Liver Regeneration: Different Sub-Populations of Parenchymal Cells at Play Choreographed by an Injury-Specific Microenvironment
Open accessAbstract
Liver regeneration is crucial for the maintenance of liver functional mass during homeostasis and diseases. In a disease context-dependent manner, liver regeneration is contributed to by hepatocytes or progenitor cells. As long as they are replicatively competent, hepatocytes are the main cell type responsible for supporting liver size homeostasisand regeneration. The concept that all hepatocytes within the lobule have the same proliferative capacity but are differentially recruited according to the localization of the wound, or whether a yet to be defined sub-population of hepatocytes supports regeneration is still debated. In a chronically or severely injured liver, hepatocytes may enter a state of replicative senescence. In such conditions, small biliary cells activate and expand, a process called ductular reaction (DR). Work in the last few decades has demonstrated that DR cells can differentiate into hepatocytes and thereby contribute to parenchymal reconstitution. In this study we will review the molecular mechanisms supporting these two processes to determine potential targets that would be amenable for therapeutic manipulation to enhance liver regeneration.
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Several studies have suggested that transplanting approximately 20-30% of the normal liver mass can provide sufficient function for the recipient.
“In the context of liver transplantation, several studies have suggested that transplanting approximately 20–30 % of the normal liver mass can provide sufficient function for the recipient.”
From Liver tissue engineering using decellularized scaffolds: Current progress, challenges, and opportunities (2024) · cites this paper as [191]
The Introduction (page unavailable) says the liver can retain function after resection of up to 70% and that regeneration enables split-liver and living-donor transplantation. It does not say that a graft of 20–30% of normal liver mass provides sufficient function for a recipient; the 70% figure concerns resection, not graft size. (LLM, conf=0.84)
Experimental — accuracy not yet measuredA human weighing 70 kg would require approximately 84 billion hepatocytes to attain at least 30% liver function.
“For instance, a human weighing 70 kg would require approximately 84 billion hepatocytes to attain at least 30 % liver function [190,191].”
From Liver tissue engineering using decellularized scaffolds: Current progress, challenges, and opportunities (2024) · cites this paper as [191]
The Introduction says hepatocytes account for 70% of liver mass, and §2.1 discusses regeneration after 30% partial hepatectomy. Neither gives a hepatocyte count needed for 30% liver function in a 70-kg human. Searches for “84 billion,” “70 kg,” and the proposed functional threshold found no supporting passage in our copy. (LLM, conf=0.75)
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Self-citation
- Authors
- Manco, R., Leclercq, I. A., & Clerbaux, L.-A.
- Affiliations
- UCLouvain (BE)
- Corresponding author
- Leclercq, Isabelle A.
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2018-12-18
- Volume
- 19
- Issue
- 12
- Pages
- 4115
- ISSN
- 1422-0067 (ISSN-L)
- PMC
- PMC6321497
- OpenAlex
- W2904514484
- Cited by
- 36
- References
- 129
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 3 · 2023: 3 · 2022: 2 · 2021: 13 · 2020: 6 · 2019: 5
- FWCI
- 0.81
- Type
- journal article
- Language
- en
- Open access
- gold
- dx.doi.org
- Licence
- Locations
- International Journal of Molecular Sciences (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Digital Access to Libraries (Université catholique de Louvain (UCL), l'Université de Namur (UNamur) and the Université Saint-Louis (USL-B)) (submittedVersion, other-oa)
- DIAL (Catholic University of Leuven) (submittedVersion, other-oa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- Belgian Federal Science Policy Office (Interuniversity Attraction Poles program (P7/83-HEPRO2)
- Fonds De La Recherche Scientifique - FNRS (PDR T.1067.14-P)
- Topics
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Health Sciences › Medicine › Surgery › Organ Transplantation Techniques and Outcomes
- Keywords
- liver regeneration, hepatocytes, replicative senescence, ductular reaction, progenitor cells, hepatocyte proliferation, liver homeostasis, therapeutic target
- MeSH terms
- Parenchymal Tissue, Animals, Cell Differentiation, Humans, Liver, Liver Regeneration, Stem Cells, Cell Lineage, Hepatocytes, Cellular Microenvironment
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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