The DOI matches its Crossref record; 118 of the 120 references it cites were found in a registry or an index.
Differential Effects of Exercise on Cancer-Related Fatigue During and Following Treatment
Abstract
Context Exercise-induced improvements in cancer-related fatigue may be moderated differentially in patients during and following treatment. These effects have not been reviewed systematically. In accordance with PRISMA guidelines, the population effect size for exercise training on cancer-related fatigue during and following treatment was estimated and the extent to which the effect is differentiated across the time course of treatment and recovery was determined.Evidence acquisition Articles published before August 2011 were retrieved using Google Scholar, MEDLINE, PsycINFO, PubMed, and Web of Science databases. Seventy studies involving 4881 cancer patients during or following treatment were selected. Articles included a cancer-related fatigue outcome measured at baseline and post-intervention and randomized allocation to exercise or non-exercise comparison. From August to October 2011, Hedges' d effect sizes were computed, study quality was evaluated, and random effects models were used to estimate sampling error and population variance.Evidence synthesis Exercise significantly reduced cancer-related fatigue by a mean effect Δ (95% CI) of 0.32 (0.21, 0.43) and 0.38 (0.21, 0.54) during and following cancer treatment, respectively. During treatment, patients with lower baseline fatigue scores and higher exercise adherence realized the largest improvements. Following treatment, improvements were largest for trials with longer durations between treatment completion and exercise initiation, trials with shorter exercise program lengths, and trials using wait-list comparisons.Conclusions Exercise reduces cancer-related fatigue among patients during and following cancer treatment. These effects are moderated differentially over the time course of treatment and recovery. Exercise has a palliative effect in patients during treatment and a recuperative effect post-treatment.
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“Meta-analyses and reviews showed that exercise interventions can effectively reduce CRF21,22,23,24”
In the citing paper
“Moderate intensity aerobic training performed three times per week and for at least 12 weeks or twice weekly combined aerobic plus resistance training lasting 6–12 weeks can significantly reduce depressive symptoms in cancer survivors during and after treatment(18, 19).”
From Exercise Guidelines for Cancer Survivors: Consensus Statement from International Multidisciplinary Roundtable (2019) · cites this paper as [18]
Citations
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CAMPBELL, K. L., WINTERS-STONE, K. M., WISKEMANN, J., MAY, A. M., SCHWARTZ, A. L., COURNEYA, K. S., ZUCKER, D. S., MATTHEWS, C. E., LIGIBEL, J. A., GERBER, L. H., et al. (2019) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000002116 · Cited by 2,988
Cancer-related fatigue—mechanisms, risk factors, and treatments
Bower, J. E. (2014) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2014.127 · Cited by 1,666
Breast Cancer, Version 4.2017, NCCN Clinical Practice Guidelines in Oncology
Gradishar, W. J., Anderson, B. O., Balassanian, R., Blair, S. L., Burstein, H. J., Cyr, A. E., ELIAS, A. D., Farrar, W. B., Forero, A., Giordano, S. H., et al. (2018) · Journal of the National Comprehensive Cancer Network · doi:10.6004/jnccn.2018.0012 · Cited by 1,612
Cancer-Related Fatigue, Version 2.2015
Berger, A. M., Mooney, K. H., Alvarez-Perez, A., BREITBART, W. S., Carpenter, K. M., Cella, D. F., Cleeland, C. S., Dotan, E., Eisenberger, M. A., Escalante, C. P., et al. (2015) · Journal of the National Comprehensive Cancer Network · doi:10.6004/jnccn.2015.0122 · Cited by 997
Mustian, K. M., Alfano, C. M., Heckler, C., Kleckner, A. S., Kleckner, I. R., Leach, C. R., Mohr, D., Palesh, O. G., Peppone, L. J., Piper, B. F., et al. (2017) · JAMA Oncology · doi:10.1001/jamaoncol.2016.6914 · Cited by 932
Metadata
- Authors
- Puetz, T. W., & Herring, M. P.
- Affiliations
- Emory University (US)
- University of Alabama at Birmingham (US)
- Corresponding author
- Puetz, Timothy W.
- ORCID
- Herring, Matthew P.
- Venue
- American Journal of Preventive Medicine
- Publisher
- Elsevier BV
- Published
- 2012-08
- Volume
- 43
- Issue
- 2
- Pages
- e1-e24
- ISSN
- 0749-3797 (ISSN-L)
- OpenAlex
- W2069263322
- Cited by
- 219
- References
- 120
- Citations by year
- 2026: 10 · 2025: 9 · 2024: 9 · 2023: 10 · 2022: 17 · 2021: 15 · 2020: 22 · 2019: 10 · 2018: 16 · 2017: 23 · 2016: 19 · 2015: 23 · 2014: 18 · 2013: 15 · 2012: 1
- FWCI
- 1.83
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Preventive Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Oncology › Cancer survivorship and care
- Health Sciences › Medicine › Oncology › Cancer-related cognitive impairment studies
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Childhood Cancer Survivors' Quality of Life
- Keywords
- cancer-related fatigue, exercise training, cancer therapy, exercise adherence, post-treatment recovery
- MeSH terms
- Exercise Therapy, Fatigue, Humans, Neoplasms, Time Factors, Randomized Controlled Trials as Topic, Practice Guidelines as Topic
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