The DOI matches its Crossref record; 60 of the 60 references it cites were found in a registry or an index.
Fusobacterium nucleatum and adverse pregnancy outcomes: Epidemiological and mechanistic evidence
Open accessAbstract
Fusobacterium nucleatum is a Gram-negative anaerobic oral commensal associated with periodontal disease. F. nucleatum has been implicated in a wide spectrum of systemic diseases, including oral, gastro-intestinal, rheumatologic, and vascular pathologies. As pregnancy risk has been linked to periodontal disease, there has also been significant research into the effects of periodontal disease on adverse pregnancy outcomes. This article reviews the epidemiological and mechanistic evidence of the role of F. nucleatum in adverse pregnancy outcomes.
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“Studies investigating the placental microbiome to understand its role in preterm pregnancies have identified bacteria associated with periodontal disease, suggesting a relationship between the oral and placental microbiomes.113, 114, 115, 116”
From The oral microbiome: Role of key organisms and complex networks in oral health and disease (2021) · cites this paper as [115]
In the citing paper
“Pathogenic bacteria from the oral cavity found at various sites within the uterus are associated with adverse pregnancy outcomes, such as preterm delivery and preeclampsia.113, 114, 115”
From The oral microbiome: Role of key organisms and complex networks in oral health and disease (2021) · cites this paper as [115]
In the citing paper
“Similarly, bacteria of oral origin, namely Fusobacterium nucleatum, were identified in samples of amniotic fluid and cord blood from women with pregnancy complications, suggesting oral translocation via hematogenous mechanisms.115”
From The oral microbiome: Role of key organisms and complex networks in oral health and disease (2021) · cites this paper as [115]
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Citations
Cites
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“nucleatum, were found to be significantly enriched in the placentas of women with preeclampsia compared with controls [45].”
ResultXu, M., Yamada, M., Mei, L., Liu, H., Chen, S. G., & Han, Y. W. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m611567200 · Cited by 199 · cited 1×
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Self-citationMarkers of periodontal infection and preterm birth
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Oral Health and Adverse Pregnancy Outcomes – What’s Next?
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Self-citationIntra-amniotic bacterial colonization in premature labor
Wahbeh, C. J., Hill, G. B., Eden, R. D., & Gall, S. A. (1984) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(84)90558-1 · Cited by 130
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“Moreover, pregnancy renders women susceptible to periodontal disease, as the hormonal changes lead to weakened gingival epithelial barriers and increased inflammation, evidenced by increased rates of gingivitis and progression of periodontitis during gestation [14].”
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“nucleatum mutant without FadA is severely deficient in colonizing the murine placenta, while its complement clone restores the colonization [49,58].”
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“nucleatum has been detected in placental and fetal tissues, including amniotic fluid [24], cord blood [26], fetal membranes [35], and neonatal gastric aspirates [36], from pregnancies affected by PPROM as well as preterm birth with intact membranes.”
BackgroundIntraamniotic infection with fusobacteria
Chaim, W., & Mazor, M. (1992) · Archives of Gynecology and Obstetrics · doi:10.1007/bf02718272 · Cited by 60
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BackgroundNithianantham, S., Xu, M., Yamada, M., Ikegami, A., Shoham, M., & Han, Y. W. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m805503200 · Cited by 39 · cited 1×
“The crystal structure of mFadA reveals a predominantly alpha-helical hairpin structure, with the monomers linked together head-to-tail via a novel leucine-chain motif [57].”
BackgroundSelf-citationFurther evidence for periodontal disease as a risk indicator for adverse pregnancy outcomes
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“As the quantity of antibodies in serum is related to the severity of periodontal disease [44], these findings support a link between oral F.”
ResultLevels of periodontal pathogens in neonatal gastric aspirates and possible maternal sites of origin
Gonzales‐Marin, C., Spratt, D. A., Millar, M. R., Simmonds, M. C., Kempley, S. T., & Allaker, R. P. (2011) · Molecular Oral Microbiology · doi:10.1111/j.2041-1014.2011.00616.x · Cited by 26
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Acute chorioamnionitis at term caused by the oral pathogen Fusobacterium nucleatum.
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Self-citationPerinatally Acquired Pseudomonas Infection: A Newly Recognized Maternal Risk Factor
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Background
Cited by
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The oral microbiome: Role of key organisms and complex networks in oral health and disease
Sedghi, L., DiMassa, V., Harrington, A., Lynch, S. V., & Kapila, Y. L. (2021) · Periodontology 2000 · doi:10.1111/prd.12393 · Cited by 755
Hajishengallis, G., & Lamont, R. J. (2021) · Periodontology 2000 · doi:10.1111/prd.12371 · Cited by 314
Wu, J., Li, Q., & Fu, X. (2019) · Translational Oncology · doi:10.1016/j.tranon.2019.03.003 · Cited by 259
“FadA can also bind to endothelial cells VE-cadherin, which a linker molecule on endothelial cells [33].”
BackgroundInfluentialPeriodontal diseases and adverse pregnancy outcomes: Mechanisms
Figuero, E., Han, Y. W., & Furuichi, Y. (2020) · Periodontology 2000 · doi:10.1111/prd.12295 · Cited by 183
Self-citationMuraoka, A., Suzuki, M. M., Hamaguchi, T., Watanabe, S., Iijima, K., Murofushi, Y., Shinjo, K., Osuka, S., Hariyama, Y., Ito, M., et al. (2023) · Science Translational Medicine · doi:10.1126/scitranslmed.add1531 · Cited by 192
Metadata
- Authors
- Vander Haar, E. L., So, J., Gyamfi-Bannerman, C., & Han, Y. W.
- Affiliations
- Columbia University Irving Medical Center (US)
- Corresponding author
- Han, Yiping W.
- ORCID
- Han, Yiping W.
- Venue
- Anaerobe
- Publisher
- Elsevier BV
- Published
- 2018-04
- Volume
- 50
- Pages
- 55-59
- ISSN
- 1075-9964 (ISSN-L)
- PMC
- PMC6750227
- OpenAlex
- W2791709251
- Cited by
- 155
- References
- 60
- Citations by year
- 2026: 23 · 2025: 23 · 2024: 21 · 2023: 28 · 2022: 20 · 2021: 20 · 2020: 13 · 2019: 4 · 2018: 1
- FWCI
- 1.39
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Anaerobe (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion, cc-by-nc-nd)
- Funders
- NIH (DE014924, DE023332, CA192111)
- Topics
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Health Sciences › Medicine › Obstetrics and Gynecology › Preterm Birth and Chorioamnionitis
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Keywords
- Fusobacterium nucleatum, adverse pregnancy outcomes, periodontal disease, oral commensals, oral microbiota, systemic inflammation, pregnancy complications, periodontitis
- MeSH terms
- Animals, Female, Fusobacterium Infections, Humans, Mouth Mucosa, Periodontal Diseases, Pregnancy, Pregnancy Complications, Pregnancy Complications, Infectious, Pregnancy Outcome, Virulence, Fusobacterium nucleatum
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