The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.
The modification of natural products for medical use
Open accessAbstract
Drug innovation is characterized by painstaking molecular-level syntheses and modifications as the basic components of research and development. Similarly, natural products are chemically tailored and modified based upon their structural and biological properties. To some extent, the modification of natural products is quite different from de novo structure-based drug discovery. This review describes the general strategies and principles for the modification of natural products to drugs, as illustrated by several successful medicines that originated from natural products.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Ligand efficiency: a useful metric for lead selection
Hopkins, A. L., Groom, C. R., & Alex, A. (2004) · Drug Discovery Today · doi:10.1016/s1359-6446(04)03069-7 · Cited by 1,846
Structures of a histone deacetylase homologue bound to the TSA and SAHA inhibitors
Finnin, M. S., Donigian, J. R., Cohen, A., Richon, V. M., Rifkind, R. A., Marks, P. A., Breslow, R., & Pavletich, N. P. (1999) · Nature · doi:10.1038/43710 · Cited by 1,714
Structural mechanism for statin inhibition of HMG-CoA reductase
Istvan, E. S., & Deisenhofer, J. (2001) · Science · doi:10.1126/science.1059344 · Cited by 1,644
Alberts, A. W., Chen, J., Kuron, G., Hunt, V, Huff, J., Hoffman, C., Rothrock, J., Lopez, M., Joshua, H., Harris, E., et al. (1980) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.77.7.3957 · Cited by 1,628
Ehrenkranz, J. R. L., Lewis, N. G., Ronald Kahn, C., & Roth, J. (2005) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.532 · Cited by 930
Meng, W., Ellsworth, B. A., Nirschl, A. A., McCann, P. J., Patel, M., Girotra, R. N., Wu, G., Sher, P. M., Morrison, E. P., Biller, S. A., et al. (2008) · Journal of Medicinal Chemistry · doi:10.1021/jm701272q · Cited by 634
GERTH, K., BEDORF, N., HÖFLE, G., IRSCHIK, H., & REICHENBACH, H. (1996) · The Journal of Antibiotics · doi:10.7164/antibiotics.49.560 · Cited by 631
Grempler, R., Thomas, L., Eckhardt, M., Himmelsbach, F., Sauer, A., Sharp, D. E., Bakker, R. A., Mark, M., Klein, T., & Eickelmann, P. (2012) · Diabetes, Obesity and Metabolism · doi:10.1111/j.1463-1326.2011.01517.x · Cited by 608
FUJITA, T., INOUE, K., YAMAMOTO, S., IKUMOTO, T., SASAKI, S., TOYAMA, R., CHIBA, K., HOSHINO, Y., & OKUMOTO, T. (1994) · The Journal of Antibiotics · doi:10.7164/antibiotics.47.208 · Cited by 540
Towle, M. J., Salvato, K. A., Budrow, J., Wels, B. F., Kuznetsov, G., Aalfs, K. K., Welsh, S., Zheng, W., Seletsky, B. M., Palme, M. H., et al. (2001) · PubMed · Cited by 483
Higgins, D. L., Chang, R., Debabov, D. V., Leung, J., Wu, T., Krause, K. M., Sandvik, E., Hubbard, J. M., Kaniga, K., Schmidt, D. E., et al. (2005) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.49.3.1127-1134.2005 · Cited by 425
Total synthesis of halichondrin B and norhalichondrin B
Aicher, T. D., Buszek, K. R., Fang, F. G., Forsyth, C. J., Jung, S. H., Kishi, Y., Matelich, M. C., Scola, P. M., Spero, D. M., & Yoon, S. K. (1992) · Journal of the American Chemical Society · doi:10.1021/ja00034a086 · Cited by 400
Nomura, S., Sakamaki, S., Hongu, M., Kawanishi, E., Koga, Y., Sakamoto, T., Yamamoto, Y., Ueta, K., Kimata, H., Nakayama, K., et al. (2010) · Journal of Medicinal Chemistry · doi:10.1021/jm100332n · Cited by 385
Synthesis and Structure-Activity Relationships of Novel Retinoid X Receptor-Selective Retinoids
Boehm, M. F., Zhang, L., Badea, B. A., White, S. K., Mais, D. E., Berger, E., Suto, C. M., Goldman, M. E., & Heyman, R. A. (1994) · Journal of Medicinal Chemistry · doi:10.1021/jm00044a014 · Cited by 370
Arteether, a new antimalarial drug: synthesis and antimalarial properties
Brossi, A., Venugopalan, B., Dominguez Gerpe, L., Yeh, H. J. C., Flippen-Anderson, J. L., Buchs, P., Luo, X. D., Milhous, W., & Peters, W. (1988) · Journal of Medicinal Chemistry · doi:10.1021/jm00398a026 · Cited by 320
Synthesis and Histone Deacetylase Inhibitory Activity of New Benzamide Derivatives
Suzuki, T., Ando, T., Tsuchiya, K., Fukazawa, N., Saito, A., Mariko, Y., Yamashita, T., & Nakanishi, O. (1999) · Journal of Medicinal Chemistry · doi:10.1021/jm980565u · Cited by 293
Chackalamannil, S., Wang, Y., Greenlee, W. J., Hu, Z., Xia, Y., Ahn, H.-S., Boykow, G., Hsieh, Y., Palamanda, J., Agans-Fantuzzi, J., et al. (2008) · Journal of Medicinal Chemistry · doi:10.1021/jm800180e · Cited by 269
Artemisone—A Highly Active Antimalarial Drug of the Artemisinin Class
Haynes, R. K., Fugmann, B., Stetter, J., Rieckmann, K., Heilmann, H., Chan, H., Cheung, M., Lam, W., Wong, H., Croft, S. L., et al. (2006) · Angewandte Chemie International Edition · doi:10.1002/anie.200503071 · Cited by 260
Retinobenzoic acids. 1. Structure-activity relationships of aromatic amides with retinoidal activity
Kagechika, H., Kawachi, E., Hashimoto, Y., Shudo, K., & Himi, T. (1988) · Journal of Medicinal Chemistry · doi:10.1021/jm00119a021 · Cited by 235
Total Synthesis of (–)‐Epothilone A
Balog, A., Meng, D., Kamenecka, T., Bertinato, P., Su, D., Sorensen, E. J., & Danishefsky, S. J. (1996) · Angewandte Chemie International Edition in English · doi:10.1002/anie.199628011 · Cited by 234
Ohtake, Y., Sato, T., Kobayashi, T., Nishimoto, M., Taka, N., Takano, K., Yamamoto, K., Ohmori, M., Yamaguchi, M., Takami, K., et al. (2012) · Journal of Medicinal Chemistry · doi:10.1021/jm300884k · Cited by 174
Su, D., Meng, D., Bertinato, P., Balog, A., Sorensen, E. J., Danishefsky, S. J., Zheng, Y., Chou, T., He, L., & Horwitz, S. B. (1997) · Angewandte Chemie International Edition in English · doi:10.1002/anie.199707571 · Cited by 164
Imamura, M., Nakanishi, K., Suzuki, T., et al. (2012) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2012.03.051 · Cited by 134
Potent Immunosuppressants, 2-Alkyl-2-aminopropane-1,3-diols
Fujita, T., Hirose, R., Yoneta, M., Sasaki, S., Inoue, K., Kiuchi, M., Hirase, S., Chiba, K., Sakamoto, H., & Arita, M. (1996) · Journal of Medicinal Chemistry · doi:10.1021/jm960391l · Cited by 133
A Robust Platform for the Synthesis of New Tetracycline Antibiotics
Sun, C., Wang, Q., Brubaker, J. D., Wright, P. M., Lerner, C., Noson, K., Charest, M. G., Siegel, D. R., Wang, Y.-M., & Myers, A. G. (2008) · Journal of the American Chemical Society · doi:10.1021/ja806629e · Cited by 132
Subtype Selective Substrates for Histone Deacetylases
Heltweg, B., Dequiedt, F., Marshall, B. L., Brauch, C., Yoshida, M., Nishino, N., Verdin, E. M., & Jung, M. (2004) · Journal of Medicinal Chemistry · doi:10.1021/jm0497592 · Cited by 125
Preclinical discovery of ixabepilone, a highly active antineoplastic agent
Lee, F. Y., Borzilleri, R. M., Fairchild, C. R., Kamath, A. V., Smykla, R. A., Kramer, R. A., & Vite, G. D. (2008) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s00280-008-0724-8 · Cited by 121
From micrograms to grams: scale-up synthesis of eribulin mesylate
Yu, M. J., Zheng, W., & Seletsky, B. M. (2013) · Natural Product Reports · doi:10.1039/c3np70051h · Cited by 120
Hunt, J. T. (2009) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-08-0999 · Cited by 112
Simple compounds, 2-alkyl-2-amino-1,3-propanediols have potent immunosuppressive activity
Fujita, T., Yoneta, M., Hirose, R., Sasaki, S., Inoue, K., Kiuchi, M., Hirase, S., Adachi, K., Arita, M., & Chiba, K. (1995) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/0960-894x(95)00126-e · Cited by 101
Malabarba, A., Ciabatti, R., Scotti, R., et al. (1995) · The Journal of Antibiotics · doi:10.7164/antibiotics.48.869 · Cited by 73
The Total Synthesis of 6-Demethyl-6-Deoxytetracycline
Conover, L. H., Butler, K., Johnston, J. D., Korst, J. J., & Woodward, R. B. (1962) · Journal of the American Chemical Society · doi:10.1021/ja00875a063 · Cited by 66
Sarver, R. W., Bills, E., Bolton, G., Bratton, L. D., Caspers, N. L., Dunbar, J. B., Harris, M. S., Hutchings, R. H., Kennedy, R. M., Larsen, S. D., et al. (2008) · Journal of Medicinal Chemistry · doi:10.1021/jm7015057 · Cited by 65
A model for the taxol (paclitaxel)/epothilone pharmacophore
Winkler, J. D., & Axelsen, P. H. (1996) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/s0960-894x(96)00555-0 · Cited by 41
An indirubin derivative, E804, exhibits potent angiosuppressive activity
Chan, Y., Kwok, H., Chan, L., Leung, K. S., Shi, J., Mak, N. K., Wong, R. N., & Yue, P. Y.-K. (2011) · Biochemical Pharmacology · doi:10.1016/j.bcp.2011.12.003 · Cited by 30
Sanda, T., Kuwano, T., Nakao, S., Iida, S., Ishida, T., Komatsu, H., Shudo, K., Kuwano, M., Ono, M., & Ueda, R. (2005) · Leukemia · doi:10.1038/sj.leu.2403754 · Cited by 25
[Potential antileukemic agents, synthesis of derivatives of indirubin, indigo, and isoindigotin].
Wu, K., My, Z., Fang, Z. Y., et al. (1985) · PubMed · Cited by 11
Metadata
- Authors
- Guo, Z.
- Venue
- Acta Pharmaceutica Sinica B
- Publisher
- Elsevier BV
- Published
- 2017-03
- Volume
- 7
- Issue
- 2
- Pages
- 119-136
- ISSN
- 2211-3835 (ISSN-L)
- OpenAlex
- W2550772067
- Cited by
- 328
- References
- 37
- FWCI
- 12.94
- Type
- journal article
- Language
- en
- Open access
- gold
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
