Impact of cellular senescence signature on ageing research

The hallmarks of cancer

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Cancer-related inflammation

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Inflammation and metabolic disorders

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A biomarker that identifies senescent human cells in culture and in aging skin in vivo.

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Telomeres shorten during ageing of human fibroblasts

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Inflamm‐aging: An Evolutionary Perspective on Immunosenescence

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Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

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The senescence-associated secretory phenotype: the dark side of tumor suppression

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Czym jest i czym nie jest starzenie komórki?

Sikora, E., Bielak-Żmijewska, A., & Mosieniak, G. (2018) · Postępy Biochemii · doi:10.18388/pb.2018_120 · Cited by 45

The Senescence Hypothesis of Disease Progression in Alzheimer Disease: an Integrated Matrix of Disease Pathways for FAD and SAD

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Aberrant Glycosylation in the Left Ventricle and Plasma of Rats with Cardiac Hypertrophy and Heart Failure

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Insight into the role of PIKK family members and NF-кB in DNAdamage-induced senescence and senescence-associated secretory phenotype of colon cancer cells

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Morphological and biochemical studies on aging and autophagy

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Epigenetic Modifications in Alzheimer's Disease: Cause or Effect?

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Anti-photoageing and anti-melanogenesis activities of chrysin

Zhu, L., Lu, Y. Q., Yu, W.-G., Zhao, X., & Lü, Y. (2016) · Pharmaceutical Biology · doi:10.1080/13880209.2016.1179334 · Cited by 39

The weakness of senescent dermal fibroblasts

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A new face of old cells: An overview about the role of senescence and telomeres in inflammatory bowel diseases

Sienkiewicz, M., Sroka, K., Binienda, A., Jurk, D., & Fichna, J. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.102083 · Cited by 39

Adult Cardiac Stem Cell Aging: A Reversible Stochastic Phenomenon?

Cianflone, E., Torella, M., Chimenti, C., Angelis, A. D., Beltrami, A. P., Urbanek, K., Rota, M., & Torella, D. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/5813147 · Cited by 40

Basal Level of Autophagy Is Increased in Aging Human Skin Fibroblasts In Vitro, but Not in Old Skin

Demirovic, D., Nizard, C., & Rattan, S. I. S. (2015) · PLoS ONE · doi:10.1371/journal.pone.0126546 · Cited by 36

Quantitative model of cell cycle arrest and cellular senescence in primary human fibroblasts

Schäuble, S., Klement, K., Marthandan, S., Münch, S., Heiland, I., Schuster, S., Hemmerich, P., & Diekmann, S. (2012) · PLoS ONE · doi:10.1371/journal.pone.0042150 · Cited by 35

Altered Processing of β-Amyloid in SH-SY5Y Cells Induced by Model Senescent Microglia

Angelova, D. M., & Brown, D. R. (2018) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.8b00334 · Cited by 36

Melatonin, tunneling nanotubes, mesenchymal cells, and tissue regeneration

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HRAS mutants identified in Costello syndrome patients can induce cellular senescence: possible implications for the pathogenesis of Costello syndrome

Niihori, T., Aoki, Y., Okamoto, N., Kurosawa, K., Ohashi, H., Mizuno, S., Kawame, H., Inazawa, J., Ohura, T., Arai, H., et al. (2011) · Journal of Human Genetics · doi:10.1038/jhg.2011.85 · Cited by 34

Nanoparticle-mediated decrease of lamin B1 pools promotes a TRF protein-based adaptive response in cultured cells

Mytych, J., Pacyk, K., Pępek, M., Żebrowski, J., Lewińska, A., & Wnuk, M. (2015) · Biomaterials · doi:10.1016/j.biomaterials.2015.02.072 · Cited by 35

Comparison of the Health Benefits of Different Eras of Japanese Foods : Lipid and Carbohydrate Metabolism Focused Research

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Hepatotoxic responses of 4-nonylphenol on African catfish (Clarias gariepinus): antixoidant and histochemical biomarkers

Abd‐Elkareem, M., Khalil, N. S. A., & Sayed, A. E. H. (2018) · Fish Physiology and Biochemistry · doi:10.1007/s10695-018-0485-1 · Cited by 35

Rejuvenation of senescent cells—The road to postponing human aging and age-related disease?

Sikora, E. (2012) · Experimental Gerontology · doi:10.1016/j.exger.2012.09.008 · Cited by 32

Light-sheet-based 2D light scattering cytometry for label-free characterization of senescent cells

Lin, M., Xu, Q., Liu, Q., Shao, C., & Su, X. (2016) · Biomedical Optics Express · doi:10.1364/boe.7.005170 · Cited by 31

Beyond the Complement Cascade: Insights into Systemic Immunosenescence and Inflammaging in Age-Related Macular Degeneration and Current Barriers to Treatment

Khan, A. H., Chowers, I., & Lotery, A. J. (2023) · Cells · doi:10.3390/cells12131708 · Cited by 31

Atherosclerotic disease in octogenarians: A challenge for science and clinical practice

de Freitas, W. M., de Carvalho, L. S. F., Moura, F. A., & Sposito, A. C. (2012) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2012.06.070 · Cited by 29

Explaining differences in the lifespan and replicative capacity of cells: a general model and comparative analysis of vertebrates

Gillooly, J. F., Hayward, A., Hou, C., & Burleigh, J. G. (2012) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.2012.1129 · Cited by 29

MicroRNA and Senescence: The Senectome, Integration and Distributed Control

Bilsland, A. E., Revie, J., & Keith, W. N. (2013) · Critical Reviews™ in Oncogenesis · doi:10.1615/critrevoncog.2013007197 · Cited by 30

The Intricate Interplay between Mechanisms Underlying Aging and Cancer

Piano, A. (2014) · Aging and Disease · doi:10.14336/ad.2014.0209 · Cited by 28

Identification of early-onset photoreceptor degeneration in transgenic mouse models of Alzheimer's disease

Zhang, J., Gao, F., Ma, Y., Xue, T., & Shen, Y. (2021) · iScience · doi:10.1016/j.isci.2021.103327 · Cited by 28

Inhibition of Cardiac Hypertrophy Effects in D‐Galactose‐Induced Senescent Hearts by Alpinate Oxyphyllae Fructus Treatment

Chang, Y., Chang, H., Lin, H.-J., Tsai, C., Tsai, C.-T., Chang, H.-N., Lin, S.-L., PadmaViswanadha, V., Chen, R., & Huang, C. (2017) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2017/2624384 · Cited by 28

Model Senescent Microglia Induce Disease Related Changes in α-Synuclein Expression and Activity

Angelova, D. M., & Brown, D. R. (2018) · Biomolecules · doi:10.3390/biom8030067 · Cited by 30

UNC5B Promotes Vascular Endothelial Cell Senescence via the ROS‐Mediated P53 Pathway

Yang, Z. L., Li, H., Luo, P., Yan, D., Yang, N., Zhang, Y., Huang, Y., Liu, Y., Zhang, L., Yan, J., et al. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/5546711 · Cited by 27

Articular Cartilage Aging-Potential Regenerative Capacities of Cell Manipulation and Stem Cell Therapy

Krajewska–Włodarczyk, M., Owczarczyk-Saczonek, A. B., Placek, W. J., Osowski, A., & Wojtkiewicz, J. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19020623 · Cited by 27

Adaptive changes induced by noble-metal nanostructures in vitro and in vivo

Huang, Q., Zhang, J., Zhang, Y., Timashev, P. S., Ma, X., & Liang, X. (2020) · Theranostics · doi:10.7150/thno.42569 · Cited by 26

Inhibition of NADPH Oxidases Activity by Diphenyleneiodonium Chloride as a Mechanism of Senescence Induction in Human Cancer Cells

Piszczatowska, K., Przybylska, D., Sikora, E., & Mosieniak, G. (2020) · Antioxidants · doi:10.3390/antiox9121248 · Cited by 26

Inorganic arsenic exposure-induced premature senescence and senescence-associated secretory phenotype (SASP) in human hepatic stellate cells

Okamura, K., Sato, M., Suzuki, T., & Nohara, K. (2022) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2022.116231 · Cited by 26

Fiji-Based Tool for Rapid and Unbiased Analysis of SA-β-Gal Activity in Cultured Cells

Krzystyniak, A., Głuchowska, A., Mosieniak, G., & Sikora, E. (2023) · Biomolecules · doi:10.3390/biom13020362 · Cited by 24

Non-Coding RNAs in Cardiac Aging

Wang, H., Bei, Y., Shi, J., Xiao, J., & Kong, X. (2015) · Cellular Physiology and Biochemistry · doi:10.1159/000430141 · Cited by 26

Gas6 Delays Senescence in Vascular Smooth Muscle Cells through the PI3K/ Akt/FoxO Signaling Pathway

Jin, C.-W., Wang, H., Chen, Y., Tang, M., Fan, G., Wang, Z., Li, L., Zhang, Y., Zhang, W., & Zhong, M. (2015) · Cellular Physiology and Biochemistry · doi:10.1159/000373940 · Cited by 25

Magnesium Lithospermate B fromSalvia miltiorrhizaB unge Ameliorates Aging‐Induced Renal Inflammation and SenescenceviaNADPH Oxidase‐Mediated Reactive Oxygen Generation

Park, C. H., Shin, S. H., Lee, E. K., Kim, S., Kim, M., Roh, S., Yokozawa, T., & Chung, H. Y. (2017) · Phytotherapy Research · doi:10.1002/ptr.5789 · Cited by 24

Accumulation of annexin A5 at the nuclear envelope is a biomarker of cellular aging

Klement, K., Melle, C., Murzik, U., Diekmann, S., Norgauer, J., & Hemmerich, P. H. (2012) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2012.06.003 · Cited by 25

Inhibitory effect of vitamin C on intrinsic aging in human dermal fibroblasts and hairless mice

Jeong, J.-H., Kim, M., Kim, C., & Hwang, J. (2017) · Food Science and Biotechnology · doi:10.1007/s10068-017-0252-6 · Cited by 25

Anti-aging formula protects skin from oxidative stress-induced senescence through the inhibition of CXCR2 expression

Zhu, S., Jia, L., Wang, X., Liu, T., Qin, W., Ma, H., Lv, Y., Hu, J., Guo, Q., Tan, S., et al. (2023) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2023.116996 · Cited by 24

Testing of geroprotectors in experiments on cell cultures: Choosing the correct model system

Khokhlov, A. N., Клебанов, А. А., Karmushakov, A. F., Shilovsky, G. A., Nasonov, M. M., & Васильевна, М. Г. (2014) · Moscow University Biological Sciences Bulletin · doi:10.3103/s0096392514020035 · Cited by 23

Shining the Light on Senescence Associated LncRNAs

Ghanam, A. R., Xu, Q., Ke, S., Azhar, M., Cheng, Q., & Song, X. (2017) · Aging and Disease · doi:10.14336/ad.2016.0810 · Cited by 23

Declined adipogenic potential of senescent MSCs due to shift in insulin signaling and altered exosome cargo

Voynova, E., Kulebyakin, K. Y., Grigorieva, O., Novoseletskaya, E. S., Basalova, N. A., Alexandrushkina, N., Arbatskiy, M. S., Vigovskiy, M. A., Sorokina, A., Zinoveva, A., et al. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.1050489 · Cited by 23

Application of Yeast to Study the Tau and Amyloid-β Abnormalities of Alzheimer's Disease

Porzoor, A., & Macreadie, I. G. (2013) · Journal of Alzheimer s Disease · doi:10.3233/jad-122035 · Cited by 22

Cardiac Stem Cells: Biology and Clinical Applications

Goichberg, P., Chang, J., Liao, R., & Leri, A. (2014) · Antioxidants and Redox Signaling · doi:10.1089/ars.2014.5875 · Cited by 24

Nuclear ribonucleoprotein-containing foci increase in size in non-dividing cells from patients with myotonic dystrophy type 2

Giagnacovo, M., Malatesta, M., Cardani, R., Meola, G., & Pellicciari, C. (2012) · Histochemistry and Cell Biology · doi:10.1007/s00418-012-0984-6 · Cited by 21

Persistent Amplification of DNA Damage Signal Involved in Replicative Senescence of Normal Human Diploid Fibroblasts

Suzuki, M., Suzuki, K., Kodama, S., Yamashita, S., & Watanabe, M. (2012) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2012/310534 · Cited by 21

The role of autophagy in escaping therapy-induced polyploidy/senescence

Dudkowska, M., Staniak, K., Bojko, A., & Sikora, E. (2021) · Advances in cancer research · doi:10.1016/bs.acr.2021.01.004 · Cited by 21

The Growth Suppression Activity of Diosmin and PGV-1 Co-Treatment on 4T1 Breast Cancer Targets Mitotic Regulatory Proteins

Musyayyadah, H., Wulandari, F., Nangimi, A. F., Anggraeni, A., Ikawati, M., & Meiyanto, E. (2021) · Asian Pacific Journal of Cancer Prevention · doi:10.31557/apjcp.2021.22.9.2929 · Cited by 21

miR‐181b regulates vascular endothelial aging by modulating an MAP3K3 signaling pathway

Zhou, H., Yang, D., Cheng, H. S., McCoy, M. G., Pérez‐Cremades, D., Haemmig, S., Wong, D., Chen, L., & Feinberg, M. W. (2022) · The FASEB Journal · doi:10.1096/fj.202200046r · Cited by 21

Promyelocytic Leukemia (PML) Protein Plays Important Roles in Regulating Cell Adhesion, Morphology, Proliferation and Migration

Tang, F. M. K., Liang, Y., Chan, J. Y. H., Wong, S. W., Chen, E., Yao, Y., Gan, J., Xiao, L., Leung, H. C., Kung, H. F., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0059477 · Cited by 20

γH2AX is increased in peripheral blood lymphocytes of Alzheimer’s disease patients in the South Australian Neurodegeneration, Nutrition and DNA Damage (SAND) study of aging

Siddiqui, M. S., Francois, M., Hecker, J., Faunt, J., Fenech, M. F., & Leifert, W. R. (2018) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/j.mrgentox.2018.03.001 · Cited by 20

c-Myc activation promotes cofilin-mediated F-actin cytoskeleton remodeling and telomere homeostasis as a response to oxidant-based DNA damage in medulloblastoma cells

Lewińska, A., Klukowska‐Rötzler, J., Deręgowska, A., Adamczyk‐Grochala, J., & Wnuk, M. (2019) · Redox Biology · doi:10.1016/j.redox.2019.101163 · Cited by 20

The biological mechanism and emerging therapeutic interventions of liver aging

Wang, W., Xu, K., Shang, M., Li, X., Tong, X., Liu, Z., Zhou, L., & Zheng, S. (2023) · International Journal of Biological Sciences · doi:10.7150/ijbs.87679 · Cited by 20

On Deep Landscape Exploration of COVID-19 Patients Cells and Severity Markers

Vázquez-Jiménez, A., de León, U. A.-P., Matadamas-Guzman, M. L., Muciño-Olmos, E. A., Martínez-López, Y. E., Escobedo-Tapia, T., & Reséndis-Antonio, O. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.705646 · Cited by 18

Evolution of the term “cellular senescence” and its impact on the current cytogerontological research

Khokhlov, A. N. (2013) · Moscow University Biological Sciences Bulletin · doi:10.3103/s0096392513040123 · Cited by 18

Diet-induced weight loss is sufficient to reduce senescent cell number in white adipose tissue of weight-cycled mice

List, E. O., Jensen, E., Kowalski, J., Buchman, M., Berryman, D. E., & Kopchick, J. J. (2016) · Nutrition and Healthy Aging · doi:10.3233/nha-1614 · Cited by 18

Aging Effects on Cardiac Progenitor Cell Physiology

Rota, M., Goichberg, P., Anversa, P., & Leri, A. (2015) · Comprehensive physiology · doi:10.1002/cphy.c140082 · Cited by 22

Increased Age Is Associated With Epigenetic and Structural Changes in Chromatin From Neuronal Nuclei

Rodrigues, H. F., de Souza, T. A., Ghiraldini, F. G., Mello, M. L. S., & Moraes, A. D. S. (2013) · Journal of Cellular Biochemistry · doi:10.1002/jcb.24705 · Cited by 17

Effects of ginsenoside Rg1 on the senescence of vascular smooth muscle cells

Li, S. G., Yan, M., Zhang, D., Ye, M., & Deng, J. J. (2016) · Genetics and Molecular Research · doi:10.4238/gmr.15038409 · Cited by 17

Risk factors of using late-autophagy inhibitors: Aspects to consider when combined with anticancer therapies

Skrzeszewski, M., Maciejewska, M., Kobza, D., Gawrylak, A., Kiéda, C., & Waś, H. (2024) · Biochemical Pharmacology · doi:10.1016/j.bcp.2024.116277 · Cited by 17

[Hormesis: What doesn't kill you makes you stronger].

López‐Díazguerrero, N. E., González‐Puertos, V. Y., Hernández-Bautista, R., Alarcón‐Aguilar, A., Luna‐López, A., & Fainstein, M. K. (2013) · PubMed · Cited by 16

CD34+ cells from patients with myelodysplastic syndrome present different p21 dependent premature senescence

Xiao, Y., Wang, J., Song, H. K., Zou, P., Zhou, D., & Liu, L. (2012) · Leukemia Research · doi:10.1016/j.leukres.2012.11.006 · Cited by 16

Effect of persistent activation of phosphoinositide 3-kinase on heart

Niizuma, S., Inuzuka, Y., Okuda, J., Kato, T., Kawashima, T., Tamaki, Y., Iwanaga, Y., Yoshida, Y., Kosugi, R., Watanabe-Maeda, K., et al. (2012) · Life Sciences · doi:10.1016/j.lfs.2012.02.010 · Cited by 14

Signs of Similarities and Differences in Cellular Models of Aging: A Scoping Review

Васильевна, М. Г., & Khokhlov, A. N. (2022) · Moscow University Biological Sciences Bulletin · doi:10.3103/s0096392522030087 · Cited by 14

Senescence-associated β-galactosidase—A biomarker of aging, DNA damage, or cell proliferation restriction?

Васильевна, М. Г., Колесников, А. В., Клебанов, А. А., & Khokhlov, A. N. (2015) · Moscow University Biological Sciences Bulletin · doi:10.3103/s0096392515040082 · Cited by 14

Global mapping of transcription factor motifs in human aging

Alfego, D., Rodeck, U., & Kriete, A. (2018) · PLoS ONE · doi:10.1371/journal.pone.0190457 · Cited by 13

Snake venoms promote stress‐induced senescence in human fibroblasts

Lewińska, A., Bocian, A., Petrilla, V., Adamczyk‐Grochala, J., Szymura, K., Hendzel, W., Kaleniuk, E., Hus, K. K., Petrillová, M., & Wnuk, M. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.27382 · Cited by 13

The Role of Nibrin in Doxorubicin-Induced Apoptosis and Cell Senescence in Nijmegen Breakage Syndrome Patients Lymphocytes

Alster, O., Bielak-Żmijewska, A., Mosieniak, G., Moreno‐Villanueva, M., Dudka, W., Wojtala, A., Kusio-Kobiałka, M., Korwek, Z., Bürkle, A., Piwocka, K., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0104964 · Cited by 13

Telomere dysfunction and tumor suppression responses in dyskeratosis congenita: Balancing cancer and tissue renewal impairment

Hartwig, F. P., & Collares, T. V. (2013) · Ageing Research Reviews · doi:10.1016/j.arr.2013.03.003 · Cited by 11

Cell proliferation arrest and redox state status as part of different stages during senescence establishment in mouse fibroblasts

Triana-Martínez, F., López‐Díazguerrero, N. E., Maciel-Barón, L. Á., Morales-Rosales, S. L., Galván‐Arzate, S., Fernández, F. J., Zentella‐Dehesa, A., Pérez, V., Gómez-Quiroz, L. E., & Königsberg, M. (2013) · Biogerontology · doi:10.1007/s10522-013-9488-6 · Cited by 12

Effects of Differentiation and Antisenescence from BMSCs to Hepatocy-Like Cells of the PAAm-IGF-1/TNF-α Biomaterial

Yang, R., Wu, L., Chen, J., Chen, W., Zhang, L., Zhang, L., You, R., Yin, L., Li, C., & Guan, Y. (2016) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.6b10377 · Cited by 12

Long-term arsenite exposure induces premature senescence in B cell lymphoma A20 cells

Okamura, K., & Nohara, K. (2015) · Archives of Toxicology · doi:10.1007/s00204-015-1500-2 · Cited by 12

The key role of PML in IFN-α induced cellular senescence of human mesenchymal stromal cells

Fu, S., Wei, J., WANG, G., Wang, B., Wang, Y., Lai, X., & Huang, H. (2014) · International Journal of Oncology · doi:10.3892/ijo.2014.2738 · Cited by 13

Intervention in Genotoxic Stress–Induced Senescence by Cordycepin Through Activation of eIF2α and Suppression of Sp1

Gu, L., Johno, H., Nakajima, S., Yoshitomi, T., Takahashi, S., & Kitamura, M. (2013) · Toxicological Sciences · doi:10.1093/toxsci/kft111 · Cited by 12

The role of gender and labour status in immunosenescence of 65+ Polish population

Dudkowska, M., Janiszewska, D., Karpa, A., Broczek, K., Dabrowski, M., & Sikora, E. (2017) · Biogerontology · doi:10.1007/s10522-017-9702-z · Cited by 11

E2FBP1 antagonizes the p16INK4A‐Rb tumor suppressor machinery for growth suppression and cellular senescence by regulating promyelocytic leukemia protein stability

Fukuyo, Y., Takahashi, A., Hara, E., Horikoshi, N., Pandita, T. K., & Nakajima, T. (2011) · International Journal of Oral Science · doi:10.4248/ijos11071 · Cited by 11

The Role of Nrf2 in D-Galactose-Induced Cardiac Aging in Mice: Involvement of Oxidative Stress

Yang, X., Jia, J., Ding, L., Yu, Z., & Qu, C. (2020) · Gerontology · doi:10.1159/000510470 · Cited by 11

Multiple time-series expression trajectories imply dynamic functional changes during cellular senescence

Ge, M., Yu, Q., Li, G., Yang, L., He, Y., Li, J., & Kong, Q. (2022) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2022.08.005 · Cited by 12

Palbociclib-Induced Cellular Senescence Is Modulated by the mTOR Complex 1 and Autophagy

Cayo, Á., Venturini, W., Rebolledo-Mira, D., Moore‐Carrasco, R., Herrada, A. A., Nova‐Lamperti, E., Valenzuela, C. A., & Brown, N. E. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24119284 · Cited by 11

Focusing the spotlight on GSK-3 in aging

Zhou, J., & Force, T. L. (2013) · Aging · doi:10.18632/aging.100568 · Cited by 11

Hepatic Global Transcriptomic Profiles of Holstein Cows According to Parity Reveal Age-Related Changes in Early Lactation

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What will happen to molecular and cellular biomarkers of aging in case its program is canceled (provided such a program does exist)?

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