier Universitaire Amiens-Picardie (FR)
- Corresponding author
- Parinaud, Jean
- ORCID
- Venue
- European Journal of Obstetrics & Gynecology and Reproductive Biology
- Publisher
- Elsevier BV
- Published
- 2018-10
- Volume
- 229
- Pages
- 20-25
- ISSN
- 0028-2243 (ISSN-L)
- 0301-2115
- OpenAlex
- W2886001423
- Cited by
- 40
- References
- 39
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 8 · 2022: 9 · 2021: 5 · 2020: 5 · 2019: 6
- FWCI
- 2.45
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Obstetrics & Gynecology and Reproductive Biology (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Issues in Pregnancy
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Assisted Reproductive Technology and Twin Pregnancy
- Keywords
- Turner syndrome, pregnancy outcomes, perinatal prognosis, oocyte donation, assisted reproduction, preconception care, preeclampsia, hypertension in pregnancy, preterm birth, stillbirth, intrauterine fetal death
- MeSH terms
- Adult, Female, France, Humans, Pregnancy, Pregnancy Complications, Pregnancy Outcome, Retrospective Studies, Turner Syndrome, Oocyte Donation, Guideline Adherence, Young Adult
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
