Inflammasome Components NALP 1 and 3 Show Distinct but Separate Expression Profiles in Human Tissues Suggesting a Site-specific Role in the Inflammatory Response

The Inflammasome

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Gout-associated uric acid crystals activate the NALP3 inflammasome

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Cryopyrin activates the inflammasome in response to toxins and ATP

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NALP3 Forms an IL-1β-Processing Inflammasome with Increased Activity in Muckle-Wells Autoinflammatory Disorder

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Mutation of a new gene encoding a putative pyrin-like protein causes familial cold autoinflammatory syndrome and Muckle–Wells syndrome

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Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3

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NOD-LRR PROTEINS: Role in Host-Microbial Interactions and Inflammatory Disease

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Interleukin-1 and neuronal injury

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Critical role for NALP3/CIAS1/Cryopyrin in innate and adaptive immunity through its regulation of caspase-1

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Neonatal-Onset Multisystem Inflammatory Disease Responsive to Interleukin-1β Inhibition

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Nalp1b controls mouse macrophage susceptibility to anthrax lethal toxin

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Spectrum of clinical features in Muckle‐Wells syndrome and response to anakinra

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NALPs: a novel protein family involved in inflammation

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NLRs join TLRs as innate sensors of pathogens

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Identification of Bacterial Muramyl Dipeptide as Activator of the NALP3/Cryopyrin Inflammasome

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Flagellin-Deficient Legionella Mutants Evade Caspase-1- and Naip5-Mediated Macrophage Immunity

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Interleukin‐1β, Interleukin‐18, and the Interleukin‐1β Converting Enzymea

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Cytosolic recognition of flagellin by mouse macrophages restricts Legionella pneumophila infection

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A randomised phase II study of interleukin-1 receptor antagonist in acute stroke patients

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Association of mutations in the NALP3/CIAS1/PYPAF1 gene with a broad phenotype including recurrent fever, cold sensitivity, sensorineural deafness, and AA amyloidosis

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CATERPILLER: A Novel Gene Family Important in Immunity, Cell Death, and Diseases

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Cutting Edge: CATERPILLER: A Large Family of Mammalian Genes Containing CARD, Pyrin, Nucleotide-Binding, and Leucine-Rich Repeat Domains

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Mini‐review: Specificity and expression of CIITA, the master regulator of MHC class II genes

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The pyrin domain: a possible member of the death domain-fold family implicated in apoptosis and inflammation

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Cutting Edge: CIAS1/Cryopyrin/PYPAF1/NALP3/ CATERPILLER 1.1 Is an Inducible Inflammatory Mediator with NF-κB Suppressive Properties

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ASC is essential for LPS‐induced activation of procaspase‐1 independently of TLR‐associated signal adaptor molecules

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A Novel Enhancer of the Apaf1 Apoptosome Involved in Cytochrome c-dependent Caspase Activation and Apoptosis

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Molecular Cloning and Characterization of DEFCAP-L and -S, Two Isoforms of a Novel Member of the Mammalian Ced-4 Family of Apoptosis Proteins

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Characterization of interleukin-1 production by microglia in culture

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Hereditary Periodic Fever Syndromes

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Expression of Apoptosis-associated Speck-like Protein Containing a Caspase Recruitment Domain, a Pyrin N-terminal Homology Domain-containing Protein, in Normal Human Tissues

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Structural, expression, and evolutionary analysis of mouse CIAS1

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Over expression of interleukin-1alpha, interleukin-1beta and interleukin-1 receptor antagonist in testicular tissues from sexually immature mice as compared to adult mice.

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The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance

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The NALP3 inflammasome is involved in the innate immune response to amyloid-β

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The Inflammasomes: Guardians of the Body

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The Inflammasome NLRs in Immunity, Inflammation, and Associated Diseases

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NLRP3 inflammasome in cancer and metabolic diseases

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The NLRP3 inflammasome protects against loss of epithelial integrity and mortality during experimental colitis

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The inflammasome: a danger sensing complex triggering innate immunity

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Fatty acid and endotoxin activate inflammasomes in mouse hepatocytes that release danger signals to stimulate immune cells

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Inflammasomes in the CNS

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NALP1 in Vitiligo-Associated Multiple Autoimmune Disease

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Sequencing Chromosomal Abnormalities Reveals Neurodevelopmental Loci that Confer Risk across Diagnostic Boundaries

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Uptake of particulate vaccine adjuvants by dendritic cells activates the NALP3 inflammasome

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Common variants in the NLRP3 region contribute to Crohn's disease susceptibility

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Inflammasomes in liver diseases

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The NLRP3 and NLRP1 inflammasomes are activated in Alzheimer’s disease

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The Intestinal Immune System in Obesity and Insulin Resistance

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Dendritic cell subsets in health and disease

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InflammasomesPreprint

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Differential Expression of NLRP3 among Hematopoietic Cells

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Amyloid-β induces NLRP1-dependent neuronal pyroptosis in models of Alzheimer’s disease

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A Molecular Platform in Neurons Regulates Inflammation after Spinal Cord Injury

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Inhibition of the Inflammasome Complex Reduces the Inflammatory Response after Thromboembolic Stroke in Mice

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NLRP1 Inflammasome Activation Induces Pyroptosis of Hematopoietic Progenitor Cells

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Mitochondrial dysfunction and oxidative stress activate inflammasomes: impact on the aging process and age-related diseases

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MCC950, a specific small molecule inhibitor of NLRP3 inflammasome attenuates colonic inflammation in spontaneous colitis mice

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The NLRP3 inflammasome: Contributions to intestinal homeostasis

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Innate Immune Recognition in Infectious and Noninfectious Diseases of the Lung

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NOD-Like Receptors: Master Regulators of Inflammation and Cancer

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NLRP3: A promising therapeutic target for autoimmune diseases

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Glucocorticoids sensitize the innate immune system through regulation of the NLRP3 inflammasome

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Danger Signals and Inflammasomes: Stress-Evoked Sterile Inflammation in Mood Disorders

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NLRP1 haplotypes associated with vitiligo and autoimmunity increase interleukin-1β processing via the NLRP1 inflammasome

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NLRP1 inflammasome contributes to chronic stress-induced depressive-like behaviors in mice

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NLRP3 inflammasome pathways in atherosclerosis

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The role of inflammasome in Alzheimer's disease

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Maternal extracellular vesicles and platelets promote preeclampsia via inflammasome activation in trophoblasts

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The Pathogenic Role of NLRP3 Inflammasome Activation in Inflammatory Bowel Diseases of Both Mice and Humans

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Inflammasome signaling at the heart of central nervous system pathology

Chakraborty, S., Kaushik, D. K., Gupta, M., & Basu, A. (2010) · Journal of Neuroscience Research · doi:10.1002/jnr.22343 · Cited by 186 · see citing works

Antiviral immune responses in the genital tract: clues for vaccines

Iwasaki, A. (2010) · Nature reviews. Immunology · doi:10.1038/nri2836 · Cited by 187 · see citing works

NLRP1 inflammasome is activated in patients with medial temporal lobe epilepsy and contributes to neuronal pyroptosis in amygdala kindling-induced rat model

Tan, C., Zhang, J., Tan, M., Chen, H., Meng, D., Jiang, T., Meng, X.-F., Li, Y., Sun, Z., Li, M., et al. (2015) · Journal of Neuroinflammation · doi:10.1186/s12974-014-0233-0 · Cited by 185 · see citing works

The NLRP1 inflammasome: new mechanistic insights and unresolved mysteries

Mitchell, P. S., Sandstrom, A., & Vance, R. E. (2019) · Current Opinion in Immunology · doi:10.1016/j.coi.2019.04.015 · Cited by 175 · see citing works

Inflammasomes are Differentially Expressed in Cardiovascular and other Tissues

Yin, Y., Yan, Y., Jiang, X., Mai, J., Chen, N., Wang, H., & Yang, X.-F. (2009) · International Journal of Immunopathology and Pharmacology · doi:10.1177/039463200902200208 · Cited by 177 · see citing works

Polimorphisms in Inflammasome Genes Are Involved in the Predisposition to Systemic Lupus Erythematosus

Pontillo, A., Girardelli, M., Kamada, A. J., Pancoto, J. A. T., Donadi, E. A., Crovella, S., & Sandrin‐Garcia, P. (2012) · Autoimmunity · doi:10.3109/08916934.2011.637532 · Cited by 178 · see citing works

Danger- and pathogen-associated molecular patterns recognition by pattern-recognition receptors and ion channels of the transient receptor potential family triggers the inflammasome activation in immune cells and sensory neurons

Santoni, G., Cardinali, C., Morelli, M. B., Santoni, M., Nabissi, M., & Amantini, C. (2015) · Journal of Neuroinflammation · doi:10.1186/s12974-015-0239-2 · Cited by 176 · see citing works

Reactive oxygen species activated NLRP3 inflammasomes initiate inflammation in hyperosmolarity stressed human corneal epithelial cells and environment-induced dry eye patients

Zheng, Q., Ren, Y., Reinach, P. S., Xiao, B., Lu, H., Zhu, Y., Qu, J., & Chen, W. (2015) · Experimental Eye Research · doi:10.1016/j.exer.2015.02.013 · Cited by 175 · see citing works

Diverse viral proteases activate the NLRP1 inflammasome

Tsu, B. V., Beierschmitt, C., Ryan, A. P., Agarwal, R., Mitchell, P. S., & Daugherty, M. D. (2021) · eLife · doi:10.7554/elife.60609 · Cited by 175 · see citing works

Expression and regulation of the NALP3 inflammasome complex in periodontal diseases

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Inflammasomes in neurological diseases: emerging pathogenic and therapeutic concepts

Mamik, M. K., & Power, C. (2017) · Brain : a journal of neurology · doi:10.1093/brain/awx133 · Cited by 151 · see citing works

Inflammasomes in inflammatory disorders: the role of TLRs and their interactions with NLRs

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Amyloid‐β oligomers set fire to inflammasomes and induce Alzheimer's pathology

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The Therapeutic Potential of Modifying Inflammasomes and NOD-Like Receptors

Virgilio, F. D. (2013) · Pharmacological Reviews · doi:10.1124/pr.112.006171 · Cited by 158 · see citing works

Inflammation, physical activity, and chronic disease: An evolutionary perspective

Burini, R. C., Anderson, E., Durstine, J. L., & Carson, J. A. (2020) · Sports Medicine and Health Science · doi:10.1016/j.smhs.2020.03.004 · Cited by 166 · see citing works

Reactive oxygen species activated NLRP3 inflammasomes prime environment-induced murine dry eye

Zheng, Q., Ren, Y., Reinach, P. S., She, Y., Xiao, B., Hua, S., Qu, J., & Chen, W. (2014) · Experimental Eye Research · doi:10.1016/j.exer.2014.05.001 · Cited by 160 · see citing works

Pharmacological Inhibition of NLRP3 Inflammasome Attenuates Myocardial Ischemia/Reperfusion Injury by Activation of RISK and Mitochondrial Pathways

Mastrocola, R., Penna, C. R. R., Tullio, F., Femminò, S., Nigro, D., Chiazza, F., Serpe, L., Collotta, D., Alloatti, G., Cocco, M., et al. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/5271251 · Cited by 160 · see citing works

Transcriptomic Analysis of Vulvovaginal Candidiasis Identifies a Role for the NLRP3 Inflammasome

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Deregulated inflammasome signaling in disease

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The microbial and danger signals that activate Nod-like receptors

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Quantitative expression of RIG-like helicase, NOD-like receptor and inflammasome-related mRNAs in humans and mice

Lech, M., Avila‐Ferrufino, A., Skuginna, V., Susanti, H. E., & Anders, H. (2010) · International Immunology · doi:10.1093/intimm/dxq058 · Cited by 151 · see citing works

Inflammasomes and human autoimmunity: A comprehensive review

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Two SNPs inNLRP3gene are involved in the predisposition to type-1 diabetes and celiac disease in a pediatric population from northeast Brazil

Pontillo, A., Brandão, L. A. C., Guimarães, R. L., Segat, L., Araújo, J., & Crovella, S. (2010) · Autoimmunity · doi:10.3109/08916930903540432 · Cited by 147 · see citing works

Sensors of the innate immune system: their mode of action

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ATP-dependent activation of an inflammasome in primary gingival epithelial cells infected byPorphyromonas gingivalis

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Genetic Variations in NALP1 Are Associated with Generalized Vitiligo in a Romanian Population

Jin, Y., Birlea, S. A., Fain, P. R., & Spritz, R. A. (2007) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5700953 · Cited by 146 · see citing works

Control of adaptive immunity by pattern recognition receptors

Carroll, S. L., Pasare, C., & Barton, G. M. (2024) · Immunity · doi:10.1016/j.immuni.2024.03.014 · Cited by 146 · see citing works

Autoinflammatory Diseases: Clinical and Genetic Advances

Farasat, S., Aksentijevich, I. A., & Toro, J. R. (2008) · Archives of Dermatology · doi:10.1001/archderm.144.3.392 · Cited by 143 · see citing works

Polymorphism in a gene coding for the inflammasome component NALP3 and recurrent vulvovaginal candidiasis in women with vulvar vestibulitis syndrome

Lev‐Sagie, A., Prus, D., Linhares, I. M., Lavy, Y., Ledger, W. J., & Witkin, S. S. (2009) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2008.10.039 · Cited by 142 · see citing works

Nlrp3: An immune sensor of cellular stress and infection

Lamkanfi, M., & Kanneganti, T.-D. (2010) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2010.01.008 · Cited by 140 · see citing works

Inflammasomes: Their Role in Normal and Complicated Pregnancies

Gomez‐Lopez, N., Motomura, K., Miller, D., Garcia‐Flores, V., Galaz, J., & Romero, R. J. (2019) · The Journal of Immunology · doi:10.4049/jimmunol.1900901 · Cited by 134 · see citing works

Biochemical regulation of the inflammasome

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Expression of inflammasome proteins and inflammasome activation occurs in human, but not in murine keratinocytes

Sand, J., Haertel, E., Biedermann, T., Contassot, E., Ernst Reichmann, A., French, L. E., Werner, S., & Beer, H. (2018) · Cell Death and Disease · doi:10.1038/s41419-017-0009-4 · Cited by 130 · see citing works

Inflammasome biology, molecular pathology and therapeutic implications

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Ventilator-induced Lung Injury Is Mediated by the NLRP3 Inflammasome

Kuipers, M. T., Aslami, H., Janczy, J. R., van der Sluijs, K. F., Vlaar, A. P. J., Wolthuis, E. K., Choi, G., Roelofs, J. J. T. H., Flavell, R. A., Sutterwala, F. S., et al. (2012) · Anesthesiology · doi:10.1097/aln.0b013e3182518bc0 · Cited by 130 · see citing works

Inflammasomes as therapeutic targets for A lzheimer's disease

White, C., Lawrence, C. B., Brough, D., & Rivers‐Auty, J. (2016) · Brain Pathology · doi:10.1111/bpa.12478 · Cited by 131 · see citing works

Pyrin Levels in Human Monocytes and Monocyte-Derived Macrophages Regulate IL-1β Processing and Release

Seshadri, S., Duncan, M., Hart, J., Gavrilin, M. A., & Wewers, M. D. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.2.1274 · Cited by 126 · see citing works

IFI16 Protein Mediates the Anti-inflammatory Actions of the Type-I Interferons through Suppression of Activation of Caspase-1 by Inflammasomes

Veeranki, S., Duan, X., Panchanathan, R., Liu, H., & Choubey, D. (2011) · PLoS ONE · doi:10.1371/journal.pone.0027040 · Cited by 129 · see citing works

Control of local immunity by airway epithelial cells

Weitnauer, M., Mijošek, V., & Dalpke, A. H. (2015) · Mucosal Immunology · doi:10.1038/mi.2015.126 · Cited by 128 · see citing works

The Role of Neuronal NLRP1 Inflammasome in Alzheimer’s Disease: Bringing Neurons into the Neuroinflammation Game

Yap, J. K. Y., Pickard, B. S., Chan, E. W. L., & Gan, S. Y. (2019) · Molecular Neurobiology · doi:10.1007/s12035-019-1638-7 · Cited by 127 · see citing works

Genetic variation in proteins of the cryopyrin inflammasome influences susceptibility and severity of rheumatoid arthritis (The Swedish TIRA project)

Kastbom, A., Verma, D., Eriksson, P., Skogh, T., Wingren, G. B., & Söderkvist, P. (2007) · Lara D. Veeken · doi:10.1093/rheumatology/kem372 · Cited by 126 · see citing works

Mitochondrial function and gastrointestinal diseases

Haque, P. S., Kapur, N., Barrett, T. A., & Theiss, A. L. (2024) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-024-00931-2 · Cited by 142 · see citing works

Intracellular sensing of microbes and danger signals by the inflammasomes

Horvath, G. L., Schrum, J. E., Nardo, C. M. D., & Latz, E. (2011) · Immunological Reviews · doi:10.1111/j.1600-065x.2011.01050.x · Cited by 125 · see citing works

NLRP1 promotes tumor growth by enhancing inflammasome activation and suppressing apoptosis in metastatic melanoma

Zhai, Z., Liu, W.-T., Kaur, M., Luo, Y., Domenico, J. M., Samson, J. M., Shellman, Y. G., Norris, D. A., Dinarello, C. A., Spritz, R. A., et al. (2017) · Oncogene · doi:10.1038/onc.2017.26 · Cited by 125 · see citing works

Critical role for NALP3/CIAS1/Cryopyrin in innate and adaptive immunity through its regulation of caspase-1

Sutterwala, F. S., Ogura, Y., Szczepanik, M., Lara-Tejero, M., Lichtenberger, G. S., Grant, E. P., Bertin, J., Coyle, A. J., Galán, J. E., Askenase, P. W., et al. (2006) · Immunity · doi:10.1016/j.immuni.2006.02.004 · Cited by 980 · see citing works

NALP3 Forms an IL-1β-Processing Inflammasome with Increased Activity in Muckle-Wells Autoinflammatory Disorder

Agostini, L., Martinon, F., Burns, K., McDermott, M. F., Hawkins, P. N., & Tschopp, J. (2004) · Immunity · doi:10.1016/s1074-7613(04)00046-9 · Cited by 1,768 · see citing works

NALP3: a key player in caspase-1 activation

Sutterwala, F. S., Ogura, Y., Zamboni, D. S., Roy, C. R., & Flavell, R. A. (2006) · Journal of Endotoxin Research · doi:10.1177/09680519060120040701 · Cited by 84 · see citing works

Research progress on NALP3 inflammasome and related diseases

Ya-ling, S. (2011) · Yati yasui yazhoubingxue zazhi · Cited by 1 · see citing works

Tissue-specific expression of the NOD-like receptor protein 3 in BALB/c mice

Huang, Z., Yu, M., Tong, S., Jia, K., Liu, R., Wang, H., Li, S., & Ning, Z. (2014) · Journal of Veterinary Science · doi:10.4142/jvs.2014.15.2.173 · Cited by 24 · see citing works