Cited by 383Cardiovascular Effects of ExerciseAtrial Fibrillation Management and OutcomesPhysical Activity and Health

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Relation of Vigorous Exercise to Risk of Atrial Fibrillation

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Aizer, Anthony, Gaziano, J. Michael, Cook, Nancy R., Manson, Joann E., Buring, Julie E., Albert, Christine M.·2009·The American Journal of Cardiology

DOI 10.1016/j.amjcard.2009.01.374PMC PMC2687527

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Abstract

Limited data suggest that athletes may have a higher risk of developing atrial fibrillation (AF); however, there has been no large prospective assessment of the relation between vigorous exercise and AF. Logistic regression analyses stratified by time were used to assess the association between frequency of vigorous exercise and risk of developing AF in 16,921 apparently healthy men in the Physicians' Health Study. During 12 years of follow-up, 1,661 men reported developing AF. With increasing frequency of vigorous exercise (0, 1, 1 to 2, 3 to 4, 5 to 7 days/week), multivariate relative risks for the full cohort were 1.0 (referent), 0.90, 1.09, 1.04, and 1.20 (p = 0.04). This risk was not significantly increased when exercise habits were updated or in models excluding variables that may be in the biological pathway through which exercise influences AF risk. In subgroup analyses, this increased risk was observed only in men <50 years of age (1.0, 0.94, 1.20, 1.05, 1.74, p <0.01) and joggers (1.0, 0.91, 1.03, 1.30, 1.53, p <0.01), where risks remained increased in all analyses. In conclusion, frequency of vigorous exercise was associated with an increased risk of developing AF in young men and joggers. This risk decreased as the population aged and was offset by known beneficial effects of vigorous exercise on other AF risk factors.

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Items 201–300 of 383

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Background
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“Physical Activity and Atrial Fibrillation There is an established body of literature supporting the concept that endurance exercise, particularly in elite athletes and military personnel, increases the risk of atrial fibrillation.(3-9) This evidence appears contrary to expectations that exercise is assumed to have a b…”
Background
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Background
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BackgroundInfluential
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Background
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Hæusler, K. G., Herm, J., Kunze, C., Krüll, M., Brechtel, L. M., Lock, J., Hohenhaus, M., Heuschmann, P. U., Fiebach, J. B., Haverkamp, W., et al. (2012) · BMC Cardiovascular Disorders · doi:10.1186/1471-2261-12-69 · Cited by 11
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Background
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Background
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Background
Exercise-Induced Atrial Remodeling in Female Amateur Marathon Runners Assessed by Three-Dimensional and Speckle Tracking Echocardiography
Lasocka, Z., Lewicka-Potocka, Z., Faran, A., Daniłowicz‐Szymanowicz, L., Nowak, R., Kaufmann, D., Kaleta-Duss, A. M., Kalinowski, L., Raczak, G., Lewicka, E., et al. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.863217 · Cited by 11
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Background
Chronic Exercise
Wehrens, X. H. T., Chiang, D. Y.-E., & Li, N. (2013) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2013.02.070 · Cited by 8
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Result
Editorial commentary: Relationship between strenuous exercise and cardiac “morbimortality”: Benefits outweigh the potential risks
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“There is increasing evidence that strenuous endurance exercise is associated with an increased prevalence of atrial fibrillation (AF). Even within ranges of exercise below those practised by athletes, a U-shaped exercise response curve has been described whereby mild exercise is associated with a lower incidence of AF…”
Background
Weekly physical activity and incident atrial fibrillation in females – A dose-response meta-analysis
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Background
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Kirchhof, P. F., Adamou, A., Knight, E., & Lip, G. Y. H. (2009) · Cited by 7
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Background
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Miguel‐dos‐Santos, R., Moreira, J. B. N., Loennechen, J. P., Wisløff, U., & Mesquita, T. (2021) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2021.07.008 · Cited by 8
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“However, postoperative CR is not always implemented; the nonlinear relationship between exercise and AF suggests that while moderate exercise may have a beneficial effect on AF, high-intensity exercise may induce recurrent AF [19-21].”
Background
A novel 1D generative adversarial network-based framework for atrial fibrillation detection using restored wrist photoplethysmography signals
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“Additionally, several studies [3]–[5] indicate that engaging in prolonged physical activity can increase the risk of having an AF episode.”
Background
Endurance Sports and Atrial Fibrillation: A Puzzling Conundrum
Ostojic, M., Ostojić, M., Petrović, O., Nedeljkovic‐Arsenovic, O., Perone, F., Banović, M., Stojmenović, T., Stojmenovič, D., Giga, V. L., Beleslin, B., et al. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13247691 · Cited by 10
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Alcarraz, A., Meza‐Ramos, A., Rubies, C., la Garza, M. S., Bolaños-Gomez, C. E., Sitges, M., Mont, L., Batlle, M., & Guasch, E. (2025) · EP Europace · doi:10.1093/europace/euaf098 · Cited by 8
“Some methods have been proposed, including life-time cumulative > 2000 h of physical activity 35 or jogging > 5 days/week, 36 but it remains unknown whether lower amounts may also increase AF risk, particularly in individuals at low baseline risk.”
Exercise and Athletic Activity in Atrial Fibrillation
Kherlopian, A., Weinshel, S., Madias, C. A., & Estes, N. A. M. (2021) · Cardiac Electrophysiology Clinics · doi:10.1016/j.ccep.2020.10.005 · Cited by 7
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Background
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Method
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“2- to 15-fold compared to the general and sedentary population, so that it can be paradoxically assumed that better is the cardiovascular fitness, higher is the incidence of AF (5-9).”
Background
Exercise and atrial fibrillation: how health turns harm, and how to turn it back
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“frequency of PA should result in stronger PA habits.(26,28,29) The strongest test of whether engaging in PA to compensate for drinking influences habit strength would control for this feature of PA.”
Background
Long-term efficacy and impact on quality of life of atrial fibrillation catheter ablation in competitive athletes
Toso, E., GAGLIARDI, M., Peyracchia, M., Angelini, F., Anselmino, M., Ferraris, F., Giustetto, C., Scaglione, M., & Gaïta, F. (2021) · The Journal of Sports Medicine and Physical Fitness · doi:10.23736/s0022-4707.21.13257-8 · Cited by 6
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Authors: Aizer, A., Gaziano, J. M., Cook, N. R., Manson, J. E., Buring, J. E., & Albert, C. M.
Affiliations: Brigham and Women's Hospital (US)
Corresponding author: Aizer, Anthony
ORCID: Aizer, Anthony
Gaziano, J. Michael
Cook, Nancy R.
Manson, Joann E.
Buring, Julie E.
Albert, Christine M.
Venue: The American Journal of Cardiology
Publisher: Elsevier BV
Published: 2009-06
Volume: 103
Issue: 11
Pages: 1572-1577
ISSN: 0002-9149 (ISSN-L)
DOI: 10.1016/j.amjcard.2009.01.374
PMC: PMC2687527
OpenAlex: W2070824750
Cited by: 383
References: 25
Citations by year: 2026: 9 · 2025: 12 · 2024: 17 · 2023: 37 · 2022: 19 · 2021: 21 · 2020: 32 · 2019: 23 · 2018: 31 · 2017: 21 · 2016: 30 · 2015: 22 · 2014: 24 · 2013: 23 · 2012: 22
FWCI: 13.42
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: The American Journal of Cardiology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health (5r01hl043851-10)
National Heart, Lung, and Blood Institute (HL-34595, HL 26490, R01‐HL043851, R01HL034595)
National Cancer Institute (R01CA040360, CA 34944, CA-097193, R01CA097193, CA 40360, R01CA047988)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Effects of Exercise
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Atrial Fibrillation Management and Outcomes
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Physical Activity and Health
Keywords: atrial fibrillation, high-intensity exercise, exercise frequency, joggers, young men, aging, risk factors, Physicians' Health Study
MeSH terms: Adult, Age Factors, Aged, Aged, 80 and over, Atrial Fibrillation, Humans, Life Style, Male, Middle Aged, Prospective Studies, Exercise, Effect Modifier, Epidemiologic, Body Mass Index, Logistic Models, Risk Assessment

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Relation of Vigorous Exercise to Risk of Atrial Fibrillation

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