Cited by 474Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model OrganismsEpigenetics and DNA Methylation

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A systematic review of leukocyte telomere length and age in adults

Müezzinler, Aysel, Zaineddin, Aida Karina, Brenner, Hermann·2013·Ageing Research Reviews

DOI 10.1016/j.arr.2013.01.003

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Abstract

Objective To provide a systematic review of the relationship between age and leukocyte telomere length (LTL) in adults.Methods Relevant studies were identified by a systematic search of Medline, EMBASE and ISI Web of Knowledge databases. Key data, such as age and LTL, were extracted from the studies along with correlation coefficients and yearly attrition rates where available. Obtained data were used to calculate weighted means and correlation coefficients.Results Overall, 124 cross-sectional studies and 5 longitudinal studies were identified. A statistically significant inverse correlation between mean age and mean LTL across cross-sectional studies was observed for both absolute (r=-0.338, p<0.0001) and relative LTL (r=-0.295, p=0.0088). From mean LTL and ages, a yearly telomere loss of 24.7 base pairs (BP)/year was estimated by weighted linear regression. Weighted means of within study correlation of age and TL and yearly telomere loss rate estimates from cross-sectional studies were also in a similar order of magnitude (-0.380 and 21.91 BP/year). The few longitudinal studies reported somewhat higher mean telomere loss rates (between 32.2 and 45.5 BP/year).Conclusion While a decrease of LTL with age is out of question, data on variation of the decrease according to sex, age and other potential determinants especially from longitudinal data are still sparse.

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Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method
Livak, K. J., & Schmittgen, T. D. (2001) · Methods · doi:10.1006/meth.2001.1262 · Cited by 180,860
Meta-analysis of Observational Studies in Epidemiology<SUBTITLE>A Proposal for Reporting</SUBTITLE>
Stroup, D. F. (2000) · JAMA · doi:10.1001/jama.283.15.2008 · Cited by 20,623
Relative expression software tool (REST(C)) for group-wise comparison and statistical analysis of relative expression results in real-time PCR
Pfaffl, M. W. (2002) · Nucleic Acids Research · doi:10.1093/nar/30.9.e36 · Cited by 7,377
Telomeres shorten during ageing of human fibroblasts
Harley, C. B., Futcher, A. B., & Greider, C. W. (1990) · Nature · doi:10.1038/345458a0 · Cited by 5,750
Telomere measurement by quantitative PCR
Cawthon, R. (2002) · Nucleic Acids Research · doi:10.1093/nar/30.10.e47 · Cited by 3,550
Van Damme A.
Haine, M. M.-L., & Meeùs, N. (1986) · Cited by 3,464
A DNA damage checkpoint response in telomere-initiated senescence
Fagagna, F. D. D., Reaper, P. M., Clay-Farrace, L., Fiegler, H., Carr, P., von Zglinicki, T., Saretzki, G., Carter, N. P., & Jackson, S. P. (2003) · Nature · doi:10.1038/nature02118 · Cited by 2,917 · cited 1×
“This unstable state of chromosomes may lead to activation of molecular cascades involved in cellular stress responses, such as p53 and p16ink4a pathways, which may eventually result in apoptosis or cellular senescence (Harley et al., 1990; di Fagagna et al., 2003; Counter et al., 1992).”
Background
A highly conserved repetitive DNA sequence, (TTAGGG)n, present at the telomeres of human chromosomes.
Moyzis, R. K., Buckingham, J. M., Cram, L. S., Dani, M. A. C., Deaven, L. L., Jones, M. D., Meyne, J., Ratliff, R. L., & Wu, J. R. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.18.6622 · Cited by 2,326
Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity.
Counter, C. M., Avilion, A. A., LeFeuvre, C. E., Stewart, N. G., Greider, C. W., Harley, C. B., & Bacchetti, S. (1992) · The EMBO Journal · doi:10.1002/j.1460-2075.1992.tb05245.x · Cited by 2,096 · cited 1×
“This unstable state of chromosomes may lead to activation of molecular cascades involved in cellular stress responses, such as p53 and p16ink4a pathways, which may eventually result in apoptosis or cellular senescence (Harley et al., 1990; di Fagagna et al., 2003; Counter et al., 1992).”
Background
Telomeres and human disease: ageing, cancer and beyond
Blasco, M. A. (2005) · Nature Reviews Genetics · doi:10.1038/nrg1656 · Cited by 1,434
Obesity, cigarette smoking, and telomere length in women
Valdes, A., Andrew, T., Gardner, J., Kimura, M., Oelsner, E., Cherkas, L., Aviv, A., & Spector, T. (2005) · The Lancet · doi:10.1016/s0140-6736(05)66630-5 · Cited by 1,363
Telomere end-replication problem and cell aging
Levy, M. Z., Allsopp, R. C., Futcher, A. B., Greider, C. W., & Harley, C. B. (1992) · Journal of Molecular Biology · doi:10.1016/0022-2836(92)90096-3 · Cited by 1,069
Leukocyte Telomere Length and Cardiovascular Disease in the Cardiovascular Health Study
Fitzpatrick, A. L., Kronmal, R. A., Gardner, J. P., Psaty, B. M., Jenny, N. S., Tracy, R. P., Walston, J., Kimura, M., & Aviv, A. (2006) · American Journal of Epidemiology · doi:10.1093/aje/kwj346 · Cited by 773
Genetic determination of telomere size in humans: a twin study of three age groups.
Slagboom, P. E., Droog, S., & Boomsma, D. I. (1994) · PubMed Central · Cited by 734
Telomere Length as an Indicator of Biological Aging
Bénétos, A., Okuda, K., Lajemi, M., Kimura, M., Thomas, F., Skurnick, J., Labat, C., Bean, K., & Aviv, A. (2001) · Hypertension · doi:10.1161/01.hyp.37.2.381 · Cited by 627
White Cell Telomere Length and Risk of Premature Myocardial Infarction
Brouilette, S., Singh, R. K., Thompson, J. R., Goodall, A. H., & Samani, N. J. (2003) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.0000067426.96344.32 · Cited by 590
Telomere Shortening in Familial and Sporadic Pulmonary Fibrosis
Cronkhite, J. T., Xing, C., Raghu, G., Chin, K. M., Torres, F., Rosenblatt, R. L., & Kim Garcia, C. (2008) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200804-550oc · Cited by 573
The Association Between Physical Activity in Leisure Time and Leukocyte Telomere Length
Cherkas, L. F. (2008) · Archives of Internal Medicine · doi:10.1001/archinternmed.2007.39 · Cited by 572
Oestrogen and inhibition of oxidation of low-density lipoproteins in postmenopausal women
Sack, M. N., Rader, D. J., & Cannon, R. O. (1994) · The Lancet · doi:10.1016/s0140-6736(94)91117-7 · Cited by 525
Telomere shortening and mood disorders: preliminary support for a chronic stress model of accelerated aging
Simon, N. M., Smoller, J. W., McNamara, K. L., Maser, R. S., Zalta, A. K., Pollack, M. H., Nierenberg, A. A., Fava, M., & Wong, K.-K. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.02.004 · Cited by 516
Estrogen activates telomerase.
Kyo, S., Takakura, M., Kanaya, T., Zhuo, W., FUJIMOTO, K., Nishio, Y., Orimo, A., & Inoue, M. (1999) · PubMed · Cited by 509
Insulin resistance, oxidative stress, hypertension, and leukocyte telomere length in men from the Framingham Heart Study
Demissie, S., Levy, D., Benjamin, E. J., Cupples, L. A., Gardner, J. P., Herbert, A., Kimura, M., Larson, M. G., Meigs, J. B., Keaney, J. F., et al. (2006) · Aging Cell · doi:10.1111/j.1474-9726.2006.00224.x · Cited by 508
Role of Oxidative Stress in Telomere Length Regulation and Replicative Senescence
von Zglinicki, T. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb06639.x · Cited by 452
Accelerated Telomere Erosion Is Associated with a Declining Immune Function of Caregivers of Alzheimer’s Disease Patients
Damjanovic, A. K., Yang, Y., Glaser, R., Kiecolt‐Glaser, J. K., Nguyen, H., Laskowski, B. F., Zou, Y., Beversdorf, D. Q., & Weng, N. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.6.4249 · Cited by 413
Telomere length is paternally inherited and is associated with parental lifespan
Njajou, O. T., Cawthon, R. M., Damcott, C. M., Wu, S.-H., Ott, S., Garant, M. J., Blackburn, E. H., Mitchell, B. D., Shuldiner, A. R., & Hsueh, W.-C. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0702703104 · Cited by 387
Shortened Telomere Length Is Associated with Increased Risk of Cancer: A Meta-Analysis
Ma, H., Zhou, Z., Wei, S., Liu, Z., Pooley, K. A., Dunning, A. M., Svenson, U., Roos, G., Hosgood, H. D., Shen, M., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0020466 · Cited by 376 · cited 1×
“…been linked to mortality, several diseases and ageing related pathologies, including some cancers, cardiovascular diseases, obesity, Alzheimer’s disease, diabetes mellitus and osteoporosis in recent years (Jeyapalan and Sedivy, 2008; Aviv, 2002; Blasco, 2005; Ma et al., 2011; Valdes et al., 2007).”
Background
Telomere length and possible link to X chromosome
Nawrot, T. S., Staessen, J. A., Gardner, J. P., & Aviv, A. (2004) · The Lancet · doi:10.1016/s0140-6736(04)15535-9 · Cited by 370
Rise in Insulin Resistance Is Associated With Escalated Telomere Attrition
Gardner, J. P., Li, S., Srinivasan, S. R., Chen, W., Kimura, M., Lu, X., Berenson, G. S., & Aviv, A. (2005) · Circulation · doi:10.1161/01.cir.0000163550.70487.0b · Cited by 359
Telomere Length Inversely Correlates With Pulse Pressure and Is Highly Familial
Jeanclos, E. M., Schork, N. J., Kyvik, K. O., Kimura, M., Skurnick, J., & Aviv, A. (2000) · Hypertension · doi:10.1161/01.hyp.36.2.195 · Cited by 355
Cellular senescence and organismal aging
Jeyapalan, J. C., & Sedivy, J. M. (2008) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2008.04.001 · Cited by 351
Telomere length and cardiovascular risk factors in a middle‐aged population free of overt cardiovascular disease
Bekaert, S., De Meyer, T., Rietzschel, E. R., De Buyzere, M. L., De Bacquer, D., Langlois, M., Segers, P., Cooman, L., Van Damme, P., Cassiman, P., et al. (2007) · Aging Cell · doi:10.1111/j.1474-9726.2007.00321.x · Cited by 348
Common variants near TERC are associated with mean telomere length
Wellcome Trust Case Control Consortium, Codd, V., Mangino, M., van der Harst, P., Braund, P. S., Kaiser, M., Beveridge, A. J., Rafelt, S., Moore, J., Nelson, C., et al. (2010) · Nature Genetics · doi:10.1038/ng.532 · Cited by 344
Impartial comparative analysis of measurement of leukocyte telomere length/DNA content by Southern blots and qPCR
Aviv, A., Hunt, S. C., Lin, J., Cao, X., Kimura, M., & Blackburn, E. (2011) · Nucleic Acids Research · doi:10.1093/nar/gkr634 · Cited by 343
Childhood maltreatment and telomere shortening: preliminary support for an effect of early stress on cellular aging
Tyrka, A. R., Price, L. H., Kao, H.-T., Porton, B., Marsella, S. A., & Carpenter, L. L. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.08.014 · Cited by 342
Telomere length measurement-caveats and a critical assessment of the available technologies and tools
Aubert, G., Hills, M., & Lansdorp, P. M. (2012) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2011.04.003 · Cited by 342
The power of exercise: buffering the effect of chronic stress on telomere length
Puterman, E., Lin, J., Blackburn, E., O'Donovan, A., Adler, N., & Epel, E. (2010) · PLoS ONE · doi:10.1371/journal.pone.0010837 · Cited by 339
Telomere Length, Cigarette Smoking, and Bladder Cancer Risk in Men and Women
McGrath, M., Wong, J. Y. Y., Michaud, D. S., Hunter, D. J., & Vivo, I. D. (2007) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-06-0961 · Cited by 336
Shortened Telomeres in Circulating Leukocytes of Patients with Chronic Obstructive Pulmonary Disease
Savale, L., Chaouat, A., Bastuji‐Garin, S., Marcos, É., Boyer, L., Maître, B., Sarni, M., HOUSSET, B., Weitzenblum, E., Matrat, M., et al. (2009) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200809-1398oc · Cited by 329
Telomere length in white blood cells is not associated with morbidity or mortality in the oldest old: a population‐based study
Martin-Ruiz, C. M., Gussekloo, J., van Heemst, D., von Zglinicki, T., & Westendorp, R. G. J. (2005) · Aging Cell · doi:10.1111/j.1474-9726.2005.00171.x · Cited by 322
Antioxidant properties of steroids
Mooradian, A. D. (1993) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/0960-0760(93)90166-t · Cited by 309
Leukocyte telomeres are longer in African Americans than in whites: the National Heart, Lung, and Blood Institute Family Heart Study and the Bogalusa Heart Study
Hunt, S. C., Chen, W., Gardner, J. P., Kimura, M., Srinivasan, S. R., Eckfeldt, J. H., Berenson, G. S., & Aviv, A. (2008) · Aging Cell · doi:10.1111/j.1474-9726.2008.00397.x · Cited by 309
Short Telomeres in Patients with Vascular Dementia: An Indicator of Low Antioxidative Capacity and a Possible Risk Factor?
von Zglinicki, T., Serra, V., Lorenz, M., Saretzki, G. C., Lenzen-Großimlinghaus, R., Gessner, R. V., Risch, A., & Steinhagen‐Thiessen, E. (2000) · Laboratory Investigation · doi:10.1038/labinvest.3780184 · Cited by 305
Molecular inflammation hypothesis of aging based on the anti‐aging mechanism of calorie restriction
Chung, H. Y., Kim, H. J., Kim, K. W., Choi, J. S., & Yu, B. P. (2002) · Microscopy Research and Technique · doi:10.1002/jemt.10203 · Cited by 301
Leukocyte Telomere Dynamics: Longitudinal Findings Among Young Adults in the Bogalusa Heart Study
Aviv, A., Chen, W., Gardner, J. P., Kimura, M., Brimacombe, M. B., Cao, X., Srinivasan, S. R., & Berenson, G. S. (2008) · American Journal of Epidemiology · doi:10.1093/aje/kwn338 · Cited by 293
Cellular Aging Reflected by Leukocyte Telomere Length Predicts Advanced Atherosclerosis and Cardiovascular Disease Risk
Willeit, P., Willeit, J., Kloss‐Brandstätter, A., Ehrlenbach, S., Mayr, A., Gasperi, A., Weger, S., Oberhollenzer, F., Reindl, M., Kronenberg, F., et al. (2010) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.110.205492 · Cited by 289
Progressive Telomere Shortening in Aplastic Anemia
Ball, S. E., Gibson, F. M., Rizzo, S., Tooze, J. A., Marsh, J. C. W., & Gordon‐Smith, E. C. (1998) · Blood · doi:10.1182/blood.v91.10.3582 · Cited by 288
Telomere Length of Circulating Leukocytes Is Decreased in Patients With Chronic Heart Failure
van der Harst, P., van der Steege, G., de Boer, R. A., Voors, A. A., Hall, A. S., Mulder, M. J., van Gilst, W. H., & van Veldhuisen, D. J. (2007) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2007.01.027 · Cited by 285
Offspring's Leukocyte Telomere Length, Paternal Age, and Telomere Elongation in Sperm
Kimura, M., Cherkas, L. F., Kato, B. S., Demissie, S., Hjelmborg, J., Brimacombe, M. B., Cupples, L. A., Hunkin, J., Gardner, J. P., Lu, X., et al. (2005) · PLoS Genetics · doi:10.1371/journal.pgen.0040037 · Cited by 280
Telomere Length and Mortality: A Study of Leukocytes in Elderly Danish Twins
Kimura, M., Hjelmborg, J., Gardner, J. P., Bathum, L., Brimacombe, M. B., Lu, X., Christiansen, L., Vaupel, J. W., Aviv, A., & Christensen, K. (2008) · American Journal of Epidemiology · doi:10.1093/aje/kwm380 · Cited by 277
Telomere length in white blood cells, buccal cells and brain tissue and its variation with ageing and Alzheimer's disease
Thomas, P., Callaghan, N. J. O., & Fenech, M. F. (2008) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2007.12.004 · Cited by 255
A priori–defined dietary patterns and markers of cardiovascular disease risk in the Multi-Ethnic Study of Atherosclerosis (MESA)
Nettleton, J. A., Schulze, M. B., Jiang, R., Jenny, N. S., Burke, G. L., & Jacobs, D. R. (2008) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/88.1.185 · Cited by 252
Association Between Telomere Length, Specific Causes of Death, and Years of Healthy Life in Health, Aging, and Body Composition, a Population-Based Cohort Study
Njajou, O. T., Hsueh, W.-C., Blackburn, E. H., Newman, A. B., Wu, S.-H., Li, R., Simonsick, E. M., Harris, T. B., Cummings, S., & Cawthon, R. (2009) · The Journals of Gerontology Series A · doi:10.1093/gerona/glp061 · Cited by 249
No Association Between Telomere Length and Survival Among the Elderly and Oldest Old
Bischoff, C., Petersen, H. C., Graakjær, J., Andersen‐Ranberg, K., Vaupel, J. W., Bohr, V. A., Kølvraa, S., & Christensen, K. (2006) · Epidemiology · doi:10.1097/01.ede.0000199436.55248.10 · Cited by 243
Higher serum vitamin D concentrations are associated with longer leukocyte telomere length in women
Richards, J. B., Valdes, A. M., Gardner, J. P., Paximadas, D., Kimura, M., Nessa, A., Lu, X., Surdulescu, G. L., Swaminathan, R., Spector, T. D., et al. (2007) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/86.5.1420 · Cited by 237
The rate of leukocyte telomere shortening predicts mortality from cardiovascular disease in elderly men: a novel demonstration
Epel, E. S., Merkin, S. S., Cawthon, R., Blackburn, E. H., Adler, N. E., Pletcher, M. J., & Seeman, T. E. (2008) · Aging · doi:10.18632/aging.100007 · Cited by 236
Relationship between Physical Activity Level, Telomere Length, and Telomerase Activity
Ludlow, A. T., Zimmerman, J. B., Witkowski, S., Hearn, J. W., Hatfield, B. D., & Roth, S. M. (2008) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e31817c92aa · Cited by 233
Paternal age is positively linked to telomere length of children
Unryn, B. M., Cook, L. S., & Riabowol, K. T. (2005) · Aging Cell · doi:10.1111/j.1474-9728.2005.00144.x · Cited by 230
Race/ethnicity and telomere length in the Multi‐Ethnic Study of Atherosclerosis
Roux, A. V. D., Ranjit, N., Jenny, N. S., Shea, S., Cushman, M., Fitzpatrick, A. L., & Seeman, T. E. (2009) · Aging Cell · doi:10.1111/j.1474-9726.2009.00470.x · Cited by 220
Inverse association between adiposity and telomere length: The fels longitudinal study
Lee, M., Martin, H. B., Firpo, M. A., & Demerath, E. W. (2010) · American Journal of Human Biology · doi:10.1002/ajhb.21109 · Cited by 213
Longitudinal versus Cross-sectional Evaluations of Leukocyte Telomere Length Dynamics: Age-Dependent Telomere Shortening is the Rule
CHEN, W., Kimura, M., Kim, S., Cao, X., Srinivasan, S. R., Berenson, G. S., Kark, J. D., & Aviv, A. (2011) · The Journals of Gerontology Series A · doi:10.1093/gerona/glq223 · Cited by 211
Telomere length and the risk of lung cancer
Jang, J. S., Choi, Y. Y., Lee, W. K., Choi, J. E., Ick, S., Kim, Y. J., Kim, C. H., Kam, S., Jung, T. H., & Park, J. Y. (2008) · Cancer Science · doi:10.1111/j.1349-7006.2008.00831.x · Cited by 207
Telomere length and heredity: Indications of paternal inheritance
Nordfjäll, K., Larefalk, Å., Lindgren, P., Holmberg, D., & Roos, G. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0501724102 · Cited by 205
Telomere Length Trajectory and Its Determinants in Persons with Coronary Artery Disease: Longitudinal Findings from the Heart and Soul Study
Farzaneh-Far, R., Lin, J., Epel, E., Lapham, K., Blackburn, E., & Whooley, M. A. (2010) · PLoS ONE · doi:10.1371/journal.pone.0008612 · Cited by 203
The association between telomere length, physical health, cognitive ageing, and mortality in non-demented older people
Harris, S. E., Deary, I. J., MacIntyre, A., Lamb, K. J., Radhakrishnan, K., Starr, J. M., Whalley, L. J., & Shiels, P. G. (2006) · Neuroscience Letters · doi:10.1016/j.neulet.2006.07.055 · Cited by 200
Short telomere length, myocardial infarction, ischemic heart disease, and early death
Weischer, M., Bojesen, S. E., Cawthon, R. M., Freiberg, J. J., Tybjærg-Hansen, A., & Nordestgaard, B. G. (2012) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.111.237271 · Cited by 197
Influences on the reduction of relative telomere length over 10 years in the population-based Bruneck Study: introduction of a well-controlled high-throughput assay
Ehrlenbach, S., Willeit, P., Kiechl, S. J., Willeit, J., Reindl, M., Schanda, K., Kronenberg, F., & Kloss‐Brandstätter, A. (2009) · International Journal of Epidemiology · doi:10.1093/ije/dyp273 · Cited by 195
Telomere Length Is Associated With Obesity Parameters but With a Gender Difference
Nordfjäll, K., Eliasson, M., Stegmayr, B., Melander, O., Nilsson, P. M., & Roos, G. (2008) · Obesity · doi:10.1038/oby.2008.413 · Cited by 188
Blood leucocyte telomere DNA content predicts vascular telomere DNA content in humans with and without vascular disease
Wilson, W. R. W., Herbert, K. E., Mistry, Y., Stevens, S. E., Patel, H. R., Hastings, R. A., Thompson, M. M., & Williams, B. (2008) · European Heart Journal · doi:10.1093/eurheartj/ehn386 · Cited by 185
Dietary patterns, food groups, and telomere length in the Multi-Ethnic Study of Atherosclerosis (MESA)
Nettleton, J. A., Diez-Roux, A., Jenny, N. S., Fitzpatrick, A. L., & Jacobs, D. R. (2008) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.2008.26429 · Cited by 184
Breast Cancer Survival Is Associated with Telomere Length in Peripheral Blood Cells
Svenson, U., Nordfjäll, K., Stegmayr, B., Manjer, J., Nilsson, P. M., Tavelin, B., Henriksson, R., Lenner, P., & Roos, G. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-6497 · Cited by 179
Paternal age at birth is an important determinant of offspring telomere length
Meyer, T. D., Rietzschel, E. R., Buyzere, M. D., Bacquer, D. D., Criekinge, W. V., Backer, G. D., Gillebert, T. C., Oostveldt, P. V., Bekaert, S., & on behalf of the Asklepios investigators (2007) · Human Molecular Genetics · doi:10.1093/hmg/ddm271 · Cited by 179
Leukocyte telomere length is preserved with aging in endurance exercise-trained adults and related to maximal aerobic capacity
LaRocca, T. J., Seals, D. R., & Pierce, G. L. (2010) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2009.12.009 · Cited by 177
Shorter telomeres are associated with mortality in those withAPOEϵ4 and dementia
Honig, L. S., Schupf, N., Lee, J. H., Tang, M. X., & Mayeux, R. P. (2006) · Annals of Neurology · doi:10.1002/ana.20894 · Cited by 177
Mean leukocyte telomere length shortening and type 2 diabetes mellitus: a case-control study
Zee, R. Y. L., Castonguay, A. J., Barton, N. S., Germer, S., & Martin, M. (2009) · Translational research · doi:10.1016/j.trsl.2009.09.012 · Cited by 169
Telomere length in leukocytes correlates with bone mineral density and is shorter in women with osteoporosis
Valdes, A. M., Richards, J. B., Gardner, J. P., Swaminathan, R., Kimura, M., Xiaobin, L., Aviv, A., & Spector, T. D. (2007) · Osteoporosis International · doi:10.1007/s00198-007-0357-5 · Cited by 164
Short Telomere Length and Breast Cancer Risk: A Study in Sister Sets
Shen, J., Terry, M. B., Gurvich, I., Liao, Y., Senie, R. T., & Santella, R. M. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-3490 · Cited by 157
Telomere length of patients with major depression is shortened but independent from therapy and severity of the disease
Hartmann, N., Boehner, M., Groenen, F., & Kalb, R. (2010) · Depression and Anxiety · doi:10.1002/da.20749 · Cited by 156
Sex-specific telomere length profiles and age-dependent erosion dynamics of individual chromosome arms in humans
Mayer, S., Brüderlein, S., Perner, S., Waibel, I., Holdenried, A., Ciloglu, N., Hasel, C., Mattfeldt, T., Nielsen, K. V., & Möller, P. (2006) · Cytogenetic and Genome Research · doi:10.1159/000089870 · Cited by 156
Annual Ambient Black Carbon Associated with Shorter Telomeres in Elderly Men: Veterans Affairs Normative Aging Study
McCracken, J., Baccarelli, A., Hoxha, M., Dioni, L., Melly, S. J., Coull, B. A., Suh, H. H., Vokonas, P., & Schwartz, J. D. (2010) · Environmental Health Perspectives · doi:10.1289/ehp.0901831 · Cited by 140
Telomeres, sex, reactive oxygen species, and human cardiovascular aging
Aviv, A. (2002) · Journal of Molecular Medicine · doi:10.1007/s00109-002-0377-8 · Cited by 138
Telomere length is age-dependent and reduced in monocytes of Alzheimer patients
Hochstrasser, T., Marksteiner, J., & Humpel, C. (2011) · Experimental Gerontology · doi:10.1016/j.exger.2011.11.012 · Cited by 132
Telomere length in small‐for‐gestational‐age babies
Akkad, A., Hastings, R., Konje, J., Bell, S., Thurston, H., & Williams, B. (2006) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.2005.00839.x · Cited by 131
Effects of estrogens and androgens on erythrocyte antioxidant superoxide dismutase, catalase and glutathione peroxidase activities during the menstrual cycle
Massafra, C., Gioia, D., Felice, C. D., Picciolini, E., Leo, V. D., Bonifazi, M., & Bernabei, A. (2000) · Journal of Endocrinology · doi:10.1677/joe.0.1670447 · Cited by 130
A Prospective Study of Relative Telomere Length and Postmenopausal Breast Cancer Risk
Vivo, I. D., Prescott, J., Wong, J. Y. Y., Kraft, P., Hankinson, S. E., & Hunter, D. J. (2009) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-08-0998 · Cited by 129
Association of Leukocyte Telomere Length With Circulating Biomarkers of the Renin-Angiotensin-Aldosterone System
Vasan, R. S., Demissie, S., Kimura, M., Cupples, L. A., Rifai, N., White, C. C., Wang, T. J., Gardner, J. P., Cao, X., Benjamin, E. J., et al. (2008) · Circulation · doi:10.1161/circulationaha.107.731794 · Cited by 122
Telomere length and reproductive aging
Hanna, C. W., Bretherick, K. L., Gair, J., Fluker, M. R., Stephenson, M. D., & Robinson, W. P. (2009) · Human Reproduction · doi:10.1093/humrep/dep007 · Cited by 121
Oxidative stress, chronic inflammation, and telomere length in patients with periodontitis
Masi, S., Salpea, K. D., Li, K., Parkar, M., Nibali, L., Donos, N., Patel, K., Taddei, S., Deanfield, J. E., D’Aiuto, F., et al. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2010.12.031 · Cited by 118
Leukocyte telomere length is associated with cognitive performance in healthy women
Valdes, A. M., Deary, I. J., Gardner, J., Kimura, M., Lu, X., Spector, T. D., Aviv, A., & Cherkas, L. F. (2008) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2008.07.012 · Cited by 118
Shorter telomeres are associated with obesity and weight gain in the elderly
study, F. T. H. A., Njajou, O. T., Cawthon, R., Blackburn, E. H., Harris, T. B., Li, R., Sanders, J. L., Newman, A. B., Nalls, M. A., Cummings, S. R., et al. (2011) · International Journal of Obesity · doi:10.1038/ijo.2011.196 · Cited by 114
Effect of Long-Term Hormone Therapy on Telomere Length in Postmenopausal Women
Lee, D., Im, J., Kim, J., Lee, H.-R., & Shim, J. (2005) · Yonsei Medical Journal · doi:10.3349/ymj.2005.46.4.471 · Cited by 114
Telomere length and progression of diabetic nephropathy in patients with type 1 diabetes
Fyhrquist, F., Tiitu, A., Saijonmaa, O., Forsblom, C. M., Groop, P., & on behalf of the FinnDiane Study Group (2009) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2009.02139.x · Cited by 112
Genome-Wide Association Study of Relative Telomere Length
Prescott, J., Kraft, P. L., Chasman, D. I., Savage, S. A., Mirabello, L. J., Berndt, S. I., Weissfeld, J. L., Han, J., Hayes, R. B., Chanock, S. J., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0019635 · Cited by 112
Large-scale parent–child comparison confirms a strong paternal influence on telomere length
Nordfjäll, K., Svenson, U., Norrback, K., Adolfsson, R., & Roos, G. (2009) · European Journal of Human Genetics · doi:10.1038/ejhg.2009.178 · Cited by 110
Leukocyte telomere length is associated with complications of Type 2 diabetes mellitus
Testa, R., Olivieri, F., Sirolla, C., Spazzafumo, L., Rippo, M. R., Marra, M., Bonfigli, A. R., Ceriello, A., Antonicelli, R., Franceschi, C., et al. (2011) · Diabetic Medicine · doi:10.1111/j.1464-5491.2011.03370.x · Cited by 109
Association of Telomere Length in Older Men With Mortality and Midlife Body Mass Index and Smoking
Strandberg, T. E., Saijonmaa, O., Tilvis, R. S., Pitkälä, K. H., Strandberg, A. Y., Miettinen, T. A., & Fyhrquist, F. (2011) · The Journals of Gerontology Series A · doi:10.1093/gerona/glr064 · Cited by 109
Shorter Telomeres May Mark Early Risk of Dementia: Preliminary Analysis of 62 Participants from the Nurses' Health Study
Grodstein, F., van Oijen, M., Irizarry, M. C., Rosas, H. D., Hyman, B. T., Growdon, J. H., & De Vivo, I. (2008) · PLoS ONE · doi:10.1371/journal.pone.0001590 · Cited by 104
Longer Relative Telomere Length in Blood from Women with Sporadic and Familial Breast Cancer Compared with Healthy Controls
Gramatges, M. M., Telli, M. L., Balise, R. R., & Ford, J. M. (2010) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-09-0896 · Cited by 102
Shorter Leukocyte Telomere Length in Midlife Women with Poor Sleep Quality
Prather, A. A., Puterman, E., Lin, J., O'Donovan, A., Krauss, J., Tomiyama, A. J., Epel, E. S., & Blackburn, E. H. (2011) · Journal of Aging Research · doi:10.4061/2011/721390 · Cited by 100
Estimating age of humans based on telomere shortening
Tsuji, A., Ishiko, A., Takasaki, T., & Ikeda, N. (2002) · Forensic Science International · doi:10.1016/s0379-0738(02)00086-5 · Cited by 99
Telomere length and obesity
Zannolli, R., Mohn, A., Buoni, S., Pietrobelli, A., Messina, M., Chiarelli, F., & Miracco, C. (2008) · Acta Paediatrica · doi:10.1111/j.1651-2227.2008.00783.x · Cited by 98
Association of Longer Telomeres With Better Health in Centenarians
Terry, D. F., Nolan, V. G., Andersen, S. L., Perls, T. T., & Cawthon, R. (2008) · The Journals of Gerontology Series A · doi:10.1093/gerona/63.8.809 · Cited by 97
Telomere length is shorter in healthy offspring of subjects with coronary artery disease: support for the telomere hypothesis
Brouilette, S. W., Whittaker, A., Stevens, S. E., van der Harst, P., Goodall, A. H., & Samani, N. J. (2008) · Heart · doi:10.1136/hrt.2007.139675 · Cited by 96
Homocysteine levels and leukocyte telomere length
Richards, J. B., Valdes, A. M., Gardner, J. P., Kato, B. S., Siva, A., Kimura, M., Lu, X., Brown, M. J., Aviv, A., & Spector, T. D. (2008) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2007.12.035 · Cited by 95
Telomere length is associated with left ventricular function in the oldest old: the Newcastle 85+ study
Collerton, J. C., Martin-Ruiz, C. M., Kenny, R. A., Barrass, K., von Zglinicki, T., Kirkwood, T. B. L., Keavney, B. D., & the Newcastle 85 + Core Study Team (2006) · European Heart Journal · doi:10.1093/eurheartj/ehl437 · Cited by 92
Telomere length and risk of Parkinson's disease
Wang, H., Chen, H., Gao, X., McGrath, M., Deer, D., Vivo, I. D., Schwarzschild, M. A., & Ascherio, A. (2007) · Movement Disorders · doi:10.1002/mds.21867 · Cited by 87
Association of shorter mean telomere length with risk of incident myocardial infarction: A prospective, nested case–control approach
Zee, R. Y. L., Michaud, S. E., Germer, S., & Ridker, P. M. (2009) · Clinica Chimica Acta · doi:10.1016/j.cca.2009.02.004 · Cited by 87
Leukocyte telomere shortening in elderly Type2DM patients with previous myocardial infarction
Olivieri, F., Lorenzi, M., Antonicelli, R., Testa, R., Sirolla, C., Cardelli, M., Mariotti, S., Marchegiani, F., Marra, M., Spazzafumo, L., et al. (2009) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2009.03.034 · Cited by 87
No association between socio‐economic status and white blood cell telomere length
Adams, J. M., Martin-Ruiz, C. M., Pearce, M. S., White, M. J., Parker, L., & von Zglinicki, T. (2006) · Aging Cell · doi:10.1111/j.1474-9726.2006.00258.x · Cited by 85
A Percentage Analysis of the Telomere Length in Parkinson's Disease Patients
Guan, J. Z., Maeda, T., Sugano, M., Oyama, J.-I., Higuchi, Y., Suzuki, T., & Makino, N. (2008) · The Journals of Gerontology Series A · doi:10.1093/gerona/63.5.467 · Cited by 84
Low-dose persistent organic pollutants increased telomere length in peripheral leukocytes of healthy Koreans
Shin, J., Choi, Y.-Y., Jeon, H., Hwang, J. H., Kim, S.-A., Kang, J., Chang, Y., Jacobs, D. R., Park, J. Y., & Lee, D.-H. (2010) · Mutagenesis · doi:10.1093/mutage/geq035 · Cited by 84
Shortening of telomeres in recipients of both autologous and allogeneic hematopoietic stem cell transplantation
Akiyama, M., Asai, O., Kuraishi, Y., Urashima, M., Hoshi, Y., Sakamaki, H., Yabe, H., Furukawa, T., Yamada, O., Mizoguchi, H., et al. (2000) · Bone Marrow Transplantation · doi:10.1038/sj.bmt.1702144 · Cited by 83
The use of telomere length in ecology and evolutionary biology
Horn, T., Robertson, B. C., & Gemmell, N. J. (2010) · Heredity · doi:10.1038/hdy.2010.113 · Cited by 81
A genome-wide association study identifies a novel locus on chromosome 18q12.2 influencing white cell telomere length
Mangino, M., Richards, J. B., Soranzo, N., Zhai, G., Aviv, A., Valdes, A. M., Samani, N. J., Deloukas, P., & Spector, T. D. (2009) · Journal of Medical Genetics · doi:10.1136/jmg.2008.064956 · Cited by 80
Leukocyte telomere length is associated with HDL cholesterol levels: The Bogalusa heart study
Chen, W., Gardner, J. P., Kimura, M., Brimacombe, M. B., Cao, X., Srinivasan, S. R., Berenson, G. S., & Aviv, A. (2009) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2009.01.021 · Cited by 78
Telomere length changes in patients undergoing hematopoietic stem cell transplantation
Lee, J., Kook, H., Chung, I.-J., Kim, H., Park, M. R., Kim, C., Nah, J., & Hwang, T. (1999) · Bone Marrow Transplantation · doi:10.1038/sj.bmt.1701923 · Cited by 77
Telomere shortening in sleep apnea syndrome
Barceló, A., Piérola, J., López‐Escribano, H., de la Peña, M., Soriano, J. B., Alonso‐Fernández, A., Ladaria, A., & Agustí, A. G. N. (2010) · Respiratory Medicine · doi:10.1016/j.rmed.2010.03.025 · Cited by 74
Reduction of leucocyte telomere length in radiographic hand osteoarthritis: a population-based study
Zhai, G., Aviv, A., Hunter, D. J., Hart, D. J., Gardner, J. P., Kimura, M., Lu, X., Valdes, A. M., & Spector, T. D. (2006) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2006.056903 · Cited by 72
Study of telomere length and different markers of oxidative stress in patients with Parkinson's disease
Watfa, G., Dragonas, C., Brosche, T., Dittrich, R., Sieber, C. C., Alecu, C., Bénétos, A., & Nzietchueng, R. (2010) · The journal of nutrition health & aging · doi:10.1007/s12603-010-0275-7 · Cited by 70
Telomere length and its associations with oxidized-LDL carotid artery distensibility and smoking
Staessen, J. A. (2010) · Frontiers in Bioscience-Elite · doi:10.2741/e176 · Cited by 69
Association of Leukocyte Telomere Length With Echocardiographic Left Ventricular Mass
Vasan, R. S., Demissie, S., Kimura, M., Cupples, L. A., White, C. C., Gardner, J. P., Cao, X., Levy, D. A., Benjamin, E. J., & Aviv, A. (2009) · Circulation · doi:10.1161/circulationaha.109.853895 · Cited by 69
Higher circulating levels of IGF-1 are associated with longer leukocyte telomere length in healthy subjects
Barbieri, M., Paolisso, G., Kimura, M., Gardner, J. P., Boccardi, V., Papa, M., Hjelmborg, J., Christensen, K., Brimacombe, M. B., Nawrot, T. S., et al. (2009) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2009.10.002 · Cited by 66
Shared environmental factors associated with telomere length maintenance in elderly male twins
Huda, N., Tanaka, H., Herbert, B., Reed, T., & Gilley, D. P. (2007) · Aging Cell · doi:10.1111/j.1474-9726.2007.00330.x · Cited by 66
Common variants near TERC are associated with leukocyte telomere length in the Chinese Han population
Shen, Q., Zhang, Z., Yu, L., Cao, L., Zhou, D., Kan, M., Li, B., Zhang, D., He, L., & Liu, Y. (2011) · European Journal of Human Genetics · doi:10.1038/ejhg.2011.4 · Cited by 65
Telomere Shortening of Peripheral Blood Mononuclear Cells in Coronary Disease Patients with Metabolic Disorders.
Obana, N., Takagi, S., Kinouchi, Y., Tokita, Y., Sekikawa, A., Takahashi, S., Hiwatashi, N., Oikawa, S., & Shimosegawa, T. (2003) · Internal Medicine · doi:10.2169/internalmedicine.42.150 · Cited by 63
Mean Telomere Length and Risk of Incident Colorectal Carcinoma: A Prospective, Nested Case-Control Approach
Zee, R. Y. L., Castonguay, A. J., Barton, N. S., & Buring, J. E. (2009) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-09-0360 · Cited by 61
Telomere length in vascular tissues from patients with atherosclerotic disease
Nzietchueng, R., Elfarra, M., Nloga, J., Labat, C., Carteaux, J., Maureira, P., Lacolley, P. J., Villemot, J., & Benetos, A. (2011) · The journal of nutrition health & aging · doi:10.1007/s12603-011-0029-1 · Cited by 58
Novel estrogens and their radical scavenging effects, iron-chelating, and total antioxidative activities: 17α-substituted analogs of Δ9(11)-dehydro-17β-estradiol
Römer, W., Oettel, M., Menzenbach, B., Droescher, P., & Schwarz, S. (1997) · Steroids · doi:10.1016/s0039-128x(97)00068-8 · Cited by 57
Leukocytes of exceptionally old persons display ultra-short telomeres
Kimura, M., Barbieri, M., Gardner, J. P., Skurnick, J., Cao, X., van Riel, N. A. W., Rizzo, M. R., Paoliso, G., & Aviv, A. (2007) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00615.2007 · Cited by 57
Telomere Length in Human Adults and High Level Natural Background Radiation
Das, B., Saini, D., & Seshadri, M. (2009) · PLoS ONE · doi:10.1371/journal.pone.0008440 · Cited by 56
Telomere length and type 2 diabetes in males, a premature aging syndrome
Murillo-Ortiz, B. O., Albarrán-Tamayo, F., Arenas-Aranda, D. J., Benı́tez-Bribiesca, L., Malacara, J. M., Martı́nez-Garza, S., Hernández-González, M. A., Solorio, S., Garay‐Sevilla, M. E., & Mora-Villalpando, C. (2011) · The Aging Male · doi:10.3109/13685538.2011.593658 · Cited by 55
Change in the telomere length distribution with age in the Japanese population
Guan, J. Z., Maeda, T., Sugano, M., Oyama, J., Higuchi, Y., & Makino, N. (2007) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-007-9518-2 · Cited by 55
Leukocyte telomere length is associated with measures of subclinical atherosclerosis
Panayiotou, A. G., Nicolaides, A. N., GRIFFIN, M. B., Tyllis, T., Georgiou, N., Bond, D., Martin, R. M., Hoppensteadt, D., Fareed, J., & Humphries, S. E. (2010) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2010.01.037 · Cited by 54
Association Between Left Ventricular Mass and Telomere Length in a Population Study
Kuznetsova, T., Codd, V., Brouilette, S., Thijs, L., González, A., Jin, Y., Richart, T., van der Harst, P., Dı́ez, J., Staessen, J. A., et al. (2010) · American Journal of Epidemiology · doi:10.1093/aje/kwq142 · Cited by 54
Telomere Length and Mental Well-Being in Elderly Men from the Netherlands and Greece
Ottenheim, N. R., Houben, J. M. J., Kromhout, D., Kafatos, A., van der Mast, R. C., Zitman, F. G., Geleijnse, J. M., Hageman, G. J., & Giltay, E. J. (2011) · Behavior Genetics · doi:10.1007/s10519-011-9498-6 · Cited by 49
Leukocyte Telomere Length Is Associated with Disability in Older U.S. Population
Risques, R. A., Arbeev, K. G., Yashin, A. I., Ukraintseva, S. V., Martin, G. M., Rabinovitch, P. S., & Oshima, J. (2010) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2010.02948.x · Cited by 48
No Evidence for Shorter Leukocyte Telomere Length in Parkinson's Disease Patients
Eerola, J., Kananen, L., Manninen, K., Hellström, O., Tienari, P. J., & Hovatta, I. (2010) · The Journals of Gerontology Series A · doi:10.1093/gerona/glq125 · Cited by 47
Leukocyte telomere length and marital status among middle-aged adults
Mainous, A. G., Everett, C. J., Díaz, V. A., Baker, R., Mangino, M., Codd, V., & Samani, N. J. (2010) · Age and Ageing · doi:10.1093/ageing/afq118 · Cited by 47
No Association Between Physical Activity and Telomere Length in an Elderly Chinese Population 65 Years and Older
Woo, J., Tang, N. L. S., & Leung, J. C. S. (2008) · Archives of Internal Medicine · doi:10.1001/archinte.168.19.2163 · Cited by 46
Association of shorter mean telomere length with large artery stiffness in patients with coronary heart disease
Wang, Y., Chen, A.-F., Wang, H.-Z., Li-yan, X., Sui, K., & Zhang, Q.-Y. (2010) · The Aging Male · doi:10.3109/13685538.2010.529196 · Cited by 45
Telomerase activity and telomere length of peripheral blood mononuclear cells in SLE patients
Kurosaka, D., Yasuda, J., Yoshida, K., Yokoyama, T., Ozawa, Y., Obayashi, Y., Kingetsu, I., Saitô, S., & Yamada, A. (2003) · Lupus · doi:10.1191/0961203303lu426oa · Cited by 43
Cognitive performance and leukocyte telomere length in two narrow age-range cohorts: a population study
Mather, K. A., Jorm, A. F., Anstey, K. J., Milburn, P. J., Easteal, S., & Christensen, H. M. (2010) · BMC Geriatrics · doi:10.1186/1471-2318-10-62 · Cited by 42
Telomere shortening and haemodialysis
Boxall, M. C., Goodship, T. H. J., Brown, A. L., Ward, M. C., & von Zglinicki, T. (2006) · Blood Purification · doi:10.1159/000090517 · Cited by 41
Older men with higher self-rated socioeconomic status have shorter telomeres
Woo, J., Suen, E., Leung, J. C. S., Tang, N. L. S., & Ebrahim, S. B. J. (2009) · Age and Ageing · doi:10.1093/ageing/afp098 · Cited by 41
Is telomere length in peripheral blood lymphocytes correlated with cancer susceptibility or radiosensitivity?
Barwell, J., Pangon, L., Georgiou, A., Docherty, Z., Kesterton, I., Ball, J., Camplejohn, R. S., Berg, J., Aviv, A., Gardner, J. P., et al. (2007) · British Journal of Cancer · doi:10.1038/sj.bjc.6604085 · Cited by 40
Aging-Related Alterations of Subtelomeric Methylation in Sarcoidosis Patients
Maeda, T., Guan, J. Z., Higuchi, Y., Oyama, J.-I., & Makino, N. (2009) · The Journals of Gerontology Series A · doi:10.1093/gerona/glp049 · Cited by 40
Telomere Length Among the Elderly and Oldest-Old
Bischoff, C., Graakjær, J., Petersen, H. C., Jeune, B., Bohr, V. A., Kølvraa, S., & Christensen, K. (2005) · Twin Research and Human Genetics · doi:10.1375/twin.8.5.425 · Cited by 39
Relative Leukocyte Telomere Length and Risk of Incident Ischemic Stroke in Men: A Prospective, Nested Case-Control Approach
Zee, R. Y. L., Castonguay, A. J., Barton, N. S., & Ridker, P. M. (2010) · Rejuvenation Research · doi:10.1089/rej.2009.0975 · Cited by 38
Telomere shortening in peripheral blood cells was related with aging but not with white blood cell count
Satoh, H., Hiyama, K., Takeda, M., Awaya, Y., Watanabe, K., Ihara, Y., Maeda, H., Ishioka, S., & Yamakido, M. (1996) · The Japanese Journal of Human Genetics · doi:10.1007/bf01876332 · Cited by 35
An Analysis of Telomere Length in Sarcoidosis
Guan, J. Z., Maeda, T., Sugano, M., Oyama, J.-I., Higuchi, Y., Suzuki, T., & Makino, N. (2007) · The Journals of Gerontology Series A · doi:10.1093/gerona/62.11.1199 · Cited by 34
The effect of telomere length, a marker of biological aging, on bone mineral density in elderly population
Tang, N. L. S., Woo, J., Suen, E., Liao, C. D., Leung, J. C. S., & Leung, P. (2009) · Osteoporosis International · doi:10.1007/s00198-009-0948-4 · Cited by 32
Telomere Dysfunction–Related Serological Markers Are Associated With Type 2 Diabetes
Xiao, F., Zheng, X., Cui, M., Shi, G., Chen, X., Li, R., Song, Z., Rudolph, K. L., Chen, B., & Ju, Z. (2011) · Diabetes Care · doi:10.2337/dc10-2431 · Cited by 32
Serum Insulin-Like Growth Factor-I Concentration Is Associated with Leukocyte Telomere Length in a Population-Based Cohort of Elderly Men
Movérare‐Skrtic, S., Svensson, J., Karlsson, M. K., ORWOLL, E. S., Ljunggren, Ö., Mellström, D., & Ohlsson, C. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-1450 · Cited by 31
Insulin-Like Growth Factors and Leukocyte Telomere Length: The Cardiovascular Health Study
Kaplan, R. C., Fitzpatrick, A. L., Pollak, M., Gardner, J. P., Jenny, N. S., McGinn, A. P., Kuller, L. H., Strickler, H. D., Kimura, M., Psaty, B. M., et al. (2009) · The Journals of Gerontology Series A · doi:10.1093/gerona/glp036 · Cited by 31
Age-Related Changes in Subtelomeric Methylation in the Normal Japanese Population
Maeda, T., Guan, J. Z., Oyama, J.-I., Higuchi, Y., & Makino, N. (2009) · The Journals of Gerontology Series A · doi:10.1093/gerona/gln057 · Cited by 31
Aldosterone and Telomere Length in White Blood Cells
Benetos, A., Gardner, J. P., Kimura, M., Labat, C., Nzietchueng, R., Dousset, B., Zannad, F. M., Lacolley, P. J., & Aviv, A. (2005) · The Journals of Gerontology Series A · doi:10.1093/gerona/60.12.1593 · Cited by 28
Lower red blood cell counts in middle‐aged subjects with shorter peripheral blood leukocyte telomere length
Meyer, T. D., Buyzere, M. D., Langlois, M. R., Rietzschel, E. R., Cassiman, P., Bacquer, D. D., Oostveldt, P. V., Backer, G. D., Gillebert, T. C., Criekinge, W. V., et al. (2008) · Aging Cell · doi:10.1111/j.1474-9726.2008.00419.x · Cited by 27
Telomere Length in Leukocytes and Cultured Gingival Fibroblasts from Patients with Aggressive Periodontitis
Takahashi, K., Nishida, H., Takeda, H., & Shin, K. (2004) · Journal of Periodontology · doi:10.1902/jop.2004.75.1.84 · Cited by 26
Telomere length and anaemia in old age: results from the Newcastle 85-plus Study* and the Leiden 85-plus Study
den Elzen, W. P. J., Martin-Ruiz, C. M., von Zglinicki, T., Westendorp, R. G. J., Kirkwood, T. B. L., & Gussekloo, J. (2011) · Age and Ageing · doi:10.1093/ageing/afr048 · Cited by 17
In vitro and in vivo reconstitution and stability of vertebrate chromosome ends
Li, L., Lejnine, S., Макаров, В. Л., & Langmore, J. P. (1998) · Nucleic Acids Research · doi:10.1093/nar/26.12.2908 · Cited by 16
Analysis of telomere dynamics in peripheral blood cells from patients with Lynch syndrome
Bozzao, C., Lastella, P., de Leòn, M. P., Pedroni, M., Gregorio, C. D., D'Ovidio, F. D., Resta, N., Prete, F., Guanti, G., & Stella, A. (2011) · Cancer · doi:10.1002/cncr.26022 · Cited by 14
Shorter Telomere Length in Peripheral Blood Cells Associated With Migraine in Women
Ren, H., Collins, V., Fernandez, F., Quinlan, S., Griffiths, L. R., & Choo, K. H. A. (2010) · Headache The Journal of Head and Face Pain · doi:10.1111/j.1526-4610.2010.01693.x · Cited by 11
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Authors: Müezzinler, A., Zaineddin, A. K., & Brenner, H.
Affiliations: German Cancer Research Center (DE)
Corresponding author: Müezzinler, Aysel
ORCID: Brenner, Hermann
Venue: Ageing Research Reviews
Publisher: Elsevier BV
Published: 2013-03
Volume: 12
Issue: 2
Pages: 509-519
ISSN: 1568-1637 (ISSN-L)
DOI: 10.1016/j.arr.2013.01.003
OpenAlex: W2000059391
Cited by: 474
References: 165
Citations by year: 2026: 14 · 2025: 19 · 2024: 34 · 2023: 31 · 2022: 49 · 2021: 41 · 2020: 46 · 2019: 60 · 2018: 36 · 2017: 49 · 2016: 38 · 2015: 28 · 2014: 23 · 2013: 5
FWCI: 3.45
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Ageing Research Reviews (publishedVersion)
PubMed (publishedVersion)
Funders: European Commission
Klaus Tschira Stiftung
Hellenic Health Foundation
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
Keywords: leukocyte telomere length, aging, telomere shortening, age-related telomere shortening, adults, sex differences
MeSH terms: Age Factors, Aged, Aged, 80 and over, Aging, Cross-Sectional Studies, Humans, Leukocytes, Longitudinal Studies, Middle Aged, Linear Models, Telomere Homeostasis, Telomere Shortening

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A systematic review of leukocyte telomere length and age in adults

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