c-Myc regulates cell size and ploidy but is not essential for postnatal proliferation in liver

Induction of apoptosis in fibroblasts by c-myc protein

Evan, G. I., Wyllie, A. H., Gilbert, C. S., Littlewood, T. D., Land, H., Brooks, M. W., Waters, C. M., Penn, L. Z., & Hancock, D. C. (1992) · Cell · doi:10.1016/0092-8674(92)90123-t · Cited by 2,941 · see citing works

Inducible Gene Targeting in Mice

Kühn, R., Schwenk, F., Aguet, M., & Rajewsky, K. (1995) · Science · doi:10.1126/science.7660125 · Cited by 1,915 · see citing works

c-Myc Target Genes Involved in Cell Growth, Apoptosis, and Metabolism

Dang, C. V. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.1.1 · Cited by 1,707 · see citing works

Liver regeneration

Fausto, N. (2000) · Journal of Hepatology · doi:10.1016/s0168-8278(00)80412-2 · Cited by 1,022 · see citing works

Predictors of morbidity and mortality after the first episode of upper gastrointestinal bleeding in liver cirrhosis

del Olmo, J. A., Peña, A., Serra, M. Á., Wassel, A., Benages, A., & Rodrigo, J. M. (2000) · Journal of Hepatology · doi:10.1016/s0168-8278(01)68827-5 · Cited by 895 · see citing works

c-Myc Can Induce DNA Damage, Increase Reactive Oxygen Species, and Mitigate p53 Function

Vafa, O., Wade, M., Kern, S., Beeche, M., Pandita, T. K., Hampton, G. M., & Wahl, G. M. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00520-8 · Cited by 876 · see citing works

MYC inactivation uncovers pluripotent differentiation and tumour dormancy in hepatocellular cancer

Shachaf, C. M., Kopelman, A. M., Arvanitis, C., Karlsson, Å., Beer, S., Mandl, S., Bachmann, M. H., Borowsky, A. D., Ruebner, B., Cardiff, R. D., et al. (2004) · Nature · doi:10.1038/nature03043 · Cited by 874 · see citing works

Constitutive c-myc expression in an IL-3-dependent myeloid cell line suppresses cell cycle arrest and accelerates apoptosis.

Askew, D. S., Ashmun, R. A., Simmons, B. C., & Cleveland, J. L. (1991) · PubMed · Cited by 867 · see citing works

c-Myc controls the balance between hematopoietic stem cell self-renewal and differentiation

Wilson, A., Murphy, M. J., Oskarsson, T., Kaloulis, K., Bettess, M. D., Oser, G. M., Pasche, A.-C., Knabenhans, C., MacDonald, H. R., & Trumpp, A. (2004) · Genes & Development · doi:10.1101/gad.313104 · Cited by 823 · see citing works

Drosophila myc Regulates Cellular Growth during Development

Johnston, L. A., Prober, D. A., Edgar, B. A., Eisenman, R. N., & Gallant, P. (1999) · Cell · doi:10.1016/s0092-8674(00)81512-3 · Cited by 648 · see citing works

Drosophila Myc Regulates Organ Size by Inducing Cell Competition

de la Cova, C., Abril, M., Bellosta, P., Gallant, P., & Johnston, L. A. (2004) · Cell · doi:10.1016/s0092-8674(04)00214-4 · Cited by 610 · see citing works

dMyc Transforms Cells into Super-Competitors

Moreno, E., & Basler, K. (2004) · Cell · doi:10.1016/s0092-8674(04)00262-4 · Cited by 597 · see citing works

A null c-myc mutation causes lethality before 10.5 days of gestation in homozygotes and reduced fertility in heterozygous female mice.Preprint

Davis, A. C., Wims, M., Spotts, G. D., Hann, S., & Bradley, A. (1993) · Genes & Development · doi:10.1101/gad.7.4.671 · Cited by 531 · see citing works

c-Myc regulates mammalian body size by controlling cell number but not cell size

Trumpp, A., Refaeli, Y., Óskarsson, T., Gasser, S., Murphy, M., Martin, G. R., & Bishop, J. M. (2001) · Nature · doi:10.1038/414768a · Cited by 434 · see citing works

Analysis of C-MYC Function in Normal Cells via Conditional Gene-Targeted Mutation

de Alborán, I. M., O’Hagan, R. C., Gärtner, F., Malynn, B. A., Davidson, L., Rickert, R. C., Rajewsky, K., DePinho, R. A., & Alt, F. W. (2001) · Immunity · doi:10.1016/s1074-7613(01)00088-7 · Cited by 398 · see citing works

c-Myc enhances protein synthesis and cell size during B lymphocyte development

Iritani, B. M., & Eisenman, R. N. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.23.13180 · Cited by 364 · see citing works

N-myc can functionally replace c-myc in murine development, cellular growth, and differentiationPreprint

Malynn, B. A., de Alborán, I. M., O’Hagan, R. C., Bronson, R. T., Davidson, L., DePinho, R. A., & Alt, F. W. (2000) · Genes & Development · doi:10.1101/gad.14.11.1390 · Cited by 331 · see citing works

Sequential protooncogene expression during rat liver regeneration.

Thompson, N. L., Mead, J. E., Braun, L., Goyette, M., Shank, P. R., & Fausto, N. (1986) · PubMed · Cited by 299 · see citing works

Apoptosis Induced by Transforming Growth Factor-β in Fetal Hepatocyte Primary Cultures

Sánchez, A., Alvarez, A. M., Benito, M., & Fabregat, I. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.13.7416 · Cited by 267 · see citing works

Identification of c-myc responsive genes using rat cDNA microarray.

Guo, Q., Malek, R. L., Kim, H., Chiao, C., He, M., Ruffy, M., Sanka, K., Lee, N. H., Dang, C. V., & Liu, E. T. (2000) · PubMed · Cited by 265 · see citing works

Hepatic polyploidy and liver growth control

Gupta, S. K. (2000) · Seminars in Cancer Biology · doi:10.1006/scbi.2000.0317 · Cited by 250 · see citing works

Mysterious liaisons: the relationship between c-Myc and the cell cycle

Obaya, Á. J., Mateyak, M. K., & Sedivy, J. M. (1999) · Oncogene · doi:10.1038/sj.onc.1202749 · Cited by 242 · see citing works

Oncogene-induced liver neoplasia in transgenic mice.

Sandgren, E. P., Quaife, C. J., Pinkert, C. A., Palmiter, R. D., & Brinster, R. L. (1989) · PubMed · Cited by 241 · see citing works

Regulated Transcription of c-Ki- ras and c- myc During Compensatory Growth of Rat Liver

Goyette, M., Petropoulos, C. J., Shank, P. R., & Fausto, N. (1984) · Molecular and Cellular Biology · doi:10.1128/mcb.4.8.1493 · Cited by 201 · see citing works

Glutathione Peroxidase-Deficient Mice Are More Susceptible to Neutrophil–Mediated Hepatic Parenchymal Cell Injury During Endotoxemia: Importance of An Intracellular Oxidant Stress

Jaeschke, H., Ho, Y.-S., Fisher, M. A., Lawson, J. A., & Farhood, A. I. (1999) · Hepatology · doi:10.1002/hep.510290222 · Cited by 200 · see citing works

Induction of ribosomal genes and hepatocyte hypertrophy by adenovirus-mediated expression of c-Myc in vivo

Kim, S., Li, Q., Dang, C. V., & Lee, L. A. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.200372597 · Cited by 187 · see citing works

dMyc is required for larval growth and endoreplication in Drosophila

Pierce, S. B., Yost, C., Britton, J. S., Loo, L. W. M., Flynn, E. M., Edgar, B. A., & Eisenman, R. N. (2004) · Development · doi:10.1242/dev.01108 · Cited by 163 · see citing works

Developmental Context Determines Latency of MYC-Induced Tumorigenesis

Beer, S., Zetterberg, A., Ihrie, R. A., McTaggart, R., Yang, Q., Bradon, N., Arvanitis, C., Attardi, L. D., Feng, S., Ruebner, B. H., et al. (2004) · PLoS Biology · doi:10.1371/journal.pbio.0020332 · Cited by 142 · see citing works

Expression of c-Ki-ras, c-Ha-ras, and c-myc in specific cell types during hepatocarcinogenesis.

Yaswen, P., Goyette, M., Shank, P. R., & Fausto, N. (1985) · Molecular and Cellular Biology · doi:10.1128/mcb.5.4.780 · Cited by 138 · see citing works

Disentangling the MYC web

Levens, D. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.102173199 · Cited by 120 · see citing works

Mechanical stimulation of osteopontin mRNA expression and synthesis in bone cell cultures

Klein‐Nulend, J., Roelofsen, J., Semeins, C. M., Bronckers, A. L. J. J., & Burger, E. H. (1997) · Journal of Cellular Physiology · doi:10.1002/(sici)1097-4652(199702)170:2 · Cited by 115 · see citing works

Drosophila dMyc is required for ovary cell growth and endoreplication

Maines, J. Z., Stevens, L. M., Tong, X., & Stein, D. (2004) · Development · doi:10.1242/dev.00932 · Cited by 110 · see citing works

Quail embryo fibroblasts transformed by four v‐myc‐containing virus isolates show enhanced proliferation but are non tumorigenic.

Palmieri, S., Kahn, P., & Graf, T. (1983) · The EMBO Journal · doi:10.1002/j.1460-2075.1983.tb01750.x · Cited by 83 · see citing works

Normal and c-Myc-promoted human keratinocyte differentiation both occur via a novel cell cycle involving cellular growth and endoreplication

Gandarillas, A., Davies, D. C., & Blanchard, J. (2000) · Oncogene · doi:10.1038/sj.onc.1203630 · Cited by 79 · see citing works

Use of transgenic mice to study myc family gene function in normal mammalian development and in cancer.

Morgenbesser, S. D., & DePinho, R. A. (1994) · PubMed · Cited by 68 · see citing works

Differential proliferative response of cultured fetal and regenerating hepatocytes to growth factors and hormones

de Juan, C., Benito, M., Alvarez, A. M., & Fabregat, I. (1992) · Experimental Cell Research · doi:10.1016/0014-4827(92)90104-g · Cited by 66 · see citing works

E2F1 blocks and c-Myc accelerates hepatic ploidy in transgenic mouse models

Conner, E. A., Lemmer, E. R., Sánchez, A., Factor, V. M., & Thorgeirsson, S. S. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(03)00125-6 · Cited by 62 · see citing works

Proto-oncogene expression and growth factors during liver regeneration.

Fausto, N., Mead, J. E., Braun, L., Thompson, N. L., Panzica, M. A., Goyette, M., Bell, G. I., & Shank, P. R. (1986) · PubMed · Cited by 56 · see citing works

Oncogenes in human primary hepatic cancer

Gu, J., Li-Fu, H., Yuan-Ching, C., & Da-Fong, W. (1986) · Journal of Cellular Physiology · doi:10.1002/jcp.1041290405 · Cited by 53 · see citing works

Regulated Transcription of c-Ki- ras and c- myc During Compensatory Growth of Rat Liver

Goyette, M., Petropoulos, C. J., Shank, P. R., & Fausto, N. (1984) · Molecular and Cellular Biology · doi:10.1128/mcb.4.8.1493-1498.1984 · Cited by 42 · see citing works

Sources of health care data for social work leaders.

McKeon, W. (2001) · PubMed · Cited by 40 · see citing works

Inhibition of c-Myc Expression Sensitizes Hepatocytes to Tumor Necrosis Factor-induced Apoptosis and Necrosis

Liu, H., Lo, C. R., Jones, B., Pradhan, Z., Srinivasan, A. N., Valentino, K. L., Stockert, R. J., & Czaja, M. J. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m001565200 · Cited by 38 · see citing works

Promotion of growth and apoptosis in c-myc nullizygous fibroblasts by other members of the myc oncoprotein family

Landay, M. F., Oster, S. K., Khosravi, F., Grove, L. E., Yin, X., Sedivy, J. M., Penn, L. Z., & Prochownik, E. V. (2000) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4400701 · Cited by 36 · see citing works

Increased expression of the N-myc gene during normal and neoplastic rat liver growth

Corral‐Debrinski, M., Paris, B., Guguen‐Guillouzo, C., Corcos, D., Kruh, J., & Defer, N. (1988) · Experimental Cell Research · doi:10.1016/0014-4827(88)90146-2 · Cited by 33 · see citing works

c-Myc-deficient B lymphocytes are resistant to spontaneous and induced cell death

de Alborán, I. M., Baena, E., & Martínez‐A, C. (2003) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401319 · Cited by 32 · see citing works

The p21Cip1 protein, a cyclin inhibitor, regulates the levels and the intracellular localization of CDC25A in mice regenerating livers

Jaime, M., Pujol, M. J., Serratosa, J., Pantoja, C., Canela-Canela, N., Casanovas, O., Serrano, M., Agell, N., & Bachs, O. (2002) · Hepatology · doi:10.1053/jhep.2002.32678 · Cited by 21 · see citing works

Expression of c-Ki-ras, c-Ha-ras, and c-myc in Specific Cell Types During Hepatocarcinogenesis

Yaswen, P., Goyette, M., Shank, P. R., & Fausto, N. (1985) · Molecular and Cellular Biology · doi:10.1128/mcb.5.4.780-786.1985 · Cited by 19 · see citing works

MYC on the Path to Cancer

Dang, C. V. (2012) · Cell · doi:10.1016/j.cell.2012.03.003 · Cited by 3,390 · see citing works

Rapid Loss of Intestinal Crypts upon Conditional Deletion of the Wnt/Tcf-4 Target Gene c-Myc

Muncan, V., Sansom, O. J., Tertoolen, L. G. J., Phesse, T. J., Begthel, H., Sancho, E., Cole, A. M., Gregorieff, A., de Alborán, I. M., Clevers, H. C., et al. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.00821-06 · Cited by 249 · see citing works

The Role for Myc in Coordinating Glycolysis, Oxidative Phosphorylation, Glutaminolysis, and Fatty Acid Metabolism in Normal and Neoplastic Tissues

Goetzman, E. S., & Prochownik, E. V. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00129 · Cited by 199 · see citing works

Polyploidization in Liver Tissue

Gentric, G., & Desdouets, C. (2014) · The American Journal of Pathology · doi:10.1016/j.ajpath.2013.06.035 · Cited by 192 · see citing works

Polyploidy in liver development, homeostasis and disease

Donne, R., Saroul-Aïnama, M., Cordier, P., Celton-Morizur, S., & Desdouets, C. (2020) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-020-0284-x · Cited by 188 · see citing works

Focal Adhesion Kinase Is Required for Intestinal Regeneration and Tumorigenesis Downstream of Wnt/c-Myc Signaling

Ashton, G. H. S., Morton, J. P., Myant, K., Phesse, T. J., Ridgway, R. A., Marsh, V. L., Wilkins, J. A., Athineos, D., Muncan, V., Kemp, R., et al. (2010) · Developmental Cell · doi:10.1016/j.devcel.2010.07.015 · Cited by 189 · see citing works

c-Myc depletion inhibits proliferation of human tumor cells at various stages of the cell cycle

Wang, H., Mannava, S., Grachtchouk, V., Zhuang, D., Soengas, M. S., Gudkov, A. V., Prochownik, E. V., & Nikiforov, M. A. (2007) · Oncogene · doi:10.1038/sj.onc.1210823 · Cited by 174 · see citing works

Mechanisms Limiting Body Growth in Mammals

Lui, J. C. K., & Baron, J. (2011) · Endocrine Reviews · doi:10.1210/er.2011-0001 · Cited by 167 · see citing works

Myc controls transcriptional regulation of cardiac metabolism and mitochondrial biogenesis in response to pathological stress in mice

Ahuja, P., Zhao, P., Angelis, E., Ruan, H., Korge, P., Olson, A., Wang, Y., Jin, E. S., Jeffrey, F. M., Portman, M., et al. (2010) · Journal of Clinical Investigation · doi:10.1172/jci38331 · Cited by 157 · see citing works

To divide or not to divide: revisiting liver regeneration

Miyaoka, Y., & Miyajima, A. (2013) · Cell Division · doi:10.1186/1747-1028-8-8 · Cited by 156 · see citing works

C‐Myc and its target FoxM1 are critical downstream effectors of constitutive androstane receptor (CAR) mediated direct liver hyperplasia†

Blanco‐Bose, W. E., Murphy, M. J., Ehninger, A., Offner, S., Dubey, C., Huang, W., Moore, D. D., & Trumpp, A. (2008) · Hepatology · doi:10.1002/hep.22475 · Cited by 138 · see citing works

BCL6 is critical for the development of a diverse primary B cell repertoire

Duy, C., Yu, J. J., Nahar, R. R., Swaminathan, S., Kweon, S.-M., Polo, J. M., Valls, E., Klemm, L., Shojaee, S., Cerchietti, L. C. A., et al. (2010) · The Journal of Experimental Medicine · doi:10.1084/jem.20091299 · Cited by 129 · see citing works

Endogenous Myc controls mammalian epidermal cell size, hyperproliferation, endoreplication and stem cell amplification

Zanet, J., Pibre, S., Jacquet, C., Ramirez, A., de Alborán, I. M., & Gandarillas, A. (2005) · Journal of Cell Science · doi:10.1242/jcs.02298 · Cited by 123 · see citing works

Hypertrophic growth in cardiac myocytes is mediated by Myc through a Cyclin D2‐dependent pathway

Zhong, W., Mao, S., Tobis, S., Angelis, E., Jordan, M. C., Roos, K. P., Fishbein, M. C., de Alborán, I. M., & MacLellan, W. R. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601252 · Cited by 115 · see citing works

Opposing effects of TIGAR- and RAC1-derived ROS on Wnt-driven proliferation in the mouse intestinePreprint

Cheung, E. C., Lee, P., Ceteci, F., Nixon, C., Blyth, K., Sansom, O. J., & Vousden, K. H. (2015) · Genes & Development · doi:10.1101/gad.271130.115 · Cited by 109 · see citing works

Pancreatic Inactivation of c-Myc Decreases Acinar Mass and Transdifferentiates Acinar Cells Into Adipocytes in Mice

Bonal, C., Thorel, F., Ait‐Lounis, A., Reith, W., Trumpp, A., & Herrera, P. L. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.10.015 · Cited by 103 · see citing works

Cellular plasticity balances the metabolic and proliferation dynamics of a regenerating liver

Chembazhi, U. V., Bangru, S., Hernaez, M., & Kalsotra, A. (2021) · Genome Research · doi:10.1101/gr.267013.120 · Cited by 102 · see citing works

Myc's other life: stem cells and beyond

Laurenti, E., Wilson, A., & Trumpp, A. (2009) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2009.09.006 · Cited by 101 · see citing works

Placental rescue reveals a sole requirement for c-Myc in embryonic erythroblast survival and hematopoietic stem cell function

Dubois, N. C., Adolphe, C., Ehninger, A., Wang, R. A., Robertson, E. J., & Trumpp, A. (2008) · Development · doi:10.1242/dev.022707 · Cited by 95 · see citing works

Cyclin D2–Cyclin-Dependent Kinase 4/6 Is Required for Efficient Proliferation and Tumorigenesis following Apc Loss

Cole, A. M., Myant, K., Reed, K. R., Ridgway, R. A., Athineos, D., BRINK, G. R. V. D., Muncan, V., Clevers, H. C., Clarke, A. R., Siciński, P., et al. (2010) · Cancer Research · doi:10.1158/0008-5472.can-10-0315 · Cited by 89 · see citing works

MicroRNA‐122 regulates polyploidization in the murine liver

Hsu, S., Delgado, E. R., Otero, P. A., Teng, K., Kutay, H., Meehan, K. M., Moroney, J. B., Monga, J. K., Hand, N. J., Friedman, J. R., et al. (2016) · Hepatology · doi:10.1002/hep.28573 · Cited by 84 · see citing works

c-MYC—Making Liver Sick: Role of c-MYC in Hepatic Cell Function, Homeostasis and Disease

Zheng, K., Cubero, F., & Nevzorova, Y. (2017) · Genes · doi:10.3390/genes8040123 · Cited by 84 · see citing works

c-Myc–mediated control of cell fate in megakaryocyte-erythrocyte progenitors

Guo, Y., Niu, C. S., Breslin, P., Tang, M., Zhang, S., Wei, W., Kini, A. R., Paner, G. P., Alkan, S., Morris, S. W., et al. (2009) · Blood · doi:10.1182/blood-2009-01-197947 · Cited by 82 · see citing works

Interactions between Myc and Mediators of Inflammation in Chronic Liver Diseases

Liu, T., Zhou, Y., Ko, K. S., & Yang, H. (2015) · Mediators of Inflammation · doi:10.1155/2015/276850 · Cited by 84 · see citing works

Role of Myc in hepatocellular proliferation and hepatocarcinogenesis

Qu, A., Jiang, C., Cai, Y., Kim, J. H., Tanaka, N., Ward, J. M., Shah, Y. M., & Gonzalez, F. J. (2013) · Journal of Hepatology · doi:10.1016/j.jhep.2013.09.024 · Cited by 80 · see citing works

c-mycin the hematopoietic lineage is crucial for its angiogenic function in the mouse embryo

He, C., Hu, H., Braren, R., Fong, S.-Y., Trumpp, A., Carlson, T. R., & Wang, R. A. (2008) · Development · doi:10.1242/dev.020131 · Cited by 74 · see citing works

Myc Function in DrosophilaPreprint

Gallant, P. (2013) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a014324 · Cited by 74 · see citing works

B-catenin deficiency, but not Myc deletion, suppresses the immediate phenotypes of APC loss in the liver

Reed, K. R., Athineos, D., Méniel, V. S., Wilkins, J. A., Ridgway, R. A., Burke, Z. D., Muncan, V., Clarke, A. R., & Sansom, O. J. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0805778105 · Cited by 69 · see citing works

Lessons from Functional Analysis of Genome-Wide Association Studies

Sur, I., Tuupanen, S., Whitington, T., Aaltonen, L. A., & Taipale, J. (2013) · Cancer Research · doi:10.1158/0008-5472.can-13-0789 · Cited by 66 · see citing works

The mysterious human epidermal cell cycle, or an oncogene-induced differentiation checkpoint

Gandarillas, A. (2012) · Cell Cycle · doi:10.4161/cc.22529 · Cited by 61 · see citing works

Universal encoding of pan-cancer histology by deep texture representations

Komura, D., Kawabe, A., Fukuta, K., Sano, K., Umezaki, T., Koda, H., Suzuki, R. H., Tominaga, K., Ochi, M., Konishi, H., et al. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.110424 · Cited by 62 · see citing works

Mice deficient of Myc super-enhancer region reveal differential control mechanism between normal and pathological growth

Dave, K., Sur, I., Yan, J., Zhang, J., Kaasinen, E., Zhong, F., Blaas, L., Li, X., Kharazi, S., Gustafsson, C., et al. (2017) · eLife · doi:10.7554/elife.23382 · Cited by 60 · see citing works

Aurora kinase A mediates c‐Myc's oncogenic effects in hepatocellular carcinoma

Lu, L.-F., Han, H., Tian, Y., Li, W., Zhang, J., Feng, M., & Li, Y. (2014) · Molecular Carcinogenesis · doi:10.1002/mc.22223 · Cited by 55 · see citing works

Role of c-Myc in intestinal tumorigenesis of the Apc min/+ mouse1

Ignatenko, N. A., Holubec, H., Besselsen, D. G., Blohm-Mangone, K. A., Padilla‐Torres, J., Nagle, R. B., de Alborán, I. M., Guillen-Rodriguez, J., & Gerner, E. W. (2006) · Cancer Biology & Therapy · doi:10.4161/cbt.5.12.3376 · Cited by 54 · see citing works

MYC in liver cancer: mechanisms and targeted therapy opportunities

Liu, F., Liao, Z., & Zhang, Z. (2023) · Oncogene · doi:10.1038/s41388-023-02861-w · Cited by 52 · see citing works

Dexamethasone-Induced Liver Enlargement Is Related to PXR/YAP Activation and Lipid Accumulation but Not Hepatocyte Proliferation

Jiao, T., Yao, X., Zhao, Y.-Y., Zhou, Y., Gao, Y., Fan, S., Chen, P., Li, X., Jiang, Y., Xiao, Y., et al. (2020) · Drug Metabolism and Disposition · doi:10.1124/dmd.120.000061 · Cited by 49 · see citing works

Somatic polyploidy is associated with the upregulation of c-MYC interacting genes and EMT-like signature

Vázquez‐Martín, A., Anatskaya, O. V., Giuliani, A., Erenpreisa, J. A., Huang, S., Salmiņa, K., Inashkina, I., Huna, A., Nikolsky, N. N., & Vinogradov, A. E. (2016) · Oncotarget · doi:10.18632/oncotarget.12118 · Cited by 47 · see citing works

c-Myc is essential for hematopoietic stem cell differentiation and regulates Lin−Sca-1+c-Kit− cell generation through p21

Baena, E., Ortiz, M., Martínez‐A, C., & de Alborán, I. M. (2007) · Experimental Hematology · doi:10.1016/j.exphem.2007.05.015 · Cited by 47 · see citing works

Myc and ChREBP transcription factors cooperatively regulate normal and neoplastic hepatocyte proliferation in mice

Wang, H., Dolezal, J. M., Kulkarni, S., Lu, J. L., Mandel, J. A., Jackson, L. E., Alencastro, F., Duncan, A. W., & Prochownik, E. V. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.ra118.004099 · Cited by 46 · see citing works

Control of Cell Proliferation and Growth by Myc Proteins

Bernard, S., & Eilers, M. (2006) · Springer eBooks · doi:10.1007/400_004 · Cited by 47 · see citing works

Myc heterozygosity attenuates the phenotypes of APC deficiency in the small intestine

Athineos, D., & Sansom, O. J. (2010) · Oncogene · doi:10.1038/onc.2010.5 · Cited by 45 · see citing works

Myc in model organisms: A view from the flyroom

de la Cova, C., & Johnston, L. A. (2006) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2006.07.010 · Cited by 44 · see citing works

Conditional Deletion ofc-mycDoes Not Impair Liver Regeneration

Li, F., Xiang, Y., Potter, J. J., Dinavahi, R., Dang, C. V., & Lee, L. A. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-4242 · Cited by 44 · see citing works

Role of HNF4alpha-cMyc interaction in liver regeneration and recovery after acetaminophen-induced acute liver injury

Kotulkar, M., Paine‐Cabrera, D., Abernathy, S., Robarts, D. R., Parkes, W. S., Lin‐Rahardja, K., Numata, S., Lebofsky, M., Jaeschke, H., & Apte, U. M. (2023) · Hepatology · doi:10.1097/hep.0000000000000367 · Cited by 43 · see citing works

MYC—an emerging player in mitochondrial diseases

Purhonen, J., Klefström, J. T., & Kallijärvi, J. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1257651 · Cited by 40 · see citing works

Abnormal lipid processing but normal long-term repopulation potential of myc−/− hepatocytes

Edmunds, L. R., Otero, P. A., Sharma, L., D'Souza, S. S., Dolezal, J. M., David, S., Lu, J. L., Lamm, L., Basantani, M. K., Zhang, P., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.8856 · Cited by 39 · see citing works

B Lymphocyte Commitment Program Is Driven by the Proto-Oncogene c-myc

Vallespinós, M., Fernández‐Antorán, D., Rodríguez, L., Álvaro-Blanco, J., Baena, E., Ortiz, M., Dukovska, D., Martínez, D., Rojas, A. M., Campanero, M. R., et al. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1002753 · Cited by 38 · see citing works

Postnatal liver growth and regeneration are independent of c-myc in a mouse model of conditional hepatic c-myc deletion

Sanders, J. A., Schorl, C., Patel, A. J., Sedivy, J. M., & Gruppuso, P. A. (2012) · BMC Physiology · doi:10.1186/1472-6793-12-1 · Cited by 38 · see citing works

c-Myc affects mRNA translation, cell proliferation and progenitor cell function in the mammary gland

Stoelzle, T., Schwarb, P., Trumpp, A., & Hynes, N. E. (2009) · BMC Biology · doi:10.1186/1741-7007-7-63 · Cited by 38 · see citing works

p21 loss blocks senescence following Apc loss and provokes tumourigenesis in the renal but not the intestinal epithelium

Cole, A. M., Ridgway, R. A., Derkits, S., Parry, L., Barker, N., Clevers, H. C., Clarke, A. R., & Sansom, O. J. (2010) · EMBO Molecular Medicine · doi:10.1002/emmm.201000101 · Cited by 35 · see citing works

Polyploidy and Myc Proto-Oncogenes Promote Stress Adaptation via Epigenetic Plasticity and Gene Regulatory Network Rewiring

Anatskaya, O. V., & Vinogradov, A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23179691 · Cited by 27 · see citing works

cMyc increases cell number through uncoupling of cell division from cell size in CHO cells

Kuystermans, D., & Al-Rubeai, M. (2009) · BMC Biotechnology · doi:10.1186/1472-6750-9-76 · Cited by 33 · see citing works

Defining the role of APC in the mitotic spindle checkpoint in vivo: APC-deficient cells are resistant to Taxol

Radulescu, S., Ridgway, R. A., Appleton, P., Kroboth, K., Patel, S., Woodgett, J. R., Taylor, S. S., Näthke, I. S., & Sansom, O. J. (2010) · Oncogene · doi:10.1038/onc.2010.373 · Cited by 32 · see citing works

Deficiency of the oxygen sensor PHD1 augments liver regeneration after partial hepatectomy

Mollenhauer, M., Kiss, J., Dudda, J., Kirchberg, J., Rahbari, N. N., Radhakrishnan, P., Niemietz, T., Rausch, V., Weitz, J., & Schneider, M. A. (2012) · Langenbeck s Archives of Surgery · doi:10.1007/s00423-012-0998-5 · Cited by 31 · see citing works

Growth-promoting and tumourigenic activity of c-Myc is suppressed by Hhex

Marfil, V., Blazquez, M., Serrano, F., Castell, J. V., & Bort, R. (2014) · Oncogene · doi:10.1038/onc.2014.240 · Cited by 30 · see citing works

Excessive hepatomegaly of mice with hepatocyte-targeted elimination of integrin linked kinase following treatment with 1,4-bis [2-(3,5-dichaloropyridyloxy)] benzene

Donthamsetty, S., Bhave, V., Kliment, C. R., Bowen, W. C., Mars, W. M., Bell, A. W., Stewart, R. E., Orr, A. V., Wu, C., & Michalopoulos, G. K. (2010) · Hepatology · doi:10.1002/hep.24040 · Cited by 30 · see citing works

NADPH oxidase 4 (Nox4) deletion accelerates liver regeneration in mice

Herranz‐Itúrbide, M., López‐Luque, J., Gonzalez‐Sanchez, E., Caballero‐Díaz, D., Crosas‐Molist, E., Martín‐Mur, B., Gut, M. O., Esteve‐Codina, A., Jaquet, V., Jiang, J. X., et al. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101841 · Cited by 27 · see citing works

Irs2 Inactivation Suppresses Tumor Progression in Pten+/− Mice

Szabolcs, M. J., Keniry, M. E., Simpson, L., Reid, L. J., Koujak, S., Schiff, S. C., Davidian, G., Licata, S. E., Gruvberger-Saal, S. K., Murty, V. V. V. S., et al. (2008) · American Journal Of Pathology · doi:10.2353/ajpath.2009.080086 · Cited by 24 · see citing works

p27Kip1 Mediates Addiction of Ovarian Cancer Cells to MYCC (c-MYC) and Their Dependence on MYC Paralogs

Prathapam, T., Aleshin, A. A., Guan, Y., Gray, J. W., & Martin, G. S. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.151902 · Cited by 22 · see citing works

Coordinated Cross-Talk Between the Myc and Mlx Networks in Liver Regeneration and Neoplasia

Wang, H., Lu, J. L., Alencastro, F., Roberts, A., Fiedor, J., Carroll, P. A., Eisenman, R. N., Ranganathan, S., Torbenson, M. S., Duncan, A. W., et al. (2022) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2022.02.018 · Cited by 18 · see citing works

Cell size does not always correspond to genome size: Phylogenetic analysis in geckos questions optimal DNA theories of genome size evolution

Starostová, Z., Kratochvíl, L., & Flajšhans, M. (2008) · Zoology · doi:10.1016/j.zool.2007.10.005 · Cited by 20 · see citing works

Regulation of Normal and Neoplastic Proliferation and Metabolism by the Extended Myc Network

Prochownik, E. V. (2022) · Cells · doi:10.3390/cells11243974 · Cited by 17 · see citing works

Computational modeling identifies key gene regulatory interactions underlying phenobarbital-mediated tumor promotion

Luisier, R., Unterberger, E. B., Goodman, J. I., Schwarz, M., Moggs, J. G., Terranova, R., & van Nimwegen, E. (2014) · Nucleic Acids Research · doi:10.1093/nar/gkt1415 · Cited by 18 · see citing works

An E2F5-TFDP1-BRG1 Complex Mediates Transcriptional Activation of MYCN in Hepatocytes

Fan, Z., Kong, M., Miao, X., Guo, Y., Ren, H., Wang, J., Wang, S., Tang, N., Shang, L., Zhu, Z., et al. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.742319 · Cited by 16 · see citing works

Controlling cell length

Kharitonova, M. A., & Vasiliev, J. M. (2008) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2008.07.008 · Cited by 15 · see citing works

Lessons in aging from Myc knockout mouse models

Prochownik, E. V., & Wang, H. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1244321 · Cited by 14 · see citing works

High dietary inorganic phosphate enhances cap-dependent protein translation, cell-cycle progression, and angiogenesis in the livers of young mice

Xu, C., Jin, H., Lim, H.-T., Kim, J., Shin, J., Lee, E.-S., Chung, Y.-S., Lee, Y.-S., Beck, G. R., Lee, K. H., et al. (2008) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.90213.2008 · Cited by 14 · see citing works

Manipulating Myc for reparative regeneration

Ascanelli, C., Dahir, R., & Wilson, C. H. (2024) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2024.1357589 · Cited by 14 · see citing works

Myc beyond Cancer: Regulation of Mammalian Tissue Regeneration

Illi, B., & Nasi, S. (2023) · Pathophysiology · doi:10.3390/pathophysiology30030027 · Cited by 12 · see citing works

Hepatocyte-specific C-C motif chemokine ligand 9 signaling promotes liver fibrosis progression in mice

Wang, C., Dong, D., Zhao, N., Zhao, S., Hua, J., Bai, C., Cui, R., Zhao, T., Ji, N., Li, H., et al. (2025) · Hepatology · doi:10.1097/hep.0000000000001393 · Cited by 10 · see citing works

The Role of the Proto-Oncogene c-myc in B Lymphocyte Differentiation

Fernández‐Antorán, D., Lobo, V. J. S.-A., & de Alborán, I. M. (2012) · Critical Reviews in Immunology · doi:10.1615/critrevimmunol.v32.i4.30 · Cited by 6 · see citing works

The fate of pyruvate dictates cell growth by modulating cellular redox potentialPreprint

Toshniwal, A. G., Lam, G., Bott, A. J., Cluntun, A. A., Skabelund, R. A., Nam, H.-J., Wisidagama, D. R., Thummel, C. S., & Rutter, J. P. (2024) · eLife · doi:10.7554/elife.103705 · Cited by 6 · see citing works

A Novel Mouse Model of Combined Hepatocellular-Cholangiocarcinoma Induced by Diethylnitrosamine and Loss of Ppp2r5d

Omella, J. D., Cortesi, E. E., Verbinnen, I., Remmerie, M., Wu, H., Cubero, F. J., Roskams, T., & Janssens, V. (2023) · Cancers · doi:10.3390/cancers15164193 · Cited by 5 · see citing works

Temporal myc dynamics permit mitotic bypass, promoting polyploid phenotypes

Loycano, M. A., Pienta, K. J., & Amend, S. R. (2025) · Cancer Letters · doi:10.1016/j.canlet.2025.217526 · Cited by 5 · see citing works

Hierarchies of Transcriptional Regulation During Liver Regeneration

Kurinna, S. M., & Barton, M. C. (2010) · Progress in molecular biology and translational science · doi:10.1016/b978-0-12-385233-5.00007-6 · Cited by 5 · see citing works

ESRP2–microRNA-122 axis promotes the postnatal onset of liver polyploidization and maturation

Bangru, S., Chen, J., Baker, N., Das, D., Chembazhi, U. V., Derham, J. M., Chorghade, S., Arif, W., Alencastro, F., Duncan, A. W., et al. (2025) · Genes & Development · doi:10.1101/gad.352129.124 · Cited by 4 · see citing works

Endomitosis: a new cell fate in the cell cycle leading to polyploidy in megakaryocytes and hepatocytes

Hua, Q., Zhang, X.-C., Tian, R.-F., She, Z.-G., & Huang, Z. (2025) · Journal of Zhejiang University SCIENCE B · doi:10.1631/jzus.b2400127 · Cited by 4 · see citing works

TCR-Independent Metabolic Reprogramming Precedes Lymphoma-Driven Changes in T-cell Fate

Hesterberg, R. S., Liu, M., Elmarsafawi, A. G., Koomen, J. M., Welsh, E. A., Hesterberg, S. G., Ranatunga, S., Yang, C., Li, W., Lawrence, H. R., et al. (2022) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-21-0813 · Cited by 3 · see citing works

The fate of pyruvate dictates cell growth by modulating cellular redox potential

Toshniwal, A. G., Lam, G., Bott, A. J., Cluntun, A. A., Skabelund, R. A., Nam, H.-J., Wisidagama, D. R., Thummel, C. S., & Rutter, J. P. (2025) · eLife · doi:10.7554/elife.103705.3 · Cited by 3 · see citing works

Changes in Hepatocyte Ploidy During Liver Regeneration

Duncan, A. W. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-420128-6.00012-9 · Cited by 3 · see citing works

High levels of Myc expression are required for the robust proliferation of hepatocytes, but not for the sustained weak proliferation

Goto, M., Ooshio, T., Yamamoto, M., Tanaka, H., Fujii, Y., Meng, L., Kamikokura, Y., Okada, Y., & Nishikawa, Y. (2023) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2023.166644 · Cited by 3 · see citing works

Hepatoblastoma Cell Lines: Past, Present and Future

Prochownik, E. V., Henchy, C., & Wang, H. (2025) · Cells · doi:10.3390/cells14242013 · Cited by 2 · see citing works

Proto-oncogenes Crosstalk, Feedback and Expression, and Anticancer Drugs Resistance

Elalfy, M. M., Elhadidy, M. G., & Nashar, E. M. E. (2023) · Archives of Pharmacology and Therapeutics · doi:10.33696/pharmacol.4.040 · Cited by 2 · see citing works

Aberrant differentiation and proliferation of hepatocytes in chronic liver injury and liver tumors

Nishikawa, Y. (2024) · Pathology International · doi:10.1111/pin.13441 · Cited by 1 · see citing works

Liver Regeneration

Nevzorova, Y. A., & Trautwein, C. (2012) · Elsevier eBooks · doi:10.1016/b978-1-4377-0881-3.00002-4 · Cited by 1 · see citing works

Hepatocyte Growth, Proliferation and Experimental Carcinogenesis

Ledda‐Columbano, G. M., & Columbano, A. (2010) · Molecular pathology library · doi:10.1007/978-1-4419-7107-4_54 · Cited by 1 · see citing works

Islet‐cell autoantigen 69 accelerates liver regeneration by downregulating Tgfbr1 and attenuating Tgfβ signaling in mice

Chen, L., Tao, F., Zhang, Y., Shu, C., Xiang, W., Yang, L., Chen, X., Hong, Y., Chen, B., Li, K., et al. (2020) · FEBS Letters · doi:10.1002/1873-3468.13859 · Cited by 1 · see citing works

ESRP2-microRNA-122 axis directs the postnatal onset of liver polyploidization and maturationPreprint

Bangru, S., Chen, J., Baker, N., Das, D., Chembazhi, U. V., Derham, J. M., Chorghade, S., Arif, W., Alencastro, F., Duncan, A. W., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.07.06.602336 · Cited by 1 · see citing works

The fate of pyruvate dictates cell growth by modulating cellular redox potentialPreprint

Toshniwal, A. G., Lam, G., Bott, A. J., Cluntun, A. A., Skabelund, R. A., Nam, H.-J., Wisidagama, D. R., Thummel, C. S., & Rutter, J. P. (2024) · eLife · doi:10.7554/elife.103705.1 · Cited by 1 · see citing works

Constitutive Androstane Receptor Regulates Bile Acid Homeostasis and Metabolism During Liver Regeneration

Zhou, W., Chembazhi, U. V., Huang, J., Bangru, S., Dean, A. E., Asokakumar, A., Kalsotra, A., Rudnick, D. A., & Anakk, S. (2026) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2026.101858

Neural stem cell characteristics affected by oncogenic pathways and in a human motoneuron disease

Kerosuo, L. (2009) · Työväentutkimus Vuosikirja

Revealing host factors important for hepatocyte : infection by plasmodium

Rodrigues, C. D. (2007) · Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)

Regulation of metabolism by the oncoprotein c-Myc

Edmunds, L. R. (2015) · D-Scholarship@Pitt (University of Pittsburgh)

Beta-Catenin and the Survival of Hepatocytes

Nejak‐Bowen, K. N., & Monga, S. P. (2017) · Springer eBooks · doi:10.1007/978-3-319-58106-4_6

Mice deficient of Myc super-enhancer region reveal a differential control mechanism between normal and pathological growthPreprint

Dave, K., Sur, I., Yan, J., Zhang, J., Kaasinen, E., Zhong, F., Blaas, L., Li, X., Månsson, R., & Taipale, J. (2016) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/082602

Faculty Opinions recommendation of Focal adhesion kinase is required for intestinal regeneration and tumorigenesis downstream of Wnt/c-Myc signaling.

Gautier, J., & Dominguez-Sola, D. (2010) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.5045965.5584055

Identification and Analysis of Hub Transcriptional Factors Related to Acetaminophen-Induced Liver InjuryPreprint

Yao, J., Zhao, Q., Bai, J., Wang, H., Yao, R., He, J., Zhang, X., & Zhou, X. (2022) · Research Square · doi:10.21203/rs.3.rs-2057247/v1

Data from Cyclin D2–Cyclin-Dependent Kinase 4/6 Is Required for Efficient Proliferation and Tumorigenesis following Apc Loss

Cole, A. M., Myant, K., Reed, K. R., Ridgway, R. A., Athineos, D., BRINK, G. R. V. D., Muncan, V., Clevers, H. C., Clarke, A. R., Siciński, P., et al. (2023) · doi:10.1158/0008-5472.c.6500706

Data from TCR-Independent Metabolic Reprogramming Precedes Lymphoma-Driven Changes in T-cell Fate

Hesterberg, R. S., Liu, M., Elmarsafawi, A. G., Koomen, J. M., Welsh, E. A., Hesterberg, S. G., Ranatunga, S., Yang, C., Li, W., Lawrence, H. R., et al. (2023) · doi:10.1158/2326-6066.c.6550956.v1

Identification and Analysis of Hub Transcriptional Factors in vitro hepatocyte model of Acetaminophen- Induced Liver InjuryPreprint

Zhao, Q., Bai, J., Zhao, N., & Yao, J. (2023) · Research Square · doi:10.21203/rs.3.rs-3300466/v1

Postnatal liver growth and regeneration are independent of c-myc in a mouse model of conditional hepatic c-myc deletion

Sanders, J. A., Schorl, C., Patel, A. J., Sedivy, J. M., & Gruppuso, P. A. (2012) · BMC Physiology · doi:10.1186/1472-6793-12-1 · Cited by 38 · see citing works

Research Article Conditional Deletion of c-myc Does Not Impair Liver Regeneration

Li, F., Xiang, Y., Potter, J., Dinavahi, R., Dang, C. V., & Lee, L. A. (2008)

Conditional Deletion ofc-mycDoes Not Impair Liver Regeneration

Li, F., Xiang, Y., Potter, J. J., Dinavahi, R., Dang, C. V., & Lee, L. A. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-4242 · Cited by 44 · see citing works

Coordinated regulation of c-Myc and Max in rat liver development

S, J. A., & Jennifer, A. (2005)

Abstract B25: Novel hepatic phenotypes caused by conditional c-Myc deletion

Edmunds, L. R., Sharma, L., Otero, P. A., D'Souza, S. S., Dolezal, J. M., Zeng, X., Ding, Y., Ding, F., Beck, M. E., Kratz, L. E., et al. (2016) · Molecular Cancer Research · doi:10.1158/1557-3125.metca15-b25