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Cited by 60Mangiferin and Mango ExtractsPhytochemicals and Antioxidant ActivitiesAntioxidant Activity and Oxidative Stress

Mangifera indica L. (Vimang) Protection against Serum Oxidative Stress in Elderly Humans

Pardo-Andreu, Gilberto L., Philip, Sarah J., Riaño, Annia, Sánchez, Carlos, Viada, Carmen, Núñez-Sellés, Alberto J., Delgado, René·2006·Archives of Medical Research
DOI 10.1016/j.arcmed.2005.04.017
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Abstract

Background We searched for the protective effect of a natural extract from stem bark of Mangifera indica L. extract (Vimang) on age-related oxidative stress. Methods Healthy subjects were classified in two groups, elderly (>65 years) and young group (<26 years). The elderly group received a daily dose of 900 mg of extract (three coated Vimang tablets, 300 mg each, before meals) for 60 days. Serum concentration of lipid peroxides, serum peroxidation potential, extracellular superoxide dismutase activity (EC-SOD), glutathione status (GSH, GSSG, GSSG/GSH ratio)) and total antioxidant status (TAS) were determined before (both experimental groups) and 15, 30, and 60 days after treatment (only elderly group). We confirmed the existence of an age-associated oxidative stress in human serum as documented by an age-related increase in serum lipoperoxides and GSSG and a decrease in serum antioxidant capacity and EC-SOD activity. Results Vimang tablet supplementation increased EC-SOD activity (p <0.01) and serum TAS (p <0.01). It also decreased serum thiobarbituric reactive substances (p <0.01) and GSSG levels (p <0.05). We suggested that the antioxidant components of the extract could have been utilized by the cells (especially blood and endothelial cells), sparing the intra- and extracellular antioxidant system and increasing serum peroxil scavenging capacity, thus preventing age-associated increase in GSH oxidation and lipoperoxidation. Conclusions Vimang tablets prevent age-associated oxidative stress in elderly humans, which could retard the onset of age-associated disease, improving the quality of life for elderly persons.

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Crossref · 10.1016/j.arcmed.2005.04.017

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Research works printed but not linked: 2

  1. Capote, 1998, Chemical-analytical characterization of aqueous extract of Mangifera indica L, Rev Cub Quim, 10, 111
  2. Gill del Valle, 2002, Effects of Vimang® on oxidative stress and marker of disease progression in HIV/AIDS patients, Free Radic Res, 36, 107

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Authors
Pardo-Andreu, G. L., Philip, S. J., Riaño, A., Sánchez, C., Viada, C., Núñez-Sellés, A. J., & Delgado, R.
Affiliations
University of Camagüey (CU)
ORCID
Venue
Archives of Medical Research
Publisher
Elsevier BV
Published
2006-01
Volume
37
Issue
1
Pages
158-164
ISSN
  • 0066-6769 (ISSN-L)
  • 0188-4409
DOI
10.1016/j.arcmed.2005.04.017
OpenAlex
W2168253377
Semantic Scholar
2cc68a243e8a9b652c27efb85ddd0d5d1af13203
Cited by
60
References
45
Citations by year
2026: 3 · 2025: 1 · 2023: 3 · 2022: 3 · 2020: 2 · 2019: 3 · 2018: 1 · 2017: 5 · 2016: 2 · 2015: 4 · 2014: 3 · 2013: 5 · 2012: 6
FWCI
4.42
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Archives of Medical Research (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Complementary and alternative medicine › Mangiferin and Mango Extracts
  • Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
  • Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
Keywords
mango, Vimang, stem bark extract, oxidative stress, aging, older adults, lipid peroxidation, superoxide dismutase, glutathione, antioxidant status, dietary supplementation, age-related disease prevention
MeSH terms
Administration, Oral, Adult, Aged, Aged, 80 and over, Aging, Antioxidants, Female, Glutathione, Humans, Male, Middle Aged, Plant Extracts, Superoxide Dismutase, Lipid Peroxidation, Oxidative Stress, Mangifera

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