New Roles of Cyclin D1

Genetic instabilities in human cancers

Lengauer, C., Kinzler, K. W., & Vogelstein, B. (1998) · Nature · doi:10.1038/25292 · Cited by 4,168 · see citing works

Cell cycle, CDKs and cancer: a changing paradigm

Malumbres, M., & Barbacid, M. (2009) · Nature Reviews Cancer · doi:10.1038/nrc2602 · Cited by 3,957 · see citing works

G1 cell-cycle control and cancer

Massagué, J. (2004) · Nature · doi:10.1038/nature03094 · Cited by 1,217 · see citing works

A signature of chromosomal instability inferred from gene expression profiles predicts clinical outcome in multiple human cancers

Carter, S. L., Eklund, A. C., Kohane, I. S., Harris, L. N., & Szállási, Z. (2006) · Nature Genetics · doi:10.1038/ng1861 · Cited by 1,199 · see citing works

Cyclin D1 provides a link between development and oncogenesis in the retina and breast

Sicinski, P., Donaher, J. L., Parker, S. B., Li, T., Fazeli, A., Gardner, H., Haslam, S. Z., Bronson, R. T., Elledge, S. J., & Weinberg, R. A. (1995) · Cell · doi:10.1016/0092-8674(95)90034-9 · Cited by 1,021 · see citing works

Minireview: Cyclin D1: Normal and Abnormal Functions

Fu, M., Wang, C., Li, Z., Sakamaki, T., & Pestell, R. G. (2004) · Endocrinology · doi:10.1210/en.2004-0959 · Cited by 961 · see citing works

CDK-Independent Activation of Estrogen Receptor by Cyclin D1

Zwijsen, R. M. L., Wientjens, E., Klompmaker, R., van der Sman, J., Bernards, R., & Michalides, R. J. A. M. (1997) · Cell · doi:10.1016/s0092-8674(00)81879-6 · Cited by 720 · see citing works

Deregulated cyclin E induces chromosome instability

Spruck, C., Won, K., & Reed, S. I. (1999) · Nature · doi:10.1038/45836 · Cited by 692 · see citing works

Mice lacking cyclin D1 are small and show defects in eye and mammary gland development.

Fantl, V, Stamp, G., Andrews, A., Rosewell, I., & Dickson, C. (1995) · Genes & Development · doi:10.1101/gad.9.19.2364 · Cited by 691 · see citing works

Mechanisms of Chromosomal Instability

Thompson, S. L., Bakhoum, S. F. W., & Compton, D. A. (2010) · Current Biology · doi:10.1016/j.cub.2010.01.034 · Cited by 600 · see citing works

Cdk4/CyclinD1 Overexpression in Neural Stem Cells Shortens G1, Delays Neurogenesis, and Promotes the Generation and Expansion of Basal Progenitors

Lange, C. M., Huttner, W. Β., & Calegari, F. (2009) · Cell stem cell · doi:10.1016/j.stem.2009.05.026 · Cited by 565 · see citing works

BRCA1 inhibition of estrogen receptor signaling in transfected cells.

Fan, S., Wang, J.-A., Yuan, R., Ma, Y., Meng, Q., Erdos, M., Pestell, R., Yuan, F., Auborn, K., Goldberg, I., et al. (1999) · Science · doi:10.1126/science.284.5418.1354 · Cited by 521 · see citing works

A Mechanism of Cyclin D1 Action Encoded in the Patterns of Gene Expression in Human Cancer

Lamb, J., Ramaswamy, S., Ford, H. L., Contreras, B., Martinez, R. V. P., Kittrell, F. S., Zahnow, C. A., Patterson, N. J., Golub, T. R., & Ewen, M. E. (2003) · Cell · doi:10.1016/s0092-8674(03)00570-1 · Cited by 410 · see citing works

Cyclin D1 Stimulation of Estrogen Receptor Transcriptional Activity Independent of cdk4†

Neuman, E., Ladha, M. H., Lin, N., Upton, T. M., Miller, S. J., DiRenzo, J., Pestell, R. G., Hinds, P. W., Dowdy, S. F., Brown, M. A., et al. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.9.5338 · Cited by 393 · see citing works

Distinct Initiation and Maintenance Mechanisms Cooperate to Induce G1 Cell Cycle Arrest in Response to DNA Damage

Agami, R., & Bernards, R. (2000) · Cell · doi:10.1016/s0092-8674(00)00010-6 · Cited by 391 · see citing works

The Cyclins and Cyclin-Dependent Kinase Inhibitors in Hormonal Regulation of Proliferation and Differentiation

Pestell, R. G., Albanese, C., Reutens, A. T., Segall, J. E., Lee, R. J., & Arnold, A. (1999) · Endocrine Reviews · doi:10.1210/edrv.20.4.0373 · Cited by 376 · see citing works

Cell cycle–regulated phosphorylation of p220 NPAT by cyclin E/Cdk2 in Cajal bodies promotes histone gene transcriptionPreprint

Ma, T., Tine, B. A. V., Yue, W., Garrett, M. D., Nelson, D. M., Adams, P. D., Wang, J., Qin, J., Chow, L. T., & Harper, J. W. (2000) · Genes & Development · doi:10.1101/gad.829500 · Cited by 373 · see citing works

A cyclin D1/microRNA 17/20 regulatory feedback loop in control of breast cancer cell proliferation

Yu, Z., Wang, C., Wang, M., Li, Z., Casimiro, M. C., Liu, M., Wu, K., Whittle, J. R., Ju, X., Hyslop, T., et al. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200801079 · Cited by 362 · see citing works

Rescue of Cyclin D1 Deficiency by Knockin Cyclin E

Geng, Y., Whoriskey, W. J., Park, M. Y., Bronson, R. T., Medema, R. H., Li, T., Weinberg, R. A., & Siciński, P. (1999) · Cell · doi:10.1016/s0092-8674(00)80788-6 · Cited by 336 · see citing works

A function for cyclin D1 in DNA repair uncovered by protein interactome analyses in human cancers

Jirawatnotai, S., Hu, Y., Michowski, W., Elias, J. E., Becks, L., Bienvenu, F., Zagozdzon, A., Goswami, T., Wang, Y. E., Clark, A. B., et al. (2011) · Nature · doi:10.1038/nature10155 · Cited by 333 · see citing works

Distinct roles for cyclins E and A during DNA replication complex assembly and activation

Coverley, D., Laman, H., & Laskey, R. A. (2002) · Nature Cell Biology · doi:10.1038/ncb813 · Cited by 297 · see citing works

Role of direct interaction in BRCA1 inhibition of estrogen receptor activity

Fan, S., Ma, Y.-X., Wang, C.-G., Yuan, R., Meng, Q., Wang, J.-A., Erdos, M., Goldberg, I., Webb, P., Kushner, P., et al. (2001) · Oncogene · doi:10.1038/sj.onc.1204073 · Cited by 293 · see citing works

Cyclin D1 Inhibits Peroxisome Proliferator-activated Receptor γ-mediated Adipogenesis through Histone Deacetylase Recruitment

Fu, M., Rao, M., Bouras, T., Wang, C., Wu, K., Zhang, X., Li, Z., Yao, T., & Pestell, R. G. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m500403200 · Cited by 274 · see citing works

Nuclear Cyclin D1/CDK4 Kinase Regulates CUL4 Expression and Triggers Neoplastic Growth via Activation of the PRMT5 Methyltransferase

Aggarwal, P., Vaites, L. P., Kim, J. K., Mellert, H. S., Gurung, B., Nakagawa, H., Herlyn, M., Hua, X., Rustgi, A. K., McMahon, S. B., et al. (2010) · Cancer Cell · doi:10.1016/j.ccr.2010.08.012 · Cited by 243 · see citing works

microRNA 17/20 inhibits cellular invasion and tumor metastasis in breast cancer by heterotypic signaling

Yu, Z., Willmarth, N. E., Zhou, J., Katiyar, S., Wang, M., Liu, Y., McCue, P. A., Quong, A. A., Lisanti, M. P., & Pestell, R. G. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1002080107 · Cited by 241 · see citing works

Cyclin D1 repression of nuclear respiratory factor 1 integrates nuclear DNA synthesis and mitochondrial function

Wang, C., Li, Z., Lu, Y., Du, R., Katiyar, S., Yang, J., Fu, M., Leader, J. E., Quong, A. A., Novikoff, P. M., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0603363103 · Cited by 208 · see citing works

A Centrosomal Localization Signal in Cyclin E Required for Cdk2-Independent S Phase Entry

Matsumoto, Y., & Maller, J. L. (2004) · Science · doi:10.1126/science.1103544 · Cited by 202 · see citing works

Cyclin D1 Repression of Peroxisome Proliferator-Activated Receptor γ Expression and Transactivation

Wang, C., Pattabiraman, N., Zhou, J., Fu, M., Sakamaki, T., Albanese, C., Li, Z., Wu, K., Hulit, J., Neumeister, P., et al. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.17.6159-6173.2003 · Cited by 195 · see citing works

Cyclin D1 Binds the Androgen Receptor and Regulates Hormone-Dependent Signaling in a p300/CBP-Associated Factor (P/CAF)-Dependent Manner

Reutens, A. T., Fu, M., Wang, C., Albanese, C., McPhaul, M. J., Sun, Z., Balk, S. P., Jänne, O. A., Palvimo, J. J., & Pestell, R. G. (2001) · Molecular Endocrinology · doi:10.1210/mend.15.5.0641 · Cited by 189 · see citing works

Activation of the cyclin D1 Gene by the E1A-associated Protein p300 through AP-1 Inhibits Cellular Apoptosis

Albanese, C., D’Amico, M., Reutens, A. T., Fu, M., Watanabe, G., Lee, R. J., Kitsis, R. N., Henglein, B., Avantaggiati, M. L., Somasundaram, K., et al. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.48.34186 · Cited by 189 · see citing works

Kinase-independent function of cyclin E

Geng, Y., Lee, Y.-M., Welcker, M., Swanger, J., Zagozdzon, A., Winer, J. D., Roberts, J. M., Kaldis, P., Clurman, B. E., & Sicinski, P. (2007) · Molecular Cell · doi:10.1016/j.molcel.2006.11.029 · Cited by 187 · see citing works

Cyclin D1 Determines Mitochondrial Function InVivo

Sakamaki, T., Casimiro, M. C., Ju, X., Quong, A. A., Katiyar, S., Liu, M., Jiao, X., Li, A., Zhang, X., Lu, Y., et al. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.02074-05 · Cited by 184 · see citing works

P/CAF associates with cyclin D1 and potentiates its activation of the estrogen receptor

McMahon, C. M., Suthiphongchai, T., DiRenzo, J., & Ewen, M. E. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.10.5382 · Cited by 179 · see citing works

Cyclin D1 Regulates Cellular Migration through the Inhibition of Thrombospondin 1 and ROCK Signaling

Li, Z., Wang, C., Jiao, X., Lu, Y., Fu, M., Quong, A. A., Dye, C., Yang, J., Dai, M., Ju, X., et al. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.02124-05 · Cited by 174 · see citing works

Chromosome segregation and genomic stability

Draviam, V. M., Xie, S. Z.-J., & Sorger, P. K. (2004) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2004.02.007 · Cited by 168 · see citing works

Inhibition of Cyclin D1 Kinase Activity Is Associated with E2F-Mediated Inhibition of Cyclin D1 Promoter Activity through E2F and Sp1

Watanabe, G., Albanese, C., Lee, R. J., Reutens, A. T., Vairo, G., Henglein, B., & Pestell, R. G. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.6.3212 · Cited by 164 · see citing works

Deletion of the p27 Kip1 gene restores normal development in cyclin D1-deficient mice

Geng, Y., Yu, Q., Sicińska, E., Das, M., Bronson, R. T., & Siciński, P. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.1.194 · Cited by 158 · see citing works

Cyclin D1Governs Adhesion and Motility of Macrophages

Neumeister, P., Pixley, F. J., Xiong, Y., Xie, H., Wu, K., Ashton, A. W., Cammer, M., Chan, A. Y., Symons, M. H., Stanley, E. R., et al. (2003) · Molecular Biology of the Cell · doi:10.1091/mbc.02-07-0102 · Cited by 152 · see citing works

p300 Modulates the BRCA1 inhibition of estrogen receptor activity.

Fan, S., Ma, Y. X., Wang, C., Yuan, R., Meng, Q., Wang, J., Erdos, M. R., Goldberg, I. D., Webb, P., Kushner, P. J., et al. (2002) · PubMed · Cited by 148 · see citing works

Mechanisms leading to chromosomal instability

Gollin, S. M. (2004) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2004.09.004 · Cited by 143 · see citing works

Cyclin D1 Genetic Heterozygosity Regulates Colonic Epithelial Cell Differentiation and Tumor Number in ApcMin Mice

Hulit, J., Wang, C., Li, Z., Albanese, C., Rao, M., Vizio, D. D., Shah, S., Byers, S. W., Mahmood, R., Augenlicht, L. H., et al. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.17.7598-7611.2004 · Cited by 143 · see citing works

BRCA1 Regulates Acetylation and Ubiquitination of Estrogen Receptor-α

Ma, Y., Fan, S., Hu, C., Meng, Q., Fuqua, S. A. W., Pestell, R. G., Tomita, Y. A., & Rosen, E. M. (2009) · Molecular Endocrinology · doi:10.1210/me.2009-0218 · Cited by 140 · see citing works

<i>Rb</i> intrinsically promotes erythropoiesis by coupling cell cycle exit with mitochondrial biogenesis

Sankaran, V. G., Orkin, & Walkley, C. R. (2008) · Genes &amp; Development · doi:10.1101/gad.1627208 · Cited by 133 · see citing works

Nuclear accumulation of cyclin D1 during S phase inhibits Cul4-dependent Cdt1 proteolysis and triggers p53-dependent DNA rereplication

Aggarwal, P., Lessie, M. D., Lin, D. I., Pontano, L., Gladden, A. B., Nuskey, B., Goradia, A., Wasik, M. A., Klein-Szanto, A. J. P., Rustgi, A. K., et al. (2007) · Genes &amp; Development · doi:10.1101/gad.1586007 · Cited by 132 · see citing works

Cyclin D3 Promotes Adipogenesis through Activation of Peroxisome Proliferator-Activated Receptor γ

Sarruf, D. A., Iankova, I., Abella, A., Assou, S., Miard, S., & Lluis Fajas, A. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.22.9985-9995.2005 · Cited by 130 · see citing works

Cyclin D1 Kinase Activity Is Required for the Self-Renewal of Mammary Stem and Progenitor Cells that Are Targets of MMTV-ErbB2 Tumorigenesis

Jeselsohn, R. M., Brown, N. E., Arendt, L. M., Klebba, I., Hu, M. G., Kuperwasser, C., & Hinds, P. W. (2010) · Cancer Cell · doi:10.1016/j.ccr.2009.11.024 · Cited by 127 · see citing works

Cyclin D1, Id1 and EMT in breast cancer

Tobin, N. P., Sims, A. H., Lundgren, K., Lehn, S., & Landberg, G. (2011) · BMC Cancer · doi:10.1186/1471-2407-11-417 · Cited by 124 · see citing works

Cyclin D1 Induction of Cellular Migration Requires p27KIP1

Li, Z., Jiao, X., Wang, C., Ju, X., Lu, Y., Yuan, L., Lisanti, M. P., Katiyar, S., & Pestell, R. G. (2006) · Cancer Research · doi:10.1158/0008-5472.can-06-1596 · Cited by 123 · see citing works

ChIP sequencing of cyclin D1 reveals a transcriptional role in chromosomal instability in mice

Casimiro, M. C., Crosariol, M., Loro, E., Ertel, A., Yu, Z., Dampier, W., Saria, E. A., Papanikolaou, A., Stanek, T. J., Li, Z., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci60256 · Cited by 115 · see citing works

A mouse model for cyclin E-dependent genetic instability and tumorigenesis

Loeb, K. R., Kostner, H., Firpo, E. J., Norwood, T. H., Tsuchiya, K. D., Clurman, B. E., & Roberts, J. M. (2005) · Cancer Cell · doi:10.1016/j.ccr.2005.06.010 · Cited by 107 · see citing works

Cyclin D1 overexpression enhances radiation-induced apoptosis and radiosensitivity in a breast tumor cell line.

Martín‐Fernández, J. M., Balkenende, A., Verschoor, T., Lallemand, F., & Michalides, R. J. A. M. (1999) · PubMed · Cited by 106 · see citing works

Cyclin D1 Antagonizes BRCA1 Repression of Estrogen Receptor α Activity

Wang, C., Fan, S., Li, Z., Fu, M., Rao, M., Ma, Y., Lisanti, M. P., Albanese, C., Katzenellenbogen, B. S., Kushner, P. J., et al. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-0486 · Cited by 93 · see citing works

Cyclin D1 Represses p300 Transactivation through a Cyclin-dependent Kinase-independent Mechanism

Fu, M., Wang, C., Rao, M., Wu, X., Bouras, T., Zhang, X., Li, Z., Jiao, X., Yang, J., Li, A., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m503188200 · Cited by 91 · see citing works

Cyclin D1 Is a Ligand-independent Co-repressor for Thyroid Hormone Receptors

Lin, H., Zhao, L., & Cheng, S.-Y. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m203380200 · Cited by 90 · see citing works

Metabolic control of G1–S transition: cyclin E degradation by p53-induced activation of the ubiquitin–proteasome system

Mandal, S., Freije, W. A., Guptan, P., & Banerjee, U. K. (2010) · The Journal of Cell Biology · doi:10.1083/jcb.200912024 · Cited by 85 · see citing works

Alternate Cyclin D1 mRNA Splicing Modulates p27KIP1 Binding and Cell Migration

Li, Z., Wang, C., Jiao, X., Katiyar, S., Casimiro, M. C., Prendergast, G. C., Powell, M. J., & Pestell, R. G. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m706992200 · Cited by 57 · see citing works

Transcriptional Regulation by a DNA-associated Form of Cyclin D1

Bienvenu, F., Barré, B., Giraud, S., Avril, S., & Coqueret, O. (2005) · Molecular Biology of the Cell · doi:10.1091/mbc.e04-08-0654 · Cited by 47 · see citing works

Cyclin D1 Inhibits Mitochondrial Activity in B Cells

Tchakarska, G., Roussel, M., Troussard, X., & Sola, B. (2011) · Cancer Research · doi:10.1158/0008-5472.can-10-2564 · Cited by 42 · see citing works

PACSIN 2 represses cellular migration through direct association with cyclin D1 but not its alternate splice form cyclin D1b

Meng, H., Tian, L., Zhou, J., Li, Z., Jiao, X., Li, W. W., Plomann, M., Xu, Z., Lisanti, M. P., Wang, C., et al. (2011) · Cell Cycle · doi:10.4161/cc.10.1.14243 · Cited by 41 · see citing works

Radiation and the Apo2L/TRAIL apoptotic pathway preferentially inhibit the colonization of premalignant human breast cells overexpressing cyclin D1.

Zhou, Q. Y., Fukushima, P. I., DeGraff, W., et al. (2000) · PubMed · Cited by 38 · see citing works

The double dealing of cyclin D1

Tchakarska, G., & Sola, B. (2020) · Cell Cycle · doi:10.1080/15384101.2019.1706903 · Cited by 278 · see citing works

CDK6—a review of the past and a glimpse into the future: from cell-cycle control to transcriptional regulation

Tigan, A.-S., Bellutti, F., Kollmann, K., Tebb, G., & Sexl, V (2016) · Oncogene · doi:10.1038/onc.2015.407 · Cited by 204 · see citing works

Exercise rejuvenates quiescent skeletal muscle stem cells in old mice through restoration of Cyclin D1

Brett, J. O., Arjona, M., Ikeda, M., Quarta, M., de Morrée, A., Egner, I. M., Perandini, L. A., Ishak, H. D., Goshayeshi, A., Benjamin, D. I., et al. (2020) · Nature Metabolism · doi:10.1038/s42255-020-0190-0 · Cited by 162 · see citing works

An update on the implications of cyclin D1 in melanomas

González‐Ruiz, L., González‐Moles, M. Á., González‐Ruiz, I., Ruiz‐Ávila, I., Ayén, Á., & Ramos‐García, P. (2020) · Pigment Cell &amp; Melanoma Research · doi:10.1111/pcmr.12874 · Cited by 49 · see citing works

CDK4 inhibition diminishes p53 activation by MDM2 antagonists

Sriraman, A., Dickmanns, A., Najafova, Z., Johnsen, S. A., & Dobbelstein, M. (2018) · Cell Death &amp; Disease · doi:10.1038/s41419-018-0968-0 · Cited by 40 · see citing works

Cyclin E-CDK2 is a regulator of p27Kip1.Preprint

Sheaff, R. J., Groudine, M. T., Gordon, M., Roberts, J., & Clurman, B. E. (1997) · Genes & Development · doi:10.1101/gad.11.11.1464 · Cited by 910 · see citing works

Cyclin-Binding Motifs Are Essential for the Function of p21 <i> ^CIP1 </i>

Chen, J., Saha, P., Kornbluth, S., Dynlacht, B. D., & Dutta, A. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.9.4673 · Cited by 320 · see citing works

Identification of a p130 domain mediating interactions with cyclin A/cdk 2 and cyclin E/cdk 2 complexes

Lacy, S. E., & Whyte, P. (1997) · Oncogene · doi:10.1038/sj.onc.1201085 · Cited by 59 · see citing works

The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases.

Wade Harper, J. (1993) · Cell · doi:10.1016/0092-8674(93)90499-g · Cited by 5,651 · see citing works

Regulation of Cell Cycle Progression

Scorah, J., & McGowan, C. H. (2010) · Elsevier eBooks · doi:10.1016/b978-0-12-374145-5.00302-8 · Cited by 5 · see citing works