Cited by 474Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model OrganismsEpigenetics and DNA Methylation

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A systematic review of leukocyte telomere length and age in adults

Müezzinler, Aysel, Zaineddin, Aida Karina, Brenner, Hermann·2013·Ageing Research Reviews

DOI 10.1016/j.arr.2013.01.003

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Abstract

Objective To provide a systematic review of the relationship between age and leukocyte telomere length (LTL) in adults.Methods Relevant studies were identified by a systematic search of Medline, EMBASE and ISI Web of Knowledge databases. Key data, such as age and LTL, were extracted from the studies along with correlation coefficients and yearly attrition rates where available. Obtained data were used to calculate weighted means and correlation coefficients.Results Overall, 124 cross-sectional studies and 5 longitudinal studies were identified. A statistically significant inverse correlation between mean age and mean LTL across cross-sectional studies was observed for both absolute (r=-0.338, p<0.0001) and relative LTL (r=-0.295, p=0.0088). From mean LTL and ages, a yearly telomere loss of 24.7 base pairs (BP)/year was estimated by weighted linear regression. Weighted means of within study correlation of age and TL and yearly telomere loss rate estimates from cross-sectional studies were also in a similar order of magnitude (-0.380 and 21.91 BP/year). The few longitudinal studies reported somewhat higher mean telomere loss rates (between 32.2 and 45.5 BP/year).Conclusion While a decrease of LTL with age is out of question, data on variation of the decrease according to sex, age and other potential determinants especially from longitudinal data are still sparse.

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Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method
Livak, K. J., & Schmittgen, T. D. (2001) · Methods · doi:10.1006/meth.2001.1262 · Cited by 180,860
Meta-analysis of Observational Studies in Epidemiology<SUBTITLE>A Proposal for Reporting</SUBTITLE>
Stroup, D. F. (2000) · JAMA · doi:10.1001/jama.283.15.2008 · Cited by 20,623
Relative expression software tool (REST(C)) for group-wise comparison and statistical analysis of relative expression results in real-time PCR
Pfaffl, M. W. (2002) · Nucleic Acids Research · doi:10.1093/nar/30.9.e36 · Cited by 7,377
Telomeres shorten during ageing of human fibroblasts
Harley, C. B., Futcher, A. B., & Greider, C. W. (1990) · Nature · doi:10.1038/345458a0 · Cited by 5,750
Telomere measurement by quantitative PCR
Cawthon, R. (2002) · Nucleic Acids Research · doi:10.1093/nar/30.10.e47 · Cited by 3,550
Van Damme A.
Haine, M. M.-L., & Meeùs, N. (1986) · Cited by 3,464
A DNA damage checkpoint response in telomere-initiated senescence
Fagagna, F. D. D., Reaper, P. M., Clay-Farrace, L., Fiegler, H., Carr, P., von Zglinicki, T., Saretzki, G., Carter, N. P., & Jackson, S. P. (2003) · Nature · doi:10.1038/nature02118 · Cited by 2,917 · cited 1×
“This unstable state of chromosomes may lead to activation of molecular cascades involved in cellular stress responses, such as p53 and p16ink4a pathways, which may eventually result in apoptosis or cellular senescence (Harley et al., 1990; di Fagagna et al., 2003; Counter et al., 1992).”
Background
A highly conserved repetitive DNA sequence, (TTAGGG)n, present at the telomeres of human chromosomes.
Moyzis, R. K., Buckingham, J. M., Cram, L. S., Dani, M. A. C., Deaven, L. L., Jones, M. D., Meyne, J., Ratliff, R. L., & Wu, J. R. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.18.6622 · Cited by 2,326
Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity.
Counter, C. M., Avilion, A. A., LeFeuvre, C. E., Stewart, N. G., Greider, C. W., Harley, C. B., & Bacchetti, S. (1992) · The EMBO Journal · doi:10.1002/j.1460-2075.1992.tb05245.x · Cited by 2,096 · cited 1×
“This unstable state of chromosomes may lead to activation of molecular cascades involved in cellular stress responses, such as p53 and p16ink4a pathways, which may eventually result in apoptosis or cellular senescence (Harley et al., 1990; di Fagagna et al., 2003; Counter et al., 1992).”
Background
Telomeres and human disease: ageing, cancer and beyond
Blasco, M. A. (2005) · Nature Reviews Genetics · doi:10.1038/nrg1656 · Cited by 1,434

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Phillips, C. (2017) · Neural Plasticity · doi:10.1155/2017/7014146 · Cited by 72
The biological age of the heart is consistently younger than chronological age
Pavanello, S., Campisi, M., Fabozzo, A., Cibin, G., Tarzia, V., Toscano, G., & Gerosa, G. (2020) · Scientific Reports · doi:10.1038/s41598-020-67622-1 · Cited by 66
Epigenetic Clocks and Allostatic Load Reveal Potential Sex-Specific Drivers of Biological Aging
McCrory, C., Fiorito, G., McLoughlin, S., Polidoro, S., Cheallaigh, C. N., Bourke, N. M., Karisola, P., Alenius, H. T., Vineis, P., Layte, R., et al. (2019) · The Journals of Gerontology Series A · doi:10.1093/gerona/glz241 · Cited by 62
Leukocyte telomere length is related to appendicular lean mass: cross-sectional data from the Berlin Aging Study II (BASE-II)
Meyer, A., Salewsky, B., Spira, D., Steinhagen‐Thiessen, E., Norman, K., & Demuth, I. (2015) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.115.116806 · Cited by 61
Is Chronic Asthma Associated with Shorter Leukocyte Telomere Length at Midlife?
Belsky, D. W., Shalev, I., Sears, M. R., Hancox, R. J., Harrington, H. L., Houts, R., Moffitt, T. E., Sugden, K., Williams, B. S., Poulton, R., et al. (2014) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201402-0370oc · Cited by 63
Baseline biopsychosocial determinants of telomere length and 6-year attrition rate
Révész, D., Milaneschi, Y., Terpstra, E. M., & Penninx, B. W. J. H. (2016) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2016.02.007 · Cited by 65
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Bateson, M., & Nettle, D. (2018) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2016.0438 · Cited by 61
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Park, M., Verhoeven, J. E., Cuijpers, P., Reynolds III, C. F., & Penninx, B. W. J. H. (2015) · PLoS ONE · doi:10.1371/journal.pone.0128460 · Cited by 59
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Welendorf, C. R., Nicoletti, C. F., Pinhel, M. A. D. S., Noronha, N. Y., de Paula, B. M. F., & Nonino, C. B. (2019) · Nutrition · doi:10.1016/j.nut.2019.05.002 · Cited by 66
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Saßenroth, D., Meyer, A., Salewsky, B., Kroh, M., Norman, K., Steinhagen‐Thiessen, E., & Demuth, I. (2015) · PLoS ONE · doi:10.1371/journal.pone.0142131 · Cited by 58
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Lustig, A., Liu, H. B., Metter, E. J., An, Y., Swaby, M. A., Elango, P., Ferrucci, L., Hodes, R. J., & Weng, N. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01027 · Cited by 58
Longitudinal decline of leukocyte telomere length in old age and the association with sex and genetic risk
Berglund, K., Reynolds, C. A., Ploner, A., Gerritsen, L., Hovatta, I., Pedersen, N. L., & Hägg, S. (2016) · Aging · doi:10.18632/aging.100995 · Cited by 58
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Otsuka, I., Izumi, T., Boku, S., Kimura, A., Zhang, Y., Mouri, K., Okazaki, S., Shiroiwa, K., Takahashi, M., Ueno, Y., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-03599-8 · Cited by 63
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Franzke, B., Neubauer, O., & Wagner, K. (2015) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2015.08.001 · Cited by 55
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Kahl, V. F. S., Simon, D., Salvador, M. M., Branco, C. S., Dias, J. F., da Silva, F. R., de Souza, C. T., & da Silva, J. (2015) · Environmental and Molecular Mutagenesis · doi:10.1002/em.21984 · Cited by 53
Shorter telomere length in peripheral blood leukocytes is associated with childhood autism
Li, Z., Tang, J., Li, H., Chen, S., Hé, Y., Liao, Y., Wei, Z., Wan, G., Xiang, X., Xia, K., et al. (2014) · Scientific Reports · doi:10.1038/srep07073 · Cited by 54
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Aulinas, A., Ramírez, M., Barahona, M. J., Valassi, E., Resmini, E., Mato, E., Vives, A. S., Crespo, I., Bell, O. L., Surrallés, J., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0120185 · Cited by 53
The longitudinal relationship between cortisol responses to mental stress and leukocyte telomere attrition
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Mitchell, A. M., Kowalsky, J. M., Epel, E. S., Lin, J., & Christian, L. M. (2017) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2017.10.003 · Cited by 54
Effects of maternal exposure to ambient air pollution on newborn telomere length
Song, L., Zhang, B., Liu, B., Wu, M., Zhang, L., Wang, L., Xu, S., Cao, Z., & Wang, Y. (2019) · Environment International · doi:10.1016/j.envint.2019.04.064 · Cited by 53
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Milligen, B. A. L.-V., Verhoeven, J. E., Schmaal, L., van Velzen, L. S., Révész, D., Black, C. N., Han, L. K. M., Horsfall, M., Batelaan, N. M., van Balkom, A. J. L. M., et al. (2019) · BMC Psychiatry · doi:10.1186/s12888-019-2404-0 · Cited by 52
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Carroll, J., Irwin, M. R., Seeman, T. E., Roux, A. V. D., Prather, A. A., Olmstead, R., Epel, E. S., Lin, J., & Redline, S. S. (2019) · SLEEP · doi:10.1093/sleep/zsz089 · Cited by 49
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Lazarides, C., Epel, E. S., Lin, J., Blackburn, E. H., Voelkle, M. C., Buß, C., Simhan, H. N., Wadhwa, P. D., & Entringer, S. (2019) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2019.04.021 · Cited by 51
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Harris, S. E., Riggio, V., Evenden, L., Gilchrist, T. L., McCafferty, S., Murphy, L., Wrobel, N., Taylor, A. M., Corley, J., Pattie, A., et al. (2017) · Aging · doi:10.18632/aging.101333 · Cited by 50
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Song, N., Li, Z., Qin, N., Howell, C. R., Wilson, C. L., Easton, J. B., Mulder, H. L., Edmonson, M. N., Rusch, M., Zhang, J., et al. (2020) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-19-2503 · Cited by 50

Authors: Müezzinler, A., Zaineddin, A. K., & Brenner, H.
Affiliations: German Cancer Research Center (DE)
Corresponding author: Müezzinler, Aysel
ORCID: Brenner, Hermann
Venue: Ageing Research Reviews
Publisher: Elsevier BV
Published: 2013-03
Volume: 12
Issue: 2
Pages: 509-519
ISSN: 1568-1637 (ISSN-L)
DOI: 10.1016/j.arr.2013.01.003
OpenAlex: W2000059391
Cited by: 474
References: 165
Citations by year: 2026: 14 · 2025: 19 · 2024: 34 · 2023: 31 · 2022: 49 · 2021: 41 · 2020: 46 · 2019: 60 · 2018: 36 · 2017: 49 · 2016: 38 · 2015: 28 · 2014: 23 · 2013: 5
FWCI: 3.45
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Ageing Research Reviews (publishedVersion)
PubMed (publishedVersion)
Funders: European Commission
Klaus Tschira Stiftung
Hellenic Health Foundation
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
Keywords: leukocyte telomere length, aging, telomere shortening, age-related telomere shortening, adults, sex differences
MeSH terms: Age Factors, Aged, Aged, 80 and over, Aging, Cross-Sectional Studies, Humans, Leukocytes, Longitudinal Studies, Middle Aged, Linear Models, Telomere Homeostasis, Telomere Shortening

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A systematic review of leukocyte telomere length and age in adults

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