The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Remodeling of resistance arteries in essential hypertension and effects of antihypertensive treatment
Abstract
Essential hypertension is characterized by increased peripheral vascular resistance to blood flow. This resistance results mostly from energy dissipation in small arteries and arterioles. Small decreases in the lumen of these arteries significantly increase resistance. Resistance arteries may play an important role in the development, and may contribute to the complications, of hypertension. Recent studies have demonstrated that the media-lumen ratio of small arteries has prognostic significance in relation to cardiovascular events in hypertensive subjects. Almost all hypertensive patients have vascular-structure remodeling; however, only some exhibit endothelial dysfunction. In particular, endothelial dysfunction is less common in mild hypertension. In both experimental models and humans with hypertension, antihypertensive treatment may partially correct the remodeling of small arteries and arterioles. Some antihypertensive drugs can correct small artery structure and impaired endothelial function. Because the degree of remodeling predicts events in hypertensive subjects, and endothelial dysfunction results from the oxidative stress that may also predict events, correction of small artery structure and function may favorably affect outcomes in hypertension. This improvement in morbidity and mortality end points could be a long-term effect, however, making it difficult to prove in trials lasting 3 to 5 years. Nevertheless, many patients with hypertension will be treated for decades; therefore, the potential long-term benefits of vascular protection might be quite important.
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Brenner, B. M., Cooper, M. E., de Zeeuw, D., Keane, W. F., Mitch, W. E., Parving, H.-H., Remuzzi, G., Snapinn, S. M., Zhang, Z., & Shahinfar, S. (2001) · New England Journal of Medicine · doi:10.1056/nejmoa011161 · Cited by 7,493
Lewis, E. J., Hunsicker, L. G., Clarke, W. R., Berl, T., Pohl, M. A., Lewis, J. B., Ritz, E., Atkins, R. C., Rohde, R., & Raz, I. (2001) · New England Journal of Medicine · doi:10.1056/nejmoa011303 · Cited by 5,987
The ALLHAT Officers and Coordinators for the ALLHAT Collaborative Research Group (2002) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.288.23.2981 · Cited by 5,664
Landmesser, U., Dikalov, S., Price, S. R., McCann, L., Fukai, T., Holland, S. M., Mitch, W. E., & Harrison, D. G. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200314172 · Cited by 1,660
Wing, L. M. H., Reid, C. M., Ryan, P., Beilin, L. J., Brown, M. A., Jennings, G. L. R., Johnston, C. I., McNeil, J. J., Macdonald, G. J., Marley, J. E., et al. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa021716 · Cited by 1,130
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Seravalle, G., & Grassi, G. (2017) · Pharmacological Research · doi:10.1016/j.phrs.2017.05.013 · Cited by 909
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Wilcox, C. S. (2010) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2010.01.003 · Cited by 465
How NaCl raises blood pressure: a new paradigm for the pathogenesis of salt-dependent hypertension
Blaustein, M. P., Leenen, F. H. H., Chen, L., Golovina, V. A., Hamlyn, J. M., Pallone, T. L., Van Huysse, J. W., Zhang, J., & Wier, W. G. (2012) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00899.2011 · Cited by 285
Vascular Smooth Muscle Remodeling in Conductive and Resistance Arteries in Hypertension
Brown, I. A. M., Diederich, L., Good, M. E., DeLalio, L. J., Murphy, S. A., Cortese-Krott, M. M., Hall, J. L., Le, T. H., & Isakson, B. E. (2018) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.118.311229 · Cited by 266
Redox signaling, Nox5 and vascular remodeling in hypertension
Montezano, A. C., Tsiropoulou, S., Dulak-Lis, M., Harvey, A., Camargo, L. D. L., & Touyz, R. M. (2015) · Current Opinion in Nephrology and Hypertension · doi:10.1097/mnh.0000000000000153 · Cited by 93
Metadata
- Authors
- SCHIFFRIN, E.
- Venue
- American Journal of Hypertension
- Publisher
- Oxford University Press (OUP)
- Published
- 2004-12
- Volume
- 17
- Issue
- 12
- Pages
- 1192-1200
- ISSN
- 0895-7061 (ISSN-L)
- OpenAlex
- W2073656482
- Cited by
- 327
- References
- 8
- FWCI
- 7.43
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
