NOX5 Expression Is Increased in Intramyocardial Blood Vessels and Cardiomyocytes after Acute Myocardial Infarction in Humans
Open accessAbstract
Reactive oxygen species producing NADPH oxidases play important roles under different (patho)physiological conditions. NOX1, NOX2, and NOX4 are important sources of reactive oxygen species in the heart, but knowledge of the calcium-dependent NOX5 in the heart is lacking. The presence of NOX5 was studied via RT-PCR in heart tissue from patients with end-stage heart failure; the tissue was obtained during cardiac transplantation surgery. NOX5 positivity and cellular localization were studied via IHC and digital-imaging microscopy in heart tissues of patients who did not have heart disease and in infarction areas of patients who died of myocardial infarctions of different durations. Furthermore, NOX5 expression was analyzed in vitro by using Western blot analysis. NOX5 RNA was found in the hearts of controls and patients with ischemic cardiomyopathy. In controls, NOX5 localized to the endothelium of a limited number of intramyocardial blood vessels and to a limited number of scattered cardiomyocytes. In infarcted hearts, NOX5 expression increased, especially in infarctions >12 hours, which manifested as an increase in NOX5-positive intramyocardial blood vessels, as well as in endothelium, smooth muscle, and cardiomyocytes. NOX5 was found in cardiomyocyte cytoplasm, plasma membrane, intercalated disks, and cross striations. Western blot analysis confirmed NOX5 expression in isolated human cardiomyocytes. For the first time to our knowledge, we demonstrate NOX5 expression in human intramyocardial blood vessels and cardiomyocytes, with significant increases in the affected myocardium after acute myocardial infarction.
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NOX5 expression also increases in the human heart after MI.
“NOX5 expression also increases in the human heart after MI (396).”
From Sources of Vascular Nitric Oxide and Reactive Oxygen Species and Their Regulation (2019) · cites this paper as [396]
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- Authors
- Hahn, N. E., Meischl, C., Kawahara, T., Musters, R. J. P., Verhoef, V. M. J., van der Velden, J., Vonk, A. B. A., Paulus, W. J., van Rossum, A. C., Niessen, H. W. M., & Krijnen, P. A. J.
- Affiliations
- Amsterdam UMC Location Vrije Universiteit Amsterdam (NL)
- Emory University (US)
- Corresponding author
- Hahn, Nynke E.
- Venue
- The American Journal of Pathology
- Publisher
- Elsevier BV
- Published
- 2012-06
- Volume
- 180
- Issue
- 6
- Pages
- 2222-2229
- ISSN
- 0002-9440 (ISSN-L)
- OpenAlex
- W1987665013
- Cited by
- 67
- References
- 45
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 5 · 2023: 3 · 2022: 5 · 2021: 8 · 2020: 6 · 2019: 9 · 2018: 5 · 2017: 2 · 2016: 1 · 2015: 6 · 2014: 8 · 2013: 3 · 2012: 1
- FWCI
- 3.85
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- American Journal Of Pathology (publishedVersion)
- PubMed (publishedVersion)
- Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
- Pure Amsterdam UMC (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Funders
- Vrije Universiteit Amsterdam (2008V076)
- Topics
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Health Sciences › Medicine › Pathology and Forensic Medicine › Cardiac Ischemia and Reperfusion
- Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Keywords
- NADPH oxidase 5, NADPH oxidase, acute myocardial infarction, cardiomyocytes, reactive oxygen species, ischemic cardiomyopathy, end-stage heart failure, human heart tissue, endothelium, smooth muscle, intercalated discs
- MeSH terms
- NADPH Oxidase 5, Aged, Coronary Vessels, Female, Heart Failure, Humans, Male, Membrane Proteins, Middle Aged, Myocardial Infarction, RNA, Messenger, Testis, Gene Expression Regulation, Enzymologic, NADPH Oxidases, Myocytes, Cardiac, Real-Time Polymerase Chain Reaction
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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