CoChat
Sign Up
Cited by 87Traumatic Brain Injury and Neurovascular DisturbancesTraumatic Brain Injury ResearchTrauma and Emergency Care Studies

Severe traumatic brain injury: is there a gender difference in mortality?

Ottochian, Marcus, Salim, Ali, Berry, Cherisse, Chan, Linda S., Wilson, Matthew T., Margulies, Daniel R.·2009·The American Journal of Surgery
DOI 10.1016/j.amjsurg.2008.09.008
Open this paper in CoChat — free account

Abstract

Background Emerging evidence suggests that male and female nervous systems respond differently to traumatic brain injury (TBI). The objective of this study was to examine outcomes between the sexes after TBI.Patients and methods A retrospective review of all severe TBI patients admitted between January and December 2005 was performed. Isolated severe TBI was defined as a head abbreviated injury score greater than 3 with an abbreviated injury score of 3 or less for other anatomic regions. The population was stratified into age subgroups (<14 y, 14-44 y, 45-54 y, and > or =55 y). Logistic regression was used to identify independent predictors of mortality.Results A total of 1,807 TBI patients were admitted. The mortality was significantly higher for women (43.2% vs 36.2%, P < .01) with an adjusted odds ratio of 1.4 (95% confidence interval, 1.1-1.9, P < .05). After stratification, only women age 55 and older had a significant difference in mortality (odds ratio, 1.71; 95% confidence interval, 1.11-2.62, P = .02).Conclusions Female sex (particularly those age > or =55 y) is associated independently with higher mortality in isolated severe TBI. This increased mortality of postmenopausal women after isolated TBI may suggest a hormonal influence and warrants further investigation.

Integrity signals

Registry

Crossref · 10.1016/j.amjsurg.2008.09.008

Cites

19 of 19 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • A study with approximately 1800 patients showed higher mortality following severe TBI in post-menopausal women compared with age-matched men.

    “Further, a study with approximately 1800 patients showed higher mortality following severe TBI in post-menopausal women compared with age-matched men. 68”

    From Sex Differences in Traumatic Brain Injury: What We Know and What We Should Know (2019) · cites this paper as [68]

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Related

Authors
Ottochian, M., Salim, A., Berry, C., Chan, L. S., Wilson, M. T., & Margulies, D. R.
Affiliations
  • University of Southern California (US)
  • Cedars-Sinai Medical Center (US)
ORCID
Venue
The American Journal of Surgery
Publisher
Elsevier BV
Published
2009-02
Volume
197
Issue
2
Pages
155-158
ISSN
0002-9610 (ISSN-L)
DOI
10.1016/j.amjsurg.2008.09.008
OpenAlex
W2018134623
Cited by
87
References
19
Citations by year
2026: 4 · 2025: 5 · 2024: 2 · 2023: 5 · 2022: 5 · 2021: 8 · 2020: 6 · 2019: 2 · 2018: 11 · 2017: 3 · 2016: 4 · 2015: 7 · 2014: 3 · 2013: 4 · 2012: 4
FWCI
3.83
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • The American Journal of Surgery (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Neurology › Traumatic Brain Injury and Neurovascular Disturbances
  • Health Sciences › Medicine › Epidemiology › Traumatic Brain Injury Research
  • Health Sciences › Medicine › Emergency Medicine › Trauma and Emergency Care Studies
Keywords
severe traumatic brain injury, sex differences, mortality, postmenopausal women, age stratification, endocrine effects
MeSH terms
Adult, Age Factors, Aged, Brain Injuries, Female, Humans, Male, Middle Aged, Retrospective Studies, Sex Factors

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review