The pathological response to DNA damage does not contribute to p53-mediated tumour suppression

Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

Serrano, M., Lin, A. W., McCurrach, M. E., Beach, D., & Lowe, S. W. (1997) · Cell · doi:10.1016/s0092-8674(00)81902-9 · Cited by 5,178 · see citing works

p53, guardian of the genome

Lane, D. P. (1992) · Nature · doi:10.1038/358015a0 · Cited by 5,138 · see citing works

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

Donehower, L. A., Harvey, M., Slagle, B. L., McArthur, M. J., Montgomery, C. A., Butel, J. S., & Bradley, A. (1992) · Nature · doi:10.1038/356215a0 · Cited by 4,649 · see citing works

DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis

Bartkova, J., Hořejší, Z., Koed, K., Krämer, A., Tort, F., Zieger, K., Guldberg, P., Sehested, M., Nesland, J. M., Lukas, C., et al. (2005) · Nature · doi:10.1038/nature03482 · Cited by 2,688 · see citing works

Tumor spectrum analysis in p53-mutant mice

Jacks, T., Remington, L., Williams, B. O., Schmitt, E. M., Halachmi, S., Bronson, R. T., & Weinberg, R. A. (1994) · Current Biology · doi:10.1016/s0960-9822(00)00002-6 · Cited by 2,051 · see citing works

Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions

Gorgoulis, V. G., Vassiliou, L.-V. F., Karakaidos, P., Zacharatos, P., Kotsinas, A., Liloglou, T., Venere, M., DiTullio, R. A., Kastrinakis, N. G., Levy, B., et al. (2005) · Nature · doi:10.1038/nature03485 · Cited by 2,009 · see citing works

Tumor Suppression at the Mouse INK4a Locus Mediated by the Alternative Reading Frame Product p19

Kamijo, T., Zindy, F., Roussel, M. F., Quelle, D. E., Downing, J. R., Ashmun, R. A., Grosveld, G., & Sherr, C. J. (1997) · Cell · doi:10.1016/s0092-8674(00)80452-3 · Cited by 1,566 · see citing works

Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest

Ouelle, D. E., Zindy, F., Ashmun, R. A., & Sherr, C. J. (1995) · Cell · doi:10.1016/0092-8674(95)90214-7 · Cited by 1,485 · see citing works

Intrinsic tumour suppression

Lowe, S. W., Cepero, E., & Evan, G. I. (2004) · Nature · doi:10.1038/nature03098 · Cited by 1,309 · see citing works

Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization

Zindy, F., Eischen, C. M., Randle, D. H., Kamijo, T., Cleveland, J. L., Sherr, C. J., & Roussel, M. F. (1998) · Genes & Development · doi:10.1101/gad.12.15.2424 · Cited by 1,245 · see citing works

p14ARF links the tumour suppressors RB and p53

Bates, S., Phillips, A. C., Clark, P. A., Stott, F., Peters, G., Ludwig, R. L., & Vousden, K. H. (1998) · Nature · doi:10.1038/25867 · Cited by 918 · see citing works

p53 and E2F-1 cooperate to mediate apoptosis.

Wu, X., & Levine, A. J. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.9.3602 · Cited by 836 · see citing works

Mediation of c-Myc-Induced Apoptosis by p53

Hermeking, H., & Eick, D. (1994) · Science · doi:10.1126/science.8091232 · Cited by 738 · see citing works

Developmental and tissue-specific regulation of mouse telomerase and telomere length.

Prowse, K. R., & Greider, C. W. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.11.4818 · Cited by 686 · see citing works

p19ARF links the tumour suppressor p53 to Ras

Palmero, I., Pantoja, C., & Serrano, M. (1998) · Nature · doi:10.1038/25870 · Cited by 617 · see citing works

Hypervariable ultra-long telomeres in mice

Kipling, D., & Cooke, H. J. (1990) · Nature · doi:10.1038/347400a0 · Cited by 614 · see citing works

E1A signaling to p53 involves the p19ARFtumor suppressorPreprint

de Stanchina, E., McCurrach, M. E., Zindy, F., Shieh, S.-Y., Ferbeyre, G., Samuelson, A. V., Prives, C. L., Roussel, M. F., Sherr, C. J., & Lowe, S. W. (1998) · Genes & Development · doi:10.1101/gad.12.15.2434 · Cited by 607 · see citing works

The role of p53 in determining sensitivity to radiotherapy

Gudkov, A. V., & Komarova, E. A. (2003) · Nature reviews. Cancer · doi:10.1038/nrc992 · Cited by 569 · see citing works

Myc-mediated apoptosis requires wild-type p53 in a manner independent of cell cycle arrest and the ability of p53 to induce p21waf1/cip1.Preprint

Wagner, A. J., Kokontis, J. M., & Hay, N. (1994) · Genes & Development · doi:10.1101/gad.8.23.2817 · Cited by 540 · see citing works

p53-deficient mice are extremely susceptible to radiation-induced tumorigenesis

Kemp, C. J., Wheldon, T. E., & Balmain, A. (1994) · Nature Genetics · doi:10.1038/ng0994-66 · Cited by 366 · see citing works

A novel p16INK4A transcript.

Mao, L., Merlo, A. U., Bedi, G. C., Shapiro, G. I., Edwards, C. D., Rollins, B. J., & Sidransky, D. (1995) · PubMed · Cited by 329 · see citing works

The common and distinct target genes of the p53 family transcription factors

Harms, K. L., Nozell, S. E., & Chen, X. (2004) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-003-3304-4 · Cited by 296 · see citing works

Temporal dissection of p53 function in vitro and in vivo

Christophorou, M. A., Martı́n-Zanca, D., Soucek, L., Lawlor, E. R., Swigart, L. B., Verschuren, E. W., & Evan, G. I. (2005) · Nature Genetics · doi:10.1038/ng1572 · Cited by 182 · see citing works

Phosphorylation of Serine 18 Regulates Distinct p53 Functions in Mice

Sluss, H. K., Armata, H., Gallant, J., & Jones, S. N. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.3.976-984.2004 · Cited by 152 · see citing works

Arf tumor suppressor promoter monitors latent oncogenic signals in vivo

Zindy, F., Williams, R. T., Baudino, T. A., Rehg, J. E., Skapek, S. X., Cleveland, J. L., Roussel, M. F., & Sherr, C. J. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2536808100 · Cited by 150 · see citing works

Improving cancer therapy by non-genotoxic activation of p53

Laı́n, S., & Lane, D. P. (2003) · European Journal of Cancer · doi:10.1016/s0959-8049(03)00063-7 · Cited by 95 · see citing works

Could p53 be a target for therapeutic suppression?

Komarova, E., & Gudkov, A. V. (1998) · Seminars in Cancer Biology · doi:10.1006/scbi.1998.0101 · Cited by 50 · see citing works

Atm Is Dispensable for p53 Apoptosis and Tumor Suppression Triggered by Cell Cycle Dysfunction

Liao, M.-J., Yin, C., Barlow, C., Wynshaw-Boris, A. J., & Dyke, T. V. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.4.3095 · Cited by 46 · see citing works

p53 and p73: seeing double?

Soengas, M. S., & Lowe, S. W. (2000) · Nature Genetics · doi:10.1038/82497 · Cited by 14 · see citing works

Cellular senescence: when bad things happen to good cells

Campisi, J., & d'Adda di Fagagna, F. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2233 · Cited by 4,441 · see citing works

Blinded by the Light: The Growing Complexity of p53

Vousden, K. H., & Prives, C. (2009) · Cell · doi:10.1016/j.cell.2009.04.037 · Cited by 3,163 · see citing works

Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas

Xue, W., Zender, L., Miething, C., Dickins, R. A., Hernando, E., Krizhanovsky, V., Cordon-Cardo, C., & Lowe, S. W. (2007) · Nature · doi:10.1038/nature05529 · Cited by 2,473 · see citing works

p53 in health and disease

Vousden, K. H., & Lane, D. P. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2147 · Cited by 2,275 · see citing works

The Bcl-2 apoptotic switch in cancer development and therapy

Adams, J. M., & Cory, S. (2007) · Oncogene · doi:10.1038/sj.onc.1210220 · Cited by 2,178 · see citing works

An Oncogene-Induced DNA Damage Model for Cancer Development

Halazonetis, T. D., Gorgoulis, V. G., & Bartek, J. (2008) · Science · doi:10.1126/science.1140735 · Cited by 1,851 · see citing works

Restoration of p53 function leads to tumour regression in vivo

Ventura, A., Kirsch, D. G., McLaughlin, M. E., Tuveson, D. A., Grimm, J., Lintault, L., Newman, J., Reczek, E. E., Weissleder, R., & Jacks, T. (2007) · Nature · doi:10.1038/nature05541 · Cited by 1,820 · see citing works

Cellular senescence in cancer and aging.

Collado, M., Blasco, M. A., & Serrano, M. (2007) · Cell · doi:10.1016/j.cell.2007.07.003 · Cited by 1,708 · see citing works

How does p53 induce apoptosis and how does this relate to p53-mediated tumour suppression

Aubrey, B. J., Kelly, G. L., Janic, A., Herold, M. J., & Strasser, A. (2018) · Cell Death & Differentiation · doi:10.1038/cdd.2017.169 · Cited by 1,395 · see citing works

Guidelines for the welfare and use of animals in cancer research

Workman, P., Aboagye, E. O., Balkwill, F. R., Balmain, A., Bruder, G., Chaplin, D. J., Double, J. A., Everitt, J. I., Farningham, D. A. H., Glennie, M. J., et al. (2010) · British Journal of Cancer · doi:10.1038/sj.bjc.6605642 · Cited by 1,450 · see citing works

Unravelling mechanisms of p53-mediated tumour suppression

Bieging-Rolett, K. T., Mello, S. S., & Attardi, L. D. (2014) · Nature reviews. Cancer · doi:10.1038/nrc3711 · Cited by 1,389 · see citing works

MDM2, MDMX and p53 in oncogenesis and cancer therapy

Wade, M., Li, Y.-C., & Wahl, G. M. (2013) · Nature Reviews Cancer · doi:10.1038/nrc3430 · Cited by 1,279 · see citing works

Mutant p53: one name, many proteinsPreprint

Freed-Pastor, W. A., & Prives, C. L. (2012) · Genes & Development · doi:10.1101/gad.190678.112 · Cited by 1,246 · see citing works

Strategies to improve radiotherapy with targeted drugs

Begg, A. C., Stewart, F. A., & Vens, C. (2011) · Nature reviews. Cancer · doi:10.1038/nrc3007 · Cited by 1,115 · see citing works

Census and evaluation of p53 target genes

Fischer, M. (2017) · Oncogene · doi:10.1038/onc.2016.502 · Cited by 971 · see citing works

Broad targeting of resistance to apoptosis in cancer

Mohammad, R. M., Muqbil, I., Lowe, L. J., Yedjou, C. G., Hsu, H.-Y., Lin, L., Siegelin, M. D., Fimognari, C., Kumar, N. B., Dou, Q. P., et al. (2015) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2015.03.001 · Cited by 876 · see citing works

DNA damage checkpoints: from initiation to recovery or adaptation

Bartek, J., & Lukas, J. (2007) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2007.02.009 · Cited by 784 · see citing works

Drugging the p53 pathway: understanding the route to clinical efficacy

Khoo, K. H., Verma, C. S., & Lane, D. P. (2014) · Nature Reviews Drug Discovery · doi:10.1038/nrd4236 · Cited by 723 · see citing works

The effects of deregulated DNA damage signalling on cancer chemotherapy response and resistance

Bouwman, P., & Jonkers, J. (2012) · Nature Reviews Cancer · doi:10.1038/nrc3342 · Cited by 615 · see citing works

Tumour suppression by p53: a role for the DNA damage response?

Meek, D. W. (2009) · Nature reviews. Cancer · doi:10.1038/nrc2716 · Cited by 604 · see citing works

Modeling the Therapeutic Efficacy of p53 Restoration in Tumors

Martins, C. P., Brown-Swigart, L., & Evan, G. I. (2006) · Cell · doi:10.1016/j.cell.2006.12.007 · Cited by 600 · see citing works

The expanding universe of p53 targets

Menendez, D., Inga, A., & Resnick, M. A. (2009) · Nature Reviews Cancer · doi:10.1038/nrc2730 · Cited by 568 · see citing works

Distinct p53 Transcriptional Programs Dictate Acute DNA-Damage Responses and Tumor Suppression

Brady, C. A., Jiang, D., Mello, S. S., Johnson, T. M., Jarvis, L. A., Kozak, M. M., Broz, D. K., Basak, S., Park, E. J., McLaughlin, M. E., et al. (2011) · Cell · doi:10.1016/j.cell.2011.03.035 · Cited by 533 · see citing works

eRNAs Are Required for p53-Dependent Enhancer Activity and Gene Transcription

Melo, C. A., Drost, J., Wijchers, P. J., van de Werken, H., de Wit, E., Vrielink, J. A. F. O., Elkon, R., Melo, S. A., Léveillé, N., Kalluri, R., et al. (2013) · Molecular Cell · doi:10.1016/j.molcel.2012.11.021 · Cited by 544 · see citing works

HIF-Dependent Antitumorigenic Effect of Antioxidants In Vivo

Gao, P., Zhang, H., Dinavahi, R., Li, F., Xiang, Y., Raman, V., Bhujwalla, Z. M., Felsher, D. W., Cheng, L., Pevsner, J., et al. (2007) · Cancer Cell · doi:10.1016/j.ccr.2007.08.004 · Cited by 523 · see citing works

Coping with stress: multiple ways to activate p53

Horn, H. F., & Vousden, K. H. (2007) · Oncogene · doi:10.1038/sj.onc.1210263 · Cited by 522 · see citing works

The p53 network: cellular and systemic DNA damage responses in aging and Cancer

Reinhardt, H. C., & Schumacher, B. (2012) · Trends in Genetics · doi:10.1016/j.tig.2011.12.002 · Cited by 458 · see citing works

Strategies for optimizing the response of cancer and normal tissues to radiation

Moding, E. J., Kastan, M. B., & Kirsch, D. G. (2013) · Nature Reviews Drug Discovery · doi:10.1038/nrd4003 · Cited by 461 · see citing works

A complex barcode underlies the heterogeneous response of p53 to stress

Murray-Zmijewski, F., Slee, E. A., & Lu, X. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2451 · Cited by 420 · see citing works

Biology and management of pancreatic cancer

Ghaneh, P., Costello, E., & Neoptolemos, J. P. (2007) · Postgraduate Medical Journal · doi:10.1136/gut.2006.103333 · Cited by 419 · see citing works

Reactive Oxygen Species in Normal and Tumor Stem Cells

Zhou, D., Shao, L., & Spitz, D. R. (2014) · Advances in cancer research · doi:10.1016/b978-0-12-420117-0.00001-3 · Cited by 400 · see citing works

The role of mutant p53 in human cancer

Goh, A. M., Coffill, C. R., & Lane, D. P. (2010) · The Journal of Pathology · doi:10.1002/path.2784 · Cited by 398 · see citing works

Two faces of p53: aging and tumor suppression

Rodier, F., Campisi, J., & Bhaumik, D. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkm744 · Cited by 399 · see citing works

p53 — a Jack of all trades but master of none

Junttila, M. R., & Evan, G. I. (2009) · Nature reviews. Cancer · doi:10.1038/nrc2728 · Cited by 344 · see citing works

p53-Mediated Hematopoietic Stem and Progenitor Cell Competition

Bondar, T., & Medzhitov, R. (2010) · Cell Stem Cell · doi:10.1016/j.stem.2010.03.002 · Cited by 342 · see citing works

siRNA Targeted to p53 Attenuates Ischemic and Cisplatin-Induced Acute Kidney Injury

Molitoris, B. A., Dagher, P. C., Sandoval, R. M., Campos, S. B., Ashush, H., Fridman, E., Brafman, A., Faerman, A., Atkinson, S. J., Thompson, J. D., et al. (2009) · Journal of the American Society of Nephrology · doi:10.1681/asn.2008111204 · Cited by 338 · see citing works

p53 Acetylation: Regulation and Consequences

Reed, S. M., & Quelle, D. E. (2014) · Cancers · doi:10.3390/cancers7010030 · Cited by 330 · see citing works

Hematopoietic Stem Cell Injury Induced by Ionizing Radiation

Shao, L., Luo, Y., & Zhou, D. (2013) · Antioxidants and Redox Signaling · doi:10.1089/ars.2013.5635 · Cited by 337 · see citing works

Tumor-Suppressor Functions of the TP53 PathwayPreprint

Aubrey, B. J., Strasser, A., & Kelly, G. L. (2016) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a026062 · Cited by 331 · see citing works

p53 and Tumor Suppression: It Takes a Network

Boutelle, A. M., & Attardi, L. D. (2021) · Trends in Cell Biology · doi:10.1016/j.tcb.2020.12.011 · Cited by 322 · see citing works

How cell death shapes cancer

Labi, V., & Erlacher, M. (2015) · Cell Death and Disease · doi:10.1038/cddis.2015.20 · Cited by 296 · see citing works

Loss of p53 in enterocytes generates an inflammatory microenvironment enabling invasion and lymph node metastasis of carcinogen-induced colorectal tumors

Schwitalla, S., Ziegler, P. K., Horst, D., Becker, V., Kerle, I., Begus-Nahrmann, Y., Lechel, A., Rudolph, K. L., Langer, R., Slotta-Huspenina, J., et al. (2013) · Cancer Cell · doi:10.1016/j.ccr.2012.11.014 · Cited by 296 · see citing works

p53 Efficiently Suppresses Tumor Development in the Complete Absence of Its Cell-Cycle Inhibitory and Proapoptotic Effectors p21, Puma, and Noxa

Valente, L. J., Gray, D. H. D., Michalak, E. M., Hofbauer, J. P., Egle, A., Scott, C. L., Janic, A., & Strasser, A. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.04.012 · Cited by 292 · see citing works

Regulation of the p53 response and its relationship to cancer

Meek, D. W. (2015) · Biochemical Journal · doi:10.1042/bj20150517 · Cited by 291 · see citing works

Apoptosis and oncogenesis: give and take in the BCL-2 family

Llambi, F., & Green, D. R. (2011) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2010.12.001 · Cited by 261 · see citing works

Keeping the senescence secretome under control: molecular reins on the senescence-associated secretory phenotype.

Malaquin, N., Martinez, A., & Rodier, F. (2016) · Experimental Gerontology · doi:10.1016/j.exger.2016.05.010 · Cited by 247 · see citing works

Selective activation of p53-mediated tumour suppression in high-grade tumours

Junttila, M. R., Karnezis, A. N., Garcia, D. A., Madriles, F., Kortlever, R. M., Rostker, F., Swigart, L. B., Pham, D. M., Seo, Y., Evan, G. I., et al. (2010) · Nature · doi:10.1038/nature09526 · Cited by 244 · see citing works

Liver cancer initiation is controlled by AP-1 through SIRT6-dependent inhibition of survivin

Min, L., Ji, Y., Bakiri, L., Qiu, Z., Cen, J., Chen, X., Chen, L., Scheuch, H., Zheng, H., Qin, L., et al. (2012) · Nature Cell Biology · doi:10.1038/ncb2590 · Cited by 246 · see citing works

Retinoblastoma Has Properties of a Cone Precursor Tumor and Depends Upon Cone-Specific MDM2 Signaling

Xu, X. L., Fang, Y., Lee, T. C., Forrest, D., Gregory, C. Y., Almeida, D., Liu, A., Jhanwar, S. C., Abramson, D. H., & Cobrinik, D. E. (2009) · Cell · doi:10.1016/j.cell.2009.03.051 · Cited by 246 · see citing works

Cordycepin prevents radiation ulcer by inhibiting cell senescence via NRF2 and AMPK in rodents

Wang, Z., Chen, Z., Jiang, Z., Luo, P., Liu, L., Huang, Y., Wang, H., Wang, Y., Long, L., Tan, X., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-10386-8 · Cited by 219 · see citing works

p53 Controls Radiation-Induced Gastrointestinal Syndrome in Mice Independent of Apoptosis

Kirsch, D. G., Santiago, P. M., di Tomaso, E., Sullivan, J. M., Hou, W.-S., Dayton, T. L., Jeffords, L. B., Sodha, P., Mercer, K. L., Cohen, R., et al. (2009) · Science · doi:10.1126/science.1166202 · Cited by 238 · see citing works

p53 alterations in human cancer: more questions than answers

Soussi, T. (2007) · Oncogene · doi:10.1038/sj.onc.1210280 · Cited by 232 · see citing works

Deconstructing networks of p53-mediated tumor suppression in vivo

Kaiser, A. M., & Attardi, L. D. (2017) · Cell Death and Differentiation · doi:10.1038/cdd.2017.171 · Cited by 227 · see citing works

PI3K/Akt-mediated regulation of p53 in cancer

Abraham, A., & O’Neill, E. (2014) · Biochemical Society Transactions · doi:10.1042/bst20140070 · Cited by 219 · see citing works

Control of metabolism by p53 – Cancer and beyond

Labuschagne, C. F., Zani, F., & Vousden, K. H. (2018) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2018.06.001 · Cited by 219 · see citing works

Emerging mechanisms of cell competition

Baker, N. E. (2020) · Nature Reviews Genetics · doi:10.1038/s41576-020-0262-8 · Cited by 212 · see citing works

Tumour suppression by p53: the importance of apoptosis and cellular senescence

Zuckerman, V., Wolyniec, K., Sionov, R. V., Haupt, S., & Haupt, Y. (2009) · The Journal of Pathology · doi:10.1002/path.2584 · Cited by 210 · see citing works

Inflammation and p53: A Tale of Two Stresses

Gudkov, A. V., Gurova, K. V., & Komarova, E. A. (2011) · Genes & Cancer · doi:10.1177/1947601911409747 · Cited by 204 · see citing works

Deciphering p53 signaling in tumor suppression

Mello, S. S., & Attardi, L. D. (2017) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2017.11.005 · Cited by 203 · see citing works

In several cell types tumour suppressor p53 induces apoptosis largely via Puma but Noxa can contribute

Michalak, E. M., Villunger, A., Adams, J. M., & Strasser, A. (2008) · Cell Death and Differentiation · doi:10.1038/cdd.2008.16 · Cited by 205 · see citing works

Therapeutic targeting of tumor suppressor genes

Morris, L. G. T., & Chan, T. A.-T. (2014) · Cancer · doi:10.1002/cncr.29140 · Cited by 201 · see citing works

BRD7 is a candidate tumour suppressor gene required for p53 function

Drost, J., Mantovani, F., Tocco, F., Elkon, R., Comel, A., Holstege, H. H., Kerkhoven, R. M., Jonkers, J., Voorhoeve, P. M., Agami, R., et al. (2010) · Nature Cell Biology · doi:10.1038/ncb2038 · Cited by 199 · see citing works

Deconstructing p53 transcriptional networks in tumor suppression

Bieging, K. T., & Attardi, L. D. (2012) · Trends in Cell Biology · doi:10.1016/j.tcb.2011.10.006 · Cited by 194 · see citing works

20 years studying p53 functions in genetically engineered mice

Donehower, L. A., & Lozano, G. (2009) · Nature reviews. Cancer · doi:10.1038/nrc2731 · Cited by 193 · see citing works

RNA polymerases I and III, non-coding RNAs and cancer

White, R. J. (2008) · Trends in Genetics · doi:10.1016/j.tig.2008.10.003 · Cited by 190 · see citing works

Outcomes of p53 activation - spoilt for choice

Vousden, K. H. (2006) · Journal of Cell Science · doi:10.1242/jcs.03293 · Cited by 188 · see citing works

Reactivation of mutant p53: molecular mechanisms and therapeutic potential

Selivanova, G., & Wiman, K. G. (2007) · Oncogene · doi:10.1038/sj.onc.1210295 · Cited by 186 · see citing works

ATR signaling can drive cells into senescence in the absence of DNA breaks

Toledo, L. I., Murga, M., Gutierrez-Martinez, P., Soria, R., & Fernandez-Capetillo, O. (2008) · Genes & Development · doi:10.1101/gad.452308 · Cited by 183 · see citing works

Large-Scale Mutagenesis in p19ARF- and p53-Deficient Mice Identifies Cancer Genes and Their Collaborative Networks

Uren, A. G., Kool, J., Matentzoglu, K., de Ridder, J., Mattison, J., van Uitert, M., Lagcher, W., Sie, D., Tanger, E., Cox, T., et al. (2008) · Cell · doi:10.1016/j.cell.2008.03.021 · Cited by 179 · see citing works

TRIM59 Is Up-regulated in Gastric Tumors, Promoting Ubiquitination and Degradation of p53

Zhou, Z., Ji, Z., Wang, Y., Li, J., Cao, H., Zhu, H. H., & Gao, W. (2014) · Gastroenterology · doi:10.1053/j.gastro.2014.07.021 · Cited by 170 · see citing works

Ionizing radiation-induced long-term expression of senescence markers in mice is independent of p53 and immune status

Le, O. N. L., Rodier, F., Fontaine, F., Coppe, J., Campisi, J., DeGregori, J., Laverdière, C., Kokta, V., Haddad, E., & Beauséjour, C. M. (2010) · Aging Cell · doi:10.1111/j.1474-9726.2010.00567.x · Cited by 168 · see citing works

Transcription-independent ARF regulation in oncogenic stress-mediated p53 responses

Chen, D., Shan, J., Zhu, W.-G., Qin, J., & Gu, W. (2010) · Nature · doi:10.1038/nature08820 · Cited by 160 · see citing works

Melanocytic nevus-like hyperplasia and melanoma in transgenic BRAFV600E mice

Goel, V., Ibrahim, N., Jiang, G., Singhal, M., Fee, S., Flotte, T. J., Westmoreland, S. V., Haluska, F. S., Hinds, P. W., & Haluska, F. G. (2009) · Oncogene · doi:10.1038/onc.2009.95 · Cited by 165 · see citing works

The role of DNA damage responses in p53 biology

Speidel, D. (2015) · Archives of Toxicology · doi:10.1007/s00204-015-1459-z · Cited by 165 · see citing works

Targeting the DNA Damage Response in Cancer

Ljungman, M. E. (2009) · Chemical Reviews · doi:10.1021/cr900047g · Cited by 163 · see citing works

Reactive Oxygen Species Induced p53 Activation: DNA Damage, Redox Signaling, or Both?

Shi, T., & Dansen, T. B. (2020) · Antioxidants and Redox Signaling · doi:10.1089/ars.2020.8074 · Cited by 164 · see citing works

Wild-Type p53: Tumors Can't Stand It

Kastan, M. B. (2007) · Cell · doi:10.1016/j.cell.2007.02.022 · Cited by 158 · see citing works

Mechanisms of p53 degradation

Chao, C. C. ‐. (2014) · Clinica Chimica Acta · doi:10.1016/j.cca.2014.08.015 · Cited by 152 · see citing works

Exploring the multiple roles of guardian of the genome: P53

Feroz, W., & Sheikh, A. M. A. (2020) · Egyptian Journal of Medical Human Genetics · doi:10.1186/s43042-020-00089-x · Cited by 161 · see citing works

Irradiation selects for p53-deficient hematopoietic progenitors.

Marusyk, A., Porter, C. C., Zaberezhnyy, V., & DeGregori, J. (2010) · PLoS Biology · doi:10.1371/journal.pbio.1000324 · Cited by 151 · see citing works

Deletion of Puma protects hematopoietic stem cells and confers long-term survival in response to high-dose γ-irradiation

Yu, H. M., Shen, H., Yuan, Y., XuFeng, R., Hu, X., Garrison, S. P., Zhang, L., Yu, J., Zambetti, G. P., & Cheng, T. (2010) · Blood · doi:10.1182/blood-2009-10-248278 · Cited by 141 · see citing works

Induction of p53-Dependent Senescence by the MDM2 Antagonist Nutlin-3a in Mouse Cells of Fibroblast Origin

Efeyan, A., Ortega-Molina, A., Velasco-Miguel, S., Herranz, D., Vassilev, L. T., & Serrano, M. (2007) · Cancer Research · doi:10.1158/0008-5472.can-07-0200 · Cited by 140 · see citing works

Cooperation between the ribosomal proteins L5 and L11 in the p53 pathway

Horn, H. F., & Vousden, K. H. (2008) · Oncogene · doi:10.1038/onc.2008.189 · Cited by 140 · see citing works

Reactivation of p53: from peptides to small molecules

Brown, C. J., Cheok, C. F., Verma, C. S., & Lane, D. P. (2010) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2010.11.004 · Cited by 135 · see citing works

Biomass-derived carbon dots with pharmacological activity for biomedicine: Recent advances and future perspectives

Liu, Y., Zhang, L., Cai, H., Qu, X., Chang, J., Waterhouse, G. I. N., & Lu, S. (2024) · 中国科学通报：英文版 · doi:10.1016/j.scib.2024.08.011 · Cited by 134 · see citing works

The p53 pathway in hematopoiesis: lessons from mouse models, implications for humans

Pant, V., Quintás-Cardama, A., & Lozano, G. (2012) · Blood · doi:10.1182/blood-2012-05-356014 · Cited by 129 · see citing works

Classic and novel roles of p53: prospects for anticancer therapy

Fuster, J. J., Sanz-Gonzalez, S. M., Moll, U. M., & Andrés, V. (2007) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2007.03.002 · Cited by 126 · see citing works

Combined Hyperthermia and Radiotherapy for the Treatment of Cancer

Kaur, P., Hurwitz, M., Krishnan, S., & Asea, A. A. A. (2011) · Cancers · doi:10.3390/cancers3043799 · Cited by 124 · see citing works

Phosphorylation of Tip60 by GSK-3 Determines the Induction of PUMA and Apoptosis by p53

Charvet, C., Wissler, M., Brauns‐Schubert, P., Wang, S.-J., Tang, Y., Sigloch, F. C., Mellert, H. S., Brandenburg, M., Lindner, S. E., Breit, B., et al. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.03.033 · Cited by 122 · see citing works

Predictors of Progression in Barrett's Esophagus: Current Knowledge and Future Directions

Prasad, G. A., Bansal, A. K., Sharma, P., & Wang, K. K. (2010) · The American Journal of Gastroenterology · doi:10.1038/ajg.2010.2 · Cited by 122 · see citing works

p53 and the Carcinogenicity of Chronic InflammationPreprint

Gudkov, A. V., & Komarova, E. A. (2016) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a026161 · Cited by 122 · see citing works

Comprehensive Mapping of p53 Pathway Alterations Reveals an Apparent Role for Both SNP309 and <i>MDM2</i> Amplification in Sarcomagenesis

Ito, M., Barys, L., O'Reilly, T., Young, S., Gorbatcheva, B., Monahan, J., Zumstein-Mecker, S., Choong, P. F., Dickinson, I., Crowe, P., et al. (2011) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-10-2050 · Cited by 115 · see citing works

Pathologies Associated with the p53 ResponsePreprint

Gudkov, A. V., & Komarova, E. A. (2010) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a001180 · Cited by 116 · see citing works

The ubiquitin ligase APCCdh1 is required to maintain genome integrity in primary human cells

Engelbert, D., Schnerch, D., Baumgarten, A., & Wäsch, R. (2007) · Oncogene · doi:10.1038/sj.onc.1210703 · Cited by 113 · see citing works

Wip1 Phosphatase Regulates p53-Dependent Apoptosis of Stem Cells and Tumorigenesis in the Mouse Intestine

Demidov, O. N., Timofeev, O. N., Lwin, H. N. Y., Kek, C., Appella, E., & Bulavin, D. V. (2007) · Cell stem cell · doi:10.1016/j.stem.2007.05.020 · Cited by 113 · see citing works

West Nile virus capsid protein induces p53-mediated apoptosis via the sequestration of HDM2 to the nucleolus

Yang, M.-R., Lee, S. R., Oh, W., Lee, E., Yeh, J., Nah, J., Joo, Y.-S., Shin, J., Lee, H., Pyo, S., et al. (2007) · Cellular Microbiology · doi:10.1111/j.1462-5822.2007.01027.x · Cited by 112 · see citing works

The Anti-Cancer Activities of Vernonia amygdalina Extract in Human Breast Cancer Cell Lines Are Mediated through Caspase-Dependent and p53-Independent Pathways

Wong, F. C., Woo, C. C., Hsu, A., & Tan, B. K. H. (2013) · PLoS ONE · doi:10.1371/journal.pone.0078021 · Cited by 108 · see citing works

Cellular senescence: hot or what?

Evan, G. I., & di Fagagna, F. D. (2009) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2008.11.009 · Cited by 109 · see citing works

Lucifer's Labyrinth—Ten Years of Path Finding in Cell Death

Meier, P., & Vousden, K. H. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.11.016 · Cited by 106 · see citing works

A mitochondria-targeted inhibitor of cytochrome c peroxidase mitigates radiation-induced death

Atkinson, J., Kapralov, A. A., Yanamala, N. V. K., Tyurina, Y. Y., Amoscato, A. A., Pearce, L. L., Peterson, J., Huang, Z., Jiang, J., Samhan-Arias, A. K., et al. (2011) · Nature Communications · doi:10.1038/ncomms1499 · Cited by 106 · see citing works

Policing of oncogene activity by p53

Efeyan, A., Garcı́a-Cao, I., Herranz, D., Velasco-Miguel, S., & Serrano, M. (2006) · Nature · doi:10.1038/443159a · Cited by 114 · see citing works

Can less be more for p53?

Berns, A. J. M. (2006) · Nature · doi:10.1038/443153a · Cited by 12 · see citing works

End of the old guard?

McCarthy, N. J. (2006) · Nature reviews. Cancer · doi:10.1038/nrc2000 · Cited by 1 · see citing works

Tumour suppression by p53: a role for the DNA damage response?

Meek, D. W. (2009) · Nature reviews. Cancer · doi:10.1038/nrc2716 · Cited by 604 · see citing works

The role of DNA damage responses in p53 biology

Speidel, D. (2015) · Archives of Toxicology · doi:10.1007/s00204-015-1459-z · Cited by 165 · see citing works