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Identification of natural compounds with antiviral activities against SARS-associated coronavirus
Open accessAbstract
More than 200 Chinese medicinal herb extracts were screened for antiviral activities against Severe Acute Respiratory Syndrome-associated coronavirus (SARS-CoV) using 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium inner salt (MTS) assay for virus-induced cytopathic effect (CPE). Four of these extracts showed moderate to potent antiviral activities against SARS-CoV with 50% effective concentration (EC50) ranging from 2.4 ± 0.2 to 88.2 ± 7.7 μg/ml. Out of the four, Lycoris radiata was most potent. To identify the active component, L. radiata extract was subjected to further fractionation, purification, and CPE/MTS assays. This process led to the identification of a single substance lycorine as an anti-SARS-CoV component with an EC50 value of 15.7 ± 1.2 nM. This compound has a CC50 value of 14980.0 ± 912.0 nM in cytotoxicity assay and a selective index (SI) greater than 900. The results suggested that four herbal extracts and the compound lycorine are candidates for the development of new anti-SARS-CoV drugs in the treatment of SARS.
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Identification of a novel coronavirus in patients with severe acute respiratory syndrome
Drosten, C., Günther, S., Preiser, W., van der Werf, S., Brodt, H.-R., Becker, S., Rabenau, H., Panning, M., Kolesnikova, L., Fouchier, R. A. M., et al. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa030747 · Cited by 4,574
Donnelly, C. A., Ghani, A. C., Leung, G. M., Hedley, A. J., Fraser, C., Riley, S., Abu-Raddad, L. J., Ho, L.-M., Thach, T.-Q., Chau, P., et al. (2003) · The Lancet · doi:10.1016/s0140-6736(03)13410-1 · Cited by 940 · cited 1×
“This febrile respiratory illness was initially described in early 2003 (Chan-Yeung and Yu, 2003; Donnelly et al., 2003; Lee et al., 2003; Peiris et al., 2003a; Tsang et al., 2003) and is life threatening and highly contagious.”
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Cited by
Severe acute respiratory syndrome coronavirus as an agent of emerging and reemerging infection
Cheng, V. C. C., Lau, S. K. P., Woo, P. C. Y., & Yuen, K. Y. (2007) · Clinical Microbiology Reviews · doi:10.1128/cmr.00023-07 · Cited by 1,192
Zhang, D.-H., Wu, K.-L., Zhang, X., Deng, S.-Q., & Peng, B. (2020) · Journal of Integrative Medicine · doi:10.1016/j.joim.2020.02.005 · Cited by 482
Self-citationHigh-throughput screening and identification of potent broad-spectrum inhibitors of coronaviruses.
Shen, L., Niu, J., Wang, C., Huang, B., Wang, W., Zhu, N., Deng, Y., Wang, H., Ye, F., Cen, S., et al. (2019) · Journal of Virology · doi:10.1128/jvi.00023-19 · Cited by 319
Self-citationArtemisia annua L. extracts inhibit the in vitro replication of SARS-CoV-2 and two of its variants
Nair, M. S., Huang, Y., Fidock, D. A., Polyak, S. J., Wagoner, J., Towler, M. J., & Weathers, P. J. (2021) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2021.114016 · Cited by 122
Metadata
- Authors
- LI, S., CHEN, C., ZHANG, H., GUO, H., WANG, H., WANG, L., ZHANG, X., HUA, S., YU, J., & XIAO, P.
- Venue
- Antiviral Research
- Publisher
- Elsevier BV
- Published
- 2005-07
- Volume
- 67
- Issue
- 1
- Pages
- 18-23
- ISSN
- 0166-3542 (ISSN-L)
- OpenAlex
- W2170017134
- Cited by
- 602
- References
- 2
- FWCI
- 6.12
- Type
- journal article
- Language
- en
- Open access
- green
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- LI, S., CHEN, C., ZHANG, H., GUO, H., WANG, H., WANG, L., ZHANG, X., HUA, S., YU, J., & XIAO, P. (2005). Identification of natural compounds with antiviral activities against SARS-associated coronavirus. Antiviral Research. https://doi.org/10.1016/j.antiviral.2005.02.007
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