Extracellular vesicles: biology and emerging therapeutic opportunities
Abstract
Within the past decade, extracellular vesicles have emerged as important mediators of intercellular communication, being involved in the transmission of biological signals between cells in both prokaryotes and higher eukaryotes to regulate a diverse range of biological processes. In addition, pathophysiological roles for extracellular vesicles are beginning to be recognized in diseases including cancer, infectious diseases and neurodegenerative disorders, highlighting potential novel targets for therapeutic intervention. Moreover, both unmodified and engineered extracellular vesicles are likely to have applications in macromolecular drug delivery. Here, we review recent progress in understanding extracellular vesicle biology and the role of extracellular vesicles in disease, discuss emerging therapeutic opportunities and consider the associated challenges.
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The exosome is a suitable vehicle for drug delivery because of its high biocompatibility and low immunogenicity.
“The exosome is a suitable vehicle for drug delivery because of its high biocompatibility and low immunogenicity55.”
From Neurons secrete miR-132-containing exosomes to regulate brain vascular integrity (2017) · cites this paper as [55]
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- Authors
- EL Andaloussi, S., Mäger, I., Breakefield, X. O., & Wood, M. J. A.
- Venue
- Nature Reviews Drug Discovery
- Published
- 2013-04-15
- Volume
- 12
- Issue
- 5
- Pages
- 347-357
- ISSN
- 1474-1776
- 1474-1784
- Cited by
- 3,254
- References
- 11
- Language
- en
- Licence
- www.springer.com/tdm (tdm)
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