Excessive appetitive arousal in Prader–Willi syndrome
Abstract
This study focused on genetic and behavioural aspects of one important component of the motivation to eat - how appetitive arousal is elicited through the presentation of food-associated stimuli. Individuals with Prader-Willi syndrome, a genetic disorder associated with hyperphagia, and control participants completed a computerised response task in the presence of motivational stimuli. In controls, appetitive arousal was specific to particular stimuli. In contrast, individuals with PWS showed a non-specific pattern of arousal. Over-activation of the anticipatory motivation system may be one consequence of the genetic disorder in PWS.
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The incentive salience of food is heightened in PWS, and this heightened motivation is not diminished with satiation.
“suggesting that the incentive salience of food is heightened in this population, and that this heightened motivation is not diminished with satiation [676].”
From Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings (2012) · cites this paper as [676]
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- Authors
- Hinton, E. C., Isles, A. R., Williams, N. M., & Parkinson, J. A.
- Affiliations
- Cardiff University (GB)
- Bangor University (GB)
- Corresponding author
- Hinton, E.C.
- Venue
- Appetite
- Publisher
- Elsevier BV
- Published
- 2010-02
- Volume
- 54
- Issue
- 1
- Pages
- 225-228
- ISSN
- 0195-6663 (ISSN-L)
- OpenAlex
- W2002762348
- Cited by
- 19
- References
- 34
- Citations by year
- 2025: 1 · 2022: 1 · 2021: 3 · 2019: 1 · 2015: 1 · 2013: 3 · 2012: 2
- FWCI
- 1.35
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Appetite (publishedVersion)
- PubMed (publishedVersion)
- Bristol Research (University of Bristol) (publishedVersion)
- ORCA Online Research @Cardiff (Cardiff University) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Syndromes and Imprinting
- Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
- Keywords
- Prader-Willi syndrome, hyperphagia, food cues, genetic disorders, eating behaviour
- MeSH terms
- Adult, Appetite, Arousal, Cues, Feeding Behavior, Female, Humans, Hunger, Hyperphagia, Male, Motivation, Photic Stimulation, Prader-Willi Syndrome, Surveys and Questionnaires, Task Performance and Analysis
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