The DOI matches its Crossref record; 60 of the 60 references it cites were found in a registry or an index.
Fusobacterium nucleatum and adverse pregnancy outcomes: Epidemiological and mechanistic evidence
Open accessAbstract
Fusobacterium nucleatum is a Gram-negative anaerobic oral commensal associated with periodontal disease. F. nucleatum has been implicated in a wide spectrum of systemic diseases, including oral, gastro-intestinal, rheumatologic, and vascular pathologies. As pregnancy risk has been linked to periodontal disease, there has also been significant research into the effects of periodontal disease on adverse pregnancy outcomes. This article reviews the epidemiological and mechanistic evidence of the role of F. nucleatum in adverse pregnancy outcomes.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Figures
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Studies investigating the placental microbiome to understand its role in preterm pregnancies have identified bacteria associated with periodontal disease, suggesting a relationship between the oral and placental microbiomes.113, 114, 115, 116”
From The oral microbiome: Role of key organisms and complex networks in oral health and disease (2021) · cites this paper as [115]
In the citing paper
“Pathogenic bacteria from the oral cavity found at various sites within the uterus are associated with adverse pregnancy outcomes, such as preterm delivery and preeclampsia.113, 114, 115”
From The oral microbiome: Role of key organisms and complex networks in oral health and disease (2021) · cites this paper as [115]
In the citing paper
“Similarly, bacteria of oral origin, namely Fusobacterium nucleatum, were identified in samples of amniotic fluid and cord blood from women with pregnancy complications, suggesting oral translocation via hematogenous mechanisms.115”
From The oral microbiome: Role of key organisms and complex networks in oral health and disease (2021) · cites this paper as [115]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Intrauterine infection and preterm delivery
Goldenberg, R. L., Hauth, J. C., & Andrews, W. W. (2000) · New England Journal of Medicine · doi:10.1056/nejm200005183422007 · Cited by 2,548 · cited 1×
“Currently, there are two major pathways by which bacteria and other pathogens may trigger an inflammatory response leading to pregnancy complications [1,6].”
BackgroundThe Placenta Harbors a Unique Microbiome
Aagaard, K., Ma, J., Antony, K. M., Ganu, R., Petrosino, J., & Versalovic, J. (2014) · Science Translational Medicine · doi:10.1126/scitranslmed.3008599 · Cited by 2,494 · cited 1×
“Although the presence of a placental microbiome in healthy term pregnancies has been debated [21], recent research suggests that the placental microbiome most closely resembles the human oral microbiome [22].”
BackgroundRubinstein, M. R., Wang, X., Liu, W., Hao, Y., Cai, G., & Han, Y. W. (2013) · Cell Host & Microbe · doi:10.1016/j.chom.2013.07.012 · Cited by 2,476
Self-citationThe bacteria of periodontal diseases
Moore, W. E., & Moore, L. V. H. (1994) · Periodontology 2000 · doi:10.1111/j.1600-0757.1994.tb00019.x · Cited by 1,077 · cited 1×
“One such oral species of interest is Fusobacterium nucleatum, a Gram-negative anaerobe commonly found within the oral cavity and implicated in various forms of periodontal diseases [27,28].”
BackgroundGriffen, A. L., Beall, C. J., Campbell, J. H., Firestone, N. D., Kumar, P., Yang, Z. K., Podar, M., & Leys, E. J. (2011) · The ISME Journal · doi:10.1038/ismej.2011.191 · Cited by 1,006 · cited 1×
“One such oral species of interest is Fusobacterium nucleatum, a Gram-negative anaerobe commonly found within the oral cavity and implicated in various forms of periodontal diseases [27,28].”
BackgroundFusobacterium nucleatum: a commensal-turned pathogen
Han, Y. W. (2015) · Current Opinion in Microbiology · doi:10.1016/j.mib.2014.11.013 · Cited by 869 · cited 2×
“nucleatum has also been implicated in a wide variety of systemic diseases, including GI disorders, atherosclerosis, rheumatoid arthritis and respiratory tract infections [29,30], which is well summarized in a prior review [31].”
BackgroundSelf-citationStrauss, J., Kaplan, G. G., Beck, P. L., Rioux, K. P., Panaccione, R., DeVinney, R., Lynch, T., & Allen‐Vercoe, E. (2011) · Inflammatory Bowel Diseases · doi:10.1002/ibd.21606 · Cited by 578 · cited 1×
“nucleatum has also been implicated in a wide variety of systemic diseases, including GI disorders, atherosclerosis, rheumatoid arthritis and respiratory tract infections [29,30], which is well summarized in a prior review [31].”
BackgroundLauder, A. P., Roche, A. M., Sherrill-Mix, S., Bailey, A., Laughlin, A. L., Bittinger, K., Leite, R., Elovitz, M. A., Parry, S., & Bushman, F. D. (2016) · Microbiome · doi:10.1186/s40168-016-0172-3 · Cited by 539
Han, Y. W., & Wang, X. (2013) · Journal of Dental Research · doi:10.1177/0022034513487559 · Cited by 489
Self-citationPeriodontal infection and preterm birth
JEFFCOAT, M. K., GEURS, N. C., REDDY, M. S., CLIVER, S. P., GOLDENBERG, R. L., & HAUTH, J. C. (2001) · The Journal of the American Dental Association · doi:10.14219/jada.archive.2001.0299 · Cited by 476
Cited by
Sorted by citations
The oral microbiome: Role of key organisms and complex networks in oral health and disease
Sedghi, L., DiMassa, V., Harrington, A., Lynch, S. V., & Kapila, Y. L. (2021) · Periodontology 2000 · doi:10.1111/prd.12393 · Cited by 755
Hajishengallis, G., & Lamont, R. J. (2021) · Periodontology 2000 · doi:10.1111/prd.12371 · Cited by 314
Wu, J., Li, Q., & Fu, X. (2019) · Translational Oncology · doi:10.1016/j.tranon.2019.03.003 · Cited by 259
“FadA can also bind to endothelial cells VE-cadherin, which a linker molecule on endothelial cells [33].”
BackgroundInfluentialPeriodontal diseases and adverse pregnancy outcomes: Mechanisms
Figuero, E., Han, Y. W., & Furuichi, Y. (2020) · Periodontology 2000 · doi:10.1111/prd.12295 · Cited by 183
Self-citationMuraoka, A., Suzuki, M. M., Hamaguchi, T., Watanabe, S., Iijima, K., Murofushi, Y., Shinjo, K., Osuka, S., Hariyama, Y., Ito, M., et al. (2023) · Science Translational Medicine · doi:10.1126/scitranslmed.add1531 · Cited by 192
Fan, Z., Tang, P., Li, C., Yang, Q., Xu, Y., Su, C., & Li, L. (2023) · Journal of Oral Microbiology · doi:10.1080/20002297.2022.2145729 · Cited by 150
More Than Just a Periodontal Pathogen –the Research Progress on Fusobacterium nucleatum
Chen, Y., Huang, Z., Tang, Z., Huang, Y., Huang, M., Liu, H., Ziebolz, D., Schmalz, G., Jia, B., & Zhao, J. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.815318 · Cited by 154
Wang, S., Liu, Y., Li, J., Zhao, L., Yan, W., Lin, B., Guo, X., & Wei, Y. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.710165 · Cited by 132
“…since it has been isolated from clinical infections and multiple tumor samples, such as periodontitis (Kim E. H. et al., 2020), adverse pregnancy (Vander Haar et al., 2018; Figuero et al., 2020), appendicitis (Hattori et al., 2019), CRC (Castellarin et al., 2012; Kostic et al., 2012), and breast…”
BackgroundShaping Microbiota During the First 1000 Days of Life
Selma‐Royo, M., Tarrazó, M., García‐Mantrana, I., Gómez-Gallego, C., Salminen, S., & Collado, M. C. (2019) · Advances in experimental medicine and biology · doi:10.1007/5584_2018_312 · Cited by 98
Oral bacteria, oral health, and adverse pregnancy outcomes
Xu, B., & Han, Y. W. (2022) · Periodontology 2000 · doi:10.1111/prd.12436 · Cited by 98
Self-citationThe Contribution of the Human Oral Microbiome to Oral Disease: A Review
Morrison, A. G., Sarkar, S., Umar, S., Lee, S. T. M., & Thomas, S. M. (2023) · Microorganisms · doi:10.3390/microorganisms11020318 · Cited by 92
Rudin, A. D., Khamzeh, A., Venkatakrishnan, V., Basic, A., Christenson, K., & Bylund, J. (2021) · Cellular Microbiology · doi:10.1111/cmi.13348 · Cited by 67
“F. nucleatum is also the periodontitis associated species that is most commonly isolated from infections in other body sites (Bolstad et al., 1996) and its presence is implicated in conditions such as colorectal cancer (Brennan & Garrett, 2019) and preterm deliveries (Vander Haar et al., 2018).”
BackgroundMi, N., Lin, X., & Jin, Y. (2022) · Frontiers in Medicine · doi:10.3389/fmed.2022.963956 · Cited by 77
Pathogenesis of periodontitis – A potential role for epithelial-mesenchymal transition
Saliem, S. S., Bede, S. Y. H., Cooper, P. R., Abdulkareem, A. A., Milward, M. R., & Abdullah, B. H. (2022) · Japanese Dental Science Review · doi:10.1016/j.jdsr.2022.09.001 · Cited by 75
“in disease is however not only limited to periodontitis but extends to other systemic conditions including APO, gastrointestinal disease, atherosclerosis, and carcinomas [9,11,13,185].”
BackgroundHajishengallis, G., Li, X., Divaris, K., & Chavakis, T. (2022) · Periodontology 2000 · doi:10.1111/prd.12421 · Cited by 70
Fusobacterium nucleatum: ecology, pathogenesis and clinical implications
Jiang, S., Chen, Y., & Fang, J. (2025) · Nature Reviews Microbiology · doi:10.1038/s41579-025-01237-z · Cited by 76
“Strong evidence implicates this pathobiont in adverse pregnancy outcomes, such as preterm birth, stillbirth and intra-amniotic infection 107 .”
Wang, Y., Wang, L., Sun, T., Shen, S., Li, Z., Ma, X., Gu, X., Zhang, X., Peng, A. F., Xu, X., et al. (2023) · International Journal of Oral Science · doi:10.1038/s41368-022-00213-0 · Cited by 62
“nucleatum) is one of the most frequently detected pathogens and has attracted increasing attention in recent years as an opportunistic pathogen in many systematic diseases, such as colorectal cancer,(5) cardiovascular diseases,(6) Alzheimer’s disease,(7) and adverse pregnancy outcomes.(8) F.”
BackgroundChopra, A., Radhakrishnan, R. A., & Sharma, M. (2020) · Critical Reviews in Microbiology · doi:10.1080/1040841x.2020.1747392 · Cited by 63
“The FadA adhesins of F. nucleatum binds to the cadherins on the maternal endothelium and invade the cell to cell junction of the maternal and foetal cells (Han et al. 2004; Liu et al. 2007; Xu et al. 2007; Fardini et al. 2011; Vander Haar et al. 2018).”
BackgroundParhi, L., Abed, J., Shhadeh, A., Alon‐Maimon, T., Udi, S., Ben‐Arye, S. L., Tam, J., Parnas, O., Padler‐Karavani, V., Goldman‐Wohl, D., et al. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.110537 · Cited by 54
Localization of HeLa cell tumor-suppressor gene to the long arm of chromosome II.
Misra, B. C., & Srivatsan, E. S. (1989) · PubMed · Cited by 58
Quercetin Preserves Oral Cavity Health by Mitigating Inflammation and Microbial Dysbiosis
Mooney, E. C., Holden, S. E., Xia, X., Li, Y., Jiang, M., Banson, C. N., Zhu, B., & Sahingur, S. E. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.774273 · Cited by 66
Udayasuryan, B., Zhou, Z., Ahmad, R. N., Sobol, P., Deng, C., Nguyen, T. T. D., Kodikalla, S., Morrison, R. G., Goswami, I., Slade, D. J., et al. (2024) · Communications Biology · doi:10.1038/s42003-024-06201-w · Cited by 59
“However,itbehaves as an opportunistic pathogen in disease conditions including gingivitis, periodontitis, in fl ammatory bowel disease, myocarditis, and in preterm birth complications 9,10 .”
Borges, L. G. D. A., Pastuschek, J., Heimann, Y., Dawczynski, K., PEONS study group, Bergner, M., Haase, R., Stubert, J., Olbertz, D. M., Plumeier, I., et al. (2023) · BMC Medicine · doi:10.1186/s12916-023-02805-x · Cited by 59
Umaña, A., Sanders, B. E., Yoo, C. C., Casasanta, M. A., Udayasuryan, B., Verbridge, S. S., & Slade, D. J. (2019) · Journal of Bacteriology · doi:10.1128/jb.00273-19 · Cited by 60
“nucleatum to the fetal-placental unit, where multiple studies support a role for this bacterium in preterm birth (82, 83).”
BackgroundPlacental microbial–metabolite profiles and inflammatory mechanisms associated with preterm birth
Parris, K. M., Amabebe, E., Cohen, M. C., & Anumba, D. O. C. (2020) · Journal of Clinical Pathology · doi:10.1136/jclinpath-2020-206536 · Cited by 44
Vaginal dysbiosis and the potential of vaginal microbiome-directed therapeutics
Valeriano, V. D., Lahtinen, E., Hwang, I., Zhang, Y., Du, J., & Schuppe‐Koistinen, I. (2024) · Frontiers in Microbiomes · doi:10.3389/frmbi.2024.1363089 · Cited by 49
“…in murine models that bind and infect epithelial and endothelial cells of the fetal-placental units, with TLR4 in fl ammatory cascades that lead to poor outcomes such as preterm birth, chorioamnionitis, neonatal sepsis, stillbirth, and preeclampsia (Han et al., 2004; Vander Haar et al., 2018).”
Modulation of the Host Cell Transcriptome and Epigenome by Fusobacterium nucleatum
Despins, C. A., Brown, S. D., Robinson, A. V., Mungall, A. J. J., Allen‐Vercoe, E., & Holt, R. A. (2021) · mBio · doi:10.1128/mbio.02062-21 · Cited by 40
Murray, P. E., Coffman, J. A., & Garcı́a-Godoy, F. (2024) · Pathogens · doi:10.3390/pathogens13121084 · Cited by 46
Ma, X., Sun, T., Zhou, J., Zhi, M., Shen, S., Wang, Y., Gu, X., Li, Z., Gao, H., Wang, P., et al. (2023) · Microbiology Spectrum · doi:10.1128/spectrum.05184-22 · Cited by 34
Further evidence for periodontal disease as a risk indicator for adverse pregnancy outcomes
Turton, M., & Africa, C. W. J. (2016) · International Dental Journal · doi:10.1111/idj.12274 · Cited by 36
Targeting Fusobacterium nucleatum in colorectal cancer: therapeutic strategies and future directions
Kowsarkhizi, A. S., Yousefi, B., Rahimi, A., & Aliramezani, A. (2025) · Infectious Agents and Cancer · doi:10.1186/s13027-025-00676-w · Cited by 39
“It can translocate from the oral cavity to extraoral sites, including the placenta, where it may trigger inflammation and adverse pregnancy outcomes such as preterm labor, fetal growth restriction, and miscarriage [16].”
Fusobacterium nucleatum : a novel immune modulator in breast cancer?
Little, A., Tangney, M., Tunney, M. M., & Buckley, N. E. (2023) · Expert Reviews in Molecular Medicine · doi:10.1017/erm.2023.9 · Cited by 33
Reexamining the role of Fusobacterium nucleatum subspecies in clinical and experimental studies
Krieger, M., Guo, M., & Merritt, J. L. (2024) · Gut Microbes · doi:10.1080/19490976.2024.2415490 · Cited by 33
A Crosstalk between Diet, Microbiome and microRNA in Epigenetic Regulation of Colorectal Cancer
Guz, M., Jeleniewicz, W., Malm, A., & Korona‐Głowniak, I. (2021) · Nutrients · doi:10.3390/nu13072428 · Cited by 31
“FadA may also bind to the vascular endothelial cadherins (VE-cadherin) increasing endothelial cells permeability allowing bacteria to penetrate through endothelium, overcome blood-brain and placental barrier and colonize the distant parts of the human body [81].”
BackgroundPeriodontal Pathogens and Adverse Pregnancy Outcomes: A Narrative Review
AlSharief, M., & Alabdurubalnabi, E. M. (2023) · Life · doi:10.3390/life13071559 · Cited by 34
Ectopic colonization by oral bacteria as an emerging theme in health and disease
Hernández‐Cabanyero, C., & Vonaesch, P. (2024) · FEMS Microbiology Reviews · doi:10.1093/femsre/fuae012 · Cited by 27
“…pias et al. 2022 , Rashidi et al. 2023 ), undernutrition (Vonaesch et al. 2018 , 2022 , Chen et al. 2020 , Col-lard et al. 2022 ), preterm birth (Van der Haar et al. 2018 , Yin et al. 2021 ), neurological diseases (Nicholson and Landry 2022 ), liver diseases (Joossens 2021 ), lung diseases…”
BackgroundLeaky Gum: The Revisited Origin of Systemic Diseases
Park, D.-Y., Park, J. Y., Lee, D., Hwang, I., & Kim, H. (2022) · Cells · doi:10.3390/cells11071079 · Cited by 25
He, Z., Tian, W., Wei, Q., & Xu, J. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.968649 · Cited by 27
“nucleatum acts as an opportunistic pathogen in multiple inflammatory diseases, including periodontitis (5), inflammatory bowel disease (6), liver abscesses (7), rheumatoid arthritis (8), and chorioamnionitis (9).”
BackgroundInsight into the Relationship between Oral Microbiota and the Inflammatory Bowel Disease
Han, Y., Wang, B., Gao, H., He, C., Hua, R., Chen, L., Xin, S., Wang, Y., & Xu, J. (2022) · Microorganisms · doi:10.3390/microorganisms10091868 · Cited by 27
“In early pregnancy, periodontal pathogens could reach the placenta by specific routes and colonize the placenta, which may lead to adverse pregnancy outcomes such as premature delivery, amnionitis, and stillbirth [20].”
BackgroundSelf-citationPotential Use of Biotherapeutic Bacteria to Target Colorectal Cancer-Associated Taxa
Lawrence, G. W., Begley, M., Cotter, P. D., & Guinane, C. M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21030924 · Cited by 25
Shahid, M., Quinlivan, J. A., Peek, M. J., Castaño‐Rodríguez, N., & Mendz, G. L. (2021) · Journal of obstetrics and gynaecology research · doi:10.1111/jog.15086 · Cited by 25
Seidel, C. L., Gerlach, R. G., Weider, M., Wölfel, T., Schwarz, V., Ströbel, A., Schmetzer, H. M., Bogdan, C., & Gölz, L. (2022) · BMC Oral Health · doi:10.1186/s12903-022-02180-8 · Cited by 25
“) nucleatum were linked to adverse pregnancy outcomes [7, 17, 18].”
BackgroundComprehensive human amniotic fluid metagenomics supports the sterile womb hypothesis
Wang, H., Yang, G. X., Hu, Y., Lam, P. M. W., Sangha, K. K., Siciliano, D., Swenerton, A., Miller, R. R., Tilley, P. A. G., von Dadelszen, P., et al. (2022) · Scientific Reports · doi:10.1038/s41598-022-10869-7 · Cited by 25
Merchant, A. T., Gupta, R. D., Akonde, M., Reynolds, M. A., Smith‐Warner, S. A., Liu, J., Tarannum, F., Beck, J. D., & Mattison, D. R. (2022) · JAMA Network Open · doi:10.1001/jamanetworkopen.2022.47632 · Cited by 25
Thomas, C., Timofeeva, I., Bouchoucha, E., Canceill, T., Champion, C., Groussolles, M., Arnaud, C., Vayssière, C., Nabet, C., & Laurencin‐Dalicieux, S. (2023) · Acta Obstetricia Et Gynecologica Scandinavica · doi:10.1111/aogs.14529 · Cited by 23
Witt, R. G., Blair, L. M., Frascoli, M., Rosen, M., Nguyen, Q.-H. L., Bercovici, S., Zompì, S., Romero, R. J., & MacKenzie, T. C. (2020) · PLoS ONE · doi:10.1371/journal.pone.0231239 · Cited by 22
Santacroce, L., Muzio, E. L., Bottalico, L., Spirito, F., Charitos, I. A., Passarelli, P. C., & Jirillo, E. (2022) · Endocrine Metabolic & Immune Disorders - Drug Targets · doi:10.2174/1871530322666220629101357 · Cited by 22
VINOGRADOV, E. V., Michael, F. S., & Cox, A. D. (2018) · Carbohydrate Research · doi:10.1016/j.carres.2018.08.011 · Cited by 21
Fusobacterium nucleatum dissemination by neutrophils
Ellett, F. E., Kacamak, N. I., Álvarez, C., OLIVEIRA, E. H. D. S., Hastürk, H., Paster, B. J., Kantarcı, A., & Irimia, D. (2023) · Journal of Oral Microbiology · doi:10.1080/20002297.2023.2217067 · Cited by 20
Targeted elimination of Fusobacterium nucleatum alleviates periodontitis
Yakar, N., Ünlü, Ö., Cen, L., Hastürk, H., Chen, T., Shi, W., He, X., & Kantarcı, A. (2024) · Journal of Oral Microbiology · doi:10.1080/20002297.2024.2388900 · Cited by 20
Duran-Pinedo, A. E., Solbiati, J., Teles, F., Yanping, Z., & Frias‐Lopez, J. (2025) · Microbiome · doi:10.1186/s40168-025-02108-8 · Cited by 19
Addressing controversy in Fusobacterium nomenclature: what exactly does “ F. nucleatum ” refer to?
Zepeda‐Rivera, M. A., Dewhirst, F. E., Bullman, S., & Johnston, C. D. (2025) · Gut Microbes · doi:10.1080/19490976.2025.2514797 · Cited by 19
Karimi, N., Samiee, N., & Moradi, Y. (2023) · Health Science Reports · doi:10.1002/hsr2.1630 · Cited by 18
“40,41 Fusobacterium and Streptococcus thermophiles species were also associated with chorioamnionitis in preterm labor.”
BackgroundGao, H., Sun, T., Yang, F., Yuan, J., Yang, M., Kang, W., Tang, D., Zhang, J., & Feng, Q. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00807 · Cited by 18
Exploring the composition of placental microbiome and its potential origin in preterm birth
Saadaoui, M., Djekidel, M. N., Murugesan, S., Kumar, M., Elhag, D. A., Singh, P., Kabeer, B. S. A., Marr, A. K., Kino, T., Brummaier, T., et al. (2025) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2024.1486409 · Cited by 18
Fusobacterium nucleatum and non-coding RNAs: orchestrating oncogenic pathways in colorectal cancer
Sadeghloo, Z., Ebrahimi, S., Hakemi-Vala, M., Totonchi, M., Sadeghi, A., & Fatemi, N. (2025) · Gut Pathogens · doi:10.1186/s13099-025-00757-6 · Cited by 18
Periodontal diseases and adverse pregnancy outcomes. Present and future
Bobetsis, Y. A., Ide, M., Gürsoy, M., & Madianos, P. (2023) · Periodontology 2000 · doi:10.1111/prd.12486 · Cited by 25
The rise and evolving role of Fusobacterium nucleatum subspecies
Wolf, M., Steinberg, T., Scholz, K. J., Kruse, A., Rezasoltani, S., Conrads, G., Al‐Ahmad, A., & Cieplik, F. (2025) · Current Research in Microbial Sciences · doi:10.1016/j.crmicr.2025.100414 · Cited by 15
Chen, B., Hao, M., Cui, H., Zeng, R., Ma, H., Long, A., & Li, X. (2025) · Gels · doi:10.3390/gels11100813 · Cited by 16
“Under certain conditions, Fn can translocate across mucosal barriers to distant tissues and has been associated with several systemic conditions, including atherosclerosis, colorectal cancer, and adverse pregnancy outcomes [5–7].”
HicA Toxin-Based Counterselection Marker for Allelic Exchange Mutations in Fusobacterium nucleatum
Bibek, G. C., Zhou, P., & Wu, C. (2023) · Applied and Environmental Microbiology · doi:10.1128/aem.00091-23 · Cited by 17
A Potential Link Between Oral Microbiota and Female Reproductive Health
Marcickiewicz, J., Jamka, M., & Walkowiak, J. (2025) · Microorganisms · doi:10.3390/microorganisms13030619 · Cited by 16
Predicting preterm birth using machine learning techniques in oral microbiome
Hong, Y. M., Lee, J., Cho, D. H., Jeon, J. H., Kang, J., Kim, M., Lee, S., & Kim, J. K. (2023) · Scientific Reports · doi:10.1038/s41598-023-48466-x · Cited by 17
Low Abundance Fusobacterium Nucleatum Supports Early Pregnancy Development – An In Vitro Study
Heusler, M., Einenkel, R., Ehrhardt, J., Muzzio, D. O., & Zygmunt, M. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.698045 · Cited by 14
Barraza-Ortega, E., Gómez‐Gil, B., García-Gasca, T., Lizárraga, D., Díaz, N., & García-Gasca, A. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26178574 · Cited by 18
Comparative genomics reveal a novel phylotaxonomic order in the genus Fusobacterium
Molteni, C., Forni, D., Cagliani, R., & Sironi, M. (2024) · Communications Biology · doi:10.1038/s42003-024-06825-y · Cited by 13
“Also, F. nucleatum can colonizethe placenta and cause preterm birth, intra-amniotic infection, stillbirth, neonatal sepsis, and hypertensive disorders of pregnancy 1,8,9 .”
Zheng, Z., Jin, W., Guo, W., Zhao, J., & Zuo, Y. (2025) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2025.1564169 · Cited by 12
Fusobacterium nucleatum and Prevotella in women with periodontitis and preterm birth
Lima, K.-M., Alves, C.-M., Vidal, F. C. B., Gomes‐Filho, I. S., Costa, J.-C., Coletta, R. D., Rodrigues, V. P., & Lopes, F. (2023) · Medicina oral, patología oral y cirugía bucal · doi:10.4317/medoral.25874 · Cited by 13
“Although the exact mechanisms that clearly explain the participation of periodontitis in the adverse effects of pregnancy have not yet been established, some theories try to seek an explanation through two mechanisms: by the action of periodontal pathogens or by the effect of inflammatory mediators, such as interleuki…”
BackgroundThe oral mucosal barrier: a dynamic gateway in oral and systemic health
Xin, Y., & Lei, H. (2026) · Tissue Barriers · doi:10.1080/21688370.2025.2610035 · Cited by 11
The microbiota of pregnant women with SARS-CoV-2 and their infants
Leftwich, H. K., Vargas-Robles, D., Rojas-Correa, M., Yap, Y. R., Bhattarai, S. K., Ward, D. V., Fujimori, G., Forconi, C. S., Yeboah, T., Carter, A., et al. (2023) · Microbiome · doi:10.1186/s40168-023-01577-z · Cited by 10
Choudhury, A., Scano, C., Barton, A., Kearney, C. M., & Greathouse, K. L. (2025) · Microbial Biotechnology · doi:10.1111/1751-7915.70241 · Cited by 10
“…to treat infections associated with this pathogen, particularly in the context of colorectal cancer, periodontal disease and even reproductive diseases such as pre-term birth and endometriosis (Han et al. 2004; Vander Haar et al. 2018; Sun et al. 2019; Chen et al. 2022; Muraoka et al. 2023).”
Wei, Y., Hu, X. Y., Shao, J., Wang, S., Zhang, Y., Xie, W.-Z., Wu, Y., Zeng, X.-T., & Zhang, L. (2023) · Materials Today Communications · doi:10.1016/j.mtcomm.2023.107715 · Cited by 10
Do the clinical criteria used to diagnose periodontitis affect the association with prematurity?
Moncunill‐Mira, J., Brunet‐Llobet, L., Cuadras, D., Colomé, N. L., Pascal, R., Rovira, C., Nadal, A., & Miranda‐Rius, J. (2020) · Odontology · doi:10.1007/s10266-020-00562-4 · Cited by 10
Self-Assembled PHMB Titanium Coating Enables Anti-Fusobacterium nucleatum Strategy
Zhao, J., Jin, S., Delgado, A. H. S., Chen, Z., Matinlinna, J. P., & Tsoi, J. K. H. (2021) · Coatings · doi:10.3390/coatings11101190 · Cited by 10
Shaping Microbiota During the First 1000 Days of Life
Samarra, A., Ventura, E. F., Bernabeu, M., Cabrera‐Rubio, R., Bäuerl, C., Selma‐Royo, M., & Collado, M. C. (2024) · Advances in experimental medicine and biology · doi:10.1007/978-3-031-58572-2_1 · Cited by 10
Wu, P., Bie, M., Zhou, J., Wang, J., & Жао, Л. (2024) · Journal of Periodontal Research · doi:10.1111/jre.13278 · Cited by 8
Hauk, V. C., D’Eramo, L., Calo, G., Merech, F., Doga, L., Lara, B., Gliosca, L., Massone, C., Molgatini, S. L., Ramhorst, R., et al. (2022) · American Journal of Reproductive Immunology · doi:10.1111/aji.13558 · Cited by 8
Fulminant Sepsis and Perinatal Death at 23 Weeks Due to Fusobacterium nucleatum
Bonasoni, M. P., Comitini, G., Pati, M., Bardaro, M., Russello, G., Carretto, E., Dea, G. D., Palicelli, A., Bernardelli, G., Chesi, E., et al. (2022) · Fetal and Pediatric Pathology · doi:10.1080/15513815.2022.2131487 · Cited by 8
Reevaluating the Fusobacterium Virulence Factor LandscapePreprint
Umaña, A., Sanders, B. E., Yoo, C. C., Casasanta, M. A., Udayasuryan, B., Verbridge, S. S., & Slade, D. J. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/534297 · Cited by 8
Wolf, M., Scholz, K. J., Al‐Ahmad, A., Steinberg, T., Kruse, A., Rezasoltani, S., Cieplik, F., & Conrads, G. (2026) · Virulence · doi:10.1080/21505594.2026.2629110 · Cited by 8
“Additionally, FadA plays a crucial role in the colonization of Fpo ATCC 12,230 in the mouse placenta [5] and was also shown to be a key driver of host cell signaling in this strain.”
The Oral Microbiome Throughout Pregnancy
Koerner, R., Prescott, S. M., Alman, A. C., Duffy, A., & Groer, M. E. (2023) · MCN The American Journal of Maternal/Child Nursing · doi:10.1097/nmc.0000000000000930 · Cited by 9
Fusobacterium necrophorum pelvic peritonitis and bacteremia mimicking intestinal necrosis
Ishihara, T., Yanagi, H., Oki, M., & Ozawa, H. (2021) · IDCases · doi:10.1016/j.idcr.2021.e01134 · Cited by 7
“nucleatum infection is associated with oral infections such as periodontal disease and obstetric infections that are harmful to pregnancy [2,4].”
BackgroundCho, H. Y., Shim, S. S., Park, H. J., & Cha, D. H. (2021) · Microbiology Research · doi:10.3390/microbiolres13010001 · Cited by 7
The Composition of Subgingival Microbiome in Hidradenitis Suppurativa and Periodontitis Patients
Jastrząb, B., Paśnik-Chwalik, B., Dębska-Łasut, K., Konopka, T. P., Krajewski, P. K., Szepietowski, J. C., & Matusiak, Ł. (2023) · Pathogens · doi:10.3390/pathogens12030377 · Cited by 7
Periodontal Disease and Birth Outcomes: Are We Missing Something?
Pessolano, L. G., Kramer, C. D., Simas, A. M., Weinberg, E. O., Genco, C. A., & Schreiber, B. M. (2020) · Current Oral Health Reports · doi:10.1007/s40496-020-00255-5 · Cited by 7
The oral - X axis: from periodontal dysbiosis to systemic disease
Jin, W., Tang, L., Yang, J., Hu, X., Guo, W., Ai, H., Zuo, Y., & Jin, Z. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1806445 · Cited by 7
Wang, X., Cheng, M.-T., Chen, Z.-P., Jiang, Y.-L., Ge, Y., Xia, R., & Hou, W.-T. (2021) · Acta Crystallographica Section D Structural Biology · doi:10.1107/s2059798321010810 · Cited by 6
Park, J., Lee, T., Noh, E. J., Jang, A., Ahn, J., Kim, D., Jung, D., Song, E., Lee, Y., Lee, Y., et al. (2021) · American Journal of Reproductive Immunology · doi:10.1111/aji.13403 · Cited by 6
Novel and emerging antimicrobial strategies in the management of oral infections
Ünlü, Ö., Yakar, N., & Kantarcı, A. (2025) · Periodontology 2000 · doi:10.1111/prd.70015 · Cited by 5
Periodontitis and Systemic Health: An Interconnected Relationship
Diehl, D. (2025) · Advances in experimental medicine and biology · doi:10.1007/978-3-032-03176-1_5 · Cited by 7
Kaiumov, K. A., Lyamin, A. V., Zhestkov, A. V., & Владимировна, Б. И. (2023) · Clinical Microbiology and Antimicrobial Chemotherapy · doi:10.36488/cmac.2023.1.13-18 · Cited by 5
Infección pulmonar y torácica por Fusobacterium nucleatum
Claudio Hoffmeister, B., Ducasse, K., Marcela González, L., Carlos Quilodrán, S., & Alejandro Joyas, M. (2021) · Andes pediatrica · doi:10.32641/andespediatr.v92i1.1744 · Cited by 5
Maternal periodontal diseases affect the leukocyte profiles of umbilical cord blood: A cohort study
Zhao, D., Cheng, T., Hu, D., Xu, X., Zhang, F., Yu, R., Li, H., Wen, P., Chen, L., Fu, M., et al. (2023) · Oral Diseases · doi:10.1111/odi.14683 · Cited by 4
Chen, P., Lin, X., Zhang, C., Xie, Y., Guo, Z., & Ren, F. (2024) · Gene · doi:10.1016/j.gene.2024.148729 · Cited by 4
An Overview of the Etiopathogenic Mechanisms Involved in the Expression of the Oral Microbiota
Popovici, I. A., Orǎșanu, C. I., Cozaru, G. C., Ionescu, A.-C., Kajanto, L. A., Cîmpineanu, B., Chisoi, A., Mitroi, A. N., Poinăreanu, I., Vodă, R. I., et al. (2025) · Clinics and Practice · doi:10.3390/clinpract15040080 · Cited by 5
Yan, Q., Liang, Y., Jin, Y., & Yang, J. (2022) · Sustainable Computing Informatics and Systems · doi:10.1016/j.suscom.2022.100718 · Cited by 4
Bibek, G. C., Zhou, P., & Wu, C. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.01.20.524997 · Cited by 4
“nucleatum plays an essential role in extra-oral diseases like preterm 48 birth (11, 12) and colorectal cancer (13-16).”
BackgroundStinson, L. F., Berman, Y. E., Li, S., Keelan, J. A., Dickinson, J. E., Doherty, D. A., Newnham, J. P., & Payne, M. S. (2023) · Microorganisms · doi:10.3390/microorganisms11071698 · Cited by 3
“have been repeatedly associated with preterm birth [11].”
BackgroundZhang, Z., Zhang, Y., Wu, A., Xu, C., & Li, Z. (2025) · mBio · doi:10.1128/mbio.00509-25 · Cited by 3
A New Method for Gene Deletion to Investigate Cell Wall Biogenesis in Fusobacterium nucleatum
Bibek, G. C., Zhou, P., & Wu, C. (2023) · Methods in molecular biology · doi:10.1007/978-1-0716-3491-2_6 · Cited by 3
Liu, J., Zhang, X.-Y., Zhao, Q., Mu, X.-H., Yang, C., Ning, Y., Xiong, X., Qin, X., & Chen, L. (2024) · Immunity Inflammation and Disease · doi:10.1002/iid3.1247 · Cited by 3
Metadata
- Authors
- Vander Haar, E. L., So, J., Gyamfi-Bannerman, C., & Han, Y. W.
- Affiliations
- Columbia University Irving Medical Center (US)
- Corresponding author
- Han, Yiping W.
- ORCID
- Han, Yiping W.
- Venue
- Anaerobe
- Publisher
- Elsevier BV
- Published
- 2018-04
- Volume
- 50
- Pages
- 55-59
- ISSN
- 1075-9964 (ISSN-L)
- PMC
- PMC6750227
- OpenAlex
- W2791709251
- Cited by
- 155
- References
- 60
- Citations by year
- 2026: 23 · 2025: 23 · 2024: 21 · 2023: 28 · 2022: 20 · 2021: 20 · 2020: 13 · 2019: 4 · 2018: 1
- FWCI
- 1.39
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Anaerobe (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion, cc-by-nc-nd)
- Funders
- NIH (DE014924, DE023332, CA192111)
- Topics
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Health Sciences › Medicine › Obstetrics and Gynecology › Preterm Birth and Chorioamnionitis
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Keywords
- Fusobacterium nucleatum, adverse pregnancy outcomes, periodontal disease, oral commensals, oral microbiota, systemic inflammation, pregnancy complications, periodontitis
- MeSH terms
- Animals, Female, Fusobacterium Infections, Humans, Mouth Mucosa, Periodontal Diseases, Pregnancy, Pregnancy Complications, Pregnancy Complications, Infectious, Pregnancy Outcome, Virulence, Fusobacterium nucleatum
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
