Cited by 583Antioxidant Activity and Oxidative StressExercise and Physiological ResponsesGenetics, Aging, and Longevity in Model Organisms

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Ageing, age-related diseases and oxidative stress: What to do next?

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Luo, Jiao, Mills, Kevin, le Cessie, Saskia, Noordam, Raymond, van Heemst, Diana·2020·Ageing Research Reviews

DOI 10.1016/j.arr.2019.100982

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Abstract

Among other mechanisms, oxidative stress has been postulated to play an important role in the rate of ageing. Oxidative damage contributes to the hallmarks of ageing and essential components in pathological pathways which are thought to drive multiple age-related diseases. Nonetheless, results from studies testing the hypothesis of oxidative stress in ageing and diseases showed controversial results. While observational studies mainly found detrimental effects of high oxidative stress levels on disease status, randomized clinical trials examining the effect of antioxidant supplementation on disease status generally showed null effects. However, re-evaluations of these counterinitiative observations are required considering the lack of reliability and specificity of traditionally used biomarkers for measuring oxidative stress. To facilitate these re-evaluations, this review summarizes the basic knowledge of oxidative stress and the present findings regarding the role of oxidative damage in ageing and age-related diseases. Meanwhile, two approaches are highlighted, namely proper participants selection, together with the development of reliable biomarkers. We propose that oxidized vitamin E metabolites may be used to accurately monitor individual functional antioxidant level, which might serve as promising key solutions for future elucidating the impact of oxidative stress on ageing and age-related diseases.

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Authors: Luo, J., Mills, K., le Cessie, S., Noordam, R., & van Heemst, D.
Affiliations: Leiden University Medical Center (NL)
Great Ormond Street Hospital (GB)
ORCID: Luo, Jiao
Mills, Kevin
Noordam, Raymond
Venue: Ageing Research Reviews
Publisher: Elsevier BV
Published: 2020-01
Volume: 57
Pages: 100982
ISSN: 1568-1637 (ISSN-L)
DOI: 10.1016/j.arr.2019.100982
OpenAlex: W2985538915
Cited by: 581
References: 237
Citations by year: 2026: 53 · 2025: 90 · 2024: 109 · 2023: 115 · 2022: 105 · 2021: 79 · 2020: 29
FWCI: 5.16
Type: journal article
Language: en
Open access: green
hdl.handle.net
Licence: cc-by
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Ageing Research Reviews (publishedVersion)
PubMed (publishedVersion)
Leiden Repository (Leiden University) (submittedVersion, cc-by)
Data Archiving and Networked Services (DANS) (submittedVersion, cc-by)
UCL Discovery (University College London) (submittedVersion)
Funders: Velux Stiftung (1156)
Topics: Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
Health Sciences › Medicine › Physiology (medical) › Exercise and Physiological Responses
Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Keywords: oxidative stress, aging, age-related diseases, oxidative damage, antioxidant supplementation, oxidative stress biomarkers
MeSH terms: Aging, Animals, Antioxidants, Humans, Sensitivity and Specificity, Reproducibility of Results, Biomarkers, Oxidative Stress

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Ageing, age-related diseases and oxidative stress: What to do next?

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