Cited by 246Immunotherapy and Immune ResponsesImmune Response and InflammationImmune responses and vaccinations

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Impact of aging on dendritic cell functions in humans

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Agrawal, Anshu, Gupta, Sudhir·2011·Ageing Research Reviews

DOI 10.1016/j.arr.2010.06.004PMC PMC3030666

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Abstract

Aging is a paradox of reduced immunity and chronic inflammation. Dendritic cells are central orchestrators of the immune response with a key role in the generation of immunity and maintenance of tolerance. The functions of DCs are compromised with age. There is no major effect on the numbers and phenotype of DC subsets in aged subjects; nevertheless, their capacity to phagocytose antigens and migrate is impaired with age. There is aberrant cytokine secretion by various DC subsets with CDCs secreting increased basal level of pro-inflammatory cytokines but the response on stimulation to foreign antigens is decreased. In contrast, the response to self-antigens is increased suggesting erosion of peripheral self tolerance. PDC subset also secretes reduced IFN-α in response to viruses. The capacity of DCs to prime T cell responses is also affected. Aging thus has a profound affect on DC functions. Present review summarizes the effect of advancing age on DC functions in humans in the context of both immunity and tolerance.

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Authors: Agrawal, A., & Gupta, S.
Affiliations: University of California, Irvine (US)
Corresponding author: Agrawal, Anshu
Gupta, Sudhir
ORCID: Agrawal, Anshu
Gupta, Sudhir
Venue: Ageing Research Reviews
Publisher: Elsevier BV
Published: 2011-07
Volume: 10
Issue: 3
Pages: 336-345
ISSN: 1568-1637 (ISSN-L)
DOI: 10.1016/j.arr.2010.06.004
PMC: PMC3030666
OpenAlex: W2035279182
Cited by: 246
References: 119
Citations by year: 2026: 22 · 2025: 31 · 2024: 17 · 2023: 22 · 2022: 23 · 2021: 13 · 2020: 16 · 2019: 14 · 2018: 11 · 2017: 12 · 2016: 6 · 2015: 12 · 2014: 14 · 2013: 15 · 2012: 10
FWCI: 0.81
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Ageing Research Reviews (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: Ellison Medical Foundation
National Institutes of Health
National Institute on Aging (AG-027512, R21AG027512)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
Keywords: dendritic cells, aging, immunosenescence, chronic inflammation, dendritic cell migration, cytokine production, inflammatory cytokines, self-tolerance, plasmacytoid dendritic cells, interferon-alpha, T cell priming, dendritic cell subsets
MeSH terms: Aged, Aged, 80 and over, Aging, Animals, Cell Movement, Dendritic Cells, Humans, Signal Transduction, Cytokines, Models, Animal, Mice

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Impact of aging on dendritic cell functions in humans

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