Impact of cellular senescence signature on ageing research

The hallmarks of cancer

Hanahan, D., & Weinberg, R. A. (2000) · Cell · doi:10.1016/s0092-8674(00)81683-9 · Cited by 29,219

Cancer-related inflammation

Mantovani, A., Allavena, P., Sica, A., & Balkwill, F. (2008) · Nature · doi:10.1038/nature07205 · Cited by 11,399

Inflammation and metabolic disorders

Hotamisligil, G. S. (2006) · Nature · doi:10.1038/nature05485 · Cited by 9,199

The serial cultivation of human diploid cell strains

Hayflick, L., & Moorhead, P. S. (1961) · Experimental Cell Research · doi:10.1016/0014-4827(61)90192-6 · Cited by 8,508

A biomarker that identifies senescent human cells in culture and in aging skin in vivo.

Dimri, G. P., Lee, X., Basile, G., Acosta, M., Scott, G., Roskelley, C., Medrano, E. E., Linskens, M., Rubelj, I., & Pereira-Smith, O. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.20.9363 · Cited by 7,477

The DNA-damage response in human biology and disease

Jackson, S. P., & Bartek, J. (2009) · Nature · doi:10.1038/nature08467 · Cited by 6,092

Telomeres shorten during ageing of human fibroblasts

Harley, C. B., Futcher, A. B., & Greider, C. W. (1990) · Nature · doi:10.1038/345458a0 · Cited by 5,750

Inflamm‐aging: An Evolutionary Perspective on Immunosenescence

FRANCESCHI, C., BONAFÈ, M., VALENSIN, S., OLIVIERI, F., DE LUCA, M., OTTAVIANI, E., & DE BENEDICTIS, G. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb06651.x · Cited by 5,358

Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

Serrano, M., Lin, A. W., McCurrach, M. E., Beach, D., & Lowe, S. W. (1997) · Cell · doi:10.1016/s0092-8674(00)81902-9 · Cited by 5,218

The senescence-associated secretory phenotype: the dark side of tumor suppression

Coppé, J.-P., Desprez, P.-Y., Krtolica, A., & Campisi, J. (2010) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev-pathol-121808-102144 · Cited by 5,206

Emerging role of NF-κB signaling in the induction of senescence-associated secretory phenotype (SASP)

Salminen, A., Kauppinen, A., & Kaarniranta, K. (2012) · Cellular Signalling · doi:10.1016/j.cellsig.2011.12.006 · Cited by 763

Effects of increased paternal age on sperm quality, reproductive outcome and associated epigenetic risks to offspring

Sharma, R. K., Agarwal, A. K., Rohra, V. K., Assidi, M., Abu-Elmagd, M. M., & Turki, R. F. (2015) · Reproductive Biology and Endocrinology · doi:10.1186/s12958-015-0028-x · Cited by 486

Specific lipofuscin staining as a novel biomarker to detect replicative and stress-induced senescence. A method applicable in cryo-preserved and archival tissues

Georgakopoulou, E., Tsimaratou, K., Evangelou, K., Fernandez, M.-P., Zoumpourlis, V, Trougakos, I., Kletsas, D., Bartek, J., Serrano, M., & Gorgoulis, V. (2012) · Aging · doi:10.18632/aging.100527 · Cited by 390

Inflammaging decreases adaptive and innate immune responses in mice and humans

Frasca, D., & Blomberg, B. B. (2016) · Biogerontology · doi:10.1007/s10522-015-9578-8 · Cited by 357

Astrocytes in the aging brain express characteristics of senescence-associated secretory phenotype: Astrocyte senescence in aging brain

Salminen, A., Ojala, J., Kaarniranta, K., Haapasalo, A., Hiltunen, M., & Soininen, H. (2011) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2011.07738.x · Cited by 333

Targeting Janus Kinases and Signal Transducer and Activator of Transcription 3 To Treat Inflammation, Fibrosis, and Cancer: Rationale, Progress, and Caution

Bharadwaj, U., Kasembeli, M. M., Robinson, P., & Tweardy, D. J. (2020) · Pharmacological Reviews · doi:10.1124/pr.119.018440 · Cited by 314

Molecular mechanisms of aging and anti-aging strategies

Li, Y., Tian, X., Luo, J., Bao, T., Wang, S., & Wu, X. (2024) · Cell Communication and Signaling · doi:10.1186/s12964-024-01663-1 · Cited by 380

Persistent γH2AX: A promising molecular marker of DNA damage and aging

Siddiqui, M. S., François, M., Fenech, M. F., & Leifert, W. R. (2015) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2015.07.001 · Cited by 277

MiR-146a as marker of senescence-associated pro-inflammatory status in cells involved in vascular remodelling

Olivieri, F., Lazzarini, R., Recchioni, R., Marcheselli, F., Rippo, M. R., Nuzzo, S., Albertini, M. C., Graciotti, L., Babini, L., Mariotti, S., et al. (2012) · AGE · doi:10.1007/s11357-012-9440-8 · Cited by 206

MicroRNAs linking inflamm-aging, cellular senescence and cancer

Olivieri, F., Rippo, M. R., Monsurrò, V., Salvioli, S., Capri, M., Procopio, A. D., & Franceschi, C. (2013) · Ageing Research Reviews · doi:10.1016/j.arr.2013.05.001 · Cited by 210

Assessing cell and organ senescence biomarkers

de Jesus, B. B., & Blasco, M. A. (2012) · Circulation Research · doi:10.1161/circresaha.111.247866 · Cited by 187

Intrinsic skin aging: the role of oxidative stress.

Poljšak, B., Dahmane, R. G., & Godić, A. (2012) · PubMed · Cited by 195

Receptor for advanced glycation end-products promotes premature senescence of proximal tubular epithelial cells via activation of endoplasmic reticulum stress-dependent p21 signaling

Liu, J., Huang, K., Cai, G.-Y., Chen, X.-M., Yang, J.-R., Lin, L.-R., Yang, J., Huo, B.-G., Zhan, J., & He, Y.-N. (2014) · Cellular Signalling · doi:10.1016/j.cellsig.2013.10.002 · Cited by 181

Senescence in chronic liver disease: Is the future in aging?

Aravinthan, A. D., & Alexander, G. J. M. (2016) · Journal of Hepatology · doi:10.1016/j.jhep.2016.05.030 · Cited by 174

Beclin 1 interactome controls the crosstalk between apoptosis, autophagy and inflammasome activation: Impact on the aging process

Salminen, A., Kaarniranta, K., & Kauppinen, A. (2013) · Ageing Research Reviews · doi:10.1016/j.arr.2012.11.004 · Cited by 173

IL-6-STAT3 signaling and premature senescence

Kojima, H., Inoue, T., Kunimoto, H., & Nakajima, K. (2013) · JAK-STAT · doi:10.4161/jkst.25763 · Cited by 170

Human peripheral late/exhausted memory B cells express a senescent-associated secretory phenotype and preferentially utilize metabolic signaling pathways

Frasca, D., Diaz, A., Romero, M., & Blomberg, B. B. (2017) · Experimental Gerontology · doi:10.1016/j.exger.2016.12.001 · Cited by 160

Curcumin induces permanent growth arrest of human colon cancer cells: Link between senescence and autophagy

Mosieniak, G., Adamowicz, M., Alster, O., Jaskowiak, H., Szczepankiewicz, A. A., Wilczynski, G. M., Ciechomska, I. A., & Sikora, E. (2012) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2012.05.004 · Cited by 160

Polyploidy Formation in Doxorubicin-Treated Cancer Cells Can Favor Escape from Senescence

Mosieniak, G., Śliwińska, M. A., Alster, O., Strzeszewska, A., Sunderland, P., Piechota, M. J., Waś, H., & Sikora, E. (2015) · Neoplasia · doi:10.1016/j.neo.2015.11.008 · Cited by 165

Is senescence-associated β-galactosidase a marker of neuronal senescence?

Piechota, M. J., Sunderland, P., Wysocka, A., Nalberczak‐Skóra, M., Śliwińska, M. A., Radwańska, K., & Sikora, E. (2016) · Oncotarget · doi:10.18632/oncotarget.12752 · Cited by 163

Microglia change from a reactive to an age-like phenotype with the time in culture

Caldeira, C., Oliveira, A. F., Cunha, C., Vaz, A. R., Falcão, A. S., Fernandes, A., & Brites, D. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00152 · Cited by 156

Cellular senescence in the aging retina and developments of senotherapies for age-related macular degeneration

Lee, K. S., Lin, S., Copland, D. A., Dick, A. D., & Liu, J. (2021) · Journal of Neuroinflammation · doi:10.1186/s12974-021-02088-0 · Cited by 150

Impact of Advanced Paternal Age on Fertility and Risks of Genetic Disorders in Offspring

Kaltsas, A., Moustakli, E., Zikopoulos, A., Georgiou, I. A., Dimitriadis, F., Symeonidis, E. N., Markou, E., Michaelidis, T. M., Tien, D. M. B., Giannakis, I., et al. (2023) · Genes · doi:10.3390/genes14020486 · Cited by 161

Molecular links between cellular senescence, longevity and age-related diseases – a systems biology perspective

Tăcutu, R., Budovsky, A., Yanai, H., & Fraifeld, V. E. (2011) · Aging · doi:10.18632/aging.100413 · Cited by 146

Rhizoma Coptidis and Berberine as a Natural Drug to Combat Aging and Aging-Related Diseases via Anti-Oxidation and AMPK Activation

Xu, Z., Feng, W., Shen, Q., Yu, N., Yu, K., Wang, S., Chen, Z., Shioda, S., & Guo, Y. (2017) · Aging and Disease · doi:10.14336/ad.2016.0620 · Cited by 148

A comparison of replicative senescence and doxorubicin-induced premature senescence of vascular smooth muscle cells isolated from human aorta

Bielak-Zmijewska, A., Wnuk, M., Przybylska, D., Grabowska, W., Lewinska, A., Alster, O., Korwek, Z., Cmoch, A., Myszka, A., Pikula, S., et al. (2014) · Biogerontology · doi:10.1007/s10522-013-9477-9 · Cited by 139

The Role of Curcumin in the Modulation of Ageing

Bielak-Żmijewska, A., Grabowska, W., Ciolko, A., Bojko, A., Mosieniak, G., Bijoch, Ł., & Sikora, E. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20051239 · Cited by 146

The Telomere/Telomerase System in Chronic Inflammatory Diseases. Cause or Effect?

Kordinas, V., Ioannidis, A., & Chatzipanagiotou, S. (2016) · Genes · doi:10.3390/genes7090060 · Cited by 146

Toll like receptor signaling in “inflammaging”: microRNA as new players

Olivieri, F., Rippo, M. R., Prattichizzo, F., Babini, L., Graciotti, L., Recchioni, R., & Procopio, A. D. (2013) · Immunity & Ageing · doi:10.1186/1742-4933-10-11 · Cited by 141

Escherichia coli Producing Colibactin Triggers Premature and Transmissible Senescence in Mammalian Cells

Sécher, T., Samba‐Louaka, A., Oswald, É., & Nougayrède, J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0077157 · Cited by 146

Ursolic acid-mediated changes in glycolytic pathway promote cytotoxic autophagy and apoptosis in phenotypically different breast cancer cells

Lewińska, A., Adamczyk‐Grochala, J., Kwasniewicz, E., Deręgowska, A., & Wnuk, M. (2017) · APOPTOSIS · doi:10.1007/s10495-017-1353-7 · Cited by 122

Effects of d ‐galactose‐induced ageing on the heart and its potential interventions

Bo‐Htay, C., Palee, S., Apaijai, N., Chattipakorn, S. C., & Chattipakorn, N. (2018) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.13472 · Cited by 122

SIRT1 ameliorates age-related senescence of mesenchymal stem cells via modulating telomere shelterin

Chen, H., Liu, X., Zhu, W., Chen, H., Hu, X., Jiang, Z., Xu, Y., Wang, L., Zhou, Y., Chen, P., et al. (2014) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2014.00103 · Cited by 119

A common signature of cellular senescence; does it exist?

Sikora, E., Bielak-Żmijewska, A., & Mosieniak, G. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101458 · Cited by 124

Key Aging-Associated Alterations in Primary Microglia Response to Beta-Amyloid Stimulation

Caldeira, C., Cunha, C., Vaz, A. R., Falcão, A. S., Barateiro, A., Seixas, E., Fernandes, A., & Brites, D. (2017) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2017.00277 · Cited by 117

The STAT3-IGFBP5 axis is critical for IL-6/gp130-induced premature senescence in human fibroblasts

Kojima, H., Kunimoto, H., Inoue, T., & Nakajima, K. (2012) · Cell Cycle · doi:10.4161/cc.11.4.19172 · Cited by 120

Effects of (−)-epicatechin on molecular modulators of skeletal muscle growth and differentiation

Gutiérrez-Salmeán, G., Ciaraldi, T. P., Nogueira, L., Barboza, J., Taub, P. R., Hogan, M. C., Henry, R. R., Meaney, E., Villarreal, F. J., Ceballos, G. M., et al. (2013) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2013.09.007 · Cited by 113

Cellular Senescence - its role in cancer and the response to ionizing radiation

Sabin, R. J., & Anderson, R. M. (2011) · Genome Integrity · doi:10.1186/2041-9414-2-7 · Cited by 123

PGC-1α protects RPE cells of the aging retina against oxidative stress-induced degeneration through the regulation of senescence and mitochondrial quality control. The significance for AMD pathogenesis

Kaarniranta, K., Kajdanek, J., Morawiec, J., Pawlowska, E., & Blasiak, J. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19082317 · Cited by 112

Noncancerous disease-targeting AIEgens

Duo, Y., Luo, G., Zhang, W., Wang, R., Xiao, G. G., Li, Z., Li, X., Chen, M., Yoon, J., & Tang, B. Z. (2023) · Chemical Society Reviews · doi:10.1039/d2cs00610c · Cited by 106

Conserved senescence associated genes and pathways in primary human fibroblasts detected by RNA-seq

Marthandan, S., Baumgart, M., Priebe, S., Groth, M., Schaer, J., Kaether, C., Guthke, R., Cellerino, A., Platzer, M., Diekmann, S., et al. (2016) · PLOS ONE · doi:10.1371/journal.pone.0154531 · Cited by 91

The role of myeloid-derived suppressor cells (MDSC) in the inflammaging process

Salminen, A., Kaarniranta, K., & Kauppinen, A. (2018) · Ageing Research Reviews · doi:10.1016/j.arr.2018.09.001 · Cited by 101

Morphological and Functional Characteristic of Senescent Cancer Cells

Sikora, E., Mosieniak, G., & Śliwińska, M. A. (2016) · Current Drug Targets · doi:10.2174/1389450116666151019094724 · Cited by 102

Curcumin induces G2/M arrest and triggers autophagy, ROS generation and cell senescence in cervical cancer cells

Wang, T., Wu, X., Rudaisat, M. A., Song, Y., & Cheng, H. (2020) · Journal of Cancer · doi:10.7150/jca.45176 · Cited by 98

Cellular Senescence in Ageing, Age-Related Disease and Longevity

Sikora, E., Bielak-Żmijewska, A., & Mosieniak, G. (2013) · Current Vascular Pharmacology · doi:10.2174/1570161111666131219094045 · Cited by 92

Ginger (Zingiber officinale Roscoe) in the Prevention of Ageing and Degenerative Diseases: Review of Current Evidence

Sahardi, N. F. N. M., & Makpol, S. (2019) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2019/5054395 · Cited by 101

Diosmin-induced senescence, apoptosis and autophagy in breast cancer cells of different p53 status and ERK activity

Lewińska, A., Adamczyk‐Grochala, J., Kwasniewicz, E., Deręgowska, A., & Wnuk, M. (2016) · Toxicology Letters · doi:10.1016/j.toxlet.2016.11.018 · Cited by 92

Cellular Senescence in Age‐Related Macular Degeneration: Can Autophagy and DNA Damage Response Play a Role?

Błasiak, J., Piechota, M. J., Pawłowska, E., Szatkowska, M., Sikora, E., & Kaarniranta, K. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/5293258 · Cited by 94

mTOR Activity and Autophagy in Senescent Cells, a Complex Partnership

Cayo, Á., Segovia, R., Venturini, W., Moore‐Carrasco, R., Valenzuela, C. A., & Brown, N. E. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22158149 · Cited by 96

Immunosenescence in monocytes, macrophages, and dendritic cells: Lessons learned from the lung and heart

Linton, P., & Thoman, M. L. (2014) · Immunology Letters · doi:10.1016/j.imlet.2014.06.017 · Cited by 87

Nampt Expression Decreases Age-Related Senescence in Rat Bone Marrow Mesenchymal Stem Cells by Targeting Sirt1

Ma, C., Pi, C., Yang, Y. J., Lin, L., Shi, Y., Li, Y., Li, Y., & He, X. (2017) · PLoS ONE · doi:10.1371/journal.pone.0170930 · Cited by 86

Metabolic requirements of human pro-inflammatory B cells in aging and obesity

Frasca, D., Diaz, A., Romero, M., Thaller, S. R., & Blomberg, B. B. (2019) · PLoS ONE · doi:10.1371/journal.pone.0219545 · Cited by 87

Myeloid-derived suppressor cells (MDSC): an important partner in cellular/tissue senescence

Salminen, A., Kauppinen, A., & Kaarniranta, K. (2018) · Biogerontology · doi:10.1007/s10522-018-9762-8 · Cited by 84

Autophagy Dysfunction, Cellular Senescence, and Abnormal Immune-Inflammatory Responses in AMD: From Mechanisms to Therapeutic Potential

Wang, S., Wang, X., Cheng, Y., Ouyang, W., Sang, X., Liu, J., Su, Y., Liu, Y., Li, C., Yang, L., et al. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/3632169 · Cited by 83

Adipogenic Differentiation Is Impaired in Replicative Senescent Human Subcutaneous Adipose-Derived Stromal/Progenitor Cells

Mitterberger, M. C., Lechner, S., Mattesich, M., & Zwerschke, W. (2013) · The Journals of Gerontology Series A · doi:10.1093/gerona/glt043 · Cited by 85

Senescent B cells in aging and age-related diseases: Their role in the regulation of antibody responses

Frasca, D. (2018) · Experimental Gerontology · doi:10.1016/j.exger.2017.07.002 · Cited by 82

Is DNA damage indispensable for stress-induced senescence?

Bielak-Żmijewska, A., Mosieniak, G., & Sikora, E. (2017) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2017.08.004 · Cited by 86

Transgenic overexpression of macrophage matrix metalloproteinase-9 exacerbates age-related cardiac hypertrophy, vessel rarefaction, inflammation, and fibrosis

Toba, H., Cannon, P. L., Yabluchanskiy, A., Iyer, R. P., D'Armiento, J. M., & Lindsey, M. L. (2016) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00633.2016 · Cited by 76

Tackling Salinity in Sustainable Agriculture—What Developing Countries May Learn from Approaches of the Developed World

Shokat, S., & Großkinsky, D. K. (2019) · Sustainability · doi:10.3390/su11174558 · Cited by 74

Feed-forward regulation between cellular senescence and immunosuppression promotes the aging process and age-related diseases

Salminen, A. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101280 · Cited by 77

The gut microbiota metabolite urolithin A, but not other relevant urolithins, induces p53-dependent cellular senescence in human colon cancer cells

Giménez‐Bastida, J. A., Ávila‐Gálvez, M. Á., Espín, J. C., & González‐Sarrías, A. (2020) · Food and Chemical Toxicology · doi:10.1016/j.fct.2020.111260 · Cited by 76

Cellular senescence: a hitchhiker’s guide

Aravinthan, A. D. (2015) · Human Cell · doi:10.1007/s13577-015-0110-x · Cited by 83

Radiation-induced senescence in securin-deficient cancer cells promotes cell invasion involving the IL-6/STAT3 and PDGF-BB/PDGFR pathways

Yu, Y.-C., Yang, P., Chuah, Q.-Y., Huang, Y.-H., Peng, C.-W., Lee, Y., & Chiu, S.-J. (2013) · Scientific Reports · doi:10.1038/srep01675 · Cited by 72

Neuregulin-1 attenuates stress-induced vascular senescence

Shakeri, H., Gevaert, A. B., Schrijvers, D. M., Meyer, G. R. Y. D., Keulenaer, G. W. D., Guns, P., Lemmens, K., & Segers, V. F. M. (2018) · Cardiovascular Research · doi:10.1093/cvr/cvy059 · Cited by 70

Differential DNA methylation in experienced meditators after an intensive day of mindfulness-based practice: Implications for immune-related pathways

Chaix, R., Fagny, M., Cosín‐Tomás, M., Alvarez-López, M., Lemée, L., Regnault, B., Davidson, R. J., Antoine Lutz, A., & Kaliman, P. (2019) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2019.11.003 · Cited by 82

Secreted protein acidic and rich in cysteine facilitates age-related cardiac inflammation and macrophage M1 polarization

Toba, H., Brás, L. E. D. C., Baicu, C. F., Zile, M. R., Lindsey, M. L., & Bradshaw, A. D. (2015) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00402.2014 · Cited by 69

High-order chromatin structure and the epigenome in SAHFs

Chandra, T., & Narita, M. (2012) · Nucleus · doi:10.4161/nucl.23189 · Cited by 75

Berberine suppresses gero-conversion from cell cycle arrest to senescence

Zhao, H., Halicka, H. D., Li, J., & Darżynkiewicz, Z. (2013) · Aging · doi:10.18632/aging.100593 · Cited by 71

Centenarian lamins: rapamycin targets in longevity

Lattanzi, G., Ortolani, M., Columbaro, M., Prencipe, S., Mattioli, E., Lanzarini, C., Maraldi, N. M., Cenni, V., Garagnani, P., Salvioli, S., et al. (2013) · Journal of Cell Science · doi:10.1242/jcs.133983 · Cited by 70

The senescent hepatocyte gene signature in chronic liver disease

Aravinthan, A. D., Shannon, N. B., Heaney, J., Hoare, M., Marshall, A., & Alexander, G. (2014) · Experimental Gerontology · doi:10.1016/j.exger.2014.09.011 · Cited by 65

Carcinogen-specific mutational and epigenetic alterations in INK4A, INK4B and p53 tumour-suppressor genes drive induced senescence bypass in normal diploid mammalian cells

Yasaei, H., Gilham, E., Pickles, J. C., Roberts, T. P. L., O’Donovan, M. R., & Newbold, R. F. (2012) · Oncogene · doi:10.1038/onc.2012.45 · Cited by 63

Inhibition of ATM blocks the etoposide-induced DNA damage response and apoptosis of resting human T cells

Korwek, Z., Sewastianik, T., Bielak-Żmijewska, A., Mosieniak, G., Alster, O., Moreno-Villaneuva, M., Bürkle, A., & Sikora, E. (2012) · DNA repair · doi:10.1016/j.dnarep.2012.08.006 · Cited by 60

Human adipose-derived stem cells cultured in keratinocyte serum free medium: Donor’s age does not affect the proliferation and differentiation capacities

Ding, D., Chou, H.-L., Hung, W.-T., Liu, H.-W., & Chu, T. (2013) · Journal of Biomedical Science · doi:10.1186/1423-0127-20-59 · Cited by 62

Macromolecular Degradation Systems and Cardiovascular Aging

Nakayama, H., Nishida, K., & Otsu, K. (2016) · Circulation Research · doi:10.1161/circresaha.115.307495 · Cited by 56

Targeting normal and cancer senescent cells as a strategy of senotherapy

Sikora, E., Bielak-Żmijewska, A., & Mosieniak, G. (2019) · Ageing Research Reviews · doi:10.1016/j.arr.2019.100941 · Cited by 59

Derivation of Cell-Engineered Nanovesicles from Human Induced Pluripotent Stem Cells and Their Protective Effect on the Senescence of Dermal Fibroblasts

Lee, H., Cha, H., & Park, J. H. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21010343 · Cited by 59

Neuregulin-1, a potential therapeutic target for cardiac repair

Wang, Y., Wei, J.-L., Zhang, P., Zhang, X., Wang, Y., Chen, W., Zhao, Y., & Cui, X. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.945206 · Cited by 58

Nicotinamide phosphoribosyltransferase postpones rat bone marrow mesenchymal stem cell senescence by mediating NAD+–Sirt1 signaling

Pi, C., Yang, Y. J., Sun, Y., Wang, H., Sun, H., Ma, M., Lin, L., Shi, Y., Li, Y., Li, Y., et al. (2019) · Aging · doi:10.18632/aging.101993 · Cited by 56

Interleukin-1β Drives Cellular Senescence of Rat Astrocytes Induced by Oligomerized Amyloid β Peptide and Oxidative Stress

Shang, D., Hong, Y., Xie, W., Tu, Z., & Xu, J. L. (2020) · Frontiers in Neurology · doi:10.3389/fneur.2020.00929 · Cited by 54

Senolytics: Eliminating Senescent Cells and Alleviating Intervertebral Disc Degeneration

Wu, Y., Shen, S., Shi, Y., Tian, N., Zhou, Y., & Zhang, X. (2022) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2022.823945 · Cited by 53

Activation-induced and damage-induced cell death in aging human T cells

Sikora, E. (2015) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2015.03.011 · Cited by 50

Senescence-associated Long Non-coding RNA (SALNR) Delays Oncogene-induced Senescence through NF90 Regulation

Wu, C.-L., Wang, Y., Jin, B., Chen, H., Xie, B., & Mao, Z.-B. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.661785 · Cited by 50

NOX4 downregulation leads to senescence of human vascular smooth muscle cells

Przybylska, D., Janiszewska, D., Goździk, A., Bielak-Żmijewska, A., Sunderland, P., Sikora, E., & Mosieniak, G. (2016) · Oncotarget · doi:10.18632/oncotarget.12079 · Cited by 52

A prototypical non-malignant epithelial model to study genome dynamics and concurrently monitor micro-RNAs and proteins in situ during oncogene-induced senescence

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Restorative Biological Processes and Health

Robles, T. F., & Carroll, J. (2011) · Social and Personality Psychology Compass · doi:10.1111/j.1751-9004.2011.00368.x · Cited by 51

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Li, Q., Liu, X., & Wei, J. J. (2014) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2014.08.109 · Cited by 49

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Wang, J., Wu, P., Chen, P. C.-H., Lee, C.-W., Chen, W., & Hung, S. (2016) · Stem Cells Translational Medicine · doi:10.5966/sctm.2015-0226 · Cited by 52

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Manukyan, M., & Singh, P. B. (2014) · Scientific Reports · doi:10.1038/srep04789 · Cited by 45

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Bo‐Htay, C., Shwe, T., Higgins, L., Palee, S., Shinlapawittayatorn, K., Chattipakorn, S. C., & Chattipakorn, N. (2019) · GeroScience · doi:10.1007/s11357-019-00132-9 · Cited by 53

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Fujimura, K., Wakino, S., Minakuchi, H., Hasegawa, K., Hosoya, K., Komatsu, M., Kaneko, Y., Shinozuka, K., Washida, N., Kanda, T., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0094373 · Cited by 46

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Fujioka, K., Kajita, K., Wu, Z., Hanamoto, T., Ikeda, T., Mori, I., Okada, H., Yamauchi, M., Uno, Y., Morita, H., et al. (2012) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00112.2011 · Cited by 43

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DNA double strand break responses and chromatin alterations within the aging cell

Klement, K., & Goodarzi, A. A. (2014) · Experimental Cell Research · doi:10.1016/j.yexcr.2014.09.003 · Cited by 48

Iron homeostasis and neurodegeneration in the ageing brain: Insight into ferroptosis pathways

Alrouji, M., Anwar, S., Venkatesan, K., Shahwan, M. J., Hassan, M. I., Islam, A., & Shamsi, A. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102575 · Cited by 45

Regulated expression of the lncRNA TERRA and its impact on telomere biology

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Cellular senescence and senescence biomarkers: pathophysiological significance, molecular mechanisms, and clinical perspectives

Borukaeva, I. K., Хараева, З. Ф., Tkhabisimova, I. K., Барасбиевич, Х. А., Алимбекович, У. Т., Shogenov, B. M., & Kunizhev, A. M. (2026) · Бюллетень Восточно-Сибирского научного центра Сибирского отделения Российской академии медицинских наук · doi:10.29413/abs.2026-11.1.11 · Cited by 1

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Jadhav, S., Patil, A., Nagre, S., Gurde, A. A., Patel, P., & Bhusse, S. (2026) · International Journal of Advanced Biochemistry Research · doi:10.33545/26174693.2026.v10.i7f.9032

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Mohamad Kamal, N. S., Safuan, S., Shamsuddin, S., & Foroozandeh, P. (2020) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2020.151108 · Cited by 287

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Markina, Y. V., Kirichenko, T. V., Zhivodernikov, I. V., Markin, A. M., Eremin, I. I., Deev, R. V., & Kotenko, K. V. (2025) · I P Pavlov Russian Medical Biological Herald · doi:10.17816/pavlovj634546