The DOI matches its Crossref record; 60 of the 60 references it cites were found in a registry or an index.
Fusobacterium nucleatum and adverse pregnancy outcomes: Epidemiological and mechanistic evidence
Open accessAbstract
Fusobacterium nucleatum is a Gram-negative anaerobic oral commensal associated with periodontal disease. F. nucleatum has been implicated in a wide spectrum of systemic diseases, including oral, gastro-intestinal, rheumatologic, and vascular pathologies. As pregnancy risk has been linked to periodontal disease, there has also been significant research into the effects of periodontal disease on adverse pregnancy outcomes. This article reviews the epidemiological and mechanistic evidence of the role of F. nucleatum in adverse pregnancy outcomes.
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“Studies investigating the placental microbiome to understand its role in preterm pregnancies have identified bacteria associated with periodontal disease, suggesting a relationship between the oral and placental microbiomes.113, 114, 115, 116”
From The oral microbiome: Role of key organisms and complex networks in oral health and disease (2021) · cites this paper as [115]
In the citing paper
“Pathogenic bacteria from the oral cavity found at various sites within the uterus are associated with adverse pregnancy outcomes, such as preterm delivery and preeclampsia.113, 114, 115”
From The oral microbiome: Role of key organisms and complex networks in oral health and disease (2021) · cites this paper as [115]
In the citing paper
“Similarly, bacteria of oral origin, namely Fusobacterium nucleatum, were identified in samples of amniotic fluid and cord blood from women with pregnancy complications, suggesting oral translocation via hematogenous mechanisms.115”
From The oral microbiome: Role of key organisms and complex networks in oral health and disease (2021) · cites this paper as [115]
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Cites
Intrauterine infection and preterm delivery
Goldenberg, R. L., Hauth, J. C., & Andrews, W. W. (2000) · New England Journal of Medicine · doi:10.1056/nejm200005183422007 · Cited by 2,548 · cited 1×
“Currently, there are two major pathways by which bacteria and other pathogens may trigger an inflammatory response leading to pregnancy complications [1,6].”
BackgroundThe Placenta Harbors a Unique Microbiome
Aagaard, K., Ma, J., Antony, K. M., Ganu, R., Petrosino, J., & Versalovic, J. (2014) · Science Translational Medicine · doi:10.1126/scitranslmed.3008599 · Cited by 2,494 · cited 1×
“Although the presence of a placental microbiome in healthy term pregnancies has been debated [21], recent research suggests that the placental microbiome most closely resembles the human oral microbiome [22].”
BackgroundRubinstein, M. R., Wang, X., Liu, W., Hao, Y., Cai, G., & Han, Y. W. (2013) · Cell Host & Microbe · doi:10.1016/j.chom.2013.07.012 · Cited by 2,476
Self-citationThe bacteria of periodontal diseases
Moore, W. E., & Moore, L. V. H. (1994) · Periodontology 2000 · doi:10.1111/j.1600-0757.1994.tb00019.x · Cited by 1,077 · cited 1×
“One such oral species of interest is Fusobacterium nucleatum, a Gram-negative anaerobe commonly found within the oral cavity and implicated in various forms of periodontal diseases [27,28].”
BackgroundGriffen, A. L., Beall, C. J., Campbell, J. H., Firestone, N. D., Kumar, P., Yang, Z. K., Podar, M., & Leys, E. J. (2011) · The ISME Journal · doi:10.1038/ismej.2011.191 · Cited by 1,006 · cited 1×
“One such oral species of interest is Fusobacterium nucleatum, a Gram-negative anaerobe commonly found within the oral cavity and implicated in various forms of periodontal diseases [27,28].”
BackgroundFusobacterium nucleatum: a commensal-turned pathogen
Han, Y. W. (2015) · Current Opinion in Microbiology · doi:10.1016/j.mib.2014.11.013 · Cited by 869 · cited 2×
“nucleatum has also been implicated in a wide variety of systemic diseases, including GI disorders, atherosclerosis, rheumatoid arthritis and respiratory tract infections [29,30], which is well summarized in a prior review [31].”
BackgroundSelf-citationStrauss, J., Kaplan, G. G., Beck, P. L., Rioux, K. P., Panaccione, R., DeVinney, R., Lynch, T., & Allen‐Vercoe, E. (2011) · Inflammatory Bowel Diseases · doi:10.1002/ibd.21606 · Cited by 578 · cited 1×
“nucleatum has also been implicated in a wide variety of systemic diseases, including GI disorders, atherosclerosis, rheumatoid arthritis and respiratory tract infections [29,30], which is well summarized in a prior review [31].”
BackgroundLauder, A. P., Roche, A. M., Sherrill-Mix, S., Bailey, A., Laughlin, A. L., Bittinger, K., Leite, R., Elovitz, M. A., Parry, S., & Bushman, F. D. (2016) · Microbiome · doi:10.1186/s40168-016-0172-3 · Cited by 539
Han, Y. W., & Wang, X. (2013) · Journal of Dental Research · doi:10.1177/0022034513487559 · Cited by 489
Self-citationPeriodontal infection and preterm birth
JEFFCOAT, M. K., GEURS, N. C., REDDY, M. S., CLIVER, S. P., GOLDENBERG, R. L., & HAUTH, J. C. (2001) · The Journal of the American Dental Association · doi:10.14219/jada.archive.2001.0299 · Cited by 476
Cited by
Sorted by citations
The oral microbiome: Role of key organisms and complex networks in oral health and disease
Sedghi, L., DiMassa, V., Harrington, A., Lynch, S. V., & Kapila, Y. L. (2021) · Periodontology 2000 · doi:10.1111/prd.12393 · Cited by 755
Hajishengallis, G., & Lamont, R. J. (2021) · Periodontology 2000 · doi:10.1111/prd.12371 · Cited by 314
Wu, J., Li, Q., & Fu, X. (2019) · Translational Oncology · doi:10.1016/j.tranon.2019.03.003 · Cited by 259
“FadA can also bind to endothelial cells VE-cadherin, which a linker molecule on endothelial cells [33].”
BackgroundInfluentialPeriodontal diseases and adverse pregnancy outcomes: Mechanisms
Figuero, E., Han, Y. W., & Furuichi, Y. (2020) · Periodontology 2000 · doi:10.1111/prd.12295 · Cited by 183
Self-citationMuraoka, A., Suzuki, M. M., Hamaguchi, T., Watanabe, S., Iijima, K., Murofushi, Y., Shinjo, K., Osuka, S., Hariyama, Y., Ito, M., et al. (2023) · Science Translational Medicine · doi:10.1126/scitranslmed.add1531 · Cited by 192
Metadata
- Authors
- Vander Haar, E. L., So, J., Gyamfi-Bannerman, C., & Han, Y. W.
- Affiliations
- Columbia University Irving Medical Center (US)
- Corresponding author
- Han, Yiping W.
- ORCID
- Han, Yiping W.
- Venue
- Anaerobe
- Publisher
- Elsevier BV
- Published
- 2018-04
- Volume
- 50
- Pages
- 55-59
- ISSN
- 1075-9964 (ISSN-L)
- PMC
- PMC6750227
- OpenAlex
- W2791709251
- Cited by
- 155
- References
- 60
- Citations by year
- 2026: 23 · 2025: 23 · 2024: 21 · 2023: 28 · 2022: 20 · 2021: 20 · 2020: 13 · 2019: 4 · 2018: 1
- FWCI
- 1.39
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Anaerobe (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion, cc-by-nc-nd)
- Funders
- NIH (DE014924, DE023332, CA192111)
- Topics
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Health Sciences › Medicine › Obstetrics and Gynecology › Preterm Birth and Chorioamnionitis
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Keywords
- Fusobacterium nucleatum, adverse pregnancy outcomes, periodontal disease, oral commensals, oral microbiota, systemic inflammation, pregnancy complications, periodontitis
- MeSH terms
- Animals, Female, Fusobacterium Infections, Humans, Mouth Mucosa, Periodontal Diseases, Pregnancy, Pregnancy Complications, Pregnancy Complications, Infectious, Pregnancy Outcome, Virulence, Fusobacterium nucleatum
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