Cited by 506Hydrogels: synthesis, properties, applicationsAdvanced Drug Delivery SystemsAdvanced Materials and Mechanics

Studies on thermoresponsive polymers: Phase behaviour, drug delivery and biomedical applications

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Gandhi, Arijit, Paul, Abhijit, Sen, Suma Oommen, Sen, Kalyan Kumar·2015·Asian Journal of Pharmaceutical Sciences

Abstract

The present review aims to highlight the applications of thermoresponsive polymers. Thermo-responsive polymers show a sharp change in properties upon a small or modest change in temperature. This behaviour can be utilized for the preparation of so-called ‘smart’ drug delivery systems, which mimic biological response behaviour to a certain extent. Such materials are used in the development of several applications, such as drug delivery systems, tissue engineering scaffolds and gene delivery. Advances in this field are particularly relevant to applications in the areas of regenerative medicine and drug delivery. This review addresses summary of the main applications of thermoresponsive polymers which are categorized based on their 3-dimensional structure; hydrogels, interpenetrating networks, micelles, films and particles. The physico-chemical behaviour underlying the phase transition is also discussed in brief.

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Crossref · 10.1016/j.ajps.2014.08.010

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97 of 97 references verified0 citation errors · 0 not checkable

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  • Thermo-responsive polymers show sol-gel transitions with a change in external temperature, and hydrogels made of thermoresponsive polymers find drug delivery applications through simple chemical modifications.

    “Thermo-responsive polymers show sol-gel transitions with a change in temperature of the external environment and hydrogels made of thermoresponsive polymers find tremendous drug delivery applications through simple chemical modifications [29,30,31,32]”

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Authors
Gandhi, A., Paul, A., Sen, S. O., & Sen, K. K.
Corresponding author
Paul, Abhijit
Venue
Asian Journal of Pharmaceutical Sciences
Publisher
Elsevier BV
Published
2015-04
Volume
10
Issue
2
Pages
99-107
ISSN
1818-0876 (ISSN-L)
OpenAlex
W2089905805
Cited by
506
References
97
Citations by year
2026: 13 · 2025: 27 · 2024: 29 · 2023: 32 · 2022: 52 · 2021: 76 · 2020: 69 · 2019: 69 · 2018: 67 · 2017: 40 · 2016: 31 · 2015: 1
FWCI
10.95
Type
journal article
Language
en
Open access
Locations
  • Asian Journal of Pharmaceutical Sciences (publishedVersion, cc-by-nc-nd)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
  • Physical Sciences › Engineering › Mechanical Engineering › Advanced Materials and Mechanics
Keywords
thermoresponsive polymers, smart drug delivery, phase transitions, hydrogels, interpenetrating polymer networks, micelles, tissue engineering scaffolds, gene delivery, regenerative medicine, biomedical applications

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