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Cited by 156Cardiovascular Health and Disease PreventionBlood Pressure and Hypertension StudiesCardiovascular and exercise physiology

Increased skin capillary density in treated essential hypertensive patients

DEBBABI, H, UZAN, L, MOURAD, J, SAFAR, M, LEVY, B, TIBIRICA, E·2006·American Journal of Hypertension
DOI 10.1016/j.amjhyper.2005.10.021
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Abstract

BACKGROUND: Microvascular rarefaction is a hallmark of essential hypertension. We measured the skin capillary density in nondiabetic hypertensive subjects with effective antihypertensive treatment and evaluated possible correlations with arterial blood pressure (BP). METHODS: This cross-sectional observational study included 76 (55 +/- 1 years) consecutive outpatients with essential hypertension under chronic antihypertensive drug treatment (BP < 140/90 mm Hg), 24 age- and sex-matched patients with recently discovered and never-treated hypertension and 70 normotensive (BP < 140/90 mm Hg) age- and sex-matched healthy controls. We used intravital video-microscopy to measure basal and maximal (during venous congestion) skin capillary densities in the dorsum of the fingers. Aortic stiffness was evaluated using pulse wave velocity and central aortic pressure calculated from radial artery applanation tonometry. RESULTS: Baseline and maximal capillary densities (number/mm2) were significantly lower (59.6 +/- 2.0 and 62.0 +/- 1.9) in untreated than in treated hypertensive patients (74.0 +/- 1.4 and 79.4 +/- 1.5; P < .001) and than in normotensives (68.2 +/- 1.5 and 72.4 +/- 1.5; P < .001). Based on multiple regression analysis, after adjustment to tobacco consumption, aortic (and not brachial) systolic BP was inversely correlated with basal and postocclusive capillary densities in normotensive subjects. In hypertensives, this correlation disappears and capillary density was influenced by two independent variables, antihypertensive drug treatment and overweight. CONCLUSIONS: In nondiabetic hypertensive patients, capillary density is reduced in association with a cluster of cardiovascular risk factors involving tobacco consumption and obesity. The finding of an increased capillary density in effectively treated antihypertensives suggests that a cause-to-effect relationship between BP and capillary density should be evaluated in a long-term prospective follow-up.

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  • Publications that experimentally and explicitly demonstrate the effect of obesity or BMI on the PPG waveform are limited.

    “While, to the authors’ knowledge, publications that experimentally and explicitly demonstrate the effect of obesity or BMI on the PPG waveform are limited, we will explore works which suggest that there would be a substantial effect [56,59,60,61,62,63,64,65,66,67,68,69,70].”

    From Sources of inaccuracy in photoplethysmography for continuous cardiovascular monitoring (2021) · cites this paper as [64]

  • The effect of obesity on dermal capillary density could lead to a decrease in the dominant 'DC' component of a PPG waveform due to the increased blood volume of the obese.

    “This effect of obesity could lead to a decrease in the dominant “DC” component of a PPG waveform due to the increased blood volume of the obese [61,62,63,64].”

    From Sources of inaccuracy in photoplethysmography for continuous cardiovascular monitoring (2021) · cites this paper as [64]

  • The majority of findings find that dermal capillary density does negatively correlate on average with increasing BMI.

    “In adults, while some studies show that at rest there is no significant change in dermal capillary density, the majority of findings find that dermal capillary density does negatively correlate on average with increasing BMI [62,63,64,65].”

    From Sources of inaccuracy in photoplethysmography for continuous cardiovascular monitoring (2021) · cites this paper as [64]

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Authors
DEBBABI, H., UZAN, L., MOURAD, J., SAFAR, M., LEVY, B., & TIBIRICA, E.
Affiliations
  • Inserm (FR)
  • Université Sorbonne Paris Nord (FR)
Corresponding author
LEVY, B
ORCID
Venue
American Journal of Hypertension
Publisher
Oxford University Press (OUP)
Published
2006-05
Volume
19
Issue
5
Pages
477-483
ISSN
0895-7061 (ISSN-L)
DOI
10.1016/j.amjhyper.2005.10.021
OpenAlex
W2070966641
Cited by
156
References
31
Citations by year
2026: 2 · 2025: 7 · 2024: 6 · 2023: 5 · 2022: 8 · 2021: 7 · 2020: 9 · 2019: 2 · 2018: 9 · 2017: 6 · 2016: 8 · 2015: 9 · 2014: 14 · 2013: 12 · 2012: 7
FWCI
5.71
Type
journal article
Language
en
Open access
closed
Locations
  • American Journal of Hypertension (publishedVersion)
  • PubMed (publishedVersion)
  • Arca - Repositório Institucional da Fiocruz (submittedVersion)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
  • Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
Keywords
essential hypertension, antihypertensive therapy, untreated hypertension, microvascular rarefaction, venous congestion, aortic stiffness, pulse wave velocity, applanation tonometry, arterial blood pressure, obesity, smoking, cardiovascular risk factors
MeSH terms
Antihypertensive Agents, Blood Pressure, Capillaries, Cross-Sectional Studies, Female, Follow-Up Studies, Humans, Hypertension, Male, Microcirculation, Middle Aged, Severity of Illness Index, Skin, Microscopy, Video

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