General RBP expression in human tissues as a function of age
Abstract
Gene expression patterns vary dramatically in a tissue-specific and age-dependent manner. RNA-binding proteins that regulate mRNA turnover and/or translation (TTR-RBPs) critically affect the subsets of expressed proteins. Although many proteins implicated in age-related processes are encoded by mRNAs that are targets of TTR-RBPs, very little is known regarding the tissue- and age-dependent expression of TTR-RBPs in humans. Recent analysis of TTR-RBPs expression using human tissue microarray has provided us interesting insight into their possibly physiologic roles as a function of age. This analysis has also revealed striking discrepancies between the levels of TTR-RBPs in senescent human diploid fibroblasts (HDFs), widely used as an in vitro model of aging, and the levels of TTR-RBPs in tissues from individuals of advancing age. In this article, we will review our knowledge of human TTR-RBP expression in different tissues as a function of age.
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Post-transcriptional regulatory pathways contribute to control senescence through the action of RBPs and noncoding RNAs, particularly specific miRNAs.
“Post-transcriptional regulatory pathways also contribute to control senescence through the action of mRNA-binding proteins (RBPs) and noncoding RNAs, particularly specific microRNAs (miRNAs), the levels of which help to mediate the senescence state [179,180].”
From Mechanisms and Regulation of Cellular Senescence (2021) · cites this paper as [179]
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Mechanisms and Regulation of Cellular Senescence
Roger, L., Tomas, F., & Gire, V. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222313173 · Cited by 395 · see citing works
- Authors
- Masuda, K., Kuwano, Y., Nishida, K., & Rokutan, K.
- Affiliations
- Tokushima University (JP)
- Corresponding author
- Masuda, Kiyoshi
- Venue
- Ageing Research Reviews
- Publisher
- Elsevier BV
- Published
- 2012-09
- Volume
- 11
- Issue
- 4
- Pages
- 423-431
- ISSN
- 1568-1637 (ISSN-L)
- OpenAlex
- W2036088954
- Cited by
- 28
- References
- 10
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 2 · 2023: 3 · 2022: 1 · 2021: 2 · 2020: 3 · 2019: 2 · 2018: 1 · 2017: 1 · 2016: 1 · 2015: 3 · 2014: 1 · 2013: 2 · 2012: 1
- FWCI
- 0.20
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Ageing Research Reviews (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Japan Society for the Promotion of Science (22390146, 24790705, 22790649, 24590943)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Keywords
- RNA-binding proteins, tissue-specific gene expression, age-related gene expression, aging, mRNA turnover, translational regulation
- MeSH terms
- Aging, Animals, Humans, RNA Processing, Post-Transcriptional, RNA, Messenger, RNA-Binding Proteins, Cellular Senescence
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