Cited by 80Immunotherapy and Immune ResponsesImmune responses and vaccinationsImmune Response and Inflammation

Role of dendritic cells in innate and adaptive immune response in human aging

Gupta, Sudhir·2014·Experimental Gerontology

Abstract

Aging is associated with a progressive decline in T cell function, chronic inflammation, hyperimmunoglobulinemia, autoimmunity, poor response to vaccines, and increased susceptibility to infection as well as diseases associated with chronic inflammation. DCs in aging appear to be functionally impaired with regard to response to uptake of antigens, phagocytosis of apoptotic cells, migration, priming of CD4+ and CD8+ T cells, and production of IFN-I and IFN-III. In this review I have discussed various mechanisms, which may be responsible for impaired functions of DCs.

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Crossref · 10.1016/j.exger.2013.12.009

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72 of 72 references verified0 citation errors · 0 not checkable

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  • Circulating numbers, phenotypes, and costimulatory molecule expression of myeloid and plasmacytoid DCs appear intact in older individuals.

    “Circulating numbers of myeloid and plasmacytoid DCs, their phenotypes, and their ability to express costimulatory molecules appear to be intact in older individuals”

    From Successful and Maladaptive T Cell Aging (2017) · cites this paper as Gupta, 2014

  • Myeloid DCs from older individuals have impaired ability to endocytose and present antigen to CD4+ and CD8+ T cells.

    “myeloid (m)DCs from older individuals have impaired ability to endocytose and present antigen to CD4+ and CD8+ T cells”

    From Successful and Maladaptive T Cell Aging (2017) · cites this paper as Gupta, 2014

  • Type I IFN production in DCs from older individuals is reduced in vitro.

    “type I IFN production in DCs from older individuals is reduced”

    From Successful and Maladaptive T Cell Aging (2017) · cites this paper as Gupta, 2014

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Authors
Gupta, S.
Affiliations
University of California, Irvine (US)
Corresponding author
Gupta, Sudhir
Venue
Experimental Gerontology
Publisher
Elsevier BV
Published
2014-06
Volume
54
Pages
47-52
ISSN
0531-5565 (ISSN-L)
OpenAlex
W2057623513
Cited by
80
References
72
Citations by year
2026: 2 · 2025: 2 · 2024: 8 · 2023: 8 · 2022: 10 · 2021: 8 · 2020: 7 · 2019: 5 · 2018: 11 · 2017: 8 · 2016: 4 · 2015: 5 · 2014: 2
FWCI
0.32
Type
journal article
Language
en
Open access
closed
Locations
  • Experimental Gerontology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
  • Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
  • Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Keywords
dendritic cells, aging, innate immunity, adaptive immunity, T cell function, chronic inflammation, immunosenescence, phagocytosis of apoptotic cells, dendritic cell migration, T cell priming, type I interferon, vaccine response, autoimmunity
MeSH terms
Aging, Dendritic Cells, Disease Susceptibility, DNA, Humans, Hypergammaglobulinemia, Immunity, Innate, Autoimmunity, Cytokines, Adaptive Immunity

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