The DOI matches its Crossref record; 154 of the 154 references it cites were found in a registry or an index.
Extracellular vesicle activities regulating macrophage- and tissue-mediated injury and repair responses
Open accessAbstract
Macrophages are typically identified as classically activated (M1) macrophages and alternatively activated (M2) macrophages, which respectively exhibit pro- and anti-inflammatory phenotypes, and the balance between these two subtypes plays a critical role in the regulation of tissue inflammation, injury, and repair processes. Recent studies indicate that tissue cells and macrophages interact via the release of small extracellular vesicles (EVs) in processes where EVs released by stressed tissue cells can promote the activation and polarization of adjacent macrophages which can in turn release EVs and factors that can promote cell stress and tissue inflammation and injury, and vice versa. This review discusses the roles of such EVs in regulating such interactions to influence tissue inflammation and injury in a number of acute and chronic inflammatory disease conditions, and the potential applications, advantage and concerns for using EV-based therapeutic approaches to treat such conditions, including their potential role of drug carriers for the treatment of infectious diseases.
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Cited by
Liu, C., Yan, X., Zhang, Y., Yang, M., Ma, Y., Zhang, Y., Xu, Q., Tu, K., & Zhang, M. (2022) · Journal of Nanobiotechnology · doi:10.1186/s12951-022-01421-w · Cited by 285
Cai, Y., Chen, K., Liu, C., & Qu, X. (2023) · Bioactive Materials · doi:10.1016/j.bioactmat.2023.04.019 · Cited by 112
A+T rich interaction domain protein 3a (Arid3a) impairs Mertk-mediated efferocytosis in cholestasis
Chen, R., Huang, B., Lian, M., Wei, Y., Miao, Q., Liang, J., Ou, Y., Liang, X., Zhang, H., Li, Y., et al. (2023) · Journal of Hepatology · doi:10.1016/j.jhep.2023.08.016 · Cited by 39
Lei, M., & Chen, G. (2025) · Acta Biomaterialia · doi:10.1016/j.actbio.2025.05.011 · Cited by 12
Extracellular vesicles: emerging therapeutic agents for liver fibrosis
Chiabotto, G., Semnani, A., Ceccotti, E., & Bruno, S. (2025) · Extracellular Vesicles and Circulating Nucleic Acids · doi:10.20517/evcna.2025.08 · Cited by 13
Metadata
- Authors
- Hu, Q., Lyon, C. J., Fletcher, J. K., Tang, W., Wan, M., & Hu, T. Y.
- Venue
- Acta Pharmaceutica Sinica B
- Publisher
- Elsevier BV
- Published
- 2021-06
- Volume
- 11
- Issue
- 6
- Pages
- 1493-1512
- ISSN
- 2211-3835 (ISSN-L)
- OpenAlex
- W3117144380
- Cited by
- 309
- References
- 154
- FWCI
- 7.40
- Type
- journal article
- Language
- en
- Open access
- gold
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- Hu, Q., Lyon, C. J., Fletcher, J. K., Tang, W., Wan, M., & Hu, T. Y. (2021). Extracellular vesicle activities regulating macrophage- and tissue-mediated injury and repair responses. Acta Pharmaceutica Sinica B. https://doi.org/10.1016/j.apsb.2020.12.014
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