The DOI matches its Crossref record; 73 of the 73 references it cites were found in a registry or an index.
TGF-β1 and BMP-4 carried by liposomes enhance the healing process in alveolar bone
Abstract
Objective In this work we evaluated the bone-forming potential of BMP4, TGFβ1 and BMP4/TGFβ1 mixed by performing histological and morphometric analysis. We also evaluated the immunolabelling of fibronectin (FN) and collagen type III (Col III), two determinant proteins for the early phase of bone repair. Design Histological, histomorphometric and immunohistochemistry analysis were used to evaluate new bone and blood vessels formation as well as fibronectin and collagen type III expression. 112 male Wistar rats weighing 250-300g had their maxillary second molar extracted. Sockets filled with blood clot (BC) or treated with L (empty liposome), P (PBS), BP (BMP-4 in PBS) and TP (TGF-β1 in PBS), as well as with BL (BMP-4 in liposome) and TL (TGF-β1 in liposome) administered isolated or in association (BTL) were obtained. The animals were sacrificed at 3, 7, 14 and 21 days after surgery. Results An increased percentage of bone trabeculae, and a higher number of blood vessels were observed in groups BL or TL administered isolated or in association when compared to groups BC, L, P, BP and TP. Fibronectin and collagen type III analysis revealed enhanced expression firstly detected at 3 days followed by a peak at 7 days. Lower levels of immunoreactivity were observed in the sockets filled with blood clot, and treated with L, P, BP and TP when compared with sockets from groups BL, TL and BTL. Conclusion The present study indicates growth factors carried by liposomes, either in isolated or associated forms, as successful enhancers of the healing process in rat tooth sockets. We also conclude that the expression of fibronectin and collagen type III increases during the early phases of bone repair.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Among these, major regulators within the bone remodeling cascade are bone morphogenetic proteins (BMPs), vascular endothelial growth factor (VEGF), fibroblast growth factor (FGF), platelet-derived growth factor (PDGF), transforming growth factor-β1 (TGF-β1), and insulin-like growth factor 1 (IGF-1) [39,69,70,71,72,73,74,75,76].”
From Mesenchymal Stem/Stromal Cells: Immunomodulatory and Bone Regeneration Potential after Tumor Excision in Osteosarcoma Patients (2023) · cites this paper as [69]
In the citing paper
“Following bone injury, the bone’s extracellular matrix releases a physiological amount of growth factors which play a vital role in bone repair.”
From Mesenchymal Stem/Stromal Cells: Immunomodulatory and Bone Regeneration Potential after Tumor Excision in Osteosarcoma Patients (2023) · cites this paper as [69]
In the citing paper
“BMP-2, BMP-4, BMP-5, BMP-6, and BMP-7 are vital for bone formation and repair, with applications in open tibial fractures and non-unions [39,69,70,79].”
From Mesenchymal Stem/Stromal Cells: Immunomodulatory and Bone Regeneration Potential after Tumor Excision in Osteosarcoma Patients (2023) · cites this paper as [69]
In the citing paper
“The family of BMPs plays a crucial role in inducing osteogenesis.”
From Mesenchymal Stem/Stromal Cells: Immunomodulatory and Bone Regeneration Potential after Tumor Excision in Osteosarcoma Patients (2023) · cites this paper as [69]
Citations
Cites
Bone regeneration: current concepts and future directions
Dimitriou, R., Jones, E., McGonagle, D., & Giannoudis, P. V. (2011) · BMC Medicine · doi:10.1186/1741-7015-9-66 · Cited by 2,003
Kingsley, D. M. (1994) · Genes & Development · doi:10.1101/gad.8.2.133 · Cited by 1,931
Lee, K., Silva, E. A., & Mooney, D. J. (2011) · Journal of The Royal Society Interface · doi:10.1098/rsif.2010.0223 · Cited by 1,386
Friedlaender, G. E., Perry, C. R., Cole, J. D., Cook, S. D., Cierny, G., Muschler, G. F., Zych, G. A., Calhoun, J. H., LaForte, A. J., & Yin, S. (2001) · The Journal of Bone and Joint Surgery-American Volume · doi:10.2106/00004623-200100002-00010 · Cited by 957
THE ROLE OF GROWTH FACTORS IN THE REPAIR OF BONE: BIOLOGY AND CLINICAL APPLICATIONS
LIEBERMAN, J. R., DALUISKI, A., & EINHORN, T. A. (2002) · The Journal of Bone and Joint Surgery-American Volume · doi:10.2106/00004623-200206000-00022 · Cited by 932
Tissue repair and the dynamics of the extracellular matrix
Midwood, K. S., Williams, L. V., & Schwarzbauer, J. E. (2004) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2003.12.003 · Cited by 919
Liposomal Drug Delivery Systems: An Update Review
Samad, A., Sultana, Y., & Aqil, M. (2007) · Current Drug Delivery · doi:10.2174/156720107782151269 · Cited by 906
Dynamics of bone tissue formation in tooth extraction sites: An experimental study in dogs
Cardaropoli, G., Araújo, M., & Lindhe, J. (2003) · Journal of Clinical Periodontology · doi:10.1034/j.1600-051x.2003.00366.x · Cited by 760
Tissue Engineering: Orthopedic Applications
Laurencin, C. T., Ambrosio, A. M. A., Borden, M. D., & Cooper, J. A. (1999) · Annual Review of Biomedical Engineering · doi:10.1146/annurev.bioeng.1.1.19 · Cited by 752
Matrices and scaffolds for delivery of bioactive molecules in bone and cartilage tissue engineering
Lee, S.-H., & Shin, H. (2007) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2007.03.016 · Cited by 706
Research works printed but not linked: 1
- Friedlaender, 2001, Osteogenic protein-1 (bone morphogenetic protein-7) in the treatment of tibial nonunions, Journal of Bone and Joint Surgery, 83-A, S151
Cited by
Tissue Engineering and Cell-Based Therapies for Fractures and Bone Defects
Perez, J. R., Kouroupis, D., Li, D. J., Best, T. M., Kaplan, L., & Correa, D. (2018) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2018.00105 · Cited by 390
Baron, M., Drohat, P., Crawford, B., Hornicek, F. J., Best, T. M., & Kouroupis, D. (2023) · Bioengineering · doi:10.3390/bioengineering10101187 · Cited by 19
Metadata
- Authors
- Ferreira, C. L., Abreu, F. A. M. D., Silva, G. A. B., Silveira, F. F., Barreto, L. B. A., Paulino, T. D. P., Miziara, M. N., & Alves, J. B.
- Affiliations
- Universidade Federal de Minas Gerais (BR)
- Pontifícia Universidade Católica de Minas Gerais (BR)
- Universidade de Uberaba (BR)
- Corresponding author
- Alves, José Bento
- Venue
- Archives of Oral Biology
- Publisher
- Elsevier BV
- Published
- 2013-06
- Volume
- 58
- Issue
- 6
- Pages
- 646-656
- ISSN
- 0003-9969 (ISSN-L)
- OpenAlex
- W2034872463
- Cited by
- 24
- References
- 73
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 1 · 2023: 3 · 2022: 1 · 2021: 3 · 2020: 3 · 2019: 2 · 2018: 3 · 2016: 1 · 2015: 1 · 2014: 2 · 2013: 1
- FWCI
- 2.01
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- Locations
- Archives of Oral Biology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Dentistry › Periodontics › Periodontal Regeneration and Treatments
- Health Sciences › Dentistry › Oral Surgery › Dental Implant Techniques and Outcomes
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Keywords
- TGF-β1, BMP4, liposomes, bone regeneration, alveolar bone healing, extraction sockets, bone morphogenetic proteins, fibronectin, type III collagen, angiogenesis, growth factor delivery
- MeSH terms
- Alveolar Process, Animals, Blood Coagulation, Drug Carriers, Fibronectins, Liposomes, Male, Maxilla, Osteoblasts, Osteoclasts, Osteogenesis, Random Allocation, Time Factors, Tooth Extraction, Wound Healing, Rats, Wistar, Neovascularization, Physiologic, Tooth Socket, Collagen Type III, Rats, Transforming Growth Factor beta1, Bone Morphogenetic Protein 4
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: TGF-β1 and BMP-4 carried by liposomes enhance the healing process in alveolar bone. https://app.cochat.ai/papers/10.1016/j.archoralbio.2012.11.013
- The paper
- Ferreira, C. L., Abreu, F. A. M. D., Silva, G. A. B., Silveira, F. F., Barreto, L. B. A., Paulino, T. D. P., Miziara, M. N., & Alves, J. B. (2013). TGF-β1 and BMP-4 carried by liposomes enhance the healing process in alveolar bone. Archives of Oral Biology. https://doi.org/10.1016/j.archoralbio.2012.11.013
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
