The DOI matches its Crossref record; 100 of the 102 references it cites were found in a registry or an index.
Impact of cellular senescence signature on ageing research
Abstract
Cellular senescence as the state of permanent inhibition of cell proliferation is a tumour-suppressive mechanism. However, due to the associated secretory phenotype senescence can also contribute to cancer and possibly other age-related diseases, such as obesity, diabetes, atherosclerosis and Alzheimer's disease. There are two major mechanisms of cellular senescence; replicative senescence depends on telomere erosion or dysfunction whilst stress-induced premature senescence (SIPS) is telomere-independent and also includes oncogene-induced senescence (OIS). The senescence phenotype is characterised by altered cellular morphology, increased activity for senescence-associated-β-galactosidase (SA-β-GAL), increased formation of senescence-associated heterochromatin foci (SAHF) and promyelocytic leukemia protein nuclear bodies (PML NBs), permanent DNA damage, chromosomal instability and an inflammatory secretome. Some of these markers have been identified in cells from age-related pathologies. However, to improve our understanding of the contribution of cellular senescence to organismal ageing and age-related disease, it is imperative to define an unequivocal signature of cellular senescence that is functionally connected with normal and pathological ageing. Herein, we describe the processes leading to senescence, and the current biomarkers of cellular senescence, with particular emphasis on the causal role of DNA damage responses involved in the process. We highlight the gaps in o…
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Both normal and tumor cells undergo senescence in response to various insults that cause persistent DNA damage (Kuilman et al., 2010; Rodier and Campisi, 2011; Sikora et al., 2011; Ohtani and Hara, 2013)”
From Targeting Janus Kinases and Signal Transducer and Activator of Transcription 3 To Treat Inflammation, Fibrosis, and Cancer: Rationale, Progress, and Caution (2020) · cites this paper as Sikora et al., 2011
Citations
Cites
Hanahan, D., & Weinberg, R. A. (2000) · Cell · doi:10.1016/s0092-8674(00)81683-9 · Cited by 29,219
Mantovani, A., Allavena, P., Sica, A., & Balkwill, F. (2008) · Nature · doi:10.1038/nature07205 · Cited by 11,399
Inflammation and metabolic disorders
Hotamisligil, G. S. (2006) · Nature · doi:10.1038/nature05485 · Cited by 9,199
The serial cultivation of human diploid cell strains
Hayflick, L., & Moorhead, P. S. (1961) · Experimental Cell Research · doi:10.1016/0014-4827(61)90192-6 · Cited by 8,508
A biomarker that identifies senescent human cells in culture and in aging skin in vivo.
Dimri, G. P., Lee, X., Basile, G., Acosta, M., Scott, G., Roskelley, C., Medrano, E. E., Linskens, M., Rubelj, I., & Pereira-Smith, O. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.20.9363 · Cited by 7,477
The DNA-damage response in human biology and disease
Jackson, S. P., & Bartek, J. (2009) · Nature · doi:10.1038/nature08467 · Cited by 6,092
Telomeres shorten during ageing of human fibroblasts
Harley, C. B., Futcher, A. B., & Greider, C. W. (1990) · Nature · doi:10.1038/345458a0 · Cited by 5,750
Inflamm‐aging: An Evolutionary Perspective on Immunosenescence
FRANCESCHI, C., BONAFÈ, M., VALENSIN, S., OLIVIERI, F., DE LUCA, M., OTTAVIANI, E., & DE BENEDICTIS, G. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb06651.x · Cited by 5,358
Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a
Serrano, M., Lin, A. W., McCurrach, M. E., Beach, D., & Lowe, S. W. (1997) · Cell · doi:10.1016/s0092-8674(00)81902-9 · Cited by 5,218
The senescence-associated secretory phenotype: the dark side of tumor suppression
Coppé, J.-P., Desprez, P.-Y., Krtolica, A., & Campisi, J. (2010) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev-pathol-121808-102144 · Cited by 5,206
Flagged first, then by citations
2 of the 102 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Items 201–263 of 263
Dementia Research: Populations, Progress, Problems, and Predictions
Hunter, S., Smailagic, N., & Brayne, C. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-179927 · Cited by 6
Wu, W., Yu, A., Chen, K., Lu, P., Yang, J., Liu, K., Mao, Z., & Yao, Z. (2019) · Medical Science Monitor · doi:10.12659/msm.917867 · Cited by 6
Protective mechanism against age-associated changes in the peripheral nerves
Goto, K., Naïto, K., Nakamura, S., Nagura, N., Sugiyama, Y., Obata, H., Kaneko, A., & Kaneko, K. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.117744 · Cited by 7
A stereologic study of the plantar fat pad in young and aged rats
Molligan, J., Schon, L. C., & Zhang, Z. (2013) · Journal of Anatomy · doi:10.1111/joa.12104 · Cited by 6
Zhang, M., Liu, S., Chen, Y., Chen, Y., Jiaojiao, H., Xia, Y., & Yang, Y. (2024) · Experimental Cell Research · doi:10.1016/j.yexcr.2024.114329 · Cited by 5
Hartmann, D., von Figura, G., Song, Z., Harden, S., Scott, L. C., Evans, T. J., Rudolph, K. L., Bilsland, A. E., & Keith, W. N. (2014) · Future Oncology · doi:10.2217/fon.14.166 · Cited by 5
Romero, M., Gelsomini, A., Miller, K., Suresh, D., Thaller, S. R., & Frasca, D. (2024) · Journal of Nutrition · doi:10.1016/j.tjnut.2024.10.013 · Cited by 5
Choroidal macrophages in homeostasis, aging and age-related macular degeneration
Khan, A. H., & Mulfaul, K. (2024) · Experimental Eye Research · doi:10.1016/j.exer.2024.110159 · Cited by 4
Liu, Y., Liu, Y., Wang, X., Xiu, C., Hu, Y., Wang, J., Lei, Y., & Yang, J. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e25253 · Cited by 5
Aging and cancer: molecular facts and awareness for Turkey
Gündüz, G., & Fışkın, K. (2014) · TURKISH JOURNAL OF BIOLOGY · doi:10.3906/biy-1405-9 · Cited by 4
Cell Cycle Checkpoints and Senescence
Wadhwa, R., Kaul, Z., & Kaul, S. C. (2016) · Healthy ageing and longevity · doi:10.1007/978-3-319-26239-0_9 · Cited by 4
Xing, W., Gao, W., Su, H., Wang, S., Zhang, J., Mao, G., & Yan, J. (2018) · Environmental Toxicology and Pharmacology · doi:10.1016/j.etap.2018.01.001 · Cited by 4
Gupta, K. P., Dholaniya, P. S., Chekuri, A., & Kondapi, A. K. (2015) · AGE · doi:10.1007/s11357-015-9810-0 · Cited by 4
Li, N., Wang, Q., Zhao, Y., Zhang, T., Liu, Y.-Y., Malhi, K. K., Yao, X. S., & Li, J. (2025) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.5c09679 · Cited by 3
Niu, B., An, X., Chen, Y., He, T., Xiao, Z., Zhu, X., Ping, F., Zhang, W., & Zhou, J. (2025) · Chinese Journal of Natural Medicines · doi:10.1016/s1875-5364(25)60824-7 · Cited by 3
CHARACTERISATION OF AN IN VITRO AGED CELL CULTURE MODEL
Bunc, M. (2019) · FARMACIA · doi:10.31925/farmacia.2019.2.7 · Cited by 3
Neuropathology of HIV-1 Disease
Soontornniyomkij, V. (2017) · Springer eBooks · doi:10.1007/978-1-4939-7290-6_8 · Cited by 3
Butler, C., Owen-Jones, E., Lau, M., Gillespie, D., Lown, M. T., Calder, P. C., Stanton, H., Wootton, M., Herrera, V. C., Bayer, A. J., et al. (2021) · Efficacy and Mechanism Evaluation · doi:10.3310/eme08070 · Cited by 3
Chmielewski, P. P. (2026) · Biogerontology · doi:10.1007/s10522-026-10436-x · Cited by 2
The role of d-galactose in the aging heart and brain
Bo‐Htay, C., Shwe, T., Chattipakorn, S. C., & Chattipakorn, N. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-849886-6.00022-7 · Cited by 2
Endothelial cell senescence contributes to pathological retinal angiogenesis
Shi, Z.-H., Liu, B., Dai, J., & Chen, X. (2024) · Clinical and Translational Discovery · doi:10.1002/ctd2.70007 · Cited by 1
Senescence markers in peripheral blood mononuclear cells in pediatric drug-resistant epilepsy
Günbey, C., Muratoğlu, B., Özdemir, C., Cetinkaya, D. U., & Yalnızoğlu, D. (2026) · Brain and Development · doi:10.1016/j.braindev.2026.104511 · Cited by 1
Wang, M., Zhang, N., Wang, W., Wang, B., Xu, Q., & Yang, Y. (2013) · Biogerontology · doi:10.1007/s10522-013-9460-5 · Cited by 1
Lee, J., Min, C., Kwak, S., & Seong, Y. (2012) · BioChip Journal · doi:10.1007/s13206-012-6408-9 · Cited by 1
Changes in Chromatin Structure along Aging
Moraes, A. D. S. (2014) · Journal of Gerontology & Geriatric Research · doi:10.4172/2167-7182.1000157 · Cited by 1
Suppression of Cellular Senescence by Cordycepin in Replicative Aged Human Dermal Fibroblasts
Kim, H. J., Lee, S. Y., Kim, D., Jin, M. H., Roh, S., Kim, H., Choi, I.-H., Lee, M. S., & Lee, S. H. (2015) · Journal of the Society of Cosmetic Scientists of Korea · doi:10.15230/scsk.2015.41.2.135 · Cited by 1
Novel Role of Mammalian Cell Senescence‐Sustenance of Muscle Larvae of Trichinella spp
Dąbrowska, M., Kępczyńska, A., Goździk, K., Całka-Kresa, M., Skoneczny, M., Zieliński, Z., Doligalska, M., & Sikora, E. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/1799839 · Cited by 1
Self-citation17β-estradiol delays cardiac aging through suppressing the methylation of Beclin1 in a murine model
Ye, L., Shi, X., Deng, T., Zhao, J., Wu, T., & Chen, J. (2025) · Steroids · doi:10.1016/j.steroids.2025.109587 · Cited by 1
Huang, S., Li, J., Gu, D., Li, Z., Chen, H., & Xiong, W. (2025) · Frontiers in Microbiology · doi:10.3389/fmicb.2025.1623875 · Cited by 1
Influence of donor age on cellular ability to carry out DNA repair via homologous recombination
Bernadotte, A., Mikhelson, V. M., Im, S., & Ryzak, G. A. (2014) · Advances in Gerontology · doi:10.1134/s2079057014030023 · Cited by 1
Ghori, N.-U.-H., Ghori, T., Imadi, S. R., & Gul, A. (2020) · Springer eBooks · doi:10.1007/978-981-15-0025-1_20 · Cited by 1
Li, Z., Hu, S., Liu, Z., Zhang, M., Chen, S., Yu, W., Ding, M., Fan, Y., Li, S., & Jin, J. (2026) · International Journal of Biological Sciences · doi:10.7150/ijbs.130242
“…36 h of treatment, cells were subjected to senescence detection using a Cell Senescence β-Galactosidase Staining Kit (C0602, Beyotime Biotechnology, China), followed by incubation at 37 °C for 20 h. Stained cells were imaged using a bright-field microscope equipped with a 100× objective lens [27].”
Starzenie komórkowe (senescencja) i jego konsekwencje dla człowieka
Miranowicz-Dzierżawska, K. (2015) · Occupational Safety – Science and Practice · doi:10.5604/01377043.1214549
Signaling Networks Controlling Cellular Senescence
Desai, L. P., Sanders, Y. Y., & Thannickal, V. J. (2014) · Wiley eBooks · doi:10.1002/9781118396292.ch6
Khojah, S. M. (2015) · Enlighten: Theses (The University of Glasgow)
The effect of radiation on cellular ageing
Sabin, R. J. (2012) · Brunel University Research Archive (BURA) (Brunel University London)
Trécesson, S. D. C. (2010) · OpenGrey (Institut de l'Information Scientifique et Technique)
Telomeres are guardians of chromosomal integrity
Basenko, E. Y. (2013) · Postdoc Journal · doi:10.14304/surya.jpr.v1n1.9
Age-related Senescence of Rat Bone Marrow-derived Mesenchymal Stem Cells
He, X., Ma, C., Pi, C., Yang, Y. J., Lin, L., Shi, Y., & Li, Y. (2016) · International Conference on Biomedical and Biological Engineering (BBE) · doi:10.2991/bbe-16.2016.61
Tai, L., Huang, C.-J., Choo, K., Wong, C., Cheong, S. K., & Abidin, T. T. Z. (2017) · Cytotherapy · doi:10.1016/j.jcyt.2017.02.282
Stem Cell Applications in Rejuvenation
Almadori, A., & Kalaskar, D. M. (2017) · Stem cells in clinical applications · doi:10.1007/978-3-319-55687-1_13
Monocytes and Macrophages in the Aged Lung and Heart
Thoman, M. L., Bray, W., & Linton, P. (2017) · Springer eBooks · doi:10.1007/978-3-319-64597-1_94-1
Oliveira, D. V. C. (2018) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/d.42.2019.tde-18022019-101454
Murphy, A. J., Williamson, J. B., & Lamb, D. G. (2019) · Springer eBooks · doi:10.1007/978-3-319-69892-2_677-1
Murphy, A. J., Williamson, J. B., & Lamb, D. G. (2021) · Springer eBooks · doi:10.1007/978-3-030-22009-9_677
Georgakilas, A. G. (2012) · CRC Press eBooks · doi:10.1201/b14318-8
Monocytes and Macrophages in the Aged Lung and Heart
Thoman, M. L., Bray, W., & Linton, P. (2019) · Springer eBooks · doi:10.1007/978-3-319-99375-1_94
Aging principles and interventional perspectives
Sikora, E. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-90581-7.00002-5
Self-citation17β-estradiol delays cardiac aging through suppressing the methylation of Beclin1 in a murine modelPreprint
Ye, L., Shi, X., Deng, T., Zhao, J. J., Wu, T., & Chen, J. (2023) · Research Square · doi:10.21203/rs.3.rs-2793118/v1
Cellular Senescence and SENEX Gene on the Peripheral CD4+CD25+ Treg Cells Enhancement in Elderly
Wen, M., Chai, J., & Wen, B. (2024) · Journal of Biosciences and Medicines · doi:10.4236/jbm.2024.122006
Liu, S., Fan, S.-C., Wang, R.-Q., Wang, X.-J., Lu, T.-Y., Song, J.-W., Zhu, Y.-J., Guo, Z., Zhu, N., & Yuan, P. (2026) · Vessel Plus · doi:10.20517/2574-1209.2025.115
Inhibitory effect of three components derived from Salvia miltiorrhiza against human cytomegalovirus
Wang, S., Zhou, X., Lin, Z., Su, H., Wu, X., Chang, Y., Fu, Y., Zhu, T., Sun, C., Zhang, J., et al. (2026) · Virology Journal · doi:10.1186/s12985-026-03107-3
Sharma, P., & Bhattacharyya, S. (2026) · Stem Cell Reviews and Reports · doi:10.1007/s12015-026-11117-5
State-of-the-art of the high dose influenza vaccine in Spain
Sanz-Muñoz, I., Avellà, J. M. F., Barroso-Santos, P. J., & Eiros, J. M. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1843611
Chen, J., Duan, X., Jing, Y., Liu, X., Zhang, Y., Tang, Y., Chen, C., Yang, J., Li, X., Lin, F., et al. (2026) · Journal of Ovarian Research · doi:10.1186/s13048-026-02203-w
Kojima, H., Kunimoto, H., Inoue, T., & Nakajima, K. (2013) · Springer eBooks · doi:10.1007/978-94-007-7726-2_6
ANÁLISE CITOGENÉTICA COMO BIOINDICADOR PARA PACIENTES COM DIAGNÓSTICO SUGESTIVO DE ALZHEIMER
Ramos, I. P., & Negrão (2013) · Americanae (AECID Library)
Metadata
- Authors
- Sikora, E., Arendt, T., Bennett, M., & Narita, M.
- Affiliations
- Instytut Biologii Doświadczalnej im. Marcelego Nenckiego (PL)
- Leipzig University (DE)
- University of Cambridge (GB)
- Cancer Research UK (GB)
- Corresponding author
- Sikora, Ewa
- Venue
- Ageing Research Reviews
- Publisher
- Elsevier BV
- Published
- 2011-01
- Volume
- 10
- Issue
- 1
- Pages
- 146-152
- ISSN
- 1568-1637 (ISSN-L)
- OpenAlex
- W1977970646
- Cited by
- 264
- References
- 102
- Citations by year
- 2026: 7 · 2025: 5 · 2024: 13 · 2023: 11 · 2022: 11 · 2021: 13 · 2020: 14 · 2019: 17 · 2018: 21 · 2017: 19 · 2016: 19 · 2015: 25 · 2014: 23 · 2013: 33 · 2012: 24
- FWCI
- 2.12
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Ageing Research Reviews (publishedVersion)
- PubMed (publishedVersion)
- Funders
- British Heart Foundation (RG/08/009/25841)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Keywords
- cellular senescence, senescence biomarkers, replicative senescence, stress-induced premature senescence, oncogene-induced senescence, telomere shortening, DNA damage response, senescence-associated β-galactosidase, senescence-associated heterochromatin foci, PML nuclear bodies, senescence-associated secretory phenotype, age-related diseases, aging
- MeSH terms
- Aging, DNA Damage, Humans, Phenotype, Research, Biomarkers, Telomere, Cellular Senescence, Genomic Instability
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
