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Cited by 323Nitric Oxide and Endothelin EffectsNeutrophil, Myeloperoxidase and Oxidative MechanismsRedox biology and oxidative stress

Endothelial Dysfunction: Is There a Hyperglycemia-Induced Imbalance of NOX and NOS?

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Meza, Cesar A., La Favor, Justin D., Kim, Do-Houn, Hickner, Robert C.·2019·International Journal of Molecular Sciences
DOI 10.3390/ijms20153775PMC PMC6696313
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Abstract

NADPH oxidases (NOX) are enzyme complexes that have received much attention as key molecules in the development of vascular dysfunction. NOX have the primary function of generating reactive oxygen species (ROS), and are considered the main source of ROS production in endothelial cells. The endothelium is a thin monolayer that lines the inner surface of blood vessels, acting as a secretory organ to maintain homeostasis of blood flow. The enzymatic production of nitric oxide (NO) by endothelial NO synthase (eNOS) is critical in mediating endothelial function, and oxidative stress can cause dysregulation of eNOS and endothelial dysfunction. Insulin is a stimulus for increases in blood flow and endothelium-dependent vasodilation. However, cardiovascular disease and type 2 diabetes are characterized by poor control of the endothelial cell redox environment, with a shift toward overproduction of ROS by NOX. Studies in models of type 2 diabetes demonstrate that aberrant NOX activation contributes to uncoupling of eNOS and endothelial dysfunction. It is well-established that endothelial dysfunction precedes the onset of cardiovascular disease, therefore NOX are important molecular links between type 2 diabetes and vascular complications. The aim of the current review is to describe the normal, healthy physiological mechanisms involved in endothelial function, and highlight the central role of NOX in mediating endothelial dysfunction when glucose homeostasis is impaired.

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Cited by

Sorted by citations

Authors
Meza, C. A., La Favor, J. D., Kim, D.-H., & Hickner, R. C.
Affiliations
  • Florida State University (US)
  • Department of Nutrition, Food & Exercise Sciences, Florida State University, Tallahassee, FL 32306, USA
Corresponding author
Hickner, Robert C.
ORCID
Venue
International Journal of Molecular Sciences
Publisher
MDPI AG
Published
2019-08-02
Volume
20
Issue
15
Pages
3775
ISSN
1422-0067 (ISSN-L)
DOI
10.3390/ijms20153775
PMC
PMC6696313
OpenAlex
W2965419534
Cited by
323
References
41
Citations by year
2026: 36 · 2025: 46 · 2024: 55 · 2023: 57 · 2022: 59 · 2021: 43 · 2020: 26 · 2019: 1
FWCI
3.80
Type
journal article
Language
en
Open access
Licence
Locations
  • International Journal of Molecular Sciences (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
National Institutes of Health (2R15HL113854-01A1, 1R15HL113854-01A1, K01DK115540-01)
Topics
  • Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
  • Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Keywords
endothelial dysfunction, NADPH oxidase, endothelial nitric oxide synthase, nitric oxide, hyperglycemia, type 2 diabetes, reactive oxygen species, oxidative stress, eNOS uncoupling, insulin, cardiovascular disease, glucose homeostasis
MeSH terms
Animals, Cardiovascular Diseases, Diabetes Mellitus, Type 2, Endothelium, Vascular, Glucose, Humans, Hyperglycemia, Reactive Oxygen Species, NADPH Oxidases, Nitric Oxide Synthase Type III

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

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