Studies on thermoresponsive polymers: Phase behaviour, drug delivery and biomedical applications
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The present review aims to highlight the applications of thermoresponsive polymers. Thermo-responsive polymers show a sharp change in properties upon a small or modest change in temperature. This behaviour can be utilized for the preparation of so-called ‘smart’ drug delivery systems, which mimic biological response behaviour to a certain extent. Such materials are used in the development of several applications, such as drug delivery systems, tissue engineering scaffolds and gene delivery. Advances in this field are particularly relevant to applications in the areas of regenerative medicine and drug delivery. This review addresses summary of the main applications of thermoresponsive polymers which are categorized based on their 3-dimensional structure; hydrogels, interpenetrating networks, micelles, films and particles. The physico-chemical behaviour underlying the phase transition is also discussed in brief.
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Thermo-responsive polymers show sol-gel transitions with a change in external temperature, and hydrogels made of thermoresponsive polymers find drug delivery applications through simple chemical modifications.
“Thermo-responsive polymers show sol-gel transitions with a change in temperature of the external environment and hydrogels made of thermoresponsive polymers find tremendous drug delivery applications through simple chemical modifications [29,30,31,32]”
From Review of Stimuli-Responsive Polymers in Drug Delivery and Textile Application (2019) · cites this paper as [31]
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Lombardo, D., Kiselev, M. A., & Caccamo, M. T. (2019) · Journal of Nanomaterials · doi:10.1155/2019/3702518 · Cited by 864 · see citing works
Review of Stimuli-Responsive Polymers in Drug Delivery and Textile Application
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- Authors
- Gandhi, A., Paul, A., Sen, S. O., & Sen, K. K.
- Corresponding author
- Paul, Abhijit
- ORCID
- Sen, Kalyan Kumar
- Venue
- Asian Journal of Pharmaceutical Sciences
- Publisher
- Elsevier BV
- Published
- 2015-04
- Volume
- 10
- Issue
- 2
- Pages
- 99-107
- ISSN
- 1818-0876 (ISSN-L)
- OpenAlex
- W2089905805
- Cited by
- 506
- References
- 97
- Citations by year
- 2026: 13 · 2025: 27 · 2024: 29 · 2023: 32 · 2022: 52 · 2021: 76 · 2020: 69 · 2019: 69 · 2018: 67 · 2017: 40 · 2016: 31 · 2015: 1
- FWCI
- 10.95
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- Locations
- Asian Journal of Pharmaceutical Sciences (publishedVersion, cc-by-nc-nd)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Physical Sciences › Engineering › Mechanical Engineering › Advanced Materials and Mechanics
- Keywords
- thermoresponsive polymers, smart drug delivery, phase transitions, hydrogels, interpenetrating polymer networks, micelles, tissue engineering scaffolds, gene delivery, regenerative medicine, biomedical applications
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