Rôle de l’inflammasome dans les pathologies cardiovasculaires
Abstract
NOD-like receptors (NLRs) constitute a recently identified family of intracellular pattern recognition receptors which contains more than 20 members in mammals. Some of the NLRs, the NALP subfamily, constituted from 14 members, many of them without actual identified role, form multiproteic complex known as inflammasome, that initiate inflammation by processing inactive pro-caspase-1 to its active form, allowing the cleavage and subsequent activation of pro-IL-1β and pro-IL-18. We review the identified roles of NLRs in pathologies and argue for the role of inflammasome in the development of cardiovascular diseases. The atherogenic cytokines IL-1β and IL-18 are matured in NLRPs inflammasomes. Immunocytochemistry shows that Nlrp3 inflammasome is expressed in plaques, upregulated and activated in the CD11b(+)Gr1(high) atherosclerosis-prone monocyte subset and modulated by oxLDL in murine macrophages. These results provide an unexpected role for Nlrp3 inflammasome in atherosclerosis.
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IL-1β is a major atheroprone factor that promotes development of lipid plaques and destabilizes plaques by upregulating adhesion molecules including VCAM-1 and ICAM-1.
“IL‐1β is a major atheroprone factor that plays a significant role in promoting the development of lipid plaques and destabilizing plaques by upregulating adhesion molecules, including vascular cell adhesion molecule‐1 and ICAM‐1.31, 32, 33”
From Trimethylamine‐N‐Oxide Induces Vascular Inflammation by Activating the NLRP3 Inflammasome Through the SIRT3‐SOD2‐mtROS Signaling Pathway (2017) · cites this paper as [32]
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Chen, M., Zhu, X., Ran, L., Lang, H., Yi, L., & Mi, M. (2017) · Journal of the American Heart Association · doi:10.1161/jaha.117.006347 · Cited by 600 · see citing works
- Authors
- Connat, J.-L.
- Affiliations
- Université de Bourgogne (FR)
- Corresponding author
- Connat, J.-L.
- ORCID
- Connat, J.-L.
- Venue
- Annales de Cardiologie et d'Angéiologie
- Publisher
- Elsevier BV
- Published
- 2011-02
- Volume
- 60
- Issue
- 1
- Pages
- 48-54
- ISSN
- 0003-3928 (ISSN-L)
- OpenAlex
- W1975256977
- Cited by
- 12
- References
- 60
- Citations by year
- 2023: 1 · 2021: 1 · 2019: 1 · 2018: 1 · 2017: 3 · 2014: 3 · 2013: 1 · 2012: 1
- FWCI
- 0.06
- Type
- journal article
- Language
- fr
- Open access
- closed
- Locations
- Annales de Cardiologie et d Angéiologie (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
- Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Keywords
- inflammasome, NOD-like receptors, NLRP3 inflammasome, cardiovascular disease, atherosclerosis, IL-1β, IL-18, caspase-1, pattern recognition receptors, oxidized LDL, macrophages, atherosclerotic plaque, monocytes
- MeSH terms
- NLR Family, Pyrin Domain-Containing 3 Protein, Cardiovascular Diseases, Carrier Proteins, Humans, Inflammasomes
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