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Heme-regulated eIF2α kinase activated Atf4 signaling pathway in oxidative stress and erythropoiesis

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Loss of nucleoplasmic LAP2α–lamin A complexes causes erythroid and epidermal progenitor hyperproliferation

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Mitochondrial fission‐fusion as an emerging key regulator of cell proliferation and differentiation

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AMP-Activated Protein Kinase Phosphorylates Retinoblastoma Protein to Control Mammalian Brain Development

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Cyclin D3 coordinates the cell cycle during differentiation to regulate erythrocyte size and numberPreprint

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Replication stress caused by low MCM expression limits fetal erythropoiesis and hematopoietic stem cell functionality

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Regulation of the PDK4 Isozyme by the Rb-E2F1 Complex

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Molecular and cellular mechanisms that regulate human erythropoiesis

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Regulation of Cancer Metabolism by Oncogenes and Tumor Suppressors

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Heme-regulated eIF2α kinase in erythropoiesis and hemoglobinopathies

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Cyclin E phosphorylation regulates cell proliferation in hematopoietic and epithelial lineages in vivoPreprint

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Cell cycle regulation of mitochondrial function

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Proteomic analysis of pRb loss highlights a signature of decreased mitochondrial oxidative phosphorylationPreprint

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Translational control by heme-regulated eIF2α kinase during erythropoiesis

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Increased mitochondrial function downstream from KDM5A histone demethylase rescues differentiation in pRB-deficient cellsPreprint

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Newly identified aspects of tumor suppression by RB

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Retinoblastoma protein: a central processing unit

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The multiple connections between pRB and cell metabolism

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Direct Binding of pRb/E2F-2 to GATA-1 Regulates Maturation and Terminal Cell Division during Erythropoiesis

Kadri, Z., Shimizu, R., Ohneda, O., Maouche-Chretien, L., Gisselbrecht, S., Yamamoto, M. P., Roméo, P., Leboulch, P., & Chretien, S. (2009) · PLoS Biology · doi:10.1371/journal.pbio.1000123 · Cited by 74 · see citing works

Novel insights into RB1 mutation

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The role of the RB tumour suppressor pathway in oxidative stress responses in the haematopoietic system

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The erythroblastic island as an emerging paradigm in the anemia of inflammation

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Emerging Links between E2F Control and Mitochondrial Function

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Lamin complexes in the nuclear interior control progenitor cell proliferation and tissue homeostasis

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The RB–IL-6 axis controls self-renewal and endocrine therapy resistance by fine-tuning mitochondrial activity

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The Rothmund-Thomson syndrome helicase RECQL4 is essential for hematopoiesis

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Common variants in signaling transcription-factor-binding sites drive phenotypic variability in red blood cell traits

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Combined Inactivation of pRB and Hippo Pathways Induces Dedifferentiation in the Drosophila Retina

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Rescue of myogenic defects in Rb-deficient cells by inhibition of autophagy or by hypoxia-induced glycolytic shift

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Wnt Signaling and Its Impact on Mitochondrial and Cell Cycle Dynamics in Pluripotent Stem Cells

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Regulation of RB Transcription In Vivo by RB Family Members

Burkhart, D. L., Ngai, L. K., Roake, C. M., Viatour, P., Thangavel, C., Ho, V. M., Knudsen, E. S., & Sage, J. (2010) · Molecular and Cellular Biology · doi:10.1128/mcb.00952-09 · Cited by 43 · see citing works

Cell Cycle Regulators Guide Mitochondrial Activity in Radiation-Induced Adaptive Response

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EpoR-tdTomato-Cre mice enable identification of EpoR expression in subsets of tissue macrophages and hematopoietic cells

Zhang, H., Wang, S., Liu, D., Gao, C., Han, Y., Guo, X., Qu, X., Li, W., Zhang, S., Geng, J., et al. (2021) · Blood · doi:10.1182/blood.2021011410 · Cited by 43 · see citing works

Copper deficiency alters cell bioenergetics and induces mitochondrial fusion through up-regulation of MFN2 and OPA1 in erythropoietic cells

Bustos, R. I., Jensen, E. L., Ruíz, L. M., Rivera, S., Ruiz, S., Simón, F., Riedel, C. A., Ferrick, D. A., & Elorza, Á. A. (2013) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2013.06.095 · Cited by 41 · see citing works

Metabolic alterations accompanying oncogene-induced senescence

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Chk1 Haploinsufficiency Results in Anemia and Defective Erythropoiesis

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Loss of dE2F compromises mitochondrial function

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E2F-2 Promotes Nuclear Condensation and Enucleation of Terminally Differentiated Erythroblasts

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Evidence for a mitochondrial localization of the retinoblastoma protein

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Fbw7-dependent cyclin E regulation ensures terminal maturation of bone marrow erythroid cells by restraining oxidative metabolism

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MCM8- and MCM9 Deficiencies Cause Lifelong Increased Hematopoietic DNA Damage Driving p53-Dependent Myeloid Tumors

Lutzmann, M., Bernex, F., de Jesus, C. D. C., Hodroj, D., Marty, C., Plo, I., Vainchenker, W., Tosolini, M., Forichon, L., Bret, C., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.07.095 · Cited by 33 · see citing works

Mice lacking the sodium-dependent phosphate import protein, PiT1 (SLC20A1), have a severe defect in terminal erythroid differentiation and early B cell development

Liu, L., Sánchez-Bonilla, M., Crouthamel, M. H., Giachelli, C. M., & Keel, S. (2013) · Experimental Hematology · doi:10.1016/j.exphem.2013.01.004 · Cited by 32 · see citing works

Twists in views on RB functions in cellular signaling, metabolism and stem cells

Takahashi, C., Sasaki, N., & Kitajima, S. (2012) · Cancer Science · doi:10.1111/j.1349-7006.2012.02284.x · Cited by 29 · see citing works

New Insights into the Mechanisms of Mammalian Erythroid Chromatin Condensation and Enucleation

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Loss of p16INK4A stimulates aberrant mitochondrial biogenesis through a CDK4/Rb-independent pathway

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Uncoupling of the Hippo and Rho pathways allows megakaryocytes to escape the tetraploid checkpoint

Roy, A., Lordier, L., Pioche‐Durieu, C., Souquère, S., Roy, L., Rameau, P., Lapierre, V., Cam, É. L., Plo, I., Debili, N., et al. (2016) · Haematologica · doi:10.3324/haematol.2016.149914 · Cited by 29 · see citing works

microRNA-4331 Promotes Transmissible Gastroenteritis Virus (TGEV)-induced Mitochondrial Damage Via Targeting RB1, Upregulating Interleukin-1 Receptor Accessory Protein (IL1RAP), and Activating p38 MAPK Pathway In Vitro

Zhao, X., Bai, X., Guan, L., Li, J., Song, X., Ma, X., Guo, J., Zhang, Z., Du, Q., Huang, Y., et al. (2017) · Molecular & Cellular Proteomics · doi:10.1074/mcp.ra117.000432 · Cited by 27 · see citing works

KLF1 mutation E325K induces cell cycle arrest in erythroid cells differentiated from congenital dyserythropoietic anemia patient-specific induced pluripotent stem cells

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SOD2 Deficient Erythroid Cells Up-Regulate Transferrin Receptor and Down-Regulate Mitochondrial Biogenesis and Metabolism

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Computational annotation of UTR cis-regulatory modules through Frequent Pattern Mining

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Gfi-1 regulates the erythroid transcription factor network through Id2 repression in murine hematopoietic progenitor cells

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The Role of RB in Prostate Cancer Progression

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Patterns in the tapestry of chromatin-bound RB

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A protective role of heme-regulated eIF2α kinase in cadmium-induced toxicity in erythroid cells

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Concomitant inactivation of Rb and E2f8 in hematopoietic stem cells synergizes to induce severe anemia

Hu, T., Ghazaryan, S., Sy, C. B., Wiedmeyer, C. E., Chang, V. T.-S., & Wu, L. (2012) · Blood · doi:10.1182/blood-2011-10-388231 · Cited by 22 · see citing works

Aconitase Regulation of Erythropoiesis Correlates with a Novel Licensing Function in Erythropoietin-Induced ERK Signaling

Talbot, A.-L., Bullock, G. C., Delehanty, L. L., Sattler, M., Zhao, Z. J., & Goldfarb, A. N. (2011) · PLoS ONE · doi:10.1371/journal.pone.0023850 · Cited by 22 · see citing works

The SKI proto-oncogene enhances the in vivo repopulation of hematopoietic stem cells and causes myeloproliferative disease

Singbrant, S., Wall, M., Moody, J. L., Karlsson, G., Chalk, A. M., Liddicoat, B., Russell, M. R., Walkley, C. R., & Karlsson, S. (2014) · Haematologica · doi:10.3324/haematol.2013.093971 · Cited by 22 · see citing works

Translational Isoforms of FOG1 Regulate GATA1-interacting Complexes

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Cell-cycle exit and stem cell differentiation are coupled through regulation of mitochondrial activity in the Drosophila testis

de la Maza, D. S., Hof‐Michel, S., Phillimore, L., Bökel, C., & Amoyel, M. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.110774 · Cited by 21 · see citing works

Transcriptional regulation of Elf-1 : locus-wide analysis reveals four distinct promoters, a tissue-specific enhancer, control by PU.1 and the importance of Elf-1 downregulation for erythroid maturation

Calero‐Nieto, F. J., Wood, A. D., Wilson, N. K., Kinston, S., Landry, J., & Göttgens, B. (2010) · Nucleic Acids Research · doi:10.1093/nar/gkq490 · Cited by 21 · see citing works

Global analysis of induced transcription factors and cofactors identifies Tfdp2 as an essential coregulator during terminal erythropoiesis

Chen, C., & Lodish, H. F. (2014) · Experimental Hematology · doi:10.1016/j.exphem.2014.03.001 · Cited by 19 · see citing works

Proof of Gene Doping in a Mouse Model with a Human Erythropoietin Gene Transferred Using an Adenoviral Vector

Sugasawa, T., Nakano, T., Fujita, S.-I., Matsumoto, Y., Ishihara, G., Aoki, K., Yanazawa, K., Ono, S., Tamai, S., Manevich, L., et al. (2021) · Genes · doi:10.3390/genes12081249 · Cited by 20 · see citing works

Mitochondrial regulation of erythropoiesis in homeostasis and disease

Menon, V., Slavinsky, M., Hermine, O., & Ghaffari, S. (2024) · British Journal of Haematology · doi:10.1111/bjh.19600 · Cited by 19 · see citing works

Peripheral Blood Mononuclear Cell-Derived Erythroid Progenitors and Erythroblasts Are Decreased in Burn Patients

Williams, K. N., Szilágyi, A., Conrad, P. F., Halerz, M. M., Kini, A., Li, Y., Gamelli, R. L., Shankar, R., & Muthumalaiappan, K. (2013) · Journal of Burn Care & Research · doi:10.1097/bcr.0b013e3182642ccd · Cited by 18 · see citing works

Cancer stem cells and the cell cycle: targeting the drive behind breast cancer

Velasco-Velázquez, M. A., Yu, Z., Jiao, X., & Pestell, R. G. (2009) · Expert Review of Anticancer Therapy · doi:10.1586/14737140.9.3.275 · Cited by 18 · see citing works

Deregulated G1/S control and energy stress contribute to the synthetic lethal interactions between inactivation ofRBandTSC1/TSC2

Gordon, G. M., Zhang, T., Zhao, J., & Du, W. (2013) · Journal of Cell Science · doi:10.1242/jcs.121301 · Cited by 17 · see citing works

Choosing Cell Fate Through a Dynamic Cell Cycle

Chen, X., Hartman, A. A., & Guo, S. (2015) · Current Stem Cell Reports · doi:10.1007/s40778-015-0018-0 · Cited by 16 · see citing works

Pharmacologically targetable vulnerability in prostate cancer carrying RB1-SUCLA2 deletion

Kohno, S., Linn, P., Nagatani, N., Watanabe, Y., Kumar, S., Soga, T., & Takahashi, C. (2020) · Oncogene · doi:10.1038/s41388-020-1381-6 · Cited by 14 · see citing works

Rb and hematopoiesis: stem cells to anemia

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Genome‐wide association study follow‐up identifies cyclin A2 as a regulator of the transition through cytokinesis during terminal erythropoiesis

Ludwig, L. S., Cho, H., Wakabayashi, A., Eng, J. C., Ulirsch, J. C., Fleming, M. D., Lodish, H. F., & Sankaran, V. G. (2015) · American Journal of Hematology · doi:10.1002/ajh.23952 · Cited by 16 · see citing works

p107 mediated mitochondrial function controls muscle stem cell proliferative fates

Bhattacharya, D., Shah, V., Oresajo, O., & Scimè, A. (2021) · Nature Communications · doi:10.1038/s41467-021-26176-0 · Cited by 15 · see citing works

Identification of gene networks associated with erythroid differentiation

PELLER, S., Tabach, Y., Rotschild, M., Garach-Joshua, O., Cohen, Y., Goldfinger, N., & Rotter, V. (2009) · Blood Cells Molecules and Diseases · doi:10.1016/j.bcmd.2009.01.020 · Cited by 14 · see citing works

Antibiotics for cancer therapy

Pestell, R. G., & Rizvanov, A. A. (2015) · Oncotarget · doi:10.18632/oncotarget.3388 · Cited by 14 · see citing works

Inactivation of Rb and E2f8 Synergizes To Trigger Stressed DNA Replication during Erythroid Terminal Differentiation

Ghazaryan, S., Sy, C. B., Hu, T., An, X., Mohandas, N., Fu, H., Aladjem, M. I., Chang, V. T.-S., Opavský, R., & Wu, L. (2014) · Molecular and Cellular Biology · doi:10.1128/mcb.01651-13 · Cited by 12 · see citing works

Mouse Models of Erythropoiesis and Associated Diseases

Parker, M. P., & Peterson, K. R. (2017) · Methods in molecular biology · doi:10.1007/978-1-4939-7428-3_3 · Cited by 12 · see citing works

Enhancing mitochondrial function in vivo rescues MDS-like anemia induced by pRb deficiency

Sen, T., Jain, M. V., Gram, M., Mattebo, A., Soneji, S., Walkley, C. R., & Singbrant, S. (2020) · Experimental Hematology · doi:10.1016/j.exphem.2020.06.006 · Cited by 12 · see citing works

Increased Reactive Oxygen Species and Cell Cycle Defects Contribute to Anemia in the RASA3 Mutant Mouse Model scat

Hartman, E., Brindley, E. C., Papoin, J., Ciciotte, S. L., Zhao, Y., Peters, L. L., & Blanc, L. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00689 · Cited by 11 · see citing works

Prognostic significance of mitochondrial oxidative phosphorylation complexes: Therapeutic target in the treatment of retinoblastoma

Singh, L., Saini, N., Bakhshi, S., Pushker, N., Sen, S., Sharma, A., Kaur, J., & Kashyap, S. (2015) · Mitochondrion · doi:10.1016/j.mito.2015.06.001 · Cited by 11 · see citing works

GFP reporter mice for the retinoblastoma-related cell cycle regulator p107

Burkhart, D. L., Viatour, P., Ho, V. M., & Sage, J. (2008) · Cell Cycle · doi:10.4161/cc.7.16.6441 · Cited by 11 · see citing works

Cycling on with Decreased Mitochondrial Function

Adler, E. M. (2008) · Science Signaling · doi:10.1126/stke.18ec73

Enhancing mitochondrial function in vivo rescues MDS-like anemia induced by pRb deficiency

Sen, T., Jain, M. V., Gram, M., Mattebo, A., Soneji, S., Walkley, C. R., & Singbrant, S. (2020) · Experimental Hematology · doi:10.1016/j.exphem.2020.06.006 · Cited by 12 · see citing works

Erythroid-specific deletion of pRb results in development of MDS-like anemia with a differentiation block in orthochromatic erythroblasts due to impaired mitochondrial function and heme synthesis

Sen, T., Gram, M., Soneji, S., Walkley, C. R., & Singbrant, S. (2017) · Experimental Hematology · doi:10.1016/j.exphem.2017.06.126

Rb Regulates Erythroid Differentiation through Bcl-XL-Dependent Anti-Apoptotic Effect.

Matsuoka, S., Hirao, A., Arai, F., Ito, K., Takubo, K., Nomiyama, K., Hamaguchi, I., Ikeda, Y., & Suda, T. (2004) · Blood · doi:10.1182/blood.v104.11.1261.1261

Rb Plays an Essential Role in Erythroid Differentiation through Inhibition of Apoptosis Mediated by NFKB.

Matsuoka, S., Hirao, A., Arai, F., Takubo, K., Miyamoto, K., Hosokawa, K., & Suda, T. (2005) · Blood · doi:10.1182/blood.v106.11.308.308