Food-related Neural Circuitry in Prader-Willi Syndrome: Response to High- Versus Low-calorie Foods

Dimitropoulos, Anastasia; Schultz, Robert T.

doi:10.1007/s10803-008-0546-x

Cited by 73Genetic Syndromes and ImprintingRegulation of Appetite and ObesityEating Disorders and Behaviors

Food-related Neural Circuitry in Prader-Willi Syndrome: Response to High- Versus Low-calorie Foods

Dimitropoulos, Anastasia, Schultz, Robert T.·2008·Journal of Autism and Developmental Disorders

DOI 10.1007/s10803-008-0546-x

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Abstract

Prader-Willi syndrome (PWS) is a neurodevelopmental disorder characterized by hyperphagia and food preoccupations. Although dysfunction of the hypothalamus likely has a critical role in hyperphagia, it is only one of several regions involved in the regulation of eating. The purpose of this research was to examine food-related neural circuitry using functional magnetic resonance imaging in individuals with PWS and matched controls. Individuals with PWS showed increased activation in neural circuitry known to mediate hunger and motivation (hypothalamus, OFC) in response to high- versus low-calorie foods and in comparison to controls. This suggests neural circuitry for PWS is abnormally activated during hunger, particularly for high-calorie foods, and may mediate abnormally strong hunger states, therefore playing a significant role in PWS-induced hyperphagia.

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Dimitropoulos and Schultz reported increased activation in the hypothalamus and orbitofrontal cortex in PWS during high-calorie versus low-calorie food-reward outcomes.
“Dimitropoulos and Schultz [680] reported increased activation in the hypothalamus and orbitofrontal cortex in PWS during high-calorie versus low-calorie food-reward outcomes.”
From Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings (2012) · cites this paper as [680]

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Amygdala hyperactivation relates to eating behavior: a potential indicator of food addiction in Prader-Willi syndromePreprint
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Authors: Dimitropoulos, A., & Schultz, R. T.
Affiliations: Yale University (US)
Children's Hospital of Philadelphia (US)
Corresponding author: Dimitropoulos, Anastasia
ORCID: Dimitropoulos, Anastasia
Schultz, Robert T.
Venue: Journal of Autism and Developmental Disorders
Publisher: Springer Science and Business Media LLC
Published: 2008-02-29
Volume: 38
Issue: 9
Pages: 1642-1653
ISSN: 0162-3257 (ISSN-L)
1573-3432
DOI: 10.1007/s10803-008-0546-x
OpenAlex: W2094446860
Cited by: 73
References: 59
Citations by year: 2026: 1 · 2025: 4 · 2024: 1 · 2023: 6 · 2022: 1 · 2021: 7 · 2020: 3 · 2019: 5 · 2018: 1 · 2017: 2 · 2016: 4 · 2015: 6 · 2014: 3 · 2013: 1 · 2012: 5
FWCI: 4.37
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Journal of Autism and Developmental Disorders (publishedVersion)
PubMed (publishedVersion)
Funders: Yale University
National Institutes of Health
National Institute of Mental Health (T32 MH18268, T32MH018268)
National Institute of Child Health and Human Development
Eunice Kennedy Shriver National Institute of Child Health and Human Development (P01 HD03008, L30 HD048198, P01HD003008)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Syndromes and Imprinting
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
Keywords: Prader-Willi syndrome, hyperphagia, hunger, hypothalamus, orbitofrontal cortex, high-calorie foods, low-calorie foods, food intake regulation, food preoccupation
MeSH terms: Adolescent, Adult, Energy Intake, Child, Food, Humans, Hypothalamus, Karyotyping, Magnetic Resonance Imaging, Male, Nerve Net, Obesity, Prader-Willi Syndrome, Prefrontal Cortex

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Food-related Neural Circuitry in Prader-Willi Syndrome: Response to High- Versus Low-calorie Foods

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