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Cited by 300

The DOI matches its Crossref record; 85 of the 85 references it cites were found in a registry or an index.

Intervertebral disc ageing and degeneration: The antiapoptotic effect of oestrogen

Yang, Sidong, Zhang, Feng, Ma, Jiangtao, Ding, Wenyuan·2020·Ageing Research Reviews
DOI 10.1016/j.arr.2019.100978
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Abstract

As an important part of the spinal column, the intervertebral disc (IVD) plays an important role in the intervertebral juncture and spinal movement in general. IVD degeneration (IVDD), which mimics disc ageing but at an accelerated rate, is a common and chronic process that results in severe spinal symptoms, such as lower back pain. It is generally assumed that lower back pain caused by IVDD can also develop secondary conditions, including spinal canal stenosis, spinal segmental instability, osteophyte formation, disc herniation and spinal cord and nerve root compression. Over the past few years, many researchers around the world have widely studied the relevance between oestrogen and IVDD, indicating that oestrogen can effectively alleviate IVDD development by inhibiting the apoptosis of IVD cells. Oestrogen can decrease IVD cell apoptosis in multiple ways, including the inhibition of the inflammatory cytokines IL-1β and TNF-α, reducing catabolism because of inhibition of matrix metalloproteinases, upregulating integrin α2β1 and IVD anabolism, activating the PI3K/Akt pathway, decreasing oxidative damage and promoting autophagy. In this article, we perform an overview of the literature regarding the antiapoptotic effect of oestrogen in IVDD.

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Metadata

Authors
Yang, S., Zhang, F., Ma, J., & Ding, W.
Venue
Ageing Research Reviews
Publisher
Elsevier BV
Published
2020-01
Volume
57
Pages
100978
ISSN
1568-1637 (ISSN-L)
DOI
10.1016/j.arr.2019.100978
OpenAlex
W2981923807
Cited by
300
References
85
FWCI
7.24
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Intervertebral disc ageing and degeneration: The antiapoptotic effect of oestrogen. https://app.cochat.ai/papers/10.1016/j.arr.2019.100978
The paper
Yang, S., Zhang, F., Ma, J., & Ding, W. (2020). Intervertebral disc ageing and degeneration: The antiapoptotic effect of oestrogen. Ageing Research Reviews. https://doi.org/10.1016/j.arr.2019.100978

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.