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An Assessment of Statin Safety by Hepatologists
Abstract
The purpose of the Liver Expert Panel was to provide advice to the National Lipid Association's (NLA) Safety Task Force in response to specific questions concerning liver-associated risks of statin therapy. The panel was composed of academic hepatologists with clinical and research interests in nonalcoholic fatty liver disease, lipid metabolic disorders, and drug hepatotoxicity.
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In populations with chronic liver disease including NAFLD, the risk of statin-induced DILI did not increase.
“However, in populations with chronic liver disease including NAFLD, the risk of statin-induced DILI did not increase [104][105][106].”
From Chinese guideline for the diagnosis and treatment of drug-induced liver injury: an update (2024) · cites this paper as [105]
Citations
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Statin Safety: A Systematic Review
Law, M., & Rudnicka, A. R. (2006) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2005.12.010 · Cited by 808
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Research works printed but not linked: 18
- Chalasani, 2005, Statins and hepatotoxicity, Hepatology, 41, 690, 10.1002/hep.20671 · DOI
- Mofrad, 2003, Clinical and histologic spectrum of nonalcoholic fatty liver disease associated with normal ALT values, Hepatology, 37, 1286, 10.1053/jhep.2003.50229 · DOI
- Sniderman, 2004, Is there value in liver function test and creatine phosphokinase monitoring for statin use?, Am J Cardiol, 94, 30F, 10.1016/j.amjcard.2004.07.052 · DOI
- Vuppalanchi, 2005, Patients with elevated baseline liver enzymes do not have higher frequency of hepatoxicity from lovastatin than those with normal baseline liver enzymes, Am J Med Sci, 329, 62, 10.1097/00000441-200502000-00002 · DOI · Paper page
- Chalasani, 2004, Patients with elevated liver enzymes are not at higher risk for statin hepatotoxicity, Gastroenterology, 126, 1287, 10.1053/j.gastro.2004.02.015 · DOI · Paper page
- de Denus, 2004, Statins and liver toxicity, Pharmacotherapy, 24, 584, 10.1592/phco.24.6.584.34738 · DOI
- Russo, 2004, Liver transplantation for acute liver failure from drug induced liver injury in the United States, Liver Transpl, 10, 1018, 10.1002/lt.20204 · DOI · Paper page
- Gotto, 2003, Safety and statin therapy. Reconsidering the risks and benefits, Arch Intern Med, 163, 657, 10.1001/archinte.163.6.657 · DOI
- Pelli, 2003, Autoimmune hepatitis revealed by atorvastatin, Eur J Gastroenterol Hepatol, 15, 921, 10.1097/00042737-200308000-00014 · DOI
- Siddiqui, 2005, Autoimmune hepatitis induced by statins, Gastroenterology, 128, A171
- Tolman, 2002, The liver and lovastatin, Am J Cardiol, 89, 1374, 10.1016/S0002-9149(02)02355-X · DOI
- Smith, 2003, Screening for statin-related toxicity, Arch Intern Med, 163, 688, 10.1001/archinte.163.6.688 · DOI
- Sandler, 2002, The burden of selected digestive diseases in the United States, Gastroenterology, 122, 1500, 10.1053/gast.2002.32978 · DOI · Paper page
- Neuschwanter-Tetri, 2003, Nonalcoholic steatohepatitis, Hepatology, 37, 1202, 10.1053/jhep.2003.50193 · DOI
- Rallidis, 2004, Pravastatin in patients with nonalcoholic steatohepatitis, Atherosclerosis, 174, 193, 10.1016/j.atherosclerosis.2004.01.008 · DOI
- Horlander, 2001, Atorvastatin for the treatment of NASH [abstract], Gastroenterology, 120, A544, 10.1016/S0016-5085(08)82704-7 · DOI
- Kiyici, 2003, Ursodeoxycholic acid and atorvastatin in the treatment of nonalcoholic steatohepatitis, Can J Gastroenterol, 17, 713, 10.1155/2003/857869 · DOI
- Bjornsson, 2005, Outcome and prognostic markers in severe drug-induced liver disease, Hepatology, 42, 481, 10.1002/hep.20800 · DOI · Paper page
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Metadata
- Authors
- Cohen, D. E., Anania, F. A., & Chalasani, N.
- Venue
- The American Journal of Cardiology
- Publisher
- Elsevier BV
- Published
- 2006-04
- Volume
- 97
- Issue
- 8
- Pages
- S77-S81
- ISSN
- 0002-9149
- Cited by
- 269
- References
- 1
- Language
- en
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