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Impact of aging on dendritic cell functions in humans
Open accessAbstract
Aging is a paradox of reduced immunity and chronic inflammation. Dendritic cells are central orchestrators of the immune response with a key role in the generation of immunity and maintenance of tolerance. The functions of DCs are compromised with age. There is no major effect on the numbers and phenotype of DC subsets in aged subjects; nevertheless, their capacity to phagocytose antigens and migrate is impaired with age. There is aberrant cytokine secretion by various DC subsets with CDCs secreting increased basal level of pro-inflammatory cytokines but the response on stimulation to foreign antigens is decreased. In contrast, the response to self-antigens is increased suggesting erosion of peripheral self tolerance. PDC subset also secretes reduced IFN-α in response to viruses. The capacity of DCs to prime T cell responses is also affected. Aging thus has a profound affect on DC functions. Present review summarizes the effect of advancing age on DC functions in humans in the context of both immunity and tolerance.
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“Moreover, their functions such as antigen presentation, endocytosis, and IFN production, are also reduced in aged individuals [145, 146].”
From Immunosenescence: a key player in cancer development (2020) · cites this paper as [145]
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“Despite comparable cell numbers, differentiation, and morphology in the young and aged, DCs from older persons exhibit impaired phagocytosis of antigen (113, 114).”
From Aging and Lung Disease (2020) · cites this paper as [113]
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Metadata
- Authors
- Agrawal, A., & Gupta, S.
- Affiliations
- University of California, Irvine (US)
- Corresponding author
- Agrawal, Anshu
- Gupta, Sudhir
- Venue
- Ageing Research Reviews
- Publisher
- Elsevier BV
- Published
- 2011-07
- Volume
- 10
- Issue
- 3
- Pages
- 336-345
- ISSN
- 1568-1637 (ISSN-L)
- PMC
- PMC3030666
- OpenAlex
- W2035279182
- Cited by
- 246
- References
- 119
- Citations by year
- 2026: 22 · 2025: 31 · 2024: 17 · 2023: 22 · 2022: 23 · 2021: 13 · 2020: 16 · 2019: 14 · 2018: 11 · 2017: 12 · 2016: 6 · 2015: 12 · 2014: 14 · 2013: 15 · 2012: 10
- FWCI
- 0.81
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Ageing Research Reviews (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Ellison Medical Foundation
- National Institutes of Health
- National Institute on Aging (AG-027512, R21AG027512)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
- Keywords
- dendritic cells, aging, immunosenescence, chronic inflammation, dendritic cell migration, cytokine production, inflammatory cytokines, self-tolerance, plasmacytoid dendritic cells, interferon-alpha, T cell priming, dendritic cell subsets
- MeSH terms
- Aged, Aged, 80 and over, Aging, Animals, Cell Movement, Dendritic Cells, Humans, Signal Transduction, Cytokines, Models, Animal, Mice
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