Smart Nanoparticles for Drug Delivery Application: Development of Versatile Nanocarrier Platforms in Biotechnology and Nanomedicine
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The study of nanostructured drug delivery systems allows the development of novel platforms for the efficient transport and controlled release of drug molecules in the harsh microenvironment of diseased tissues of living systems, thus offering a wide range of functional nanoplatforms for smart application in biotechnology and nanomedicine. This article highlights recent advances of smart nanocarriers composed of organic (including polymeric micelles and vesicles, liposomes, dendrimers, and hydrogels) and inorganic (including quantum dots, gold and mesoporous silica nanoparticles) materials. Despite the remarkable developments of recent synthetic methodologies, most of all nanocarriers’ action is associated with a number of unwanted side effects that diminish their efficient use in biotechnology and nanomedicine applications. This highlights some critical issues in the design and engineering of nanocarrier systems for biotechnology applications, arising from the complex environment and multiform interactions established within the specific biological media.
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A wide variety of organic, inorganic, polymeric and metallic nanostructures are frequently used as targeted and controlled drug delivery vehicles.
“A wide variety of organic, inorganic, polymeric and metallic nanostructures, including dendrimers, micelles, solid lipid nanoparticles (SLNs), carbon nanotubes, and liposomes, are frequently used as targeted and controlled drug delivery vehicles.3–5”
From Targeted therapy in chronic diseases using nanomaterial-based drug delivery vehicles (2019) · cites this paper as [4]
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- Authors
- Lombardo, D., Kiselev, M. A., & Caccamo, M. T.
- Affiliations
- Institute for Chemical and Physical Processes (IT)
- Lomonosov Moscow State University (RU)
- Corresponding author
- Lombardo, Domenico
- Venue
- Journal of Nanomaterials
- Publisher
- Wiley
- Published
- 2019-02-27
- Volume
- 2019
- Pages
- 1-26
- ISSN
- 1687-4110 (ISSN-L)
- 1687-4129
- OpenAlex
- W2917535482
- Cited by
- 864
- References
- 160
- Citations by year
- 2026: 40 · 2025: 89 · 2024: 105 · 2023: 126 · 2022: 150 · 2021: 165 · 2020: 153 · 2019: 35 · 2018: 1
- FWCI
- 35.70
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Journal of Nanomaterials (publishedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- European Commission (608184, 14-12-00516)
- Russian Science Foundation (608184, 14-12-00516)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Physical Sciences › Materials Science › Polymers and Plastics › Dendrimers and Hyperbranched Polymers
- Keywords
- smart nanoparticles, nanocarriers, drug delivery, controlled drug release, polymeric micelles, liposomes, dendrimers, hydrogels, quantum dots, gold nanoparticles, mesoporous silica nanoparticles, nanocarrier design, nanomedicine, biotechnology applications
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