Serum antioxidant capacity is increased by consumption of strawberries, spinach, red wine or vitamin C in elderly women
Open accessAbstract
It is often assumed that antioxidant nutrients contribute to the protection afforded by fruits, vegetables, and red wine against diseases of aging. However, the effect of fruit, vegetable and red wine consumption on the overall antioxidant status in human is unclear. In this study we investigated the responses in serum total antioxidant capacity following comsumption of strawberries (240 g), spinach (294 g), red wine (300 ml) or vitamin C (1250 mg) in eight elderly women. Total antioxidant capacity was determined using different methods: oxygen radical absorbance capacity (ORAC) assay, Trolox equivalent antioxidant capacity (TEAC) assay and ferric reducing ability (FRAP) assay. The results showed that the total antioxidant capacity of serum determined as ORAC, TEAC and FRAP, using the area under the curve, increased significantly by 7-25% during the 4-h period following consumption of red wine, strawberries, vitamin C or spinach. The total antioxidant capacity of urine determined as ORAC increased (P < 0.05) by 9.6, 27.5, and 44.9% for strawberries, spinach, and vitamin C, respectively, during the 24-h period following these treatments. The plasma vitamin C level after the strawberry drink, and the serum urate level after the strawberry and spinach treatments, also increased significantly. However, the increased vitamin C and urate levels could not fully account for the increased total antioxidant capacity in serum following the consumption of strawberries, spinach or red wine. We conclude that the consumption of strawberries, spinach or red wine, which are rich in antioxidant phenolic compounds, can increase the serum antioxidant capacity in humans. J. Nutr. 2383-2390, 1998
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Benefits of berry intervention were seen in healthy subjects and in those with existing metabolic risk factors.
“Benefits were seen in healthy subjects and in those with existing metabolic risk factors.”
From Berries: emerging impact on cardiovascular health (2010) · cites this paper as [32]
Human intervention studies using chokeberries, cranberries, blueberries, and strawberries (fresh, juice, or freeze-dried), or purified anthocyanin extracts have demonstrated significant improvements in LDL oxidation, lipid peroxidation, total plasma antioxidant capacity, dyslipidemia, and glucose metabolism.
“Human intervention studies using chokeberries, cranberries, blueberries, and strawberries (either fresh, or as juice, or freeze-dried), or purified anthocyanin extracts have demonstrated significant improvements in LDL oxidation, lipid peroxidation, total plasma antioxidant capacity, dyslipidemia, and glucose metabolism.”
From Berries: emerging impact on cardiovascular health (2010) · cites this paper as [32]
The most significant outcomes of clinical studies show an increase in plasma or urinary antioxidant capacity, a decrease in LDL oxidation and lipid peroxidation, a decrease in plasma glucose or total cholesterol, and an increase in HDL-cholesterol following berry intervention.
“The most significant outcomes of these clinical studies show an increase in plasma or urinary antioxidant capacity, a decrease in LDL oxidation and lipid peroxidation, a decrease in plasma glucose or total cholesterol, and an increase in HDL-cholesterol following berry intervention.”
From Berries: emerging impact on cardiovascular health (2010) · cites this paper as [32]
Of 20 trials reviewed, nine involved measures of post-prandial status, in which berry consumption was shown to significantly decrease postprandial oxidative stress, especially lipid peroxidation.
“Of 20 trials reviewed, nine involved measures of post-prandial status, in which berry consumption was shown to significantly decrease postprandial oxidative stress, especially lipid peroxidation.”
From Berries: emerging impact on cardiovascular health (2010) · cites this paper as [32]
Clinical studies in healthy humans, subjects with diabetes mellitus, dyslipidemia, metabolic syndrome, hypertension, or in smokers, show a significant decrease in CVD risk factors, especially glucose, lipids and lipid peroxidation, and systolic blood pressure, following berry intervention.
“Clinical studies in healthy humans, subjects with diabetes mellitus, dyslipidemia, metabolic syndrome, hypertension, or in smokers, show a significant decrease in CVD risk factors, especially glucose, lipids and lipid peroxidation, and systolic blood pressure, following berry intervention.”
From Berries: emerging impact on cardiovascular health (2010) · cites this paper as [32]
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Self-citation
- Authors
- Cao, G., Russell, R. M., Lischner, N., & Prior, R. L.
- Affiliations
- Tufts University (US)
- Corresponding author
- Prior, Ronald L.
- Venue
- The Journal of Nutrition
- Publisher
- Elsevier BV
- Published
- 1998-12
- Volume
- 128
- Issue
- 12
- Pages
- 2383-2390
- ISSN
- 0022-3166 (ISSN-L)
- OpenAlex
- W1929245453
- Cited by
- 502
- References
- 46
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 6 · 2023: 6 · 2022: 7 · 2021: 14 · 2020: 18 · 2019: 12 · 2018: 17 · 2017: 10 · 2016: 23 · 2015: 17 · 2014: 20 · 2013: 24 · 2012: 31
- FWCI
- 10.94
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
- Keywords
- serum antioxidant capacity, strawberry, spinach, red wine, vitamin C, older women, dietary antioxidants, phenolic compounds, plasma vitamin C, serum uric acid, aging
- MeSH terms
- Aged, Analysis of Variance, Antioxidants, Ascorbic Acid, Blood, Blood Glucose, Diet, Female, Fruit, Humans, Oxidation-Reduction, Vegetables, Wine, Area Under Curve
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