The DOI matches its Crossref record; 164 of the 165 references it cites were found in a registry or an index.
A systematic review of leukocyte telomere length and age in adults
Abstract
Objective To provide a systematic review of the relationship between age and leukocyte telomere length (LTL) in adults.Methods Relevant studies were identified by a systematic search of Medline, EMBASE and ISI Web of Knowledge databases. Key data, such as age and LTL, were extracted from the studies along with correlation coefficients and yearly attrition rates where available. Obtained data were used to calculate weighted means and correlation coefficients.Results Overall, 124 cross-sectional studies and 5 longitudinal studies were identified. A statistically significant inverse correlation between mean age and mean LTL across cross-sectional studies was observed for both absolute (r=-0.338, p<0.0001) and relative LTL (r=-0.295, p=0.0088). From mean LTL and ages, a yearly telomere loss of 24.7 base pairs (BP)/year was estimated by weighted linear regression. Weighted means of within study correlation of age and TL and yearly telomere loss rate estimates from cross-sectional studies were also in a similar order of magnitude (-0.380 and 21.91 BP/year). The few longitudinal studies reported somewhat higher mean telomere loss rates (between 32.2 and 45.5 BP/year).Conclusion While a decrease of LTL with age is out of question, data on variation of the decrease according to sex, age and other potential determinants especially from longitudinal data are still sparse.
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“Leukocyte telomere length generally decreases progressively over the lifespan, with estimates of average attrition rate ranging between 14 to 103 base pairs (bp) per year (weighted mean of 21.9 bp per year) in cross-sectional studies, and between 32.2 to 45.5 bp per year (weighted mean of 40.7 bp per year) in longitudinal studies (Muezzinler et al., 2013).”
From Psychiatric disorders and leukocyte telomere length: Underlying mechanisms linking mental illness with cellular aging (2015) · cites this paper as Muezzinler et al., 2013
In the citing paper
“Some individuals maintain and may even lengthen average LTL for some periods (Epel, 2012; Muezzinler et al., 2013).”
From Psychiatric disorders and leukocyte telomere length: Underlying mechanisms linking mental illness with cellular aging (2015) · cites this paper as Muezzinler et al., 2013
Citations
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“This unstable state of chromosomes may lead to activation of molecular cascades involved in cellular stress responses, such as p53 and p16ink4a pathways, which may eventually result in apoptosis or cellular senescence (Harley et al., 1990; di Fagagna et al., 2003; Counter et al., 1992).”
BackgroundMoyzis, R. K., Buckingham, J. M., Cram, L. S., Dani, M. A. C., Deaven, L. L., Jones, M. D., Meyne, J., Ratliff, R. L., & Wu, J. R. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.18.6622 · Cited by 2,326
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“This unstable state of chromosomes may lead to activation of molecular cascades involved in cellular stress responses, such as p53 and p16ink4a pathways, which may eventually result in apoptosis or cellular senescence (Harley et al., 1990; di Fagagna et al., 2003; Counter et al., 1992).”
BackgroundTelomeres and human disease: ageing, cancer and beyond
Blasco, M. A. (2005) · Nature Reviews Genetics · doi:10.1038/nrg1656 · Cited by 1,434
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Leucocyte telomere length and risk of cardiovascular disease: systematic review and meta-analysis
Haycock, P. C., Heydon, E. E., Kaptoge, S., Butterworth, A. S., Thompson, A., & Willeit, P. (2014) · BMJ · doi:10.1136/bmj.g4227 · Cited by 856
Measuring biological aging in humans: a quest
Ferrucci, L., Gonzalez‐Freire, M., Fabbri, E., Simonsick, E., Tanaka, T., Moore, Z., Salimi, S., Sierra, F., & de Cabo, R. (2020) · Aging Cell · doi:10.1111/acel.13080 · Cited by 781
Vaiserman, A., & Krasnienkov, D. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2020.630186 · Cited by 454
Brain age and other bodily ‘ages’: implications for neuropsychiatry
Cole, J. H., Marioni, R. E., Harris, S. E., & Deary, I. J. (2018) · Molecular Psychiatry · doi:10.1038/s41380-018-0098-1 · Cited by 450
Immunoglobulin G glycosylation in aging and diseases
Gudelj, I., Lauc, G., & Pezer, M. (2018) · Cellular Immunology · doi:10.1016/j.cellimm.2018.07.009 · Cited by 422
Metadata
- Authors
- Müezzinler, A., Zaineddin, A. K., & Brenner, H.
- Affiliations
- German Cancer Research Center (DE)
- Corresponding author
- Müezzinler, Aysel
- ORCID
- Brenner, Hermann
- Venue
- Ageing Research Reviews
- Publisher
- Elsevier BV
- Published
- 2013-03
- Volume
- 12
- Issue
- 2
- Pages
- 509-519
- ISSN
- 1568-1637 (ISSN-L)
- OpenAlex
- W2000059391
- Cited by
- 474
- References
- 165
- Citations by year
- 2026: 14 · 2025: 19 · 2024: 34 · 2023: 31 · 2022: 49 · 2021: 41 · 2020: 46 · 2019: 60 · 2018: 36 · 2017: 49 · 2016: 38 · 2015: 28 · 2014: 23 · 2013: 5
- FWCI
- 3.45
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Ageing Research Reviews (publishedVersion)
- PubMed (publishedVersion)
- Funders
- European Commission
- Klaus Tschira Stiftung
- Hellenic Health Foundation
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Keywords
- leukocyte telomere length, aging, telomere shortening, age-related telomere shortening, adults, sex differences
- MeSH terms
- Age Factors, Aged, Aged, 80 and over, Aging, Cross-Sectional Studies, Humans, Leukocytes, Longitudinal Studies, Middle Aged, Linear Models, Telomere Homeostasis, Telomere Shortening
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