Cited by 38Liver physiology and pathologyChromosomal and Genetic VariationsMicrotubule and mitosis dynamics

The origins and functions of hepatic polyploidy

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Zhang, Shuyuan, Lin, Yu-Hsuan, Tarlow, Branden, Zhu, Hao·2019·Cell Cycle

Abstract

Polyploid cells contain more than two homologous sets of chromosomes. The original observations of liver polyploidy date back to the 1940s, but functional roles for polyploid cells are still unclear. Liver polyploidy may influence regeneration, stress response, and cancer, although little evidence has established direct causal links between polyploidy and these biological phenotypes. In this review, we will introduce broad concepts about polyploidy including its distribution in nature and how polyploids form in normal and pathological situations. Then we will examine recent discoveries that have begun to clarify functionality and disease relevance of liver polyploidy. Finally, we will discuss implications and future directions of research about polyploidy in the liver.

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  1. Kaneko Y, Knudson AG. Mechanism and relevance of ploidy in neuroblastoma. Genes Chromosomes Cancer. 2000;29(2):89-95.

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Authors
Zhang, S., Lin, Y.-H., Tarlow, B., & Zhu, H.
Affiliations
The University of Texas Southwestern Medical Center (US)
Corresponding author
Zhu, Hao
Venue
Cell Cycle
Published
2019-05-26
Volume
18
Issue
12
Pages
1302-1315
ISSN
  • 1538-4101 (ISSN-L)
  • 1551-4005
OpenAlex
W2946183559
Cited by
38
References
124
Citations by year
2026: 1 · 2025: 4 · 2024: 3 · 2023: 7 · 2022: 8 · 2021: 10 · 2020: 5
FWCI
0.75
Type
journal article
Language
en
Open access
Locations
Cell Cycle (publishedVersion)
Funders
  • National Institutes of Health (R01CA190525)
  • CPRIT (RP180268)
Topics
  • Health Sciences › Medicine › Hepatology › Liver physiology and pathology
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Chromosomal and Genetic Variations
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
Keywords
polyploidy, liver, polyploid cells, liver regeneration, stress response, liver cancer

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