Cited by 139Heart Rate Variability and Autonomic ControlGenetics, Aging, and Longevity in Model OrganismsHeart rate and cardiovascular health

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Heart rate, lifespan, and mortality risk

Zhang, Gus Q., Zhang, Weiguo·2009·Ageing Research Reviews

DOI 10.1016/j.arr.2008.10.001

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Abstract

An increasing body of scientific research and observational evidence indicates that resting heart rate (HR) is inversely related to the lifespan among homeothermic mammals and within individual species. In numerous human studies with patients stratified by resting HR, increased HR is universally associated with greater risk of death. The correlation between HR and maximum lifespan seems to be due to both basal metabolic rate and cardiovascular-related mortality risk. Both intrinsic and extrinsic factors are already postulated to determine how the biological clock works, through regulating and modulating the processes such as protein oxidation, free radical production, inflammation and telomere shortening. Given the remarkable correlation between HR and lifespan, resting HR should be seriously considered as another possible cap on maximum lifespan. Future research is needed to determine whether deliberate cardiac slowing, through methods like lifestyle modification, pharmacological intervention, or medical devices, can decelerate biological clock of aging, reduce cardiovascular mortality and increase maximum lifespan in humans in general.

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See all 139

Authors: Zhang, G. Q., & Zhang, W.
Affiliations: The University of Texas Southwestern Medical Center (US)
Corresponding author: Zhang, Weiguo
ORCID: Zhang, Weiguo
Venue: Ageing Research Reviews
Publisher: Elsevier BV
Published: 2009-01
Volume: 8
Issue: 1
Pages: 52-60
ISSN: 1568-1637 (ISSN-L)
DOI: 10.1016/j.arr.2008.10.001
OpenAlex: W2009328775
Semantic Scholar: 0ba98846db474ce32a32a0feaf7580ec7842b8e3
Cited by: 139
References: 103
Citations by year: 2026: 6 · 2025: 12 · 2024: 9 · 2023: 13 · 2022: 11 · 2021: 11 · 2020: 3 · 2019: 13 · 2018: 4 · 2017: 9 · 2016: 7 · 2015: 7 · 2014: 7 · 2013: 9 · 2012: 8
FWCI: 0.50
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Ageing Research Reviews (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart rate and cardiovascular health
Keywords: resting heart rate, lifespan, mortality risk, maximum lifespan, basal metabolic rate, cardiovascular mortality, biological clock, aging, telomere shortening, free radicals, protein oxidation, inflammation, cardiac slowing
MeSH terms: Anti-Arrhythmia Agents, Cardiovascular Diseases, Heart Rate, Humans, Longevity, Exercise, Survival Rate, Risk Assessment

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