Identification of a target RNA motif for RNA-binding protein HuR

Mfold web server for nucleic acid folding and hybridization prediction

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AU-rich elements: characterization and importance in mRNA degradation

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Analysis of Microarray Data Using Z Score Transformation

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HuR and mRNA stability

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Overexpression of HuR, a nuclear-cytoplasmic shuttling protein, increases the in vivo stability of ARE-containing mRNAs

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RNA sequence analysis using covariance models

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Cloning and Characterization of HuR, a Ubiquitously Expressed Elav-like Protein

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Hypoxic Stabilization of Vascular Endothelial Growth Factor mRNA by the RNA-binding Protein HuR

Levy, N. S., Chung, S., Furneaux, H., & Levy, A. P. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.11.6417 · Cited by 663 · see citing works

HuD, a paraneoplastic encephalomyelitis antigen, contains RNA-binding domains and is homologous to Elav and sex-lethal

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HuR Regulates p21 mRNA Stabilization by UV Light

Wang, W., Furneaux, H., Cheng, H., Caldwell, M. C., Hutter, D., Liu, Y., Holbrook, N. J., & Gorospe, M. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.3.760-769.2000 · Cited by 539 · see citing works

HNS, a nuclear-cytoplasmic shuttling sequence in HuR

Fan, X. C., & STEITZ, J. A. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.26.15293 · Cited by 475 · see citing works

Eukaryotic mRNPs May Represent Posttranscriptional Operons

Keene, J. D., & Tenenbaum, S. A. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00559-2 · Cited by 460 · see citing works

HuR regulates cyclin A and cyclin B1 mRNA stability during cell proliferation

Wang, W., Caldwell, M. C., Lin, S., Furneaux, H., & Gorospe, M. (2000) · The EMBO Journal · doi:10.1093/emboj/19.10.2340 · Cited by 446 · see citing works

RNA-binding protein HuR enhances p53 translation in response to ultraviolet light irradiation

Mazan-Mamczarz, K., Galbán, S., de Silanes, I. L., Martindale, J. L., Atasoy, U., Keene, J. D., & Gorospe, M. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1432104100 · Cited by 445 · see citing works

Detection of the anti‐Hu antibody in the serum of patients with small cell lung cancer—A quantitative western blot analysis

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A polyadenylate binding protein localized to the granules of cytolytic lymphocytes induces DNA fragmentation in target cells

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Hel-N1: an Autoimmune RNA-Binding Protein with Specificity for 3' Uridylate-Rich Untranslated Regions of Growth Factor mRNAs

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ELAV/Hu proteins inhibit p27 translation via an IRES element in the p27 5′UTR

Kullmann, M., Göpfert, U., Siewe, B., & Hengst, L. (2002) · Genes & Development · doi:10.1101/gad.248902 · Cited by 327 · see citing works

HuR binding to cytoplasmic mRNA is perturbed by heat shock

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A conserved family of elav-like genes in vertebrates.

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HuR, a RNA stability factor, is expressed in malignant brain tumors and binds to adenine- and uridine-rich elements within the 3' untranslated regions of cytokine and angiogenic factor mRNAs.

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Why is Hu where? Shuttling of early-response-gene messenger RNA subsets

Keene, J. D. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.1.5 · Cited by 294 · see citing works

Role of the RNA-binding protein HuR in colon carcinogenesis

de Silanes, I. L., Fan, J., Yang, X., Zonderman, A. B., Potapova, O., Pizer, E. S., & Gorospe, M. (2003) · Oncogene · doi:10.1038/sj.onc.1206862 · Cited by 280 · see citing works

Ribonomics: identifying mRNA subsets in mRNP complexes using antibodies to RNA-binding proteins and genomic arrays

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Delineation of mRNA Export Pathways by the Use of Cell-Permeable Peptides

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Application of cDNA microarrays to examine gene expression differences in schizophrenia

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Global analysis of stress-regulated mRNA turnover by using cDNA arrays

Fan, J., Yang, X., Wang, W., Wood, W. H., Becker, K. G., & Gorospe, M. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.162212399 · Cited by 232 · see citing works

Embryonic Lethal Abnormal Visual RNA-Binding Proteins Involved in Growth, Differentiation, and Posttranscriptional Gene Expression

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ELAV protein HuA (HuR) can redistribute between nucleus and cytoplasm and is upregulated during serum stimulation and T cell activation

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Finding the most significant common sequence and structure motifs in a set of RNA sequences

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AMP-Activated Kinase Regulates Cytoplasmic HuR

Wang, W., Fan, J., Yang, X., Fürer-Galbán, S., de Silanes, I. L., von Kobbe, C., Guo, J., Georas, S. N., Foufelle, F., Hardie, D. G., et al. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.10.3425-3436.2002 · Cited by 208 · see citing works

ELAV tumor antigen, Hel-N1, increases translation of neurofilament M mRNA and induces formation of neurites in human teratocarcinoma cellsPreprint

Antic, D., Lu, N., & Keene, J. D. (1999) · Genes & Development · doi:10.1101/gad.13.4.449 · Cited by 202 · see citing works

Ectopic Expression of Hel-N1, an RNA-Binding Protein, Increases Glucose Transporter (GLUT1) Expression in 3T3-L1 Adipocytes

Jain, R. G., Andrews, L. G., McGowan, K. M., Pekala, P. H., & Keene, J. D. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.2.954 · Cited by 199 · see citing works

Role of HuR in Skeletal Myogenesis through Coordinate Regulation of Muscle Differentiation Genes

Figueroa, A., Cuadrado, A., Fan, J., Atasoy, U., Muscat, G. E. O., Muñoz‐Cánoves, P., Gorospe, M., & Múñoz, A. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.14.4991-5004.2003 · Cited by 193 · see citing works

Highly Selective Actions of HuR in Antagonizing AU-Rich Element-Mediated mRNA Destabilization

Chen, C.-Y. A., Xu, N., & Shyu, A.-B. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.20.7268-7278.2002 · Cited by 176 · see citing works

Loss of HuR Is Linked to Reduced Expression of Proliferative Genes during Replicative Senescence

Wang, W., Yang, X., Cristofalo, V. J., Holbrook, N. J., & Gorospe, M. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.17.5889-5898.2001 · Cited by 171 · see citing works

Mammalian homologs of Drosophila ELAV localized to a neuronal subset can bind in vitro to the 3' UTR of mRNA encoding the Id transcriptional repressor

King, P. H., Levine, T., Fremeau, R. T., & Keene, J. (1994) · Journal of Neuroscience · doi:10.1523/jneurosci.14-04-01943.1994 · Cited by 167 · see citing works

Selection of a subset of mRNAs from combinatorial 3' untranslated region libraries using neuronal RNA-binding protein Hel-N1.

Gao, F., Carson, C. C., Levine, T., & Keene, J. D. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.23.11207 · Cited by 156 · see citing works

The Elav-like Proteins Bind to a Conserved Regulatory Element in the 3′-Untranslated Region of GAP-43 mRNA

Chung, S., Eckrich, M., Perrone-Bizzozero, N., Kohn, D. T., & Furneaux, H. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.10.6593 · Cited by 142 · see citing works

The Proximal Region of the 3′-Untranslated Region of Cyclooxygenase-2 is Recognized by a Multimeric Protein Complex Containing HuR, TIA-1, TIAR, and the Heterogeneous Nuclear Ribonucleoprotein U

Cok, S. J., Acton, S. J., & Morrison, A. R. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m302547200 · Cited by 136 · see citing works

A U-Rich Element in the 5′ Untranslated Region Is Necessary for the Translation of p27 mRNA

Millard, S. S., Vidal, A., Markus, M., & Koff, A. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.16.5947-5959.2000 · Cited by 135 · see citing works

RNAi-mediated HuR Depletion Leads to the Inhibition of Muscle Cell Differentiation

van der Giessen, K., Marco, S. D., Clair, E., & Gallouzi, I. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m308889200 · Cited by 125 · see citing works

Regulation of Eotaxin Gene Expression by TNF-α and IL-4 Through mRNA Stabilization: Involvement of the RNA-Binding Protein HuR

Atasoy, U., Curry, S. L., de Silanes, I. L., Shyu, A., Casolaro, V., Gorospe, M., & Stellato, C. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.8.4369 · Cited by 122 · see citing works

Influence of the RNA-Binding Protein HuR in pVHL-Regulated p53 Expression in Renal Carcinoma Cells

Galbán, S., Martindale, J. L., Mazan-Mamczarz, K., de Silanes, I. L., Fan, J., Wang, W., Decker, J., & Gorospe, M. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.20.7083-7095.2003 · Cited by 116 · see citing works

Hel-N1: an Autoimmune RNA-Binding Protein with Specificity for 3' Uridylate-Rich Untranslated Regions of Growth Factor mRNAs

Levine, T., Gao, F., King, P. H., et al. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.6.3494-3504.1993 · Cited by 109 · see citing works

Chromium(VI) Induces p53-Dependent Apoptosis in Diploid Human Lung and Mouse Dermal Fibroblasts

Carlisle, D. L., Pritchard, D. E., Singh, J. V., & Patierno, S. R. (2000) · Molecular Carcinogenesis · doi:10.1002/1098-2744(200006)28:2 · Cited by 88 · see citing works

von Hippel-Lindau Protein-Mediated Repression of Tumor Necrosis Factor Alpha Translation Revealed through Use of cDNA Arrays

Galbán, S., Fan, J., Martindale, J. L., Cheadle, C., Hoffman, B. E., Woods, M. P., Temeles, G. L., Brieger, J., Decker, J., & Gorospe, M. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.7.2316-2328.2003 · Cited by 82 · see citing works

Chronic Ethanol Exposure Increases the Binding of HuR to the TNFα 3′-Untranslated Region in Macrophages

McMullen, M. R., Cocuzzi, E. T., Hatzoglou, M., & Nagy, L. E. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m304566200 · Cited by 54 · see citing works

Transcriptome-wide Identification of RNA-Binding Protein and MicroRNA Target Sites by PAR-CLIP

Hafner, M., Landthaler, M., Burger, L., Khorshid, M., Hausser, J., Berninger, P., Rothballer, A., Ascano, M., Jungkamp, A.-C., Munschauer, M., et al. (2010) · Cell · doi:10.1016/j.cell.2010.03.009 · Cited by 2,873 · see citing works

RNA regulons: coordination of post-transcriptional events

Keene, J. D. (2007) · Nature Reviews Genetics · doi:10.1038/nrg2111 · Cited by 1,321 · see citing works

AU-rich elements and associated factors: are there unifying principles?

Barreau, C. (2005) · Nucleic Acids Research · doi:10.1093/nar/gki1012 · Cited by 1,033 · see citing works

Identification of HuR target circular RNAs uncovers suppression of PABPN1 translation by <i>CircPABPN1</i>

Abdelmohsen, K., Panda, A. C., Munk, R., Grammatikakis, I., Dudekula, D. B., De, S., Kim, J., Noh, J. H., Kim, K. M., Martindale, J. L., et al. (2017) · RNA Biology · doi:10.1080/15476286.2017.1279788 · Cited by 858 · see citing works

Stress granules and neurodegeneration

Wolozin, B. L., & Ivanov, P. V. (2019) · Nature reviews. Neuroscience · doi:10.1038/s41583-019-0222-5 · Cited by 782 · see citing works

Transcriptome-wide Analysis of Regulatory Interactions of the RNA-Binding Protein HuR

Lebedeva, S., Jens, M., Theil, K., Schwanhäusser, B., Selbach, M., Landthaler, M., & Rajewsky, N. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.06.008 · Cited by 716 · see citing works

RIP-Chip: the isolation and identification of mRNAs, microRNAs and protein components of ribonucleoprotein complexes from cell extracts

Keene, J. D., Komisarow, J. M., & Friedersdorf, M. B. (2006) · Nature Protocols · doi:10.1038/nprot.2006.47 · Cited by 612 · see citing works

Integrative Regulatory Mapping Indicates that the RNA-Binding Protein HuR Couples Pre-mRNA Processing and mRNA Stability

Mukherjee, N., Corcoran, D. L., Nusbaum, J. D., Reid, D. W., Georgiev, S., Hafner, M., Ascano, M., Tuschl, T., Ohler, U., & Keene, J. D. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.06.007 · Cited by 654 · see citing works

Diverse molecular functions of Hu proteins

Hinman, M. N., & Lou, H. (2008) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-008-8252-6 · Cited by 587 · see citing works

HuR recruits let-7/RISC to repress c-Myc expressionPreprint

Kim, H. H., Kuwano, Y., Srikantan, S., Lee, E. K., Martindale, J. L., & Gorospe, M. (2009) · Genes & Development · doi:10.1101/gad.1812509 · Cited by 544 · see citing works

Phosphorylation of HuR by Chk2 Regulates SIRT1 Expression

Abdelmohsen, K., Pullmann, R., Lal, A., Kim, H. H., Galbán, S., Yang, X., Blethrow, J. D., Walker, M., Shubert, J., Gillespie, D. A., et al. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.01.011 · Cited by 527 · see citing works

Concurrent versus individual binding of HuR and AUF1 to common labile target mRNAs

Lal, A., Mazan‐Mamczarz, K., Kawai, T., Yang, X., Martindale, J. L., & Gorospe, M. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600305 · Cited by 461 · see citing works

Influence of RNA Secondary Structure on the Pre-mRNA Splicing Process

Buratti, E., & Baralle, F. E. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.24.10505-10514.2004 · Cited by 425 · see citing works

Posttranscriptional regulation of cancer traits by HuR

Abdelmohsen, K., & Gorospe, M. (2010) · Wiley Interdisciplinary Reviews - RNA · doi:10.1002/wrna.4 · Cited by 414 · see citing works

HuR function in disease

Srikantan, S. (2012) · Frontiers in Bioscience · doi:10.2741/3921 · Cited by 353 · see citing works

The neurogenetics of alternative splicing

Vuong, C. K., Black, D. L., & Zheng, S. (2016) · Nature Reviews Neuroscience · doi:10.1038/nrn.2016.27 · Cited by 340 · see citing works

Regulated protein aggregation: stress granules and neurodegeneration

Wolozin, B. L. (2012) · Molecular Neurodegeneration · doi:10.1186/1750-1326-7-56 · Cited by 338 · see citing works

Circular RNA circAGO2 drives cancer progression through facilitating HuR-repressed functions of AGO2-miRNA complexes

Chen, Y., Yang, F., Fang, E., Xiao, W., Mei, H., Li, H., Li, D., Song, H., Wang, J., Mei, H., et al. (2018) · Cell Death and Differentiation · doi:10.1038/s41418-018-0220-6 · Cited by 322 · see citing works

Multiple Functions of the RNA-Binding Protein HuR in Cancer Progression, Treatment Responses and Prognosis

Wang, J., Guo, Y., Chu, H., Guan, Y., Bi, J., & Wang, B. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms140510015 · Cited by 290 · see citing works

RNA-Binding Proteins HuR and PTB Promote the Translation of Hypoxia-Inducible Factor 1α

Galbán, S., Kuwano, Y., Pullmann, R., Martindale, J. L., Kim, H. H., Lal, A., Abdelmohsen, K., Yang, X., Dang, Y., Liu, J. O., et al. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.00973-07 · Cited by 279 · see citing works

PAR-CliP - A Method to Identify Transcriptome-wide the Binding Sites of RNA Binding Proteins

Hafner, M., Landthaler, M., Burger, L., Khorshid, M., Hausser, J., Berninger, P., Rothballer, A., Ascano, M., Jungkamp, A.-C., Munschauer, M., et al. (2010) · Journal of Visualized Experiments · doi:10.3791/2034 · Cited by 271 · see citing works

RNAcontext: A New Method for Learning the Sequence and Structure Binding Preferences of RNA-Binding Proteins

Kazan, H., Ray, D., Chan, E. T., Hughes, T. R., & Morris, Q. (2010) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1000832 · Cited by 256 · see citing works

miR-519 reduces cell proliferation by lowering RNA-binding protein HuR levels

Abdelmohsen, K., Srikantan, S., Kuwano, Y., & Gorospe, M. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0809376106 · Cited by 230 · see citing works

Role of m6A writers, erasers and readers in cancer

Fang, Z., Mei, W., Qu, C., Lu, J., Shang, L., Cao, F., & Li, F. (2022) · Experimental Hematology and Oncology · doi:10.1186/s40164-022-00298-7 · Cited by 242 · see citing works

The regulation of mRNA stability in mammalian cells: 2.0

Wu, X., & Brewer, G. (2012) · Gene · doi:10.1016/j.gene.2012.03.021 · Cited by 239 · see citing works

HuR as a Negative Posttranscriptional Modulator in Inflammation

Katsanou, V., Papadaki, O., Milatos, S., Blackshear, P. J., Anderson, P., Kollias, G. A., & Kontoyiannis, D. L. (2005) · Molecular Cell · doi:10.1016/j.molcel.2005.08.007 · Cited by 236 · see citing works

Post‐transcriptional regulation in cancer

Audic, Y., & Hartley, R. S. (2004) · Biology of the Cell · doi:10.1016/j.biolcel.2004.05.002 · Cited by 237 · see citing works

Identification and Functional Outcome of mRNAs Associated with RNA-Binding Protein TIA-1

de Silanes, I. L., Galbán, S., Martindale, J. L., Yang, X., Mazan-Mamczarz, K., Indig, F. E., Falco, G., Zhan, M., & Gorospe, M. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.21.9520-9531.2005 · Cited by 230 · see citing works

Neuronal Elav-like (Hu) proteins regulate RNA splicing and abundance to control glutamate levels and neuronal excitability

Ince-Dunn, G., Okano, H. J., Jensen, K. B., Park, W.-Y., Zhong, R., Ule, J., Mele, A., Fak, J. J., Yang, C., Zhang, C., et al. (2012) · Neuron · doi:10.1016/j.neuron.2012.07.009 · Cited by 212 · see citing works

An endoplasmic reticulum stress-regulated lncRNA hosting a microRNA megacluster induces early features of diabetic nephropathy

Kato, M. V., Wang, M., Chen, Z., Bhatt, K. S., Oh, H. J., Lanting, L. L., Deshpande, S., Jia, Y., Lai, J. Y., O'Connor, C. L., et al. (2016) · Nature Communications · doi:10.1038/ncomms12864 · Cited by 221 · see citing works

RNA binding activity of the recessive parkinsonism protein DJ-1 supports involvement in multiple cellular pathways

van der Brug, M. P., Blackinton, J. G., Chandran, J. S., Hao, L.-Y., Lal, A., Mazan-Mamczarz, K., Martindale, J. L., Xie, C., Ahmad, R., Craig, K. J. T., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0708518105 · Cited by 214 · see citing works

Signalling pathways regulating nucleo-cytoplasmic shuttling of the mRNA-binding protein HuR

Doller, A., Pfeilschifter, J. M., & Eberhardt, W. (2008) · Cellular Signalling · doi:10.1016/j.cellsig.2008.05.007 · Cited by 215 · see citing works

Cytoplasmic HuR Expression Is a Prognostic Factor in Invasive Ductal Breast Carcinoma

Heinonen, M., Bono, P., Narko, K., Chang, S.-H., Lundin, J. E., Joensuu, H., Furneaux, H., Hla, T., Haglund, C. H., & Ristimäki, A. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-3765 · Cited by 213 · see citing works

MKP-1 mRNA Stabilization and Translational Control by RNA-Binding Proteins HuR and NF90

Kuwano, Y., Kim, H. H., Abdelmohsen, K., Pullmann, R., Martindale, J. L., Yang, X., & Gorospe, M. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.00165-08 · Cited by 209 · see citing works

Long noncoding RNA OCC-1 suppresses cell growth through destabilizing HuR protein in colorectal cancer

Lan, Y., Xiao, X., He, Z., Luo, Y., Wu, C., Li, L., & Song, X. (2018) · Nucleic Acids Research · doi:10.1093/nar/gky214 · Cited by 205 · see citing works

Nuclear HuR accumulation through phosphorylation by Cdk1Preprint

Kim, H. H., Abdelmohsen, K., Lal, A., Pullmann, R., Yang, X., Galbán, S., Srikantan, S., Martindale, J. L., Blethrow, J. D., Shokat, K. M., et al. (2008) · Genes & Development · doi:10.1101/gad.1645808 · Cited by 202 · see citing works

Post-transcriptional gene regulation: From genome-wide studies to principles

Halbeisen, R. E., Galgano, A., Scherrer, T., & Gerber, A. P. (2007) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-007-7447-6 · Cited by 195 · see citing works

Analysis of Turnover and Translation Regulatory RNA-Binding Protein Expression through Binding to Cognate mRNAs

Pullmann, R., Kim, H. H., Abdelmohsen, K., Lal, A., Martindale, J. L., Yang, X., & Gorospe, M. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.00500-07 · Cited by 199 · see citing works

Primary endothelial cell–specific regulation of hypoxia‐inducible factor (HIF)‐1 and HIF‐2 and their target gene expression profiles during hypoxia

Bartoszewski, R., Moszyńska, A., Serocki, M., Cabaj, A., Polten, A., Ochocka, R., Dell'Italia, L., Bartoszewska, S., Króliczewski, J., Dąbrowski, M., et al. (2019) · The FASEB Journal · doi:10.1096/fj.201802650rr · Cited by 199 · see citing works

RNA–protein interactions and control of mRNA stability in neurons

Bolognani, F., & Perrone‐Bizzozero, N. I. (2007) · Journal of Neuroscience Research · doi:10.1002/jnr.21473 · Cited by 196 · see citing works

Functional Interplay between RNA-Binding Protein HuR and microRNAs

Srikantan, S., Tominaga, K., & Gorospe, M. (2012) · Current Protein and Peptide Science · doi:10.2174/138920312801619394 · Cited by 193 · see citing works

Regulation of the vitamin D receptor gene by environment, genetics and epigenetics

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Selective Translational Control of the Alzheimer Amyloid Precursor Protein Transcript by Iron Regulatory Protein-1

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The Role of HuR in Gemcitabine Efficacy in Pancreatic Cancer: HuR Up-regulates the Expression of the Gemcitabine Metabolizing Enzyme Deoxycytidine Kinase

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Iron drives T helper cell pathogenicity by promoting RNA-binding protein PCBP1-mediated proinflammatory cytokine production

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Hu Antigen R (HuR) Functions as an Alternative Pre-mRNA Splicing Regulator of Fas Apoptosis-promoting Receptor on Exon Definition

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Long Noncoding RNA PURPL Suppresses Basal p53 Levels and Promotes Tumorigenicity in Colorectal Cancer

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Translational Repression by RNA-Binding Protein TIAR

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The transition from HIF-1 to HIF-2 during prolonged hypoxia results from reactivation of PHDs and HIF1A mRNA instability

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The RNA-binding protein HuR in human cancer: A friend or foe?

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mRNA Openers and Closers: Modulating AU‐Rich Element‐Controlled mRNA Stability by a Molecular Switch in mRNA Secondary Structure

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NF-κB Activates Transcription of the RNA-Binding Factor HuR, via PI3K-AKT Signaling, to Promote Gastric Tumorigenesis

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Polyamine Depletion Increases Cytoplasmic Levels of RNA-binding Protein HuR Leading to Stabilization of Nucleophosmin and p53 mRNAs

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Metabolic Engineering in the -omics Era: Elucidating and Modulating Regulatory Networks

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HuR Uses AUF1 as a Cofactor To Promote p16^INK4 mRNA Decay

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Molecular basis for AU-rich element recognition and dimerization by the HuR C-terminal RRM

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Polyamines Regulate c-Myc Translation through Chk2-dependent HuR Phosphorylation

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Alternative polyadenylation variants of the RNA binding protein, HuR: abundance, role of AU-rich elements and auto-Regulation

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Post-Transcriptional Control of the Hypoxic Response by RNA-Binding Proteins and MicroRNAs

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Nuclear RNA binding regulates TDP-43 nuclear localization and passive nuclear export

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Competitive Regulation of Nucleolin Expression by HuR and miR-494

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HuR Posttranscriptionally Regulates WEE1: Implications for the DNA Damage Response in Pancreatic Cancer Cells

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Targeting the interaction between RNA-binding protein HuR and FOXQ1 suppresses breast cancer invasion and metastasis

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RNPC1 modulates the RNA-binding activity of, and cooperates with, HuR to regulate p21 mRNA stability

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HuR biological function involves RRM3-mediated dimerization and RNA binding by all three RRMs

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Regulation of senescence and the SASP by the transcription factor C/EBPβ

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Prognostic Role of HuR in Hereditary Breast Cancer

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NF90 selectively represses the translation of target mRNAs bearing an AU-rich signature motif

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Chk2-dependent HuR phosphorylation regulates occludin mRNA translation and epithelial barrier function

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Pin1 regulates TGF-β1 production by activated human and murine eosinophils and contributes to allergic lung fibrosis

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The role of post-transcriptional regulation in chemokine gene expression in inflammation and allergy

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Role of Complex Epigenetic Switching in Tumor Necrosis Factor-α Upregulation in the Prefrontal Cortex of Suicide Subjects

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Properties of the Regulatory RNA-Binding Protein HuR and its Role in Controlling miRNA Repression

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Stability of Eukaryotic Translation Initiation Factor 4E mRNA Is Regulated by HuR, and This Activity Is Dysregulated in Cancer

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Chemokine Transcripts as Targets of the RNA-Binding Protein HuR in Human Airway Epithelium

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ELAVL1 Primarily Couples mRNA Stability with the 3’UTRs of Interferon Stimulated Genes

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Translational Control of TOP2A Influences Doxorubicin Efficacy

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Finding the target sites of RNA ‐binding proteins

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Post-transcriptional RNA regulons affecting cell cycle and proliferation

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Principles of HuR-RNA targeting, interaction dynamics, and functional outcomes

Mukherjee, N. (2010) · DukeSpace (Duke University)

Genomic Analyses of the RNA-binding Protein Hu Antigen R (HuR) Identify a Complex Network of Target Genes and Novel Characteristics of Its Binding Sites

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Novel recognition motifs and biological functions of the RNA-binding protein HuD revealed by genome-wide identification of its targets

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Insights from the HuR-interacting transcriptome: ncRNAs, ubiquitin pathways, and patterns of secondary structure dependent RNA interactions

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Identification of mRNAs regulated by HuR, an RNA-binding protein

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